Comparison of the effects of citicoline and vascular rehabilitation capsules on neurotrophic and inflammatory factors in patients with cerebral infarction by Wu Dongyun, Pan Jiajun, Fang Xinhong, Chen Zhongjun

“…In addition, cerebral hemodynamics was more favourable in the BP+COPC group than in the BP+VRC group (P<0.05). …”
Get full text

Evaluating baculovirus as a vector for human prostate cancer gene therapy. by Stephanie L Swift, Guillermo C Rivera, Vincent Dussupt, Regina M Leadley, Lucy C Hudson, Corrina Ma de Ridder, Robert Kraaij, Julie E Burns, Norman J Maitland, Lindsay J Georgopoulos

“…BV was capable of preferentially transducing invasive malignant prostate cancer cell lines compared to early stage cancers and non-malignant samples, a restriction that was not a function of nuclear import. Of more clinical relevance, primary patient-derived prostate cancer cells were also efficiently transduced by BV, with robust rates observed in epithelial cells of basal phenotype, which expressed BV-encoded transgenes faster than epithelial cells of a more differentiated, luminal phenotype. …”
Get full text

A retrospective analysis of hemodynamic stability in TAVR and TTVR under general anesthesia: implications for sedation in TTVR by Jingsi Wu, Xiaoyu Shang, Yuyu Gu, Yuhang Ying, Jinbao Li, Yun Zou

“…Results The groups did not differ in characteristics, comorbidities and cardiac function, or myocardial injury indicators. More patients in the TAVR group experienced post-induction hypotension. …”
Get full text

Sex Differences in Adult Incarceration After Pediatric Traumatic Brain Injury by Anurag Modak, Kyle E. Zappi, Alexander J. Catoya, Mehdi S. Lemdani, Gretchen M. Koller, Laurel Seltzer, Ryan E. Radwanski, Susan C. Pannullo

“…Male children are 1.5 times more likely to suffer a TBI than females; however, the prevalence of incarcerated adults with a history of pTBI is ∼35–45% for both sexes. …”
Get full text

Efficacy and safety of ensifentrine in treatment of COPD: a systematic review and meta-analysis of clinical trials by Bara M. Hammadeh, Osama M. Younis, Muaath I. Alsufi, Muhammad Idrees, Ayham Mohammad Hussein, Abdullah Yousef Aldalati, Fares A. Qtaishat, Banan Qatawneh, Al Bugazia, Raed A. Hamed

“…Based on subgroup analysis, higher doses were associated with more favorable results. Conclusion: In conclusion, owing to its dual effects, ensifentrine has a significant impact on improving pulmonary function and quality of life with minimal side effects. …”
Get full text

Induced variation in BRASSINOSTEROID INSENSITIVE 1 (BRI1) confers a compact wheat architecture by Manpartik S. Gill, Andrew L. Phillips, Danuše Tarkowská, John Addy, Patrycja Sokolowska, M. John Foulkes, Stephen Pearce, Stephen G. Thomas, Peter Hedden

“…Double mutants had reduced flag-leaf angles (FLAs) conferring a more upright canopy but exhibited no differences in height or grain weight. …”
Get full text

Informal caregiving following stroke: a qualitative exploration of carer self-identification, care-related language and support experiences by Richard Brown, Audrey Bowen, Bethany Harcourt

“…Some carers adopt the role quickly, whereas others find it more difficult to see themselves as a ‘carer’ and do not access relevant support. …”
Get full text

Mechanisms of γ-ray irradiation induced oxidation corrosion in SnBi eutectic solder joints: Insights from first-principles calculations by Qilong Guan, Shengli Li, Kai Li, Xuan Li, Ruiqi Wang, Xiaojiu Tang, Chunjin Hang

“…Bi incorporation lowers the work function of the Sn-based solid solution than Bi-based solid solution, making Sn more susceptible to oxidation. …”
Get full text

Preventive strategies for reducing intraoperative awareness due to errors in anesthetic drug delivery systems: a narrative review by Qisheng Chen, Qisheng Chen, Shixuan Peng, Shixuan Peng, Shixuan Peng, Wenjun Luo, Shuzhai Li, Zhiming Zhang

“…To tackle the unique challenges of ADDS in relation to IOA, the review discusses and emphasizes comprehensive 3E prevention strategies: (1) Enhancing training and education (such as check-listing of anesthetic delivery systems preoperatively, conducting effective communication, optimizing drug combinations, and avoiding intraoperative anesthetic medication errors); (2) Employing more monitoring intraoperatively (such as monitoring anesthetic concentration, monitoring depth of anesthesia, monitoring vital signs, and monitoring neuromuscular function); and (3) Encouraging incident reporting and audit practices. …”
Get full text

Altered lower leg muscle activation patterns in patients with cerebral palsy during cycling on an ergometer by Alves-Pinto A, Blumenstein T, Turova V, Lampe R

“…The degree of muscle spasticity and mobility was assessed using the Modified Ashworth Scale and the Gross Motor Function Classification System, respectively. Muscle activation patterns were described in terms of onset and duration of activation as well as duration of cocontractions.Results: Muscle activation in CP was characterized by earlier onsets, longer periods of activation, a higher occurrence of agonist&amp;ndash;antagonist cocontractions, and a more variable cycling tempo in comparison to healthy participants. …”
Get full text

Percutaneous extracapsular repair as a cost-effective alternative for treating cranial cruciate ligament deficiency in dogs by Dominique J. Griffon, Ayman Mostafa, Ayman Mostafa, Etienne Griffon, David J. Schaeffer

“…No differences in owner assessment, radiographic progression of osteoarthritis, lameness scores, girth diameter, and gait analysis at the walk and trot were detected between groups.ConclusionThe pLFS was faster, more cost-effective, and improved limb function at 2 weeks compared to the ECR. …”
Get full text

Trade-Offs, Synergies, and Driving Factors of Ecosystem Services in the Urban–Rural Fringe of Beijing at Multiple Scales by Chang Wang, Siyuan Wang, Bing Qi, Chuling Jiang, Weiyang Sun, Yilun Cao, Yunyuan Li

“…The study also applied a self-organizing map and the NbClust function to identify and determine the optimal number of ecosystem service bundles (ESBs) for ecological functional zoning. …”
Get full text

Control system architecture of an intelligent agent based on a semiotic network by M. A. Rovbo, P. S. Sorokoumov

“…At the same time it is capable of both maintaining its functioning and achieving goals in accordance with its priorities. …”
Get full text

Characterization of Gramicidin A in Triblock and Diblock Polymersomes and Hybrid Vesicles via Continuous Wave Electron Paramagnetic Resonance Spectroscopy by Emma A. Gordon, Indra D. Sahu, Joel R. Fried, Gary A. Lorigan

“…Lineshape analysis of spin-labeled gramicidin A revealed linewidth broadening, suggesting that the thicker polymersome membranes restrict the motion of the spin label more when compared to liposome membranes. Statement of Significance: Understanding membrane proteins’ structures and functions is critical in the study of many diseases. …”
Get full text

The impact of thyroid hormones on patients with hepatocellular carcinoma. by Matthias Pinter, Lukas Haupt, Florian Hucke, Simona Bota, Theresa Bucsics, Michael Trauner, Markus Peck-Radosavljevic, Wolfgang Sieghart

“…The associations of thyroid function tests with patient, liver, and tumor characteristics as well as their impact on overall survival (OS) were investigated.…”
Get full text

H. pylori infection in patients with food-borne diseases by D. A. Lioznov, S. K. Sajfullina, A. O. Bueverov, I. V. Gorbоva, S. L. Nikolaenko

“…Normalization of bowel function was observedearlier in control group compare with H. pylori-infected patients (3,0±0,7 day of disease and 4,4±1,4 day of disease respectively, in р&lt;0,05).Conclusions: H. pylori-infected patients had clinically and laboratory more severe presentation of acute intestinal infection. …”
Get full text

The Prevalence and Characteristics of Exocrine Pancreatic Insufficiency in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis by Jun Zhang, Jiaying Hou, Dechen Liu, Yingqi Lv, Chi Zhang, Xianghui Su, Ling Li

“…Furthermore, patients with higher insulin requirements, who are more likely to be insulin-deficient, have a higher prevalence of EPI. …”
Get full text

The physiological neocerebellar extinction syndrome likely exists for human handedness but not footedness – a study on healthy young adults by Martin Musálek, Chipo Malambo, Petr Kubový

“…Our findings suggest that distinct differences in cortical representation, lateralised control, and pathway specialisation exist due to the unique demands of each limb's motor functions, which are pronounced more neocerebellar extinction syndrome in the upper extremities. …”
Get full text

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity. by Anna Ghelli, Anna Maria Porcelli, Claudia Zanna, Sara Vidoni, Stefano Mattioli, Anna Barbieri, Luisa Iommarini, Maria Pala, Alessandro Achilli, Antonio Torroni, Michela Rugolo, Valerio Carelli

“…The 11778/ND4 mutation on haplogroup U was also more resistant to inhibition of complex I dependent ATP synthesis by 2,5-HD. …”
Get full text

Quality of life of 40 patients with end-stage renal disease treated by long-term hemodiafiltration by SUN Jing-hua, SHI Ling-zhi, LIU Bing-cheng, LI Sheng-kai, JIANG Gan-ru, YIN Zhong-cheng

“…Objective To explore the quality of life of patients treated with long-term hemodiafiltration.Methods A cross-sectional study was performed on42 patients with end-stage renal disease who underwent hemodiafiltration for more than 6 months.Blood pressure,hemoglobin,calcium and phosphorus metabolism,parathyroid function,nutritional status,one-yearhospitalization and cardiovascular events were examined in these patients.Results Among the 40 patients,17 patients(42.5%)had normal blood pressure,14 patients(35%)had grade 1 hypertension,and systolic blood pressure in 77.5% of patients was <160 mmHg.The mean hemoglobin(Hb)level was(100.9±17.1)g/L,and Hb in 31 patients(77.5%)was ≥ 90 g/L,and that in 12 patients(30%)≥110 g/L.The mean serum calcium(Ca)was(2.37±0.32)mmol/L,and Ca in 16 patients(40%)was 2.1~2.5 mmol/L,and Ca in 16 patients(40%)>2.5 mmol/L.The mean phosphate(P)was(1.70±0.50)mmol/L,and P in15 patients(37.5%)was 1.13~1.78 mmol/L,and P in 18 patients(45%)>1.78 mmol/L.The mean Ca×P was(48.6±16.6),and Ca×P product in 27 patients was<55.The mean parathyroid hormone(PTH)was(500.9±548.1)ng/L,and iPTH in 5 cases(12.5%)was 150~300 ng/L,and iPTH in 20 cases(50%)>300 ng/L.The mean total protein was(71.4±6.6)g/L,and albumin was(41.6±3.7)g/L.There were no significant differences in levelsof Hb,Ca,P,PTH,TP and Alb between elderly patients and non-elderly patients,nor between diabetic patients and non-diabetic patients(P>0.05 for all).One-year cardiovascular event rate was 153.1/1000 patient-years,and one-year hospitalization rate 612.2/1000 patient-years.Conclusions Good nutritional status,pressure controland higher Hb compliance rate were observed in end-stage renal disease patients with long-term hemodiafiltration,but there was severe hypercalcemia,hyperphosphatemia and hyperparathyroidism in these patients.HDF may be more beneficial for elderly patients and diabetic patients.…”
Get full text