Nonunion Rate and Clinical Outcomes Following Percutaneous Modified Lapidus Procedure with Intramedullary Nail Fixation and Early Weightbearing by Amos Dai MD, Walter C. Hembree MD, Solangel Rodriguez Materon MD, Eslam Alkaramany MD, Nacime Salomao Barbachan Mansur MD, PhD, Gregory P. Guyton MD

“…Mean postoperative PROMIS Physical Function and Pain Interference scores were 56.1 (SD 6.8) and 43.6 (SD 6.6), respectively. …”
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Effectiveness and safety of acupoint embedding therapy for treating intractable facial paralysis: A systematic review and meta-analysis by Xiaotong Guo, Fenglei Zai, Xianliang Tang, Yongkang Deng, Jianghui Cheng

“…However, there were no significant differences in facial nerve function scores(SMD:2.04; 95 % CI: −1.25–5.32; P = 0.22) or adverse reactions(RR: 1.16; 95 % CI: 0.35–3.78; P = 0.81) between AE therapy and electroacupuncture therapy. …”
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Comparison of combined spinal-epidural anesthesia and femoral nerve combined with lateral femoral cutaneous nerve block anesthesia in elderly hip fracture surgery by Sun Jing, Shan Juanjuan, Qin Miaomiao, Liu Naihe

“…[Conclusion] Femoral nerve combined with lateral femoral cutaneous nerve block anesthesia in elderly hip fracture surgery, compared with combined spinal-epidural anesthesia, can effectively prolong the block time, reduce postoperative pain, maintain more stable hemodynamic parameters, improve postoperative cognitive function, reduce the incidence of complications, with obvious clinical advantages.…”
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Non-invasive cerebral and spinal cord stimulation for motor and gait recovery in incomplete spinal cord injury: systematic review and meta-analysis by Agustin Hernandez-Navarro, Aina Ros-Alsina, Muhammed Yurtseven, Mark Wright, Hatice Kumru

“…Abstract Background Spinal cord injury (SCI) leads to gait impairment and loss of motor function and can be traumatic or non-traumatic in nature. …”
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Hereditary Hypercalcemia Caused by a Homozygous Pathogenic Variant in the CYP24A1 Gene: A Case Report and Review of the Literature by Daniele Cappellani, Alessandro Brancatella, Martin Kaufmann, Angelo Minucci, Edda Vignali, Domenico Canale, Elisa De Paolis, Ettore Capoluongo, Filomena Cetani, Glenville Jones, Claudio Marcocci

“…Introduction. Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia. …”
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Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. by Jennie Ong, Wim Timens, Vijay Rajendran, Arjan Algra, Avrum Spira, Marc E Lenburg, Joshua D Campbell, Maarten van den Berge, Dirkje S Postma, Anke van den Berg, Joost Kluiver, Corry-Anke Brandsma

“…As miRNA levels can be influenced by TGF-β, we hypothesized that TGF-β influences miRNA expression in lung fibroblasts, thereby affecting their function.<h4>Materials and methods</h4>We investigated TGF-β1-induced miRNA expression changes in 9 control primary parenchymal lung fibroblasts using miRNA arrays. …”
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A higher composite dietary antioxidant index is associated with a decreased risk of subclinical hyperthyroidism in adults: evidence from epidemiological studies by Jie Wu, Junxian Niu, Junxian Niu, Chuyu Jia, Qingkai Yang, Dewei Li, Xuqin Dong

“…And, the protective effect of CDAI against SCHyper was more particularly stronger in non-Hispanic whites and high-income (PIR &gt; 3.5) populations.ConclusionHigher CDAI scores were independently associated with a reduced risk of SCHyper, suggesting that dietary antioxidants may protect thyroid function by alleviating oxidative stress. …”
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Suhexiang pills inhibit ischemia stroke via targeting miR-24–3p to promote the activation of Keap1/Nrf2 signaling pathway by Zhaoshuo Li, Mingcheng He, KunPeng Wang, Mi Zhang, Wenxuan Lu, Peng Zhang, Li Zhang, Zhigang Lu

“…On the one hand, this result proved the new function of miR-24–3p in regulating CIRI. On the other hand, it clarified the new mechanism of ShxP in inhibiting the progression of IS by promoting the expression of miR-24–3p. …”
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Parent-Reported Burn-Specific Health-Related Quality of Life in Children 5–7 Years After Burns: A Multicenter Cross-Sectional Study by Marina C. Heijblom, J. Nicolaas Dijkshoorn, Marianne K. Nieuwenhuis, Anouk Pijpe, Cornelis H. van der Vlies, Margriet E. van Baar, Inge Spronk

“…At a mean of 5.7 years post-burn, many parents rated their child’s health as excellent (46.1%) or very good (35.3%), with few reporting issues with ‘pain’ (2.3%), ‘physical function and sports’ (1.6%), and ‘upper extremity function’ (0.9%). …”
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Effects of Bufexamac, a class IIb HDAC inhibitor, on behavior and neuropathological features in an Aβ-induced rat model of Alzheimer's disease by Monireh Mirehei, Fereshteh Motamedi, Nader Maghsoudi, Zahra Mansouri, Soudabeh Naderi, Fariba Khodagholi, Fatemeh Abbaszadeh

“…Overall, these findings suggest that Bufexamac could be a more targeted therapy for AD than other non-selective HDAC inhibitors, which often have diverse functions and potential side effects. …”
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Glycosyltransferase B3GNT3 promotes immune evasion in pancreatic cancer by downregulating MHC-I levels on the surface of pancreatic cancer cells by Shi-Qi Yin, Hong-Tai Ma, Xia-Qing Li, Shu-Yu Xiao, Aziguli Tulamaiti, Zhi-Gang Zhang, Xin Xing

“…The expression level of B3GNT3 in PDAC cells is negatively correlated with MHC-I levels, thereby affecting the ability of CD8+ T cells to recognize tumor cells and exert their cytotoxic function, making tumor cells more prone to immune evasion.…”
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Review and Analysis of Building Sustainability Assessment Systems, focusing on the Systems Developed for Iran by Mohammad Bagher Yekta, Farshad Nasrollahi, Mahmoud Reza Saghafi

“…Among the solutions presented in the research to correct these weaknesses are: Focusing on geographical boundaries with common environmental, cultural, and economic features, focusing on a specific building function, providing accurate, comprehensive, and relevant criteria for selecting the base systems, referring to the criticisms in the literature to modify the list of primary criteria, and completing and verifying the criteria list using a valid scientific method while defining more precise criteria to choose the experts.…”
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The effects of different exercise loads in plyometric resistance training on respiratory and hormonal levels in female volleyball players by Korhan Kavuran, Ercan Tizar, Diclehan Oral, Ramazan Erdoğan, Baha Engin Çelikel, Tülay Ceylan, Süreyya Yonca Sezer, Baykal Karataş

“…Blood samples and spirometric respiratory function values were collected before and after the 8-week exercise program. …”
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Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device by Yang Jiao, Xin Wang, Aizhen Yu, Li Wu, Hongping Li

“…BackgroundFacilitating the development of the sucking function in early stages of preterm infants holds substantial potential for influencing their long-term outcomes. …”
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Hsa_circ_0072088 promotes non-small cell lung cancer progression through modulating miR-1270/TOP2A axis by Sixuan Li, Zhigang Cui, Min Gao, Yanan Shan, Yihong Ren, Yuxin Zhao, Di Wang, Tingyu Meng, Hongxu Liu, Zhihua Yin

“…The same biological function was found with the overexpression of miR-1270. …”
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Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers by Yilin Wang, Jingyuan Meng, Jiechao Zhang, Lichao Tian, Wenrui Wei, Xiaoye Tang, Qian Zhang, Daofang Ding, Xuepeng Wang, Zicheng Guo, Yong He

“…Background Muscle atrophy—the decline of skeletal muscle volume and function—is pervasive in chronic disease, aging, and inactivity. …”
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The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma by Xi Zhang, Xi Zhang, Yan Liu, Yan Liu, Bai-Zhao Peng, Xing-hong Zhou, Yan-ting You, Ying Yang, Shuai Ji, Tian-yu Zhong, Xiao-hu Chen, Yan-yan Liu, Xiao-shan Zhao

“…However, its expression and function in lung adenocarcinoma (LUAD) remain unclear. …”
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FKBP prolyl isomerase 4: a potential target for heart failure and cardioprotective effects via leonurine-pretreated mesenchymal stem cell-derived exosomes by Zhaoyi Li, De-Chong Zheng, Ruixiang Wang, Qian Ding, Yi Zhun Zhu

“…Experiments using loss-of-function and overexpression methods were carried out to learn more about the precise processes that underlie the action of MSCLeo-EXOs. …”
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A Review on Bone Tumor Management: Cutting-Edge Strategies in Bone Grafting, Bone Graft Substitute, and Growth Factors for Defect Reconstruction by Sakdejayont S, Chobpenthai T, Suksirivecharuk P, Ninatkiattikul IF, Poosiripinyo T

“…Growth factor-based therapies, including bone morphogenetic proteins (BMPs) and vascular endothelial growth factor (VEGF), have revolutionized bone healing by stimulating osteogenesis and angiogenesis.Plain Language Summary: The review compares efficacy and safety of bone graft substitutes with traditional autografts, highlighting their potential benefits and challenges, thus helping clinicians choose the most suitable option for bone tumor management.Autologous bone grafting remains the gold standard; its limitations—such as donor site morbidity and limited graft availability—have driven the development of alternative approaches like bone graft substitutes and growth factor-based therapies.Advances in materials such as ceramics, polymers, and bioactive substances offer promising solutions for bone defect reconstruction, providing enhanced properties for bone regeneration and overcoming the shortcomings of autografts.Growth factor therapies, including Bone Morphogenetic Proteins (BMPs) and Vascular Endothelial Growth Factor (VEGF), transform bone healing by stimulating osteogenesis and angiogenesis, improving the recovery and function of the affected bone.Integrating bone graft substitutes and growth factor therapies, there is significant potential to improve clinical outcomes in orthopaedic oncology, offering more effective bone defect reconstruction and enhanced quality of life for patients.Keywords: Bone tumors, bone graft, tumor management, defect reconstruction, growth factor…”
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Bioelectrical impedance analysis–derived phase angle predicts possible Sarcopenia in patients on maintenance hemodialysis: a retrospective study by Ying Zeng, Yang Chen, Yujie Yang, Ying Qiu, Ping Fu, Huaihong Yuan

“…Conclusions PhA may be a useful and simple predictor of the risk of possible sarcopenia in MHD patients, and more research is needed to further promote the use of PhA in possible sarcopenia.…”
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