Adaptive Focal Loss for Keypoint-Based Deep Learning Detectors Addressing Class Imbalance by Zhihao Su, Afzan Adam, Mohammad Faidzul Nasrudin

“…This function is specifically designed to mitigate the impact of large gradients during the early stages of training. …”
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Resilience Assessment for Corroded Reinforced Concrete Bridge Piers Against Vessel Impact by Zhijun Ouyang, Xing Wang, Biao Nie, Yuangui Liu, Hua-Peng Chen

“…Furthermore, resilience indices obtained from the negative exponential function generally exceed those from the triangular function, and this improvement becomes more significant at lower resilience levels. …”
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Efficacy of acupuncture on lower limb motor dysfunction following stroke: A systematic review and meta-analysis of randomized controlled trials. by Peng Chen, Xing Jin, Debiao Yu, Xiaoting Chen, Yaoyu Lin, Fuchun Wu, Bin Shao

“…<h4>Conclusion</h4>The results of this study suggest that acupuncture combined rehabilitation training may be more effective than conventional rehabilitation alone in improving LLMD, balance function, walking ability, and daily living activities after stroke. …”
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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets by Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu

“…With the encouraging results of cancer immunotherapy in recent years, more investigation into the impact of glutamine metabolism on immune cell function in the cancer microenvironment could lead to the discovery of new targets and therapeutic approaches. …”
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Semaglutide: an emerging treatment option for patients with obesity related HFpEF by Sanya Ashraf Khaskheli, Najaf Ahmed Rajpar

“…Initially, the use of Semaglutide, a glucagon-like peptide-1 receptor agonist, showed favourable outcomes in cardiac function of mice. This study observed that weight loss achieved using Semaglutide was met with improvements in several factors associated with HFpEF (reduced LV hypertrophy and fibrosis, improved diastolic function, reduced lung congestion and improved exercise capacity) as compared to weight loss achieved through simple dietary means3. …”
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A spectrum of cysteine mutations in fibulin-3 highlight its disulfide bonding complexity and potential to induce ER stress by Gracen E. Collier, Anna L. Roovers, John D. Hulleman

“…These cysteines, which are distributed across one atypical and five canonical calcium-binding epidermal growth factor (EGF) domains, are important for regulating FBLN3 structure, secretion, and presumably function. As evidence of this importance, a rare homozygous p.C55R mutation in FBLN3 negates its function, alters disulfide bonding, and causes marfanoid syndrome. …”
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Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study by Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

“…BackgroundObesity, through mechanisms such as insulin resistance and systemic low-grade inflammation, can damage the central nervous system and impair cognitive function. Weight-adjusted waist index (WWI) is a novel measure of obesity that may offer more precise assessments of muscle and fat mass. …”
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PALMITIC AND OLEIC ACIDS AND THEIR ROLE IN PATHOGENESIS OF ATHEROSCLEROSIS by V. N. Titov, A. M. Dygai, M. Yu. Kotlovskiy, Ye. V. Kurdoyak, A. V. Yakimenko, I. Yu. Yakimovich, N. V. Aksyutina, Yu. V. Kotlovskiy

“…On the basis of phylogenetic theory of general pathology, the cause of a noninfectious disease whose occurrence in a population is more than 5–7% is an impaired biological function or reaction to the environment. …”
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Blood Uric Acid in Mild Cognitive Impairment: A Cross-Sectional Study of Older Chinese Adults by Xue L, Xiao X, Mao X, Zhang X, Liu Y, Wu B

“…We used the MMSE and MoCA to evaluate cognitive function, and fasting venous blood to measure UA concentration. …”
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Comparative Analysis of Pioglitazone and Tirzepatide on Body Weight, Glucose Levels, Neuroinflammation, and Oxidative Stress in Diabetic Rats by Alhowail A, Aldawsari MF, Aldubayan M

“…The TZP and PIO increased survival rates and cognitive function as well as decreased glucose levels, neuroinflammation, and oxidative stress in diabetic rats, with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.Discussion: This study concluded that TZP and PIO enhanced cognitive impairment in diabetic rats, with PIO demonstrating superior efficacy in contrast to TZP.Keywords: diabetes, inflammation, cognitive impairment, oxidative stress, insulin, pioglitazone, tirzepatide…”
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Targeting mitochondria in bone and cartilage diseases: A narrative review by Daniel H. Mendelsohn, Nike Walter, Wing-Hoi Cheung, Ronald Man Yeung Wong, Rebecca Schönmehl, Lina Winter, Thaqif El Khassawna, Christian Heiss, Christoph Brochhausen, Markus Rupp

“…While mitochondrial research has been more advanced in fields such as cardiology and neurology, emerging therapeutic strategies from these areas are beginning to show potential for translation into orthopedics. …”
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The effect of adding neuromuscular electrical stimulation to exercise therapy on patellofemoral pain: A systematic review and meta-analysis. by Jiawei Zheng, Zixuan Wei, Huiwu Zuo, Kunpeng Wang, Xikai Lin, Jian Chen

“…<h4>Conclusion</h4>The study's findings revealed that adding NMES to exercise therapy offers further improvement in pain intensity, knee function, and quadriceps strength in people with PFP compared with exercise therapy alone, but did not significantly improve VMO/VL ratio, and it recommended that the duration of the intervention lasts more than4 weeks for better therapeutic outcomes.…”
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The efficacy of traditional Chinese Medical Exercise for Parkinson's disease: a systematic review and meta-analysis. by Yan Yang, Wei Qing Qiu, Yan Lei Hao, Zhan Yun Lv, Shu Ji Jiao, Jun Feng Teng

“…Compared with other therapy plus medication, Tai Chi plus medication also showed greater gains in motor function (SMD, -0.78; 95% CI -1.46 to -0.10), BBS (SMD, -0.99; 95% CI -1.44 to -0.54), and functional reach test (SMD, -0.77; 95% CI -1.51 to -0.03). …”
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Effects of Home-Based Rehabilitation for Patients With Advanced Lung Cancer Undergoing Platinum-Based Chemotherapy: A Randomized Controlled Trial by Mi Jin Hong, Yung Jin Lee, Jong Bum Park, Sin Yung Woo, Seungcheol Lee, Hokwan Ko, Ji Woong Son

“…Objective To investigate the effects of a home-based rehabilitation program on physical capacity, lung function, and health-related quality of life (QOL) in patients with advanced lung cancer undergoing platinum-based chemotherapy. …”
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Increased Degenerative Biomarkers in Females with Patellofemoral Pain: A Cross-Sectional Analysis with 6-Month Progression by Lori A. Bolgla, Tiana V. Curry-McCoy, Maya Giddens, Madelyn Overton, Bryaunna Barrera, Jasmine Crockett, Monte Hunter

“…Subjects with PFP rated pain using a 10 cm visual analog scale, and function using the Knee injury and Osteoarthritis Outcome Scores-Patellofemoral (KOOS-PF) questionnaire. …”
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Influence of industrial atmospheric pollution on the development of pathology of respiratory organs by M. P. Hrebniak, R. A. Fedorchenko

“…Due to the technogenic load, first of all, the quality of the air basin is disturbed. More than 80 % of diseases depend to some extent on its quality, but in an industrial city, atmospheric pollution determines the priority of pathology of respiratory organs. …”
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Simulation Analysis of Air Distribution in the Public Area of Single-Span Arch-Shaped Underground Station under the Centralized Air Return Mode by FENG Rao, LUO Yanping, LI Bijia, HU Zilin

“…Therefore, it is necessary to study how to reduce the ventilation and air conditioning pipelines in the public areas of such underground stations on the premise of reasonable air distribution so as to provide more innovative space for decoration. ［Method］ In the case study of a single-span arch-shaped underground station in Shenzhen, ideas of adopting the centralized air return mode in the public area and the air supply duct design with smoke exhaust function are put forward. …”
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Moderate Ischemic Mitral Insufficiency at the Time of Coronary Artery Bypass Graft; Repair or Spare? by Ahmed Abdelwahhab, Mohamad Rushdi, Mohamed Ayyad, Ahmed Elminshawy

“…At six months follow-up, CABG group had more rate of improvement than repair group (P≤0.0001). …”
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Interdisciplinary Distance Learning Workshop for IT Students by I. A. Andrianov, S. A. Rzheutskaya, M. V. Kharina

“…An additional useful function of the learning workshop as the means of developing English-language competence is presented.Conclusion. …”
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A generative adversarial network with multiscale and attention mechanisms for underwater image enhancement by Liquan Zhao, Yuda Li, Tie Zhong

“…Additionally, we propose an improved loss function by introducing color loss into the conventional loss function. …”
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