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7741
Plant-derived polyphenolic compounds for managing schizophrenia: mechanisms and therapeutic potential
Published 2025-06-01“…These plant compounds hold the potential not only to alleviate the symptoms of schizophrenia but also to enhance cognitive function. They may achieve this through various mechanisms, such as boosting antioxidant defenses, reducing neuroinflammation, balancing neurotransmitters, increasing brain-derived neurotrophic factor (BDNF) levels, and enhancing mitochondrial function. …”
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7742
Voltage-Gated Ion Channels in Neuropathic Pain Signaling
Published 2025-05-01“…These agents have improved efficacy and safety profiles in preclinical and clinical studies by attenuating pathophysiological channel activity and restoring neuronal function. This review seeks to contribute to guiding future research and drug development toward more effective mechanism-based treatments by discussing the molecular mechanisms underlying neuropathic pain and highlighting translational therapeutic opportunities.…”
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7743
Clinical application of preoperative volumetric measurement for interventional precise embolization in the treatment of hypersplenism caused by liver cirrhosis
Published 2025-07-01“…We compared the changes in liver function test results and haematological parameters between these two groups. …”
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7744
Knockout of Sirtuin 3 in endothelial cells impairs endothelial‐dependent relaxation and myogenic response in mice
Published 2024-10-01“…Female SIRT3ECKO mice had profound dysfunction in CA, whereas male mice exhibited more dysfunction in MCA. These data revealed a sex and organ‐specific role of endothelial SIRT3 in vascular function and myogenic responses. …”
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7745
Impact of smoking status on the efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review
Published 2020-04-01“…The rate ratios favoured more exacerbations in ICS users who were current or heavier smokers than those who were ex-smokers or lighter smokers (0.81 to 0.99 vs 0.92 to 1.29).Conclusions In COPD, heavier or current smokers do not gain the same benefit from ICS use on lung function and exacerbation rates as lighter or ex-smokers do, however effects may not be clinically important.PROSPERO registration number CRD42019121833…”
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7746
Long‐term effects of obesity on COVID‐19 patients discharged from hospital
Published 2021-12-01“…All the patients were invited to fill out a series of scales to assess cardiopulmonary function. Data on population baseline characteristics, clinical manifestations, laboratory examinations, chest computed tomography (CT), and lung function were collected and analyzed. …”
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7747
Type 2 diabetes clusters in the Novosibirsk region
Published 2023-07-01“…Cluster 2 in 432 patients (15.4%) with increased function of β-cells, the age of diagnosis of T2DM was older — 52.91±7.75 years, patients had a higher BMI of 35.64±7.21 kg/m2 and more high diastolic blood pressure, earlier development of diabetic retinopathy, nephropathy and polyneuropathy, and better response to metformin therapy and combined therapy with metformin and sulfonylurea. …”
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7748
Sexual dysfunction and serum prolactin level in a sample of patients with methamphetamine dependence in Eastern Province in Saudi Arabia: a cross-sectional study
Published 2025-04-01“…Abstract Background Methamphetamine usage has become more widespread, which is a global societal concern. …”
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7749
Invasive Vagus Nerve Stimulation Activates Microglia α7nAChR to Reduce Striatal Neuroinflammation in Mouse Model of Parkinson's Disease and Its Mechanism
Published 2025-06-01“…After modeling and intervention, the open field test was used to detect the autonomic motor function of each group. The rotarod test was used to detect the balance and coordination function of each group. …”
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7750
Acquisition of Case System in Romani Language
Published 2019-11-01“…It seems that Roma children need more experience with the language in order to connect the case marker with the function of the preposition in the Romani language.…”
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7751
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7752
Sex similarities and differences in the reverse and anti-remodeling effect of pressure unloading therapy in a rat model of aortic banding and debanding
Published 2024-12-01“…Pressure unloading exposes a more pronounced anti-remodeling effect on the functional level in males, which is attributed to the more progressive functional deterioration in AB animals. …”
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7753
Predicting right ventricular failure after left ventricular assist device implant: A novel approach
Published 2025-06-01“…‘No RVF’ patients were defined as patients who never demonstrated more than moderate RV dysfunction on a post‐LVAD transthoracic echocardiogram (TTE) (ordinal RV function <3), never required an RV assist device (RVAD), were not discharged on sildenafil and were not on a pulmonary vasodilator or inotropic medication at 3 months after LVAD implant. …”
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7754
Cognitive «portrait» of children with mental retardation
Published 2022-04-01“…Within the framework of a cross-sectional analytical study, the structure of cognitive function disorders and psychoemotional status in children with delayed psychoverbal development was determined. 132 children aged 5-11 years were examined: 58% boys and 42% girls. …”
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7755
Interface effects in the phase determination of Hf0.5Zr0.5O2 epitaxial thin films
Published 2025-01-01“…Here, it is demonstrated that the substrate the film is grown on is more influential than factors such as thickness, defect content, and strain. …”
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7756
Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.
Published 2021-05-01“…Treatment combined with expanded practices resulted in successful maintenance of rhesus macaques (RM) free of common EPs, with no evidence of overt microbiota diversity loss or dysbiosis and instead resulted in a more defined luminal microbiota across study subjects. …”
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7757
Comparison of combined suprascapular and axillary nerve pulsed radiofrequency and nerve block for the treatment of primary frozen shoulder: a prospective cohort study
Published 2025-12-01“…At different time after the procedure, most of the parameters of PROM improved more in group P than those in group B (flexion at 3 and 6 months, p = 0.042 and <0.001; abduction at 3 and 6 monthse, p = 0.001 and 0.001; extension at 3 and 6 months, p = 0.038 and 0.007, internal rotation at 6 months, p = 0.015; external rotation at 1, 3, and 6 months, p = 0.002, 0.002, and 0.001, respectively).Conclusions In patients with primary FS who completed both manipulation under anesthesia and intra-articular injections, PRF with SSN and AN appears to provide better pain relief, better PROM recovery, and more shoulder function improvement than nerve block treatment.…”
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7758
A new clinical classification of congenital biliary dilatation – HUAXI CBD classification
Published 2024-11-01“…Objective To propose a more concise and more suitable classification of congenital biliary dilatation (CBD), and exploring the feasibility and effectiveness of this classification in diagnosis and treatment. …”
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7759
Clinical outcomes and safety of combined calcitriol and bisphosphonates in treating postmenopausal osteoporosis: a retrospective cohort study
Published 2025-04-01“…Barthel Index scores increased more in the study group (P < 0.05). Bone metabolism markers (BALP, BGP, PINP, TRACP) and inflammatory cytokines (IL-6, TGF-β1, TNF-α) decreased more significantly in the study group, while IL-10 levels and BMD increased more markedly (P < 0.05). …”
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7760
Neuromotor Changes After a Cervical Spinal Cord Injury: Bilateral Assessment of Unilateral Tasks
Published 2024-01-01“…Cervical spinal cord injuries (cSCI) severely affect upper limb function, yet research on post-injury neuromotor abilities is limited. …”
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