Development of novel nucleic acid therapy aimed at directly controlling liver fibrosis by Tomohiro Umezu, Masakatsu Takanashi, Koji Fujita, Akio Ishikawa, Yuichirou Harada, Yoshinari Matsumoto, Masahiko Kuroda, Yoshiki Murakami

“…The original microRNA was changed to an RNA-DNA hybrid structure: the 2′ position of the RNA was modified with a fluorine base, and locked nucleic acid and phosphorothioate were crosslinked (hereafter called modified nucleic acid). …”
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Allocation and control of multi-devices voltage regulation in distribution systems via rough set theory and grasshopper algorithm: A practical study by Abdullah M. Elsayed, Ali M. El-Rifaie, Marwa F. Areed, Abdullah M. Shaheen, Mohamed Osman Atallah

“…The results validate the hybrid SRST-GOA technique as an efficient tool for achieving substantial operational and economic benefits in distribution systems.…”
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The Use of AI in Mental Health Services to Support Decision-Making: Scoping Review by Hassan Auf, Petra Svedberg, Jens Nygren, Monika Nair, Lina E Lundgren

“…The AI systems were used in health care, self-care, and hybrid care contexts, addressing a variety of mental health problems. …”
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Klasifikasi Teks Hadis Bukhari Terjemahan Indonesia Menggunakan Recurrent Convolutional Neural Network (CRNN) by Muhammad Yuslan Abu Bakar, Adiwijaya Adiwijaya

“…This research uses a hybrid method in deep learning by combining a Convolutional Neural Network and a Recurrent Neural Network, namely Convolutional Recurrent Neural Network (CRNN). …”
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Kinetics, thermodynamics, and catalysis of the cation incorporation into GeO2, SnO2, and (SnxGe1−x)O2 during suboxide molecular beam epitaxy by Wenshan Chen, Kingsley Egbo, Joe Kler, Andreas Falkenstein, Jonas Lähnemann, Oliver Bierwagen

“…The results are likely transferable to further physical and chemical vapor deposition methods, such as conventional and hybrid MBE, pulsed laser deposition, mist-, or metalorganic chemical vapor deposition.…”
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Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury by Di Wu, Wenjie Ma, Liucheng Wang, Chengcheng Long, Silin Chen, Jingyu Liu, Yiguan Qian, Jun Zhao, Changcheng Zhou, Ruipeng Jia

“…Furthermore, this membrane hybrid modification can be tailored and optimized for broader applications in treating other diseases.…”
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Identification of Psychological Factors Associated with Adherence to Self-Care Behaviors amongst Patients with Type 1 Diabetes by Dácil Alvarado-Martel, M. Ángeles Ruiz Fernández, Maribel Cuadrado Vigaray, Armando Carrillo, Mauro Boronat, Ana Expósito Montesdeoca, Ana M. Wägner

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Modelo CFD con validación de campo para el estudio de los alcances de efectividad de técnicas de mitigación de radón por despresurización = CFD model with field validation for the... by Isabel Sicilia, Borja Frutos, Carmen Alonso, Fernando Martín-Consuegra, Fernando de-Frutos, Ignacio Oteiza, Carlos Sainz, Luis S. Quindós

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Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…In this scenario, access to a validated diagnostic HRD test can optimize treatment selection and increase the effectiveness of the intervention.ObjectiveTo technically validate an in-house next-generation sequencing (NGS)-based HRD test, QIAseq Custom Panel (QIAGEN), by comparing it with the reference assay, MyChoice CDx® Plus HRD (Myriad Genetics), which is used in routine care.MethodsThis is a prospective cohort study conducted at the Oncoclínicas Precision Medicine (OCPM) laboratory using samples from patients with advanced or relapsed platinum-sensitive ovarian cancer eligible for HRD testing in a diagnostic clinical setting at Oncoclínicas and Co. …”
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Improving health outcomes and quality at the subdistrict level: Evaluation of the ‘3 feet model’ in Waterberg District, Limpopo Province, South Africa by H Schneider, F Mukinda, J Cupido, J Wessels, P Kupa, P Leboho, N Nkoana, N Bosch, Y Pillay

“…Plausible factors in implementation successes were the presence of stable and committed hybrid (clinical-managerial) subdistrict leaders and their ability to overcome entrenched silos between a variety of system actors; new collaborative relationships between primary healthcare facilities, hospitals and emergency medical services; the generation and packaging of information in ways that directed responses (‘actionable intelligence’); and support from senior district managers. …”
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Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth by Taketoshi Noguchi, Toshiyuki Sado, Katsuhiko Naruse, Hiroshi Shigetomi, Akira Onogi, Shoji Haruta, Ryuji Kawaguchi, Akira Nagai, Yasuhito Tanase, Shozo Yoshida, Takashi Kitanaka, Hidekazu Oi, Hiroshi Kobayashi

“…Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. …”
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The effect of <i>T. aestivum</i> chromosomes 1A and 1D on fertility of alloplasmic recombinant (<i>H. vulgare</i>)-<i>T. aestivum</i> lines depending on cytonuclear compatibility by L. A. Pershina, N. V. Trubacheeva, V. K. Shumny

“…All plants of F1 combinations FS×1R(1A), FS×1R(1D), PS×1R(1A), PS×1R(1D) were sterile, which indicates that a single dose of genes localized on wheat chromosomes 1A or 1D is not enough to restore male fertility in FS and PS plants. All plants of hybrid combinations F(hm)×1R(1A) and F(hm)×1R(1D) in both F1 and F2 were fertile, that is, fertility of allolines with cytonuclear coadaptation does not depend on wheat chromosomes 1A and 1D.…”
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Universal conditional networks (UniCoN) for multi-age embryonic cartilage segmentation with Sparsely annotated data by Nishchal Sapkota, Yejia Zhang, Zihao Zhao, Maria Jose Gomez, Yuhan Hsi, Jordan A. Wilson, Kazuhiko Kawasaki, Greg Holmes, Meng Wu, Ethylin Wang Jabs, Joan T. Richtsmeier, Susan M. Motch Perrine, Danny Z. Chen

“…To address these limitations, we propose novel DL methods that can be adopted by any DL architectures—including Convolutional Neural Networks (CNNs), Transformers, or hybrid models—which effectively leverage age and spatial information to enhance model performance. …”
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Explaining the Antecedents and Consequences of the Glass Cliff in Service Organizations by Sara Kavoosi, Ali Safari, Ali Shaemi Barzoki

“…Drawing from the qualitative aspect of the study, it is recommended that decision-makers and senior managers in service organizations diligently consider the origins of the glass cliff phenomenon and actively engage in managing the factors that contribute to the unique challenges faced by women in high-risk managerial positions Conclusion This investigation stands as one of the initial studies that, by leveraging a hybrid research methodology, provides a comprehensive framework to thoroughly understand the causal conditions, strategic responses, and consequences of the glass cliff phenomenon.…”
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Factores asociados a la alteración de erupción dental en niños: un estudio observacional by Sandra Gallardo Prado, Marcela Arenas González, Irene Coll Campayo, Nuria Tamayo Estebaranz, Carolina Caleza Jiménez

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Damage evolution mechanism and low-damage grinding technology of silicon carbide ceramics by Chen Li, Kechong Wang, Oleg Zakharov, Hailong Cui, Mingtao Wu, Tianchen Zhao, Yongda Yan, Yanquan Geng

“…Additionally, attention was directed towards the critical role of hybrid energy field grinding in minimizing brittle damages and promoting removal efficiency. …”
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Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance by Semeh Bejaoui, Sofie Holtsmark Nielsen, Astrid Rasmussen, John Eugenio Coia, Dorte Terp Andersen, Tobias Bruun Pedersen, Martin Vad Møller, Marc Trunjer Kusk Nielsen, Dorte Frees, Søren Persson

“…The goal of our study was to compare sequencing and assembly quality of 37 C. difficile isolates using Illumina (SPAdes assembled) and Nanopore (Flye and Unicycler assembled) data alone, along with hybrid assemblies obtained with short-read polishing of long reads. …”
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Validating a digital depression prevention program for adolescents in Jordan: cultural adaptation and user testing in a randomized controlled trial by Latefa Ali Dardas, Obada Al-leimon, Tracy Gladstone, Abd Arrahman Dabbas, Insaf Alammouri, Benjamin Van Voorhees

“…However, its effectiveness is contingent upon addressing barriers to access, enhancing program interactivity, and integrating hybrid support systems that combine digital tools with in-person guidance. …”
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Analysis of the characteristics of the ejector mode of the pulse detonation propulsion system of the combined acceleration cycle by Olena Zolotko, Oleksandr Zolotko, Oleksandr Aksonov, Vitalii Stoliarchuk, Oleksandr Cherniavskyi

“…The most famous of them include: two-mode direct-jet engine (ramjet-scramjet engine); rocket-based combined cycle (RBCC) engine; hybrid air-breathing rocket engine (Synergetic Air-Breathing Rocket Engine, SABRE). …”
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A critical review on enhancement and sustainability of energy systems: perspectives on thermo-economic and thermo-environmental analysis by Sunday O. Oyedepo, Mufutau A. Waheed, Fidelis I. Abam, Joseph O. Dirisu, Olusegun D. Samuel, Olusegun D. Samuel, Oluseyi O. Ajayi, Tosin Somorin, Abimbola P. I. Popoola, Oluwaseun Kilanko, Philip O. Babalola

“…The outcome of this study shows that (i) the sustainability of energy conversion systems can be enhanced with the use of exergy techniques assessment; (ii) by reducing energy losses, exergy efficiency initiatives can lessen their adverse effects on the environment; (iii) the best methods for efficient use of energy resources, low energy production costs, and less environmental impact can be provided by hybrid energy systems; and (iv) use of a single performance metric to optimize the energy process results in improbable outcomes. …”
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