Adiponectin and Leptin at Early Pregnancy: Association to Actual Glucose Disposal and Risk for GDM—A Prospective Cohort Study by Latife Bozkurt, Christian S. Göbl, Sabina Baumgartner-Parzer, Anton Luger, Giovanni Pacini, Alexandra Kautzky-Willer

“…Both adipokines were significantly associated with insulin sensitivity and β-cell function. Their attribution for GDM prediction was moderate to fair and more enhanced in early GDM. …”
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Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle by Yuqing Li, Yuqing Li, Yuqing Li, Wanjun Zhao, Qi Yang

“…These findings may be due to HIIT’s more pronounced effect on mitochondrial dynamics or respiratory function, but the study has only conducted preliminary observational experiments and further evidence is required for confirmation.…”
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A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study by Benjamin R. Tollitt, Samantha W. Jones, Jessica Ohana, James R. Henstock, Malcolm J. Jackson, Anne McArdle

“…Abstract Compared with 2D monolayers, 3D models more closely mimic native muscle tissue and allow functional measurements. …”
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Revisiting polychlorinated biphenyls enriching in human and disrupting of thyroid hormone receptor β1 by Qiao Wang, Junsong Bao, Yuhao Fan, Junjie Jiang, Ying Wang, Limei Chen, Jun Jin

“…It is found that the PCBs of PCB28, PCB52, and PCB153 can interfere with triiodothyronine binding to TRβ1, which are comparable to the effects of the polybrominated biphenyl BB-153, a known thyroid function disruptor. What's more, the PCB180 binds to TRβ1 more strongly than that of BB-153. …”
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Residual Postoperative Valgus After Total Knee Arthroplasty for Preoperative Valgus Deformity Results in Inferior Patient-Reported Outcomes by Anastasia A. Hunt, MD, Ian Hollyer, MD, Nicole S. Pham, MPH, William J. Maloney, MD, James I. Huddleston, III, MD

“…Patients in varus were 7.79 times more likely to achieve the minimal clinically important difference VR-12 Physical score, while patients in neutral were 3.26 times more likely to achieve the minimal clinically important difference for Knee Society Score Function when compared to valgus knees. …”
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p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms by Junjie Li, Jing Wang, Dan Su, Xiu Nie, Yueping Liu, Lianghong Teng, Junyi Pang, Huanwen Wu, Zhiyong Liang

“…Most cases with pattern A harboured loss-of-function (LOF) mutations, whereas patterns B and C tended to indicate wild-type TP53 and gain-of-function (GOF) mutations, respectively. …”
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Lymphocyte-Infiltrated Periportal Region Detection With Structurally-Refined Deep Portal Segmentation and Heterogeneous Infiltration Features by Hung-Wen Tsai, Chien-Yu Chiou, Wei-Jong Yang, Tsan-An Hsieh, Cheng-Yi Chen, Che-Wei Hsu, Yih-Jyh Lin, Min-En Hsieh, Matthew M. Yeh, Chin-Chun Chen, Meng-Ru Shen, Pau-Choo Chung

“…Moreover, the statistics of the ratio of the detected infiltrated portal boundary have high correlation to the Ishak grade (Spearman's correlations more than 0.87 with p-values less than 0.001) and medium correlation to the liver function index aspartate aminotransferase and alanine aminotransferase (Spearman's correlations more than 0.63 and 0.57 with p-values less than 0.001). …”
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Human IFN-κ Inhibited Respiratory RNA Virus Replication Dependent on Cell-to-Cell Interaction in the Early Phase by Weihui Fu, Peng Sun, Jun Fan, Longfei Ding, Songhua Yuan, Guanxing Zhai, Miaomiao Zhang, Chenli Qiu, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu, Haijuan Wang

“…In contrast, IFN-α2 started to function later but was stronger and more durable than IFN-κ. …”
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Diagnostic and prognostic value of the left atrial myopathy evaluation in cardiac amyloidosis using echocardiography by Aaisha Ferkh, Paul Geenty, Luke Stefani, Peter Emerson, Jennifer Pham, Karen Byth, Anita C. Boyd, David Richards, Mark S. Taylor, Fiona Kwok, Eddy Kizana, Liza Thomas

“…Left ventricular (LV) mass, diastolic function (average‐e′ and E/e′), LV global longitudinal strain, and LA volume and function (LA function index and strain) were more impaired in ATTR versus AL; these echocardiographic parameters were more impaired in both amyloid groups compared to HHT patients (P < 0.05). …”
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Preliminary Report: Osteoarthritis and Rheumatoid Arthritis Synovial Fluid Increased Osteoclastogenesis In Vitro by Monocyte Differentiation Pathway Regulating Cytokines by Jani Luukkonen, Johanna Huhtakangas, Sanna Palosaari, Juha Tuukkanen, Olli Vuolteenaho, Petri Lehenkari

“…Osteoclastogenesis and activity increased more in the cultures containing OA than RA synovial fluid. …”
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The Preliminary Ruling Decision in the Case of Google vs. Louis Vuitton Concerning the AdWord Service and its Impact on the Community Law by Tomáš Gongol

“…Whereas the German courts tend to currently access the responsibility for the outcome of the search engines more freely, the French courts are often more stringent. …”
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Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic β-lactam resistance modifiers. by Lucia Palacios, Helena Rosado, Vicente Micol, Adriana E Rosato, Patricia Bernal, Raquel Arroyo, Helen Grounds, James C Anderson, Richard A Stabler, Peter W Taylor

“…ECg analogs with unnatural B-ring hydroxylation patterns induced higher levels of gene expression and more profound changes to MRSA membrane fluidity than ECg but adopted a more superficial location within the bilayer. …”
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Unveiling immune cell response disparities in human primary cancer-associated fibroblasts between two- and three-dimensional cultures. by Jian-Ping Yang, Nikhil Nitin Kulkarni, Masashi Yamaji, Tsubasa Shiraishi, Thang Pham, Han Do, Nicole Aiello, Michael Shaw, Toshihiro Nakamura, Akiko Abiru, Narender R Gavva, Shane R Horman

“…Remarkably, when cultured in 2D, CAFs exhibited a myofibroblast (myCAF) subtype, whereas in 3D tumor spheroid cultures, CAFs displayed a more inflammatory (iCAF) pathological state. By integrating single-cell gene expression data with functional interrogations of critical TME-related processes [natural killer (NK)-mediated tumor killing, monocyte migration, and macrophage differentiation], we were able to reconcile form with function. …”
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siRNA Treatment Enhances Collagen Fiber Formation in Tissue-Engineered Meniscus via Transient Inhibition of Aggrecan Production by Serafina G. Lopez, Lara A. Estroff, Lawrence J. Bonassar

“…This inhibition during early maturation of these in vitro constructs increased collagen fibril diameter by more than 2-fold. This increase in fibril diameter allowed these tissues to distribute strains more effectively at the local level, particularly at the interface of the bone and soft tissue. …”
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The Impact of Traditional and Robotic Toys on 3-4 Years Old’s Play by Ryabkova I.A., Pavlovskaia D.V., Sheina E.G.

“…Character toys are of particular importance the function of which is the substitution of a character, the embodiment of a role. …”
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Transcriptomal profiling of bovine ovarian granulosa and theca interna cells in primary culture in comparison with their in vivo counterparts. by Nicholas Hatzirodos, Claire Glister, Katja Hummitzsch, Helen F Irving-Rodgers, Philip G Knight, Raymond J Rodgers

“…In vitro culture of ovarian granulosa cells and theca cells has been very important for our understanding of their function and regulation. One of the most eagerly sought attributes of cell culture is the use of chemically-defined conditions. …”
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Women in the Covid-19 Pandemic: the Psychosocial State of Female Students in Poland. by Izabela Kochan, Anna Walczak, Joanna Lewczuk

“…This study, which aims to present the psychosocial state of women who have been studying in Poland during the pandemic, shows that it is women, more than men, who have experienced the changes caused by the pandemic, both in the context of how they function and their fears. …”
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Non-surgical methods for the treatment and prevention of skin scars by V. Yu. Bogachev, B. V. Boldin, G. A. Varich

“…At the same time, preventing pathological scarring is undoubtedly more effective and cheaper than treating it later on. …”
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Mitochondrial Transplantation Promotes Remyelination and Long-Term Locomotion Recovery following Cerebral Ischemia by Tao Chen, Yuanyuan Zhu, Jia Jia, Han Meng, Chao Xu, Panpan Xian, Zijie Li, Zhengang Tang, Yin Wu, Yan Liu

“…More importantly, higher levels of myelin basic protein (MBP) and more morphologically normal myelin-wrapped axons were observed in mitochondria-treated cortex at 21 days postinjury, as revealed by light and electron microscope. …”
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Nature of the liver volume depending on the gender and age assessing volumetry from a reconstruction of the computed tomography. by Kohei Harada, Tomohiro Ishinuki, Yoshiya Ohashi, Takeo Tanaka, Ayaka Chiba, Kanako Numasawa, Tatsuya Imai, Shun Hayasaka, Takahito Tsugiki, Koji Miyanishi, Minoru Nagayama, Ichiro Takemasa, Junji Kato, Toru Mizuguchi

“…Liver volume in the males decreased more with age than LV in the females.…”
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