An intact S-layer is advantageous to Clostridioides difficile within the host. by Michael J Ormsby, Filipa Vaz, Joseph A Kirk, Anna Barwinska-Sendra, Jennifer C Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R Chaudhuri, Paula S Salgado, Robert P Fagan, Gillian R Douce

“…Structural determination of SlpA from FM2.5varB indicated an alteration in the orientation of protein domains, resulting in a reorganisation of the lattice assembly, and changes in interacting interfaces, which might alter function. Interestingly, variant FM2.5varB displayed an attenuated, FM2.5-like phenotype in vivo compared to FM2.5varA, which caused disease severity more comparable to that of R20291. …”
Get full text

Treatment-Associated Neuroplastic Changes in People with Stroke-Associated Ataxia—An fMRI Study by Patricia Meier, Christian Siedentopf, Lukas Mayer-Suess, Michael Knoflach, Stefan Kiechl, Gudrun Sylvest Schönherr, Astrid E. Grams, Elke R. Gizewski, Claudia Lamina, Malik Galijasevic, Ruth Steiger

“…<b>Background/Objectives</b>: In consideration of the significance of the pursuit of training-induced neuroplastic changes in the stroke population, who are reliant on neurorehabilitation treatment for the restoration of neuronal function, the objectives of this trial were to investigate fMRI paradigms for acute stroke patients with ataxic symptoms, to follow up on changes in motor function and balance due to recovery and rehabilitation, and to investigate the different effects of two treatment methods on neuronal plasticity. …”
Get full text

High Platelet Reactivity in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: Randomised Controlled Trial Comparing Prasugrel and Clopidogrel. by Tobias Geisler, Jean Booth, Elli Tavlaki, Athanasios Karathanos, Karin Müller, Michal Droppa, Meinrad Gawaz, Monica Yanez-Lopez, Simon J Davidson, Rod H Stables, Winston Banya, Azfar Zaman, Marcus Flather, Miles Dalby, Miles Dalby

“…<h4>Background</h4>Prasugrel is more effective than clopidogrel in reducing platelet aggregation in acute coronary syndromes. …”
Get full text

The Otago Exercise Program's effect on fall prevention: a systematic review and meta-analysis by Chenyu Wang, Sung Min Kim, Sung Min Kim, Sung Min Kim

“…However, it does not significantly impact physical function or upper limb strength. This study has limitations, including potential bias, study heterogeneity, and variations in interventions, which may affect result reliability. …”
Get full text

The Impact of Host-galaxy Properties on Supernova Classification with Hierarchical Labels by V. Ashley Villar, Sebastian Gomez, Edo Berger, Alex Gagliano

“…This objective function more naturally accounts for the hierarchical nature of SN classes and, more broadly, transients. …”
Get full text

Cauda Equina Syndrome Without Perineal Sensory Changes or Lower Extremity Neurological Deficits Following Postoperative Spinal Epidural Hematoma: A Case Report and Literature Revie... by Guanyi Liu, Qing Li, Hongfeng Ruan, Bingke Zhu, Weihu Ma, Yong Hu

“…Future studies should focus on developing more comprehensive guidelines for monitoring postoperative patients, especially regarding urinary function, to aid in the early detection of CES.…”
Get full text

B-Lines in the Assessment of Interstitial Lung Disease Associated with Scleroderma: The Role of Handheld Devices by Codrina Ancuța, Cristina Pomirleanu, Ecaterina Gănceanu, Milena Adina Man, Eugen Ancuta, Paraschiva Postolache

“…<b>Results</b>: Symptomatic lung involvement with varying degrees of dyspnea was reported in about 74% of cases (functional NYHA > 2 in more than half), chronic dry cough in one-third, Velcro rales in 42%. …”
Get full text

Precise Parameters from Bayesian Spectral Energy Distribution Fitting Indicate Thermally Driven Mass Loss Likely Driver of Radius Valley by David Jordan, Inseok Song

“…Also, the slope as a function of stellar mass for both samples appears more consistent with thermally driven processes when compared to models and previous studies.…”
Get full text

Impact of Systemic Lupus Erythematosus on Health-Related Quality of Life in Colombian Patients: A Cross-Sectional Analytical Study by Fonseca-Zuluaga PA, Pérez-Ocampo J, Velásquez-Franco CJ, Hernandez JC, Higuita-Gutiérrez LF

“…SLE significantly impacts the domains of HRQL related to physical function, body pain, social function, emotional role, and general health. …”
Get full text

Loneliness and social isolation risk factors in community-dwelling older adults receiving home health services by Chava Pollak, Yolanda Pham, Amy Ehrlich, Joe Verghese, Helena M. Blumen

“…Those who lived alone had better cognitive and physical function, were more likely to be female, White/Caucasian, and lonely– and less likely to need assistance with activities of daily living (ADLs). …”
Get full text

Among Independence, Sovereignty and Autonomy: The Dutch Caribbean by Mine Kojima

“…This paper critiques the structure and functionality of the 21st century nation-state through analysis of emancipatory decisions in the former Dutch Caribbean colonies of Aruba, Curaçao, and Suriname.Suriname, the most culturally Dutch of the Caribbean territories, was the first of the former colonies to secede from the Netherlands. …”
Get full text

The Effectiveness of Patient-Oriented Correction of Adherence to Treatment in Patients with Arterial Hypertension and Comorbid Chronic Obstructive Pulmonary Disease by Voloshyna O., Dychko T., Lysyi I., Zbitneva V.

“…In patients with comorbid pathology of AH and COPD, in addition to the significant reduction in overall adherence to treatment, low bronchodilator tolerance is significantly more common than antihypertensive therapy. Conducting the patient-oriented correction of adherence to treatment leads to significantly better control of blood pressure in patients with hypertension associated with COPD and improves the function of external respiration.…”
Get full text

The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics by Yucui Zhao, Shixiao Zhu, Yingling Dong, Tian Xie, Zhiqiang Chai, Xiumei Gao, Yongna Dai, Xiaoying Wang

“…It explores how diet-mediated alterations in intestinal microbes and their byproducts play a role in regulating the pathogenesis of IBS by influencing the “brain-gut” axis, intestinal barrier function, immune responses, and more. By doing so, this review seeks to lay a theoretical foundation for advancing the development of clinical therapeutics for IBS.…”
Get full text

Sex differences in inflammation and markers of gut integrity in long COVID by Jared C. Durieux, Ziad Koberssy, Joviane Daher, Jhony Baissary, Marc Abboud, Ornina Atieh, Christopher Woolverton, Grace A. McComsey

“…Measures of endothelial function included reactive hyperemic index (RHI ≥ 1.67 = normal endothelial function) and augmentation index (higher AIx = worse arterial elasticity). …”
Get full text

Effects of Exercise on Mental Health of Elderly by Nafiseh Hekmati Pour, Hamid Hojjati

“…Introduction: Elders due to retirement and reduction in income, more than other community members face financial difficulties and subsequently mental health problems such as depression and distress. …”
Get full text

In vivo evaluation of tissue damage from varying grasping forces using the Saroa surgical system by Hiroyasu Nakashima, Yuichiro Ueda, Yoko Miyanari, Teruyuki Nishihara, Makoto Hamasaki, Makoto Ohbu, Kenji Kawashima, Hajime Yamakage, So Miyahara, Keita Tokuishi, Ryuichi Waseda, Takeshi Shiraishi, Toshihiko Sato

“…These results showed the lung and liver were more vulnerable to grasping forces, and exhibited more severe tissue damage at higher forces. …”
Get full text

Spatial accessibility and equity of primary healthcare in Zhejiang, China by Rixiang Xu, Caiming Xu, Lang Wu, Xuefeng Xie, Tingyu Mu

“…Methods The study used the navigation function provided by Gaode Map to estimate the time it takes for residents to visit PHC institutions. …”
Get full text

Fecal microbiome analysis uncovers hidden stress effects of low stocking density on rainbow trout by Guglielmo Raymo, Fabiane Januario, Ali Ali, Ridwan O. Ahmed, Rafet Al-Tobasei, Mohamed Salem

“…Additionally, vitamin B1 biosynthesis pathways were more abundant in the moderate stocking density group, which may function towards oxidative energy metabolism and protect against oxidative stress. …”
Get full text

Integrated Geologic Modeling of Fault-Block Reservoir: A Case Study of Ss Oil Field by Zhipeng Xiao, Zhang Wei, Zhengyin Tang, Jianqing Guo, Ruijuan Geng, Tuobing Gou

“…To gain the water saturation model, the distinct Sw function formulas of the S1~S4 layer derived from the JSw function were fed into the software. …”
Get full text

Platelet recruitment kinetics are impacted by von Willebrand factor quality in hemostatic adjuncts by Kimberly A. Thomas, Alice Liu, David L. Bark, Jr., Philip C. Spinella, Susan M. Shea

“…Herein, we show ex vivo simulation of coagulopathy and resuscitation differentiated hemostatic function under flow among Cryo, PR-CryoFC, and FibCon. …”
Get full text