High-resolution transcriptional impact of AIRE: effects of pathogenic variants p.Arg257Ter, p.Cys311Tyr, and polygenic risk variant p.Arg471Cys by Amund Holte Berger, Amund Holte Berger, Amund Holte Berger, Bergithe Eikeland Oftedal, Anette Susanne Bøe Wolff, Anette Susanne Bøe Wolff, Eystein Sverre Husebye, Eystein Sverre Husebye, Per Morten Knappskog, Per Morten Knappskog, Eirik Bratland, Eirik Bratland, Stefan Johansson, Stefan Johansson

“…DiscussionOur cell-system approach differentiates between categories of AIRE variants on the transcriptional level, including the nonsense variant p.R257* (near complete loss of function), the p.C311Y variant associated with dominantly inherited APS-1 (severely impaired function), and the polygenic risk variant p.R471C (slightly increased function) linked to common organ-specific autoimmunity. …”
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Online Classification of Road Roughness Conditions with Vehicle Unsprung Mass Acceleration by Sliding Time Window by Zhongxing Li, Wenhao Yu, Xiaoli Cui

“…Suspension control systems are in need for more information of road roughness conditions to improve their performance under different roads. …”
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Estimation for Two-Dimensional Nonsymmetric Coherently Distributed Source in L-Shaped Arrays by Tao Wu, Zhenghong Deng, Qingyue Gu, Jiwei Xu

“…Compared with a symmetric source, the modeling and estimation of a nonsymmetric source are more practical. A nonsymmetric CD source is established through modeling the deterministic angular signal distribution function as a summation of Gaussian probability density functions. …”
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Research Progress in Microbial Conversion of Flavonoids by XI Jiayu, SU Yuanjin, DONG Shuqing, SHAO Shijun, LIU Hong, YANG Fude

“…Flavonoids are naturally occurring organic compounds that have a variety of biological activities such as antioxidant and anticancer function, preventing osteoporosis and modulating immunity. …”
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EXPERIMENTAL AND THEORETICAL FOUNDATIONS AND PRACTICAL IMPLEMENTATION OF TECHNOLOGY BRAIN-COMPUTER INTERFACE by A. Ya. Kaplan, A. G. Kochetova, S. L. Shishkin, I. A. Basyul, I. P. Ganin, A. N. Vasilev, S. P. Liburkina

“…At the beginning the main goal of BCI was to replace or restore motor function to people disabled by neuromuscular disorders. …”
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<i>Drosophila</i> as a Genetic Model System to Study Organismal Energy Metabolism by Arely V. Diaz, Izel Tekin, Tânia Reis

“…Metabolism at the level of a multicellular, multi-organ animal is inherently more complex than metabolism at the single-cell level. …”
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Protein-protein interaction prediction using bidirectional GRUs with explicit ensemble. by Qiuhong Lan, Zhongtuan Zheng, Zhen Tang, Xuehua Qiu, Zhixiang Yin

“…The accurate in-silico identification of these interactions is a significant area of research in biology-related fields, which is crucial for protein function prediction and drug design. Protein sequence data serves as the primary source for computational protein prediction. …”
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Du peintre à l’architecte. La mise en exposition des Nymphéas de Monet à l’Orangerie des Tuileries by Félicie Faizand de Maupeou

“…The issue of this present article is to understand how far Monet’s new function influenced his relationship with the various actors in the project. …”
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Analysis of Customer Perception of a New Product Using the Neutrosophic Biplot Method by Purificación Galindo-Villardón

“…A neutrosophic data matrix was formed and converted into a real-valued matrix using a scoring function, allowing for the application of HJ-Biplot analysis. …”
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Numerical study for the development of flood maps considering the break hypothesis in irrigation reservoirs by F.J. Sánchez-Romero, M. Pérez-Sánchez, M. Redón-Santafé, J.B. Torregrosa Soler, C. Ferrer Gisbert, J.J. Ferrán Gozálvez, A. Ferrer Gisbert, P.A. López-Jiménez

“…The need to regulate the water volume as a function of irrigation needs, as well as the availability of hydric resources, caused the building of a high number of irrigation reservoir. …”
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N2-methylguanosine and N2, N2-dimethylguanosine in cytosolic and mitochondrial tRNAs by Jonny Petrosyan, Katherine E. Bohnsack

“…Throughout the transcriptome, RNA modifications influence the folding, stability and function of RNAs as well as their interactions with RNA-binding proteins. …”
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Angiotensin Receptor–Neprilysin Inhibitor in Heart Failure Patients With Renal Dysfunction by Xiaogang Zhu, Xialing Li, Lingxuan Zhu, Zichuan Tong, Xiuying Xu

“…In HF patients with renal dysfunction, however, there is no strong evidence supporting the use of sacubitril/valsartan to reduce the absolute risk of hyperkalemia and worsening renal function; therefore, the administration of ARNI requires a careful balance between the benefits and risks. …”
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Aide à l'apprentissage du discours oral dans un contexte de communication asynchrone by John Fynn

“…Our hypothesis is that creating help items in this way builds up a new dynamic resource which will be more efficient than the current practice of giving participants a feedback list at the end of each discussion activity.…”
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Hand segmentation pipeline from depth map: an integrated approach of histogram threshold selection and shallow CNN classification by Zhengze Xu, Wenjun Zhang

“…Then, each segmentation proposal is evaluated by a 3-layers shallow convolutional neural network (CNN) which is trained as a binary classification function to predict whether it is a partition of hand. …”
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Pulmonary arterial hypertension: sex-specific differences and outcomes by Noura Alturaif, Umberto Attanasio, Valentina Mercurio

“…Women are often found to have better baseline right ventricular (RV) function and hemodynamics before treatment, as well as more favorable RV adaptation post-therapy. …”
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Early Failure Statistics Analysis of the Line Contactor of CR400BF EMU by Miao SHA, Donghui YUAN, Yang LIU, Hesheng ZHANG, Xuyuan SI, Junyi YANG

“…The result showed that the K-S test statistic of Weibull distribution was the smallest and the significance level was the highest, which used to describe the fault frequency distribution function of the line contactor can be more reasonable. …”
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Exploring the thermodynamic description of a simulation of flocking birds by Alexander V. Mantzaris, George-Rafael Domenikos

“…The energy of the birds is defined, and from the distribution function, the entropy, internal energy, temperature, heat flux, and pressure are defined. …”
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Analyse d'une formation plurilingue à distance : actions et interactions by Jean-Jacques Quintin, Monica Masperi

“…Galanet" learning schemes assemble large groups of students (from one to two hundred in general) who are geographically located in different universities and committed to completing common tasks the final objective of which is to create a quadrilingual press file publication online.The present study will be developed along two complementary axes:1. a quantitative analysis of the messages posted on the forum page of the platform for each session.2. a qualitative analysis of sample interventions generated in one of these sessions.On the one hand, the quantitative approach will allow for the highlighting of certain salient features of the e-learning experience as a whole, including how sessions function and their impact on both students and tutors.On the other hand, the qualitative approach will allow to examine and understand more fully the discursive practices elicited by the learning scenario and the plurilinguistic dimension of the forum exchanges.…”
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Rolling Bearing Fault Diagnosis Using Improved Deep Residual Shrinkage Networks by Zhijin Zhang, He Li, Lei Chen, Ping Han

“…To improve feature learning ability and accurately diagnose the faults of rolling bearings under a strong background noise environment, we present a new shrinkage function named leaky thresholding to replace the soft thresholding in the deep residual shrinkage networks (DRSNs). …”
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Active assessment of fitness and performance in a general population by Brent Winslow, Aravind Natarajan, Samantha Mravca, Justin Julian Duong, Salahuddin Choudhary, Tracy Norman Giest

“…Improving body composition, strength, endurance, and cardiorespiratory fitness is associated with increased longevity and function, but current fitness assessments are largely qualitative and episodic. …”
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