Study on the protective effect of naringin-regulated lncRNA GAS5 against mitochondrial apoptosis in osteoarthritic chondrocytes by LIN Qin, ZHU Yingkai, LIN Yanming, LAN Shujie, CHEN Changxing, FU Changlong

“…In vitro experiments, Lenti-lncRNA GAS5 was used to infect sodium nitroprusside (SNP)-induced chondrocytes, and the expression of lncRNA GAS5 was detected by fluorescence in situ hybridization in rat chondrocytes; after silencing of lncRNA GAS5, the expression level of lncRNA GAS5 in rat chondrocytes was detected by Real-time PCR; Western blot detected the protein levels of Caspase-3, Bax, MMP-13 and Cyt-C.Results① Pathological changes of cartilage tissue: The articular cartilage matrix in naringenin group was relatively complete, the surface was relatively smooth, the structure was clear, the tide line was more complete, the number of chondrocytes was more full, the arrangement was more orderly, the cartilage staining was more uniform, and the structure was significantly restored than that in the model group. ② lncRNA GAS5 expression in cartilage tissue: Compared with model group, lncRNA GAS5 expression in naringin group was decreased (<italic>P</italic>&lt;0.01). ③ Expression of proteins related to mitochondrial apoptosis in cartilage tissues: Compared with model group, the expressions of Caspase-3, Bax, MMP-13 and Cyt-C in cartilage tissues of naringin group were decreased (<italic>P</italic>&lt;0.01). ④ Fluorescence expression of lncRNA GAS5 in chondrocytes: FISH results showed that the fluorescence expression of lncRNA GAS5 was decreased after naringin treatment of SNP-induced chondrocytes (<italic>P</italic>&lt;0.01). ⑤ The protein expressions of Caspase-3, Bax, MMP-13 and Cyt-C in chondrocytes: Compared with the model group, the protein expressions of Caspase-3, Bax, MMP-13 and Cyt-C in naringin group were significantly decreased (<italic>P</italic>&lt; 0.01). …”
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The Clinicopathological Features and Prognostic Significance of HER2-Low in Early Breast Tumors Patients Prognostic Comparison of HER-Low and HER2-Negative Breast Cancer Stratified... by Sanaa Gamrani, Laila Akhouayri, Sara Boukansa, Mehdi Karkouri, Hinde El Fatemi

“…A new nomenclature has been proposed for HER2 1+ and HER2 2+ tumors that are confirmed negative according to fluorescence in situ hybridization (FISH). These tumors are now referred to as HER2-low, and it is thought that they may represent a distinct subtype of breast cancer that warrants further investigation. …”
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De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…Fluorescent in situ hybridization studies confirmed these rearrangements. …”
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Edge-Version of Fault-Tolerant Resolvability in Networks by Muhammad Faheem, Muhammad Ahmad, Zohaib Zahid, Muhammad Javaid, Mamo Abebe Ashebo

“…These findings illustrate the reliability of these network topologies in environments prone to edge failures, offering valuable insights for designing resilient communication systems such as optical networks and smart grids. By adopting an edge-based perspective, this study advances fault tolerance analysis in graph theory and practical network design.…”
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Research Progress in Computational Methods for System-Level Coupling of Electromagnetic Pulse by Haiyan Xie, Jianguo Wang

“…A simplified method based on the effective coupling length approach and its application in high-altitude electromagnetic pulse coupling with power grids are discussed. This simplified method reduces the complexity of analysis from <inline-formula> <tex-math notation="LaTeX">$N^{2}$ </tex-math></inline-formula> to N, where N represents the number of lines in the network. …”
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An intelligent attention based deep convoluted learning (IADCL) model for smart healthcare security by J. Maruthupandi, S. Sivakumar, B. Lakshmi Dhevi, S. Prasanna, R. Karpaga Priya, Shitharth Selvarajan

“…Abstract In recent times, there has been rapid growth of technologies that have enabled smart infrastructures-IoT-powered smart grids, cities, and healthcare systems. But these resource-constrained IoT devices cannot be protected by existing security mechanisms against emerging cyber threats. …”
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A Comparative Frequency Analysis of Maximum Daily Rainfall for a SE Asian Region under Current and Future Climate Conditions by Velautham Daksiya, Pradeep Mandapaka, Edmond Y. M. Lo

“…Lastly, the study employed recent statistically downscaled global gridded rainfall projections to characterize climate change impact rainfall structure. …”
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Improvement of the Resilience of a Microgrid Using Fragility Modeling and Simulation by Santhan Kumar Ch, N. Karuppiah, B. Praveen Kumar, S. Shitharth, B. Dasu

“…The effect on smaller and larger grids and their resilience is examined. A novel resilience index is used to quantify the improvement of resilience of the proposed method when compared to other methods available in the literature.…”
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Advanced Genetic Algorithms for Optimal Battery Siting: A Practical Methodology for Distribution System Operators by Edward Alejandro Ortiz, Josimar Tello-Maita, David Celeita, Agustin Marulanda Guerra

“…A critical challenge for distribution network operators is enhancing the resilience and reliability of their grids by identifying effective solutions. One promising approach to achieving this is through the deployment of battery energy storage systems, which can rapidly inject power to mitigate the impacts of network disturbances or outages. …”
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Novel Metrics for High-Density sEMG Analysis in the Time&#x2013;Space Domain During Sustained Isometric Contractions by Giovanni Corvini, Michail Arvanitidis, Deborah Falla, Silvia Conforto

“…Topographical amplitude maps were generated from two HD-sEMG grids. Once identified the coordinates of the muscle activity, novel metrics for quantifying the muscle spatial distribution over time were calculated. …”
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Searching for an Added Value of Precipitation in Downscaled Seasonal Hindcasts over East Africa: COSMO-CLM Forced by MPI-ESM by Bedassa R. Cheneka, Susanne Brienen, Kristina Fröhlich, Shakeel Asharaf, Barbara Früh

“…By using ground based and satellite gridded observation data for evaluation it is found that both COSMO-CLM and MPI-ESM overestimate June to September precipitation over the Ethiopian highlands and in parts of the lowland with respect to all reference datasets. …”
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Electric Vehicles in Last-Mile Delivery: A Bibliometric Review by Eric Mogire, Peter Kilbourn, Rose Luke

“…Findings reveal that pioneering countries such as the USA have researched integrating electric vehicles into last-mile delivery systems, focusing on technological advancements such as battery technologies and smart grids. The sustainability theme is common in most studies, focusing on controlling carbon emissions and energy efficiency. …”
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Examining Power System Resilience From the Perspective of Consumers: A Review by Saranga K. Abeygunawardane, Visvakumar Aravinthan, Xiaoheng Wang, Anil Pahwa, Chanan Singh

“…This alignment will ensure that electrical grids are not only technically robust but also equitable, accessible, and responsive to the needs of all consumers.…”
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Classification and Localization of Faults in AC Microgrids Through Discrete Wavelet Transform and Artificial Neural Networks by J. A. R. R. Jayasinghe, J. H. E. Malindi, R. M. A. M. Rajapaksha, V. Logeeshan, Chathura Wanigasekara

“…The widespread integration of renewable energy sources to the main electrical grids has led to the increased adoption of AC microgrids. …”
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Comparison of Flow Solutions for Naturally Fractured Reservoirs Using Complex Analysis Methods (CAM) and Embedded Discrete Fracture Models (EDFM): Fundamental Design Differences an... by Aaditya Khanal, Ruud Weijermars

“…A significant advantage of flow and pressure models based on CAM is the high resolution without complex gridding. Particle tracking results are presented for fractures with different hydraulic conductivity ranging from highly permeable to impervious.…”
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Three-Dimensional CST Parameterization Method Applied in Aircraft Aeroelastic Analysis by Hua Su, Chunlin Gong, Liangxian Gu

“…This paper proposes a parametric structural modeling method based on gridding feature extraction from the aerodynamic mesh generated by the three-dimensional CST method. …”
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A time-varying index for agricultural suitability across Europe from 1500–2000 by Alexander Lehner, Dylan Philippe

“…Relying on recent advances in paleoclimatology, we bridge this gap by constructing a spatio-temporal measure for agricultural suitability across Europe for a period of 500 years. Our gridded index has a 0.5° resolution and is available at a yearly level. …”
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Exploring Localized Geomagnetic Disturbances in Global MHD: Physics and Numerics by Erik M. Vandegriff, Daniel T. Welling, Agnit Mukhopadhyay, Andrew P. Dimmock, Steven K. Morley, Ramon E. Lopez

“…In particular, localized GMDs (LGMDs) can be high amplitude and can have an effect on scale sizes less than 100 km, making them hazardous to power grids and difficult to predict. In this study, we examine the ability of the Space Weather Modeling Framework (SWMF) to reproduce LGMDs in the 7 September 2017 event using both existing and new metrics to quantify the success of the model against observation. …”
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Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling Between the Ocean and the Atmosp... by Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodriguez

“…Additionally, the combination of wind stress estimation from ODYSEA with other satellite products and numerical simulations could improve the representation of wind stress in gridded products. Future efforts should focus on the assessment of the potential of ODYSEA in quantifying the production of eddy kinetic energy through horizontal energy fluxes and air–sea energy fluxes related to divergent and rotational motions.…”
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Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…We employed immunohistochemistry, multicolor immunofluorescence, and fluorescence in situ hybridization (FISH) staining to observe the presence and location of bacteria. …”
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