Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions by Martin Perreault, Ewa Wunsch, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Guy G. Poirier, Piotr Milkiewicz, Olivier Barbier

“…Using liquid chromatography coupled to tandem mass spectrometry, 11 BA glucuronide (-G) species were quantified in prebiliary and postbiliary stenting serum and urine samples from 17 patients with biliary obstruction. Stenting caused glucuronide- and fluid-specific changes in BA-G levels and BA-G/BA metabolic ratios. …”
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From tumor microenvironment to ocular hypertension: unraveling the pathogenesis and therapeutic strategies of cancer-related glaucoma by Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li

“…Mechanisms include mechanical obstruction, secondary angle closure, neovascularization, inflammation and cytokine release, alterations in aqueous humor dynamics, and secondary hemosiderosis. …”
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Treating overactive bladder symptoms after transurethral prostatic surgery for benign prostatic hyperplasia – Which medication to choose? by Cheng-Ling Lee, Hann-Chorng Kuo

“…Two patients in the solifenacin group developed urinary retention. However, the changes of variables at 4 weeks postoperatively were insignificant among the three groups. …”
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Respiratory oscillometry in individuals with fibrodysplasia ossificans progressiva by Anastasiia Vasileva, Joyce K. Y. Wu, Melissa Valaee, Ethan Ortiz, Zoltán Hantos, Lianne Tile, Irene Ho, Angela M. Cheung, Chung-Wai Chow

“…Oscillometry revealed significant diversity in respiratory mechanics and chest wall involvement from normal, airway obstruction and ventilatory inhomogeneity to extra-thoracic airflow obstruction. …”
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Study on the Effect of Deadman State on Blast Furnace Hearth Erosion Based on Solidification and Melting Model by Fei Yuan, Liangyu Chen, Lei Wang, Lei Zhao, Yan Zhong

“…The deadman, located within the hearth, poses a significant obstruction to the flow of molten iron. Changes in the state of the deadman directly affect the flow and discharge behavior of molten iron within the hearth, subsequently influencing the lifespan of the hearth. …”
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Expansion of genotypic and phenotypic findings in ADAMTS18-related ocular pathology by Ari H. August, Rebecca A. Procopio, Christopher J. Rapuano, José S. Pulido

“…Observations: A 37-year-old male with a history of bilateral congenital nasolacrimal duct obstruction, dry eye syndrome, mild myopia, and accommodative esotropia presented to the Retina Service. …”
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Project quality, regulation quality by Elena Mussinelli

“…Regulatory systems are increasingly pervasive in regulating design activity and the characteristics of works in response to a general «increase in the variety and complexity of public interests that appear worthy of protection, such as the quality of the environment, the safeguarding of the natural and historical-artistic heritage, the protection of health, the safety of persons, and security […]» (Bassanini et al., 2005). Changing interests require frequent updates to adapt regulations to rapid socio-economic, cultural, and technological changes. …”
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Gallbladder hemorrhage associated with segmental arterial mediolysis: a case report by Yuichi Hirose, Yusuke Tajima, Hiroki Sakata, Toshimasa Uekusa, Kentaro Kamada, Takashi Ikehara, Izuru Matsuda, Satomi Yoneyama, Akio Hidemura, Hiroyuki Suzuki

“…He was diagnosed with gallbladder hemorrhage and bile duct obstruction. We performed a laparoscopic cholecystectomy after endoscopic biliary drainage. …”
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Beyond Static Estimates: Dynamic Simulation of Fire–Evacuation Interaction in Historical Districts by Zhi Yue, Zhe Ma, Di Yao, Yue He, Linglong Gu, Shizhong Jing

“…Dynamic simulations of 16 scenarios reveal critical spatial impacts: within 30 min, ≥28% of streets became impassable, with central ignition points causing faster obstructions. Static models underestimate evacuation durations by up to 135%, neglecting early stage congestions and detours caused by high-temperature zones. …”
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Assessment of perfusion of free flaps used in head and neck reconstruction using pulsatility index by Akshay Kapoor, Malay Karmakar, Collin Roy, Kaushal Priya Anand

“…Objective: To detect venous or arterial obstruction in the pedicle of a free flap we can monitor resistance in the flap bed which is reflected in Pulsatility Index (PI) Therefore if we detect change in the values of the PI in these flaps then we can detect complications in flap due to vascular insufficiency early. …”
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Effect of Droplet Contamination on Camera Lens Surfaces: Degradation of Image Quality and Object Detection Performance by Hyunwoo Kim, Yoseph Yang, Youngkwang Kim, Dong-Won Jang, Dongil Choi, Kang Park, Sangkug Chung, Daegeun Kim

“…To assess the effect on object detection, performance changes were evaluated across different detection algorithms. …”
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Rubus coreanus extract prevents kidney fibrosis through TGF-β/Smad pathway inhibition. by Wencheng Jin, Ara Cho, Bogyeong Cho, Nayeon Shin, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee, Jeonghwan Lee

“…In this study, we aimed to investigate the efficacy of water-soluble extract of Rubus coreanus (MN705) in preventing kidney fibrosis in a mouse model of unilateral ureteral obstruction (UUO) and in an in vitro model of TGF-β-challenged HK-2 cells. …”
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Patient with Jaundice, Dyspnea and Hyperferritinemia after COVID-19 by V. R. Grechishnikova, P. E. Tkachenko, M. S. Zharkova, T. P. Nekrasova, V. T. Ivashkin

“…Upon instrumental examination no signs of hepatosplenomegaly, biliary tree changes, intra- and extrahepatic obstruction were found. …”
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Diagnosis and treatment of sepsis-induced cardiomyopathy using hemosorption therapy: a case report by S. V. Dil, V. V. Kirilin, N. M. Ivanov, V. V. Ryabov

“…Emergency coronary angiography revealed no coronary obstruction. Two hours after admission, asystole was recorded with effective cardiopulmonary resuscitation, mechanical ventilation, infusion of inotropic and vasopressor drugs. …”
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Brain Functional Connectivity Significantly Improves After Surgical Eradication of Porto-Systemic Shunting in Pediatric Patients by Gianvincenzo Sparacia, Giuseppe Parla, Roberto Miraglia, Jean de Ville de Goyet

“…Purpose: Porto-systemic shunting (PSS) in patients with Abernethy malformation (AM) or obstruction of the portal vein (OVP) is often associated with normal liver parenchyma and hepatic function. …”
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Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. by Benjamin J Green, Surasa Wiriyachaiporn, Christopher Grainge, Geraint B Rogers, Valia Kehagia, Laurie Lau, Mary P Carroll, Kenneth D Bruce, Peter H Howarth

“…<h4>Background</h4>Molecular microbiological analysis of airway samples in asthma has demonstrated an altered microbiome in comparison to healthy controls. Such changes may have relevance to treatment-resistant severe asthma, particularly those with neutrophilic airway inflammation, as bacteria might be anticipated to activate the innate immune response, a process that is poorly steroid responsive. …”
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Adolescent and parental proxy online record access: analysis of the empirical evidence based on four bioethical principles by Josefin Hagström, Maria Hägglund, Charlotte Blease

“…Against these policy changes, scant attention has been paid to the ethical question about whether adolescents and parents should access the adolescent’s EHR, and if so, under what conditions. …”
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Role of JAK3 in the Pathogenesis of Oxidative Stress-Induced Kidney Fibrosis by Betty Pat, David W Johnson, Glenda C Gobe

“…JAK3 protein expression and localisation were investigated in kidneys using the unilateral ureteral obstruction (UUO) model (0–7 days, rats) of kidney fibrosis that involves oxidative stress. …”
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Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats by Yaoyao Zhu, Ge Lu, Weixin Li, Chenchen Su, Pengfei Du, Shuyou Wang, Li Yang, Huanfang Xu, Yigong Fang, Xiaojing Song

“…In addition, we investigated the ovarian functional changes post-ISF obstruction and evaluated the therapeutic effects of acupuncture on ovarian dysfunction in aged rats, both in unblocked and ISF-blockade conditions.ResultsFluorescence imaging revealed ISF transport along the linea alba, with tracers migrating linearly, a pattern abolished by surgical blockade. …”
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Effects of WSSV and ammonia nitrogen stress on the enzyme activity and transcriptome of Litopenaeus vannamei by Shan Gao, Linxin Dai, Yue Wang, Zuluan Liang, Yinhuan Zhou, Chengbo Sun

“…H&E staining revealed pathological changes in the intestinal tract induced by WSSV infection, ammonia nitrogen stress, and combined ammonia nitrogen and WSSV stress in L. vannamei. …”
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