Clinical observation of different ways of blood purification combined with immune inhibitors for the treatment of serious lupus nephritis by LIU Lei, LI Liang-zhi, HU Wan-mei, TANG Yue-wu, HE Xian-hong, LIU Chun-qiu

“…Objective To observe the immune function and clinical curative effect of the different ways of blood purification combined immunosuppressor for the treatment of patients with serious lupus nephritis.Methods 35 patients diagnosed with serious lupus nephritis were divided into continuous veno-venous hemofiltration(CWH)+conventional medical treatment group(treatment group) and hemodialysis(HD)+conventional medical treatment group(control group).The changes in ANA titer,anti-ds-DNA antibodies,C3,erythrocyte sedimentation rate(ESR),serum creatinine(SCr) and24-h urinary protein quantity were compared between the two groups before and after treatment The therapeutic effect and pathological changes of the renal biopsy were statistically compared between two groups.Results The ANA titer,anti-ds-DNA antibodies,C3,ESR,SCr and 24-h urinary protein quantity had no statistically significant difference between the two groups on the first day after admission(P>0.05).After treatment for 1 month,the ANA titer,anti-ds-DNA antibodies,ESR,SCr and 24-h urinary protein quantity in the two groups were decreased significantly as compared with those pre-treatment(P<0.05).There was significant difference in the ANA titer,anti-ds-DNA antibodies,ESR and SCr between two groups(P<0.05),but there was no significant difference in the24-h urinary protein quantity(P>0.05).After treatment for 1 month,C3 levels were elevated,and there was significant difference in the treatment group before and after treatment,and between two groups(P<0.05).The respective index(AI),chronic index(CI) and tubulointerstitial lesions(TIL)scores had no statistically significant difference between the two groups.The dialysis days were shorter,and the treatment efficiency after 6 months was higher in the treatment group than in the control group.Conclusions CWH therapy can improve the patients immune indexes,has good clinical efficacy,compared with ordinary HD therapy treatment time shortened,the earlier from dialysis,could help patients with renal function recovery,and the illness is more stable.…”
Get full text

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. by Matthew Van De Pette, Simon J Tunster, Grainne I McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M John

“…Conversely, loss-of-function of Cdkn1c resulted in the complete developmental failure of the brown adipocyte lineage with a loss of markers of both brown adipose fate and function. …”
Get full text

Vestibular Agnosia: Toward a Better Understanding of Its Mechanisms by Assan Mary Cedras, Jonathan Dion, Arnaud Saj, François Champoux, Maxime Maheu

“…<b>Background/Objectives</b>: Vestibular agnosia is characterized by a reduced or absent self-motion perception while demonstrating the presence of normal peripheral vestibular function following stimulation. This condition has previously been reported by previous authors in different populations and more recently in traumatic brain injury patients. …”
Get full text

Exploring omics strategies for drug discovery from Actinomycetota isolated from the marine ecosystem by Manik Prabhu Narsing Rao, Syed Raziuddin Quadri, Manda Sathish, Ngoc Tung Quach, Wen-Jun Li, Wen-Jun Li, Arinthip Thamchaipenet, Arinthip Thamchaipenet

“…These comprehensive tools facilitate the discovery and functional analysis of new bioactive compounds by revealing the genetic blueprints underlying their biosynthesis. …”
Get full text

Clinical efficacy of a fixed-dose combination of amlodipine/indapamide/perindopril in patients with hypertension and multiple risk factors by A. A. Pirozhenko, A. S. Ryabtsev, S. V. Shlyk, N. V. Drobotya, V. V. Kaltykova

“…After 3 months of AHT, significant (p£0,05) ABPM changes and a predominance of the dipper-type 24-hour BP pattern were recorded in more than half of the patients (53%). A decrease in LVMI, LVPWT and IVS by 7%, 12% and 8%, respectively (p£0,05), while an E/A increase by 12% reflected LVH regression and LV diastolic function improvement. …”
Get full text

An open-label, controlled trial of the clinical effects of Laennec® in patients with nonalcoholic steatohepatitis or cirrhosis by M. Imawari, M. Nagase, I. Yu. Torshin, O. A. Gromova

“…At the end of the study (Week 3), the decrease in AST, ALT and GGT levels towards the normal range was even more pronounced for all three biomarkers: AST (–62 U/l; control: –23 U/l; p&lt;0.001), ALT (–78 U/l; control: –20 U/l; p&lt;0.001), GGT (–40 U/l; control: –15 U/l; p=0.005). …”
Get full text

Multimodal imaging of dark without pressure in high myopia reveals evidence that photoreceptor microscopic lesions may be reversible by Qingge Guo, Xiuxiu Jin, Xiaoyu Xin, Xiaohong Guo, Shuai Ming, Yuxiang Li, Bo Lei

“…Previous studies have concluded that DWP alone has no impact visual acuity, visual field, or other visual functions. This study aims to reveal the multimodal imaging manifestations of DWP in high myopia and to explore its impact on retinal function. …”
Get full text

Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons by Wei Zhang, Ying Jin, Fu-Ming Zhou

“…<b>Conclusions:</b> Taken together, our results suggest that chronic fluoxetine treatment, by blocking 5-HT reuptake and hence increasing the extracellular 5-HT level, can downregulate the function of 5-HT1B receptors on the GABAergic afferent axon terminals synapsing onto 5-HT neurons, allowing extrinsic GABAergic neurons to more effectively influence 5-HT neurons; simultaneously, chronic fluoxetine treatment also downregulated somatic 5-HT autoreceptor-activated GirK channel-mediated hyperpolarization and decrease in input resistance, rendering 5-HT neurons resistant to autoinhibition and leading to increased 5-HT neuron activity. …”
Get full text

Characterization of Terpene Synthases Reveals the Diversity of Terpenoids in <i>Andrographis paniculata</i> by Junhao Tang, Ying Ma, Yujun Zhao, Xiaohui Ma, Jian Wang

“…As revealed by site-directed mutagenesis, 533Val of ApTPS16 is an important site for maintaining the single main product capability, and 534Tyr of ApTPS17 may also be more important. The ApTPS17 Y534V mutation caused it to lose its main biological function. …”
Get full text

Carbon Emissions From Low‐Order Streams in a Tropical, High‐Elevation, Peatland Ecosystem Are Mediated by Catchment Morphology by Keridwen M. Whitmore, Amanda G. DelVecchia, Elizabeth Farquhar, Gerard Rocher‐Ros, Esteban Suárez, Diego A. Riveros‐Iregui

“…Confirming previous studies, we found that tropical headwater streams are an important source of CO2 to the atmosphere. More notably, we found marked, predictable spatial organization in aquatic carbon fluxes as a function of landscape position. …”
Get full text

Object detection with afordable robustness for UAV aerial imagery: model and providing method by Viacheslav Moskalenko, Artem Korobov, Yuriy Moskalenko

“…The detector training method was developed for the first time, combined the RetinaNet loss function with the gate unit loss function and applied meta-learning to the results of adaptation to various types of synthetic disturbances. …”
Get full text

Surgical versus conservative treatment for lumbar disc herniation: a prospective cohort study by Robert Theiler, Peter Jüni, Paul Hasler, Bruno R da Costa, Stephan Reichenbach, Marinella Gugliotta, Essam Dabis, Hans Landolt

“…We filled in missing outcome variable values with multiple imputation, accounted for repeated measures within patients with mixed-effects models and adjusted baseline group differences in relevant prognostic indicators by inverse probability of treatment weighting.Results Surgical treatment patients reported less back pain at 6 weeks than those receiving conservative therapy (−0.97; 95% CI −1.89 to −0.09), were more likely to report ≥50% decrease in back pain symptoms from baseline to 6 weeks (48% vs 17%, risk difference: 0.34; 95% CI 0.16 to 0.47) and reported less physical function disability at 52 weeks (−3.7; 95% CI −7.4 to −0.1). …”
Get full text

Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment by Itamar de Souza SANTOS, Claudia Kimie SUEMOTO, José Benedito Ramos VALLADÃO-JUNIOR, Simin LIU, Sandhi Maria BARRETO, Ligia Maria Giongo FEDELI, Paulo Andrade LOTUFO, Isabela Martins BENSENOR

“…ABSTRACT Background: Most studies that analyze the association between serum folate levels and cognitive function either restrict their assessments to specific clinical scenarios or do not include middle-aged individuals, to whom strategies for preventing cognitive impairment may be more feasible. …”
Get full text

Single-Institution Experience With Nononcologic Total Femoral Replacement by Ryan Ouillette, MD, Kevin Chen, BA, Matthew Dipane, BA, Alexander Christ, MD, Edward McPherson, MD, Alexandra Stavrakis, MD

“…Despite a notable revision rate and infection risk, the majority of patients maintain or regain ambulatory function, emphasizing the procedure’s role in preserving limb function. …”
Get full text

Use of Hydrocolloid Gums to Modify the Pasting, Thermal, Rheological, and Textural Properties of Sweet Potato Starch by Syed Ali Shahzad, Shahzad Hussain, Mohamed S. Alamri, Abdellatif A. Mohamed, Ali S. Ahmed, Mohamed A. Ibraheem, Akram A. Abdo Qasem

“…Rapid Visco Analyzer (RVA) measurements showed that the final viscosity was increased as a function of gum irrespective of their concentration except with cress seed gum. …”
Get full text

Corporate Real Estate alignment by Monique Arkesteijn

“…In comparison, the first two pilots were more complex because more stakeholders were involved and more interventions were possible. …”
Get full text

Multimodal dynamic retinal vessel analysis offers new insights in microvascular defects in Fabry’s disease by Abdelrahman Assaf, Konstantin Kotliar, Arno Schmidt-Trucksäss, Ines Lanzl

“…In addition, the longitudinal microstructure of retinal arteries and veins in FD was structurally and functionally altered. This was particularly notable in veins at all stages of the vascular reaction and in arteries at all stages except the baseline by more pronounced waves with periods of ~ 50–100 µm. …”
Get full text

Surfactants Adsorption onto Algerian Rock Reservoir for Enhanced Oil Recovery Applications: Prediction and Optimization Using Design of Experiments, Artificial Neural Networks, and... by Kahina Imene Benramdane, Mohamed El Moundhir Hadji, Mohamed Khodja, Nadjib Drouiche, Bruno Grassl, Seif El Islam Lebouachera

“…While DOE showed a slight advantage in relative error (9.10 × 10⁻⁵% vs. 1.88 × 10⁻⁴% for ANN), ANN proved more effective overall. Three optimization approaches—ANN-GA, DOE-GA, and DOE-DF (desirability function)—were compared, all converging to the same optimal conditions (SDS at 200 ppm and 25 °C). …”
Get full text

Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial by Jing Sun, Yi Liang, Kai-Tao Luo, Xiao-Mei Shao, Ming-Qi Tu, Xiao-Ting Wu, Fang Liu, Xin-Wei Li, Yi-Dan Chen, Qi-Fei Zhang, Cong-Hua Ji, Rong-Rong Li, Xiao-Yu Li, Fu Xu, Jian-Qiao Fang

“…The primary outcome measures included the visual analog scale score (VAS) and the physical function score of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). …”
Get full text

The effect of α-lipoic acid treatment on plasma asymmetric dimethylarginine, a biomarker of endothelial dysfunction in diabetic neuropathy by Ferenc Sztanek, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, Mariann Harangi, Péter Kempler, György Paragh

“…Peripheral sensory nerve function was assessed by current perception threshold (CPT) testing. …”
Get full text