Implication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantation by Yong Wang, Joshua E. Mendoza-Elias, Meirigeng Qi, Tricia A. Harvat, Sang Joon Ahn, Dongyoung Lee, Diana Gutierrez, Hyojin Jeon, Daniel Paushter, José Oberholzer

“…Since the introduction of the Edmonton Protocol in 2000, more attention has been placed on preserving mitochondrial function as increasing evidences suggest that impaired mitochondrial integrity can adversely affect clinical outcomes. …”
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Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas. by Hande Demir, Iikki Donner, Leena Kivipelto, Outi Kuismin, Camilla Schalin-Jäntti, Ernesto De Menis, Auli Karhu

“…Thus far, only somatic gain-of-function hot-spot mutations have been studied in these loci. …”
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Quality of life in patients after cystectomy as the main aim while making a choice for the urine derivation procedure by R. V. Savchuk, F. I. Kostуev, S. V. Golovko

“…With the aim for objectivization and standardization of the QL estimation procedure after reconstructive operative intervention on the lower urinary ways in 1 and 12 mo a social-clinical method of the investigation, basing on questionnaire «Medical Outcomes Study – Short Form» (SF-36), was applied. Sexual function was estimated, using questionnaire IIEF-5 (International Index of Erectile Function). …”
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Randomized controlled single-center trial of ferrous succinate and polysaccharide iron complex in the treatment of anemia induced by non-dialysis chronic kidney disease by YAO Yao, YU Chuan-qi, LI Ming, BIAN Fan, JIANG Geng-ru

“…Objective To compare the curative effect of ferrous succinate and polysaccharide iron complex on the anemia of non-dialysis chronic kidney disease(ND-CKD)patients.Methods Twenty ND-CKD patients in our hospital were selected and divided into two groups according to the randomization method.Blood routine,iron metabolism index,liver function,renal function,and hs-CRP were examined at the baseline and at 1 st,2 nd,3 rd,4 th,5 th and6 th month after treatment.The qualified rate and increase of hemoglobin from baseline were observed and compared.Results As compared with the polysaccharide iron complex group,hemoglobin(Hb)increased significantly after treatment with ferrous succinate complex for 3 and 6 months.The difference was not significant,although both groups showed an increase in both ferritin and transferrin saturation.The increase in red blood cells and serum iron was greater after treatment for 6 months.At 4 th,5 th and6 th month after treatment,the qualified rate in ferrous succinate complex group was significantly higher than in the polysaccharide iron complex group.There was significant difference in counts of red blood cells(RBC),Hb and red cell distribution width(RDW)between two groups after treatment for 6 months.There was no significant difference in liver function,hs-CRP and eGFR between two groups during the treatment duration of 6 months.Conclusions Iron supplement is a necessary means to correct anemia in patients with ND-CKD.Oral iron is a commonly used method of iron supplementation in clinic.After the treatment of ferrous succinate,Hb increased significantly and was more effective.Ferrous succinate can also improve RDW at the same time.…”
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Cognitive changes and quality of life in neurocysticercosis: a longitudinal study. by Mitchell T Wallin, E Javier Pretell, Javier A Bustos, Marianella Caballero, Mercedes Alfaro, Robert Kane, Jeffrey Wilken, Cynthia Sullivan, Timothy Fratto, Hector H Garcia

“…QoL at baseline suggested impaired mental function and social function in both the NCC and epilepsy group compared with healthy controls. …”
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Double Rectangle Fascia Lata Frontalis Sling: A Rationale Approach for Ptosis by Pawan Agarwal, Dhananjaya Sharma, Vikesh Agrawal, Swati Tiwari, Rajeev Kukrele

“…Background The purpose of this study was to evaluate the functional outcomes of a modified technique of double rectangle pattern for correction of severe ptosis. …”
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Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast. by Jordan B Rapp, Chiaki Noguchi, Mukund M Das, Lisa K Wong, Alison B Ansbach, Allyson M Holmes, Benoit Arcangioli, Eishi Noguchi

“…Interestingly, unlike swi3-deleted cell, the separation-of-functions mutants were proficient in the activation of the replication checkpoint, but their fork regeneration defects were more severe than those of checkpoint mutants including cds1Δ, chk1Δ and rad3Δ. …”
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Influence of implant macrodesign and insertion load during implant placement on primary stability in artificial bone by Yiwen Wang, Yoko Yamaguchi, Poyuan Hsueh, Daisuke Higuchi

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Potential small guide RNAs for tRNase ZL from human plasma, peripheral blood mononuclear cells, and cultured cell lines. by Sho Ninomiya, Mitsuoki Kawano, Takashi Abe, Tatsuya Ishikawa, Masayuki Takahashi, Masato Tamura, Yoshiaki Takahashi, Masayuki Nashimoto

“…The degraded RNA such as a 5'-half-tRNA and an rRNA fragment function as small guide RNA (sgRNA) to guide the enzyme to target RNA. …”
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Alternative splicing events driven by altered levels of GEMIN5 undergo translation by Rosario Francisco-Velilla, Salvador Abellan, Juan Antonio Garcia-Martin, Juan Carlos Oliveros, Encarnacion Martinez-Salas

“…Importantly, differential AS events in mRNAs engaged in polysomes, eventually rendering non-functional proteins, encode factors controlling cell growth. …”
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Control Index for Water Regulation in Fish Breeding Season for Dongta Spawning Ground after Operation of Datengxia Gorge Water Conservancy Project by LIU Lishi, WANG Li, GE Xiaoxia, TAN Xichang

“…After the operation of the Datengxia Gorge water conservancy project,the change in the hydrological rhythm of the downstream river channel may have a certain impact on the function of the Dongta spawning ground about 10 km downstream.To maintain the normal function of the Dongta spawning ground,we should analyze the hydrological rhythm process required for fish spawning and use it as a control index to implement ecological regulation of reservoirs and thus restore the ecological environment of river channels.According to the observation data of early fish resources and hydrology over the past dozen years,the correlation between early fish resources and hydrological characteristic values in the Dongta spawning ground is analyzed by different statistical methods such as grey relational analysis and linear regression.In combination with the practical experience of ecological regulation in the Xijiang River Basin,the control index requirements for water regulation during the fish breeding period by the Datengxia Gorge water conservancy project are put forward.Specifically,by the regulation of the Datengxia Gorge water conservancy project from May to July every year,when the section flow rate of Dahuangjiangkou exceeds 3 500 m³/s,the water rise duration shall be no less than four days,with the daily rise rate in the water rise stage of more than 1 000 m³/s.The time for water to recede shall be no less than three days,and the flow rate in the water recession stage shall be above 3 500 m³/s.The regulation shall be performed at least once each year.The research results can provide a technical reference for maximizing the function of the Dongta spawning ground in the fish breeding period by the regulation of the Datengxia Gorge water conservancy project.…”
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Modern approaches to the treatment of joint pathology: the value of hyaluronic acid by M. M. Shamuilova, Yu. V. Sedyakina, G. Yu. Knorring

“…Hyaluronic acid introduced from the outside takes on the load, replenishing the missing functions of the synovial fluid, which allows us to consider such use as prosthetics of insufficient joint function. …”
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Comparative analysis of mitochondrial and mesenchymal stem cell transplantation for angiogenesis and muscle regeneration by Mi Jin Kim, Jung Wook Hwang, Chang-Koo Yun, Ikhyun Lim, Kyunghoon Min, Yong-Soo Choi

“…Furthermore, mitochondrial transplantation promoted angiogenesis and increased vascular density in ischemic muscles by enhancing endothelial cell function. Overall, PD-MSC-derived mitochondrial transplantation demonstrated proved more effective over MSC transplantation in reducing inflammation, restoring mitochondrial function, and supporting tissue recovery, highlighting its promise as an effective therapeutic approach for CLI and other ischemic conditions by directly addressing mitochondrial dysfunction and overcoming the limitations of conventional cell therapies.…”
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Hemostatic dysfunction is increased in patients with hepatosplenic schistosomiasis mansoni and advanced periportal fibrosis. by Luiz Arthur Calheiros Leite, Adenor Almeida Pimenta Filho, Caíque Silveira Martins da Fonseca, Bianka Santana dos Santos, Rita de Cássia dos Santos Ferreira, Silvia Maria Lucena Montenegro, Edmundo Pessoa Lopes, Ana Lúcia Coutinho Domingues, James Stuart Owen, Vera Lúcia de Menezes Lima

“…<h4>Methodology/principal findings</h4>Blood samples were used for liver function tests, hemogram and prothrombin time (International Normalized Ratio, INR). …”
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The effects of high-intensity interval training on cognitive performance: a systematic review and meta-analysis by Kaihang Liu, Wei Zhao, Congcong Li, Ying Tian, Lijuan Wang, Jingyi Zhong, Xu Yan, Yezheng Wang, Liyan Wang, Hongbiao Wang

“…Acute HIIT improved executive function, less than 8 weeks of HIIT improved executive function and memory, and more than 8 weeks of HIIT improved information processing, executive function and memory. …”
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Effects of interval versus continuous exercise on cerebral vascular flow‐mediated dilatation in young healthy males by Harvey J. Walsh, Shotaro Saito, Narumi Kunimatsu, Marino Karaki, James P. Fisher, Shigehiko Ogoh

“…We hypothesized that Int‐Ex would enhance cerebral SS and, consequently, cerebral endothelial function more than Con‐Ex. Fourteen healthy males (21 ± 0.6 years) completed 32 min of Int‐Ex and work‐equivalent Con‐Ex on a semi‐recumbent bike on separate days. …”
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Quantum Entanglement of the Brain, Dynamics of Information, and Intelligent Finance by Ana Njegovanović

“…Financial entanglement is multidimensiona in time and space, dynamic, less understood and interesting because it functions in real life, like the brain. Neuroscientists who focus on mathematical frameworks for how the brain's shape affects its activity—an area of mathematical neuroscience called neural field theory  will begin to understand the relationship between brain shape, structure, and function in yet another way. …”
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Dexmedetomidine and the glymphatic system: a new perspective in managing postoperative cognitive dysfunction by Sha-Sha Zhang, Fan-Geng Meng, Yuan-Yuan Rong, Yi-Wen Zhang, Hua-Qin Liu

“…Postoperative cognitive dysfunction (POCD) is a common and significant neurological complication, occurring more frequently in elderly individuals and those with frailty or underlying neurodegenerative conditions, though it is not limited to these populations. …”
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Outcomes of Genetic Testing-Based Cardiac Rehabilitation Program in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention by Xing Yu, Yuxuan Fan, Xiaopeng Sun, Xiaojing Wang, Qi Guo, Zhiqing Fan

“…We found that the subjects with a high mutation frequency in aerobic exercise and cardiopulmonary function-related genes achieved more cardiorespiratory fitness benefits in the aerobic exercise rehabilitation program and provided evidence for the establishment of a precision medicine program for clinical research.…”
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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…Abstract Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life. …”
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