Diverse microbiome functions, limited temporal variation and substantial genomic conservation within sedimentary and granite rock deep underground research laboratories by Yuki Amano, Rohan Sachdeva, Daniel Gittins, Karthik Anantharaman, Shufei Lei, Luis E. Valentin-Alvarado, Spencer Diamond, Hikari Beppu, Teruki Iwatsuki, Akihito Mochizuki, Kazuya Miyakawa, Eiichi Ishii, Hiroaki Murakami, Alexander L. Jaffe, Cindy Castelle, Adi Lavy, Yohey Suzuki, Jillian F. Banfield

“…Despite this, hydrogen metabolism, rubisco-based CO2 fixation, reduction of nitrogen compounds and sulfate reduction are well represented functions in microbiomes from both URLs, although methane metabolism is more prevalent at the organic- and CO2-rich Horonobe URL. …”
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Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1 by Shen Chen, Kexin Nie, Hongzhan Wang, Yang Gao, Xinyue Jiang, Hao Su, Zhi Wang, Yueheng Tang, Fuer Lu, Hui Dong, Jingbin Li

“…Both low-dose WMW and high-dose WMW treatments led to reduced weight gain and improved glucose tolerance, with low-dose WMW showing more pronounced effects. WMW also reversed structural damage in BAT, enhancing mitochondrial integrity and thermogenic function, particularly at the low dose. …”
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Preparation of sulfonic acid functionalized metal organic frameworks and their application in the online solid phase extraction of parabens and sulfonamides in pre-cooked foods by Min Fang, Jianyang Ke, Zhaojie Wang, Qing Fu, Qing Yang, Lin Xu, Yuepeng Lu, Yong Yang, Xiaoming Jiang, Yongning Wu, Zhiyong Gong, Xin Liu

“…Mixed-mode sorbents exhibit two or more primary retention mechanisms, which can enhance the selectivity and capacity of the extraction process in a single step. …”
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Construction of Carbon Functional Zone in the Demonstration Zone of Green and Integrated Ecological Development of the Yangtze River Delta Based on Carbon Density Correction by Tian ZHANG, Zhen SHEN, Tingting SU, Daixin DAI

“…This shift reflects a transition toward more concentrated carbon storage and enhanced carbon sink functions. …”
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Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy by Seonghyeon Park, Ohman Kwon, Hana Lee, Younghak Cho, Jemin Yeun, Sung Hyun Yoon, Sang Yu Sun, Yubin Huh, Won Dong Yu, Sohee Park, Naeun Son, Sojeong Jeon, Sugi Lee, Dae-Soo Kim, Sun Young Lee, Jin Gyeong Son, Kyung Jin Lee, Yong Il Kim, Jin Hong Lim, Jongman Yoo, Tae Geol Lee, Mi-Young Son, Sung Gap Im

“…Here, we propose a functional polymer-based xenogeneic-free dish for the culture of intestinal stem cells (XF-DISC), ensuring substantially prolonged maintenance of ISCs derived from 3-dimensional human intestinal organoids (ISCs3D-hIO). …”
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Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…However, to use this technology more rationally in clinical practice, a deepened understanding of the molecular mechanisms behind its therapeutic effects is needed. …”
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A bespoke water T–maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice by Jeremy Davidson Bailoo, Susan E. Bergeson, Igor Ponomarev, Joshua O. Willms, Brent R. Kisby, Gail A. Cornwall, Clinton C. MacDonald, J. Josh Lawrence, J. Josh Lawrence, Vadivel Ganapathy, Sathish Sivaprakasam, Praneetha Panthagani, Scott Trasti, Justin A. Varholick, Michael Findlater, Amrika Deonarine

“…We show, across five experiments, procedural refinements to our protocol and demonstrate robust, reliable and reproducible indicators of learning, memory and executive functioning in a task that is also significantly more efficient (3 days of testing within the WTM vs. 11 days of testing within the MWM). …”
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Renal function in liver recipients: in-depth analysis of data from the Local Scientific Transplant Registry of the Burnasyan Federal Medical Biophysical Center by A. I. Sushkov, V. S. Rudakov, M. V. Popov, A. E. Kalachyan, E. V. Naydenov, A. I. Artemiev, S. E. Voskanyan

“…Renal dysfunction is common in liver transplant candidates and recipients. However, despite more than 30 years of experience with liver transplantation in Russia, this problem has not been systematically studied in large cohorts of patients.The objective was to evaluate the prevalence and severity of renal dysfunction before liver transplantation (LT), during the first postoperative week, at discharge, and one year after surgery.Material and methods. …”
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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008 by Juntong Li, Juntong Li, Sheng Ye, Xiang Li, Xiang Li, Hui Liu, Yue Yang, Xuelei Lu, Heyue Jin, Li Liu, Li Liu

“…ObjectiveThis study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults.MethodsThe study utilized data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. …”
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Exposure-response functions of the correlated environmental exposures green space, noise, and air pollution for quantifying mortality burden in health impact assessment by Xuan Chen, Ulrike Gehring, Georgia M.C. Dyer, Kees de Hoogh, Sasha Khomenko, Haneen Khreis, Natalie Mueller, Roel Vermeulen, Harry Williams, Belen Zapata-Diomedi, Mark Nieuwenhuijsen, Gerard Hoek

“…Objective: Environmental health impact assessments (HIA) on green space, air pollution (fine particulate matter (PM2.5) or nitrogen dioxide (NO2)), and noise use exposure–response functions (ERF) based on single-exposure models from epidemiological studies, not accounting for potential confounding by other commonly correlated exposures. …”
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The expression of liver–gonadal axis genes reveals the long–term effects of exogenous estradiol on gonad development and liver function in GIFT tilapia by Ye Yuan, Zexun Zhou, Shandong Chen, Yunyun Liu, Yongchun Li, Yan Miao, Shi Wang, Zhongyuan Shen, Lei Zeng, Jun Xiao, Qinbo Qin, Wuhui Li

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Enhancing Male Fertility Through Nutrition: The Role of L-Carnitine in Asthenozoospermic Patients by Jafar Shaikh, Akash More, Namrata Anjankar, Nancy Nair, Sanket S. Mahajan, Neha Nawale

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Impact of fatigue in Crohn's disease is negatively related to resting state functional connectivity between the superior parietal lobule and parahippocampal gyrus/hippocampus by Theresa A. McIver, Theresa A. McIver, Theresa A. McIver, Charles N. Bernstein, Charles N. Bernstein, Ruth Ann Marrie, Ruth Ann Marrie, Chase R. Figley, Chase R. Figley, Md Nasir Uddin, Md Nasir Uddin, Md Nasir Uddin, John D. Fisk, Lesley A. Graff, Lesley A. Graff, Ronak Patel, Erin L. Mazerolle, Jennifer Kornelsen, Jennifer Kornelsen, Jennifer Kornelsen

“…Moderation analyses tested whether brain resting state functional connectivity moderates the relationship between disease activity and fatigue.ResultsThe Crohn's disease group reported more severe fatigue than the healthy control group in each domain of the FIS. …”
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Peripubertal DEHP exposure impairs reproductive function in adult male mice by inducing damage to Sertoli cells and disrupting the blood-testis barrier by XU Guiyong, XU Guiyong, ZHANG Lu, ZHANG Lu, SUN Fengqiong, SUN Fengqiong

“…In the 25, 125, 250 and 500 mg/kg DEHP exposure groups, the thickness of the seminiferous epithelium was obviously decreased, with more cellular vacuolization and notable epithelial atrophy and degeneration. …”
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Functional Performance Decline Outperforms Sarcopenia and Its Components in Predicting New-Onset Chronic Kidney Disease: A Nationwide Multicenter Study by Liangyu Yin, Furong Li, Tangli Xiao, Jun Zhang, Yan Li, Jicong Luo, Jinghong Zhao, Jiachuan Xiong

“…Additionally, the observational nature of the study and reliance on self-reported CKD data may lead to potential confounding, misclassification, and reverse causality, requiring further validation through studies with laboratory-confirmed CKD events and larger, more diverse populations. Conclusions: The ADL score indicated that functional performance is superior to sarcopenia and its components in predicting the onset of CKD in middle-aged and older Chinese adults. …”
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Back-channeling in Celebrities Interviews: A Socio-discoursal Study by Zainab Saad Mohammed, Ahmed Adel Nouri

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(Too) many policies under one roof? About the integration of competition law enforcement and sectoral regulation within one authority by Anna Piszcz

“… The traditional institutional model of a competition agency has assumed entrusting competition protection to a single authority. Over time, more and more often national competition authorities are being entrusted not only with competition enforcement but also with other functions (tasks). …”
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The ‘process of doing’ in everyday occupations – a challenge for young adults with cerebral palsy by L. Bergqvist, A. M. Öhrvall, M. Peny-Dahlstrand

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Developing a novel flavoured low alcohol beer using New Zealand honeydew honey and yacon concentrate by Keegan Chessum, Nazimah Hamid, Barry Wong, Tony Chen, Mary Yan, Rothman Kam

“…This study provides an accessible method to produce LAB and shows how NZYC may be incorporated into LABs to yield a functional food.…”
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Advanced age, constipation, depression: what are the ways of management? by N. P. Chernus, L. A. Vinogradova, N. V. Kireeva

“…The investigation showed that depression was more frequent in the patients of group 1 (68.4 % of the cases) with compensated function of the large gut whereas in the 2nd group – 34.6 % (compensated) and in the 3rd group – 41.5 % (subcompensated)cases. …”
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