Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). by Jonathan E Foley, Jing-Ruey J Yeh, Morgan L Maeder, Deepak Reyon, Jeffry D Sander, Randall T Peterson, J Keith Joung

“…Finally, in silico analysis demonstrates that one or more potential OPEN ZFN sites can be found within the first three coding exons of more than 25,000 different endogenous zebrafish gene transcripts.…”
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Molecular Imaging of Gliomas by A. H. Jacobs, C. Dittmar, A. Winkeler, G. Garlip, W. D. Heiss

“…Before new and potentially more effective treatment strategies, such as gene- and cell-based therapies, can be effectively implemented in the clinical application, certain prerequisites have to be established. …”
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Vancomycin Therapeutic Drug Monitoring by Bhaskar Shenoy, Devesh N Joshi, Pooja Doddikoppad

“…Children above the age of 3 months with suspected MRSA sepsis should receive vancomycin 60–80 mg/kg/day (should not increase >3600 mg/day) in three to four divided doses, considering they have normal renal function. Vancomycin dose should not increase >100 mg/kg/day which is more likely to surpass the threshold level. …”
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Amelioration of Inflammatory Cytokines Mix Stimulation: A Pretreatment of CD137 Signaling Study on VSMC by Wei Zhong, Bo Li, Xiao Yang Li, Zhong Qun Wang, Chen Shao, Cui Ping Wang, Rui Chen, Jin Chuan Yan

“…This research suggested that 10 ng/ml CM pretreatment is more reasonable than other concentrations when exploring CD137 function in VSMCs.…”
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Mi-DETR: For Mitosis Detection From Breast Histopathology Images an Improved DETR by Fatma Betul Kara Ardac, Pakize Erdogmus

“…In the decoder layer, unnecessary model parameters have been filtered out using a layer reduction strategy to improve model efficiency and reduce computational costs. Additionally, a more stable model has been obtained by using the CIoU loss function instead of the L1+GIoU loss function used in the DETR model. …”
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DETERMINATION OF PASSENGER-TRAFFIC FLOWS IN REGIONAL TRANSPORT SYSTEM ON THE BASIS OF MODIFIED GRAVITY MODELS by E. A. Nurminskiy, I. N. Pugachev, N. V. Shamray, V. N. Sedyukevich

“…The most adequate results have been obtained while using an exponential attraction function for individual vehicles and a power attraction function  for passenger route auto transport. …”
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Glucose Intolerance after a Recent History of Gestational Diabetes by Katrien Benhalima, Liesbeth Leuridan, Peggy Calewaert, Roland Devlieger, Johan Verhaeghe, Chantal Mathieu

“…Of the women tested, 39.1% (66) had glucose intolerance and 5.3% (9) had diabetes. These women were more often overweight (39.7% versus 25.3%, P = 0.009), were more often treated with basal-bolus insulin injections (52.0% versus 17.4%, P = 0.032), and had a lower beta-cell function and lower insulin sensitivity, remaining significant after adjustment for age, BMI, and ethnicity (insulin secretion sensitivity index-2 (ISSI-2) in pregnancy 1.5 ± 0.5 versus 1.7 ± 0.4, P = 0.029; ISSI-2 postpartum 1.5 (1.2–1.9) versus 2.2 (1.8–2.6), P = 0.020; Matsuda index postpartum 3.8 (2.6–6.2) versus 6.0 (4.3–8.8), P = 0.021). …”
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Sibutramine monotherapy in arterial hypertension combined with obesity by S. V. Nedogoda, I. N. Barykina, U. A. Brel, T. A. Chalyabi, G. V. Mazina, E. V. Podolskaya, A. A. Ledyaeva

“…Meridia® was also associated with significant PVW reduction and improvement in flow-dependent vasodilatation, QoL, psycho-emotional status and erectile function in males.Conclusion. Sibutramine therapy in patients with obesity and AH improved hemodynamics, carbohydrate and lipid metabolism, QoL, anthropometry and organ protection parameters more effectively than traditional AHT In patients with obesity and AH, short-term Meridia® therapy was associated with a reduction in systolic and diastolic BP, without any significant increase in HR.…”
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Clinical Application of Graphene Composite in Internal Fixation of Ankle Fracture in Sports by Xiaowei Xu, Rongna Wang, Dachao Zhang, Yingge Feng

“…Composite material is a combination of multiphase combination material. In short, two or more components with different properties and different forms are used in a multimaterial combination of composite means. …”
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Clinical features and prognostic analysis of AKI in the internal medicine departments by XUE Xian, TANG Xiao-jing, ZHANG Di, SHEN Ai-wen, MEI Chang-lin

“…Objective To explore the clinical features of patients with acute kidney injury(AKI)in the internal medicine departments.Methods The kidney function indexes of the internal medicine patients were collected in Shanghai Changzheng Hospital from 2011 to 2012.According to the AKI diagnostic criteria of KDIGO in 2012,we screened out the AKI patients who met the criteria.By retrospectively studying their clinical data,we analyzed and summarized their clinical characteristics and the factors affecting the prognosis.Results From January 2011 to December 2012,there were a total of 33 332 cases of internal medicine patients in our hospital and 245 of them met the criteria of AKI.The incidence of AKI was 0.74%in internal medicine departments while the detection rate of AKI was 35.92%.The proportions of patients with AKI stage 1 to 3 were 42.45%,20.41% and 37.14%,respectively.Among all the internal medicine departments,patients in the department of nephrology accounted for 33.47%,followed by the department of cardiology(20.00%),gastroenterology(11.84%)and infectious disease(10.61%).The incidence of AKI from high to low was infection disease department(1.70%),nephrology department(1.37%),and cardiology department(1.11%).Of all the hospitalized patients with AKI,71.84% discharged with a better health condition and the kidney function discovered in only 34.69% of the discharged patients;28.16% died or gave up treatment.The most common departments with high fatality rate were the department of infectious disease(21.74%),gastroenterology and cardiology.Infection was the main cause of the AKI in internal medicine departments.Logistic regression analysis showed that higher AKI stage,more AKI risk factors,combination with liver disease or tumor were risk factors for death and giving up treatment,while chronic kidney disease was the protective factor.ConclusionsAKI is common in internal medicine system,with a high mortality rate and a higher recognition rate than perioperative AKI.Except for the department of nephrology,cardiology,departments of infectious disease and gastroenterology have heavy burden of AKI.The advanced stage of AKI,more risk factors,and comorbidities such as liver disease or tumor were associated with poor prognosis.…”
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Hardcoded vulnerability detection approach for IoT device firmware by Chao MU, Xin WANG, Ming YANG, Heng ZHANG, Zhenya CHEN, Xiaoming WU

“…With the popularization of IoT devices, more and more valuable data is generated.Analyzing and mining big data based on IoT devices has become a hot topic in the academic and industrial circles in recent years.However, due to the lack of necessary detection and protection methods, many IoT devices have serious information security risks.In particular, device hard-coded information is closely related to system encryption and decryption, identity authentication and other functions, which can provide confidentiality protection for core data.Once this information is exploited by malicious attackers, serious consequences such as sensitive information leakage, backdoor attacks, and unauthorized logins will occur.In response to this problem, a multi-type character recognition and positioning scheme was designed and a hard-coded vulnerability detection method in executable files was proposed based on the study of the characteristics of hard-coded vulnerabilities in IoT devices.The proposed method extracted the firmware of IoT devices and filtered all executable files as the source to be analyzed.Then, a solution to identify and locate three types of hard-coded characters was provided.Further, the reachability of the function, where the hard-coded character was located, was analyzed according to the function call relationship.Meanwhile, the instruction heterogeneity was mitigated by an intermediate representation (IR) model.The character and parameter hard-coded values was obtained through a data flow analysis approach.A symbolic execution method was devised to determine the trigger conditions of the hard-coded vulnerabilities, and then the vulnerability detection result was output.On the one hand, the proposed method introduced the method of symbolic execution based on the use of the intermediate representation model, which eliminated the dependency of instruction architecture and reduces the false positive rate of vulnerabilities; On the other hand, this method can integrate characters, files, and cryptographic implementation to realize the different characteristics of three types of hard-coded characters, which increased the coverage of vulnerability detection and improves the versatility of the detection method.The experimental results show that the proposed method can effectively detect three types of hard-coded vulnerabilities of characters, files and cryptographic implementation in various IoT devices, and has good detection accuracy, which can provide certain guidance for the deployment of subsequent security protection technologies.…”
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Investigation of Thyroid Disorders in Women with Diabetes in the United Arab Emirates: A Retrospective Cross-Sectional Study by Bashair M. Mussa, Narjes Saheb Sharif-Askari, Nabil Sulaiman, Salah Abusnana

“…The investigation included age, diabetes duration, body mass index, blood pressure, hemoglobin A1c, fasting and random glucose, lipid profile, thyroid function test, and levels of thyroid-stimulating hormone. …”
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Release Kinetics of Boron in Acidic Soils as Affected by Calcium Form Different Sources by Roongnapa Bowichean, Richard William Bell, Miaomiao Cheng, Suphicha Thanachit, Somchai Anusontpornperm

“…Compared at the same rates of Ca applied, CaCl2 accelerated more B release than GL with no statistical difference in some soils. …”
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Eosinophilic cationic protein as a non-invasive marker of the nature of inflammatory response in patients with chronic obstructive pulmonary disease by M. A. Karnaushkina, S. V. Fedosenko, R. S. Danilov, I. S. Komarova, V. A. Petrov

“…The study has demonstrated that high plasma levels of ECP in patients with COPD are associated with a more severe course of disease and the development of more frequent infection-related exacerbations of the disease, which require the administration of inhaled glucocorticoids and antibiotics. …”
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Device Therapy in Patients with Heart Failure: Is Medication Use Optimized and Are We Targeting Those Patients Most Likely to Benefit? by Robert Wannamaker, MD, MSc, Roopinder K. Sandhu, MD, MPH, Justin A. Ezekowitz, MBBCh, MSc, Sheri L. Koshman, PharmD, Derek S. Chew, MD, MSc, Luke R. Gagnon, MD, MSc, Chen-Hsiang Ma, MD, Chandu Sadasivan, Gavin Y. Oudit, MD, PhD, Finlay A. McAlister, MD, MSc

“…We characterized GDMT by the modified Heart Function Collaboratory score at the time of device referral and grouped patients by Multicenter Automatic Defibrillator Implantation Trial-II (MADIT-ICD) benefit–risk score. …”
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Fiscal Sustainability in Iran A Markov-Switching Fiscal Regime Change and Time-Varying Parameter Models Approach by Hossein Aghilifar, Khosrow Piraei, Hashem Zare, Mehrzad Ebrahimi

“…This has caused unsustainable fiscal policy which in turn, made the Iranian economy more and more vulnerable with regard to external shocks. …”
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EFFECT OF «TREAT-TO-TARGET» ANTIRHEUMATIC THERAPY ON DIASTOLIC DYSFUNCTION OF THE LEFT AND RIGHT VENTRICLES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS DURING 18 MONTHS OF OBSERVAT... by I. G. Kirillova, D. S. Novikova, T. V. Popkova, Yu. N. Gorbunova, E. I. Markelova, Yu. O. Korsakova, O. A. Fomicheva, A. V. Volkov, E. L. Luchikhina, N. V. Demidova, K. A. Kasumova, S. A. Vladimirov, M. A. Kanonirova, G. L. Lukina, A. A. Novikov, E. N. Aleksandrova, D. E. Karateev, E. L. Nasonov

“…The normalization of left ventricle (LV) diastolic function in early RA patients depended primarily on the efficacy of antihypertensive treatment, and of right ventricle (RV) diastolic function - on the achievement of target BP level and RA remission. …”
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Is product-service system designing different from product designing? A cognitive study of experienced product designers by Abhijna Neramballi, Tomohiko Sakao, John S Gero

“…PSS designing was found to focus more on the design issue function and the design process formulation. …”
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Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT by F D Richard Hobbs, Richard McManus, Clare Taylor, Nicholas Jones, Joy Rahman, Jane Wolstenholme, Louise Jones, Jennifer Hirst, Sam Mort, Ly-Mee Yu

“…Adverse events were experienced more often, and participants were more likely to discontinue treatment in the intervention group. …”
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Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis by Yi Quan, Huihui Shao, Nuoya Wang, Zhonggao Gao, Mingji Jin

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