Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the Che... by Enriqueta Felip, David P. Carbone, Martin Reck, Luis Paz-Ares, Yong Yuan, Nan Hu, Niels Reinmuth, Xiaoqing Zhang, Thomas John, Ying Cheng, Shun Lu, Manuel Cobo, Michael Schenker, Tudor-Eliade Ciuleanu, Stéphanie Bordenave, Oscar Juan-Vidal, Juliana Menezes, Eduardo Richardet, Hideaki Mizutani, Bogdan Zurawski, Aurelia Alexandru, Javed Mahmood, Tuli De, Irene Santi, John R. Penrod, Adam Lee

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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

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The SUPERCOLD-CGM Survey. II. [C i](1–0) Emission and the Physical Conditions of Cold Gas in Enormous Lyα Nebulae at z ∼ 2 by Jianan Li, Bjorn H. C. Emonts, Zheng Cai, Jianrui Li, Ran Wang, Montserrat Villar-Martín, Fabrizio Arrigoni Battaia, Mingyu Li, Yunjing Wu, Ilsang Yoon, Matthew D. Lehnert, Kyle Massingill, Craig Sarazin, Jason X Prochaska, Mark Lacy, Brian Mason

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Exploring the assessment of post-cardiac valve surgery pulmonary complication risks through the integration of wearable continuous physiological and clinical data by Lixuan Li, Yuekong Hu, Zhicheng Yang, Zeruxin Luo, Jiachen Wang, Wenqing Wang, Xiaoli Liu, Yuqiang Wang, Yong Fan, Pengming Yu, Zhengbo Zhang

“…Feature selection was conducted using Recursive Feature Elimination with Cross-Validated (RFECV) for each model, yielding an optimal feature subset for each, followed by a grid search to tune hyperparameters. Stratified 5-fold cross-validation was used to evaluate the generalization performance. …”
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Molecular and immune landscape of tumours in geriatric patients with non-small cell lung cancer, melanoma and renal cell carcinoma by Abdul Rafeh Naqash, April K Salama, Emil Lou, Andrew Elliott, Wafik S El-Deiry, Chul Kim, Stephen V Liu, Anwaar Saeed, Hirva Mamdani, Khalil Choucair, Dipesh Uprety, Phillip Walker, Himisha Beltran, Matthew James Oberley, Azhar Saeed, Lujia Chen

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Quantifying uncertainties in satellite NO₂ superobservations for data assimilation and model evaluation by P. Rijsdijk, P. Rijsdijk, P. Rijsdijk, H. Eskes, A. Dingemans, A. Dingemans, K. F. Boersma, K. F. Boersma, T. Sekiya, K. Miyazaki, S. Houweling, S. Houweling

“…Often the modelling system has a lower spatial resolution than the satellites used, with a model grid size in the range of 10–100 km. When the resolution mismatch is not properly bridged, the final analysis based on the satellite data may be degraded. …”
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Prototype Instrumentation for the Spatial and Temporal Characterisation of Voltage Supply Based on Two-Dimensional Higher-Order Statistics by Juan-José González-de-la-Rosa, Olivia Florencias-Oliveros, José-María Sierra-Fernández, Manuel-Jesús Espinosa-Gavira, Agustín Agüera-Pérez, José-Carlos Palomares-Salas, Victor Pallarés-López, Rafael-Jesús Real-Calvo, Isabel Santiago-Chiquero

“…Beyond the second-order parameters and permissible deviations regulated by the norm, EN 50160, the two-dimensional traces and probability density functions, along with a previously studied differential index, manage to identify different states of the electrical grid. Waveforms were measured in the wall plugs of a public building. …”
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From α-to β-diversity: Understanding the historical, present, and future diversity patterns of Fagaceae in Southwestern China by Bikram Pandey, Fengying Zhang, Basu Dev Poudel, Rong Li, Mohammed A. Dakhil, Bishal Gurung, Zhaxi Luobu, Yawen Gan, Ziyan Liao, Lin Zhang

“…We modeled the α-diversity via stacking prediction using an individual species distribution model at 50 km × 50 km grid cells. We used Sørensen dissimilarity to quantify total β-diversity and its components - turnover (βSIM) and nestedness (βNES). …”
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Evaluation of Non-Invasive Hemoglobin Monitoring in Perioperative Patients: A Retrospective Study of the Rad-67^TM (Masimo) by Philipp Helmer, Andreas Steinisch, Sebastian Hottenrott, Tobias Schlesinger, Michael Sammeth, Patrick Meybohm, Peter Kranke

“…Modified Clark’s Error Grid analysis showed 85.4% of values fell within clinically acceptable limits. …”
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Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…Five ML models were trained to predict signaling pathways, with Grid Search optimizing hyperparameters and 5-fold cross-validation ensuring unbiased performance. …”
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Quantifying the potential of using Soil Moisture Active Passive (SMAP) soil moisture variability to predict subsurface water dynamics by A. K. Nayak, X. Xu, X. Xu, S. K. Frey, S. K. Frey, O. Khader, O. Khader, A. R. Erler, D. R. Lapen, H. A. J. Russell, E. A. Sudicky, E. A. Sudicky

“…This study compares the SSM variability captured by the Soil Moisture Active and Passive (SMAP) satellite and the Soil Water Index (SWI) derived from SMAP SSM with subsurface SM and groundwater (GW) dynamics simulated by a high-resolution fully integrated surface water–groundwater model over an agriculturally dominated watershed in eastern Canada across two spatial scales, namely SMAP product grid (9 km) and watershed (<span class="inline-formula">∼4000</span> km<span class="inline-formula">²</span>). …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. Reproducibility was evaluated using Average Pairwise Pearson Correlation (APPC), while image quality was measured by Signal-to-Noise Ratio (SNR) and Contrast-to-Noise Ratio (CNR). …”
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Balancing water saving, market attractiveness, and pollution control in crop spatial planting structure planning of arid regions by Longbin Hao, Shouhong Zhang, Fan Zhang, Yufei Ren, Xinyu Zhang, Jing Yan

“…Results indicate that: (1) The grid-based 0–1 integer multi-objective approach can effectively make tradeoff among market attractiveness, pollution control, and crop suitability for crop planting structure planning in arid regions. (2) Optimal crop planting structure can increase agricultural planting profits by 4.679 billion CNY, while reduces system agricultural non-point source pollution and total water allocation by 34.72 % and 10.19 %, respectively. (3) The multi-objective approach shows better performance than single-objective models by comparing the Synthetic Degree (SD), Sustainability Index (SI), and Approximation Degree (AD). …”
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An efficient method for predicting the morphology of proppant packs based on a surrogate model by Tao ZHANG, Hangyu ZHOU, Yifan ZHANG, Jianchun GUO, Haoran GOU, Tang TANG

“…The former model enabled predictions of the distribution of proppant concentrations within the fracture at different times, whereas the latter allowed estimation of how the stacking heights of proppants varied with the injection rate. Furthermore, the grid precisions of the prediction models were optimized to enhance their accuracy and performance. …”
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Construction of a Compound Model to Enhance the Accuracy of Hepatic Fat Fraction Estimation with Quantitative Ultrasound by Zsély Boglárka, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, Pál Novák Kaposi

“…We searched a QUS parameter grid to find the optimal thresholds (AC ≥ 0.84 dB/cm/MHz, BSC-D ≥ 105), above which switching from a linear (r = 0.752, ICC = 0.715) to a nonlinear multivariable (r = 0.719, ICC = 0.641) model could improve the overall fit (r = 0.775, ICC = 0.718). …”
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On the feasibility of monitoring the content of phenolic compounds in transformer oil by M. N. Lyutikova, S. V. Nekhoroshev, V. M. Muratova, P. R. Semenyuk, A. S. Gadzhiyeva

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Diagnostic value of macular blood flow in normal tension glaucoma by A.Sh. Zagidullina, V.U. Galimova, A.I. Arslanova, A.R. Nugmanova

“…All patients underwent OCTA by measuring vascular density (VD, %) using the ETDRS grid (central Fovea and Parafovea) and retinal thick-ness using the Angio Retina 3.0 protocol of the Optovue XR Avanti with the AngioVue function (Optovue, USA). …”
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Computational analysis of Newtonian fluid in a 2-D square cavity with kinetic energy, enstrophy, and palinstrophy in the presence of bottom corner obstacle by Dalmalka Praveen Kumar, Yadagiri Rameshwar, Rifaqat Ali, S. Nazari, Mohamed Kallel, Ahmed M. Galal

“…In this study, we numerically investigate steady, two-dimensional Newtonian fluid flow within a square cavity featuring a lid-driven motion at Reynolds number Re = 100 by solving governing equations with the Fractional Step Method on a staggered grid in the Finite Volume framework, providing high-resolution streamline plots and vorticity contours. …”
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Retrieving the atmospheric concentrations of carbon dioxide and methane from the European Copernicus CO2M satellite mission using artificial neural networks by M. Reuter, M. Hilker, S. Noël, A. Di Noia, M. Weimer, O. Schneising, M. Buchwitz, H. Bovensmann, J. P. Burrows, H. Bösch, R. Lang

“…Since CO2M will not be launched until 2026, our study exploits simulated measurements over land surfaces from a comprehensive observing system simulation experiment (OSSE) that includes realistic meteorology, aerosols, surface bidirectional reflectance distribution function (BRDF), solar-induced chlorophyll fluorescence (SIF), and CO<span class="inline-formula">₂</span> and CH<span class="inline-formula">₄</span> concentrations. We created a novel hybrid learning approach that combines advantages of simulation-based and measurement-based training data to ensure coverage of a wide range of XCO<span class="inline-formula">₂</span> and XCH<span class="inline-formula">₄</span> values, making the training data representative of future concentrations as well. …”
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Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

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