Glycogen storage disease type Ib: modern understanding of the pathogenesis of neutropenia and prospects for its treatment with empagliflozin by Andrej N. Surkov, Aleksandr A. Baranov, Lejla S. Namazova-Baranova, Anna L. Arakelyan, Evgenij E. Bessonov, Natal’ya V. Zhurkova

“…Oddly enough, this hypoglycemic drug improved not only metabolic, but also glycemic control in patients with GSD Ib, despite the fact that the pathology is based on chronic hypoglycemia. More and more evidence points to the role of empagliflozin in the regulation of cellular homeostasis (for example, fatty acid metabolism, glucose, cholesterol, apoptosis and cell proliferation, in particular in the liver) by influencing the activity of sirtuin 1 (SIRT1), AMP-activated protein kinase (AMPK) and signal molecules such as -serine/threonine protein kinase (Akt) and a mechanical target of rapamycin (mTOR), which leads to an improvement in the structure and function of mitochondria, stimulation of autophagy, reducing oxidative stress and suppressing inflammation. …”
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La tranchée supérieure de l’aqueduc du Gier à Saint-Joseph (Loire) : nouvelles données et synthèse by Kilian Blanc, Guillaume Maza

“…While it is undoubtedly linked with the Gier aqueduct, it seems to be more than a levelling error, but rather part of a different aqueduct project from the one finally executed –an aqueduct that would have been around ten metres higher, narrower and likely to have developed more significantly in the Janon, Langonand and Durèze valleys. …”
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Current status and trends in the study of intestinal flora in cognitive disorders: a bibliometric and visual analysis by Qi Zhang, Zhenmei Gao, Yunqing Deng, Xiangqing Xu, Wenyu Sun, Rui Liu, Tianao Zhang, Xilei Sun

“…Future studies may focus more on gender differences in the role of gut flora in the modulation of cognitive function.…”
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Affective disorders before and after laser enucleation of the prostate by A. P. Semenov, A. G. Yusufov, R. I. Guspanov, S. V. Kotov

“…Group 2 patients had lower IIEF-5 scores (18.0 vs. 21.0 points; p < 0.001) and were more likely to have anxiety and depressive disorders before surgical treatment (45.7 and 44.3% vs. 22.8 and 22.7%; p < 0.05), with significant improvement in erectile function and affective status after surgery, in contrast to group 1 patients, whose IIEF-5 scores and incidence of affective disorders did not change significantly.Conclusion. …”
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Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity by Chuanling Liu, Yingying Li, Yanrong Li, Meng Hu, Haiyan Wang, Shasha Lu, Zhao Li, Dilinuer Dilimulati, Shunchang Jiao, Shelian Lu, Weihong Zhao

“…Thus, strengthening the cytotoxic effector function of PBNK cells and improving NK cell expansion in vitro for a convenient allogeneic therapy are essential. …”
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Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus by Leigh M. Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood

“…This study sought to clarify the relationships between dopaminergic function and cognitive control during a task by utilizing EBR and EBV as proxy measures. …”
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Inherited disorders of neonatal lung diseases by Murat Yurdakök

“…They cause a recessively inherited, progressive respiratory disease. More than 27 loss of function mutations have been identified in the surfactant protein B gene that result in lethal neonatal respiratory failure. …”
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Growth and Form Trait Variation Analysis Among Different Clones of Michelia chapensis by Zhixi DENG, Baishuan LYU, Rong HUANG, Limin ZHOU, Runhui WANG, Li CHEN, Zhijun LAI, Jiaqi CHEN, Jie ZHU, Ruping WEI, Huiquan ZHENG

“…Based on breeding values for growth traits and membership function values fifteen superior clones with comprehensive growth performance and thirteen superior clones with demonstrated vigorous growth with compact crown width were identified as more super clones.…”
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A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring by Anthony Purece, Sofie Theresa Thomsen, Dietrich Plass, Anastasia Spyropoulou, Kyriaki Machera, Philippe Palmont, Amélie Crépet, Rafiqa Benchrih, Brecht Devleesschauwer, Nina Wieland, Paul Scheepers, Deepika Deepika, Vikas Kumar, Gerardo Sanchez, Jos Bessems, Dario Piselli, Jurgen Buekers

“…To ensure more robust disease burden estimates and adequate follow-up of policy measures, more HBM studies are needed, along with increased efforts to harmonize the design of epidemiological studies upfront to guarantee meta-analysis of exposure-response functions. …”
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Study on the mechanism of Buzhong Yiqi Decoction in the treatment of rectal prolapse: related analysis of single-cell transcriptome sequencing based on surgical excision specimens by Chen Huaxian, Xiao Guozhong, Liu Fang, Lin Hongcheng

“…Related analysis of single-cell transcriptome sequencing showed that compared with the control group, the proportion of fibroblasts in the treatment group was higher, and the function of fibroblasts in the treatment group was more significant in promoting the formation of extracellular matrix and inhibiting the degradation of extracellular matrix. …”
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Effect of Sport Activity on Uncomplicated Bicuspid Aortic Valve: Long-Term Longitudinal Echocardiographic Study by Massimiliano Bianco, Fabrizio Sollazzo, Gloria Modica, Isabella Carlotta Zovatto, Rachele Di Mario, Riccardo Monti, Michela Cammarano, Vincenzo Palmieri, Paolo Zeppilli

“…Moreover, there was no significant correlation between weekly training minutes during follow-up and the echocardiographic parameters related to heart size and function. Conclusions: In BAV without major complications, high training volumes do not correspond to a more rapid and significant deterioration in valve function nor to a more rapid increase in aortic or cardiac chamber size.…”
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Probiotics as a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis by Jing Lu, Xiaoxiao Dong, Ziqi Gao, Huizhen Yan, Dilireba Shataer, Liang Wang, Yanan Qin, Minwei Zhang, Jiayi Wang, Jie Cui, Shengyang Zhou

“…Subgroup analysis revealed that these improvements were more pronounced in adults, though heterogeneity was higher compared to children, indicating more consistent effects in pediatric populations. …”
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Decoding population PM2.5 exposure in China: interplay of emissions, meteorology, and inequality (2013–2020) by Sujing Li, Sujing Li, Sujing Li, Sujing Li, Chenxi Wang, Linmeng Ma, Xingxing Wang, Guolei Du, Changhao Wu, Changhao Wu, Changhao Wu, Changhao Wu

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The potential clinical implications of slow vital capacity in patients with idiopathic pulmonary fibrosis by Ho Cheol Kim, Sydney Guthrie, Christopher S. King, Shazia Khan, Christopher A. Thomas, Vikramjit Khangoora, Steven D. Nathan

“…These findings suggest that SVC may provide a more stable and clinically meaningful measure of disease progression in IPF. …”
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The use of a combination of Diclofenac and Orphenadrine for analgesia in knee replacement by M. V. Kuzmina, I. V. Shlyk, V. A. Panafidina, A. A. Kozhevin, Yu. S. Polushin, V. O. Krivov

“…The assessment of the restoration of the supporting function of the operated leg and the ability of the patient to  perform active movements in the knee joint was carried out after 24 and 48 hours. …”
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Otimização do uso da água no perímetro irrigado do Gorutuba, utilizando-se a técnica da programação linear Optimization of water use in the Gorutuba irrigation district, Minas Gera... by Daniel Fonseca de Carvalho, Antônio Alves Soares, Carlos Antônio Alvares Soares Ribeiro, Gilberto C. Sediyama, Fernando Falco Pruski

“…A linear programming model was used with an objective function to maximize the monthly income as a function of the cultivated area with the crops used in the region, subjected to the restrictions of the irrigated area and the availability of water. …”
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Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation by Isabela C. Novaes, Soraya S. Ardestani, Allen Matheus S. Nascimento, Paulo C. R. Conti, Leonardo R. Bonjardim, Peter Svensson, Fernando G. Exposto, Yuri M. Costa

“…The electrical and mechanical pain thresholds demonstrated a loss of somatosensory function following capsaicin application to the masseter (p < 0.050). …”
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Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation by Jinfeng Liao, Yixin Yang, Jisong Li, Zheng Liu, Siyuan Song, Yu Zeng, Yi Wang, Yi Wang

“…We describe the heterogeneous nature of Bregs, focusing on their defining surface markers and regulatory functions. Meanwhile, the major cytokine secretion function and the correlation between Breg and Treg or other immune checkpoints to balance the immune responses are addressed. …”
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Partial ventilatory support modalities in acute lung injury and acute respiratory distress syndrome-a systematic review. by Sarah M McMullen, Maureen Meade, Louise Rose, Karen Burns, Sangeeta Mehta, Robert Doyle, Dietrich Henzler, Canadian Critical Care Trials Group (CCCTG)

“…No study was powered to assess mortality, one RCT showed shorter ICU length of stay, and the other demonstrated more ventilator free days. Beneficial effects of preserved spontaneous breathing were mainly physiological effects demonstrated as improvement of gas exchange, hemodynamics and non-pulmonary organ perfusion and function.…”
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A Refined Astrometric Approach Based on the Precision Premium and its Application to the Jupiter’s Satellite Himalia by Z. J. Zheng, Q. Y. Peng, F. R. Lin, D. Li

“…In our previous work, the correlation of positional precision as a function of two objects’ separation is studied and found to be effectively modeled by a sigmoidal function, which provides a good description of this rule. …”
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