Design and Development of a Multifunctional Stepladder: Usability, Sustainability, and Cost-Effectiveness by Elwin Nesan Selvanesan, Poh Kiat Ng, Kia Wai Liew, Kah Wei Gan, Peng Lean Chong, Jian Ai Yeow, Yu Jin Ng

“…This study presents the design, development, and evaluation of a multifunctional stepladder that integrates four functionalities: a stepladder, Pilates chair, wheelchair, and walking aid. …”
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Energy insufficiency induced by high purine diet: Catalysts for renal impairment in hyperuricemia nephropathy rat model by Zhenxiong Zhao, Zhikun Li, Yubin Xu, Shiqi Zhao, Qing Fan, Zhencang Zheng

“…In addition, inhibition of the peroxisome proliferator-activated receptors signaling pathway was noted in the present findings, which could further exacerbate the impediment in the β-oxidation function. In conclusion, it was discerned that a deficiency in energy supply plays a critical role in the kidney injury in hyperuricemia nephropathy rats, thereby endorsing paying more attention to renal energy supply in the therapy of hyperuricemia nephropathy.…”
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Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding. by Ziying Han, Shantoshini Dash, Cari A Sagum, Gordon Ruthel, Chaitanya K Jaladanki, Corbett T Berry, Michael P Schwoerer, Nina M Harty, Bruce D Freedman, Mark T Bedford, Hao Fan, Sachdev S Sidhu, Marius Sudol, Olena Shtanko, Ronald N Harty

“…A key regulator of YAP nuclear/cytoplasmic localization and function is angiomotin (Amot); a multi-PPxY containing protein that strongly interacts with YAP WW-domains. …”
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Prospects of application of artificial neural networks for forecasting of cargo transportation volume in transport systems by D. T. Yakupov, O. N. Rozhko

“…The neural network model consists of a hidden layer of neurons with a sigmoidal activation function and an output neuron with a linear activation function, the input values of the dynamic time series, and the predicted value is removed from the output. …”
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Health education interventions for individuals with visual or hearing impairment: a scoping review by Sohyun Jin, Geumbo Ko, Youngshin Song

“…Abstract Background Visual impairment refers to a deficiency in one or more functions of the visual system, while hearing impairment refers to a loss of auditory function, defined either by its impact on communication and daily activities or by clinical thresholds of hearing ability. …”
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Comparative Study of ASE-ASE and ASE-Laser Based Quantum Random Number Generators by Shreyam Maity, Asish Prosad, Harinee Natarajan, V. Balaswamy, Varun Raghunathan

“…We develop, for the first time to the best of out knowledge, closed-form analytical expressions to describe the signal variance as a function of realistic, non-ideal fiber-optic optical components, the signal correlations as a function of digitizer sampling rate, and minimum entropy as a function of signal variance. …”
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Calprotectin-mediated survival of Staphylococcus aureus in coculture with Pseudomonas aeruginosa occurs without nutrient metal sequestration by Wei H. Lee, Emily M. Zygiel, Celis H. Lee, Amanda G. Oglesby, Elizabeth M. Nolan

“…Treatment with CP site variants lacking functional transition-metal-binding sites and metalated CP also enhanced S. aureus survival in coculture with P. aeruginosa, revealing that this consequence of CP treatment is independent of its canonical metal-sequestering function. …”
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The effect of osteopathic manipulative treatment on lenght of stay and pain relief in pediatric appendectomy: a pilot non-randomized time-controlled clinical trial by Roberto Lo Piccolo, Roberto Lo Piccolo, Michele Maria Cantagalli, Tommaso Ferroni, Florinda Fracchiolla, Antonino Morabito, Antonino Morabito

“…Shoulder pain relief was also more pronounced in the OMT groups. Improvements in bowel function, mobilization, and nausea were observed in both groups, with no statistically significant differences.ConclusionsThis pilot study provides preliminary evidence that OMT may enhance postoperative recovery in pediatric appendectomy by reducing pain and potentially shortening hospital stays. …”
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Reduced Renshaw Recurrent Inhibition after Neonatal Sciatic Nerve Crush in Rats by Liang Shu, Jingjing Su, Lingyan Jing, Ying Huang, Yu Di, Lichao Peng, Jianren Liu

“…Our current research was designed to investigate the change of the recurrent inhibitory function in the spinal cord after the peripheral nerve crush injury in neonatal rat. …”
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Neutrophil and neutrophil-lymphocyte ratios as predictors of clinical characteristics in patients with Lymphangioleiomyomatosis by Lulu Yang, Lulu Yang, Lulu Yang, Liting Huang, Liting Huang, Liting Huang, Yingquan Luo, Siying Ren, Siying Ren, Siying Ren

“…Sirolimus treatment reduced neutrophil and NLR values in the pneumothorax group of LAM patients in (P < 0.05).ConclusionLymphangioleiomyoma patients with higher neutrophil and NLR values have worse lung function and may be more susceptible to spontaneous pneumothorax, and sirolimus treatment reduces neutrophil and NLR values in LAM patients with pneumothorax.…”
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Peripheral cytokine and monocyte phenotype associations in drug-resistant epilepsy by Tracie Huey-Lin Tan, Richard P. Sequeira, Piero Perucca, Patrick Kwan, Terence J. O’Brien, Mastura Monif

“…CD11b MFI ratio was increased in ‘classical’ and ‘intermediate’ (CD14+CD16+) monocytes. P2X7R pore function was similar between groups. Overall, while cytokine levels were similar between groups, the differences in monocyte phenotype indicates a more ‘proinflammatory’ circulating innate immune state in DRE. …”
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Dysregulated renal tubular handling of filtered glucose in patients with type 2 diabetes mellitus: a descriptive study by Asim Zulfiqar, Saira Jahan, Muhammad Nadim Akbar Khan, Shamaila Burney, Muhammad Farooq, Kiran Fatima

“…Blood glucose 80-180mg/dl was considered glucose in range and >180mg/dl glucose above range. Hyper-function of sodium glucose transport receptors was suspected if urinary glucose was <++ and the function of these receptors was considered normal if urinary sugar was ++ or more. …”
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Integration of artificial intelligence and advanced optimization techniques for continuous gas lift under restricted gas supply: A case study by Leila Zeinolabedini, Forough Ameli, Abdolhossein Hemmati-Sarapardeh

“…A penalty function was used to incorporate this constraint into the optimization procedure. …”
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Liver Injury Associated with Antituberculosis Medications by Syifa Mustika, Lia Susanti

“…Conventional antituberculosis therapy, comprising a combination of first-line medications, is essential for controlling tuberculosis. However, more than 7% of patients undergoing treatment may develop drug-induced liver injury (DILI), mainly from isoniazid and rifampicin. …”
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Impact of resistance exercise rehabilitation and whey protein supplementation in elderly patients with heart failure with preserved ejection fraction with sarcopenia: a study proto... by Rui Li, Hong Jiang, Yan Gao, Yi Chen, Mo Zhou, Yuhao Wei, Meishan Lu, Jieren Xi, Zhizhou Lin, Xiaoyun Zheng

“…Introduction Heart failure with preserved ejection fraction (HFpEF) affects more than half of the patients with heart failure. …”
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Acute kidney injury caused by ureteral obstruction after Deflux® injection treatment for vesicoureteral reflux after pediatric kidney transplantation: a case report by Yujiro Aoki, Yuko Hamasaki, Junya Hashimoto, Ayuko Zaitsu, Maho Maeda, Masaki Muramatsu, Takeshi Kawamura, Seiichiro Shishido, Ken Sakai

“…The graft function gradually recovered. Four months later, the ureteral stent was removed. …”
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Vascular markers of cognitive dysfunction in patients with uncontrolled arterial hypertension by V. I. Podzolkov, A. E. Bragina, D. U. Natkina, N. A. Druzhinina, T. A. Safronova

“…To study the state of cognitive function and associated vascular factors in patients with uncontrolled AH. …”
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Simulation of the African ITCZ during austral summer seasons and ENSO phases: application of an RCM derived from stretched grid ESM by Teke S. Ramotubei, Teke S. Ramotubei, Willem A. Landman, Mohau J. Mateyisi, Shingirai S. Nangombe, Asmerom F. Beraki, Asmerom F. Beraki

“…Furthermore, the RCM is also out of phase with a southerly shift of the stream function compared to the 500 hPa reanalysis stream function. …”
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Drosophila model of HPV18-Induced pathogenesis reveals a role for E6 oncogene in regulation of NF-κB and Wnt to inhibit apoptosis by Mojgan Padash Barmchi, Rami N. Hassan, Mehrnaz Afkhami, John P. Masly, Harrison Brown, Quincy P. Collins, Michael J. Grunsted

“…E6 has several functions contributing to tumorigenesis one of which is blocking programmed cell death, apoptosis. …”
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Comparative assessment of the effect of anesthetics (propofol, sevoflurane, desflurane) on hemodynamics and gas exchange in the lungs during operations for acute pulmonary embolism by E. V. Taranov, N. K. Pastukhova, V. V. Pichugin, S. A. Fedorov, Yu. D. Brichkin, S. N. Nezabudkin, S. A. ZhIlyaev, K. I. Nikitin

“…The indicators of central hemodynamics, myocardial contractile function and the functional state of the lungs during the operation were studied.Results. …”
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