Effect and Mechanism of Action of Pushing Method on Rats with Skeletal Muscle Overuse Injury based on Wnt/β-catenin Signaling Pathway by DUAN Miaomiao, HUANG Bo, RUAN Lei, MU Pangpang, CHEN Yiming, PENG Liang

“…Catenin protein expression levels.Results(1) Comparison of motor function：compared with the blank group, the time of passing through the balance beam and the number of times of sliding paw were significantly increased in the model group and intervention group after intervention, and the difference was statistically significant (<italic>P</italic>&lt;0.05); compared with the model group, the time of passing through the paw and the number of times of sliding paw were significantly decreased in the intervention group after intervention, and the difference was statistically significant (<italic>P</italic>&lt;0.05). (2) Gastrocnemius muscle histopathological changes：the model group can be seen in the gastrocnemius muscle a large number of myocytes can be seen within the cracks, myogenic fibers fracture; compared with the model group, the degree of damage to the gastrocnemius muscle tissues in the intervention group to reduce the degree of damage, can be seen in the form of myofibers is regular, neatly arranged. (3) Ultrastructural changes in gastrocnemius muscle tissue：local myogenic fiber bundles were broken and dissolved, and a small amount of Z-line structure was dissolved and blurred; compared with the model group, the gastrocnemius muscle cells in the intervention group were slightly edematous, and the structure of the myogenic fiber bundles was clear; part of the myogenic fiber bundles were broken, and the structure of the Z-lines was clear and more neatly arranged. (4) Gastrocnemius muscle tissue MyoD, MyoG and Pax7 mRNA transcript levels：compared with the blank group, MyoD, MyoG and Pax7 mRNA transcript levels were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, MyoD, MyoG and Pax7 mRNA transcript levels were significantly higher in the intervention group (<italic>P</italic>&lt;0.05). (5) Gastrocnemius muscle tissue MyoD, MyoG and Pax7 protein expression level：compared with the blank group, MyoD, MyoG and Pax7 protein expression water were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, MyoD, MyoG and Pax7 protein expression level was significantly higher in the intervention group (<italic>P</italic>&lt;0.05). (6) Wnt3a, Axin2 and β-catenin protein expression levels in gastrocnemius muscle tissues：compared with the blank group, Wnt3a, Axin2 and β-catenin protein expression levels were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, Wnt3a, Axin2 and β-catenin protein expression levels were significantly higher in the intervention group (<italic>P</italic>&lt;0.05).ConclusionPushing method can improve the gastrocnemius muscle injury and motor function in rats with overuse injury model, and its mechanism may be related to the activation of Wnt/β-catenin signaling pathway.…”
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The significant impact of meconium ileus on clinical outcomes among Brazilian individuals with cystic fibrosis—a retrospective analysis of a patient registryResearch in context by Luiz Vicente Ribeiro F. da Silva-Filho, Gianluca Belchior, Angela Tavares Paes, Nicole Costa Soriano Freire, Cintia Steinhaus, Matias Epifanio, Adriana S.C. Knabben, Adriana Goya, Alberto A. Vergara, Albin E. Augustin, Ana Cristina C.F. Fonseca, Antonio F. Ribeiro, Bruna Ziegler, Bruno P. Pessoa, Carlos A. Riedi, Claudia Castro-e-Silva, Claudia M. Gonçalves, Cleyde M.A. Nakaie, Constantino G.B. Cartaxo, Daniela S.P. Borgli, Daniela G. Meneses, Daniele M.T. Ferrao, Dayse V. Oliveira, Debora C. Chong-e-Silva, Denise M.C. Haidar, Edna L.S. Souza, Eduardo Piacentini-Filho, Elenara F.A. Procianoy, Elizabet V. Guimarães, Elizabeth P.S. Silva, Evalto M. Araujo-Filho, Fabiola V. Adde, Fernanda B.S. Malini, Flavia F. Fernandes, Francyelly W. Yamamoto, Gilberto B. Fischer, Glaunir M. Foletto, Izabela Sad, Jocemara Gurmini, Katharina V.N. Moura, Katia I. Oliveira, Lais R. Mota, Leonardo A. Pinto, Liana S. Coelho, Lilian C.F. Andries, Lorenna J.A. Prado, Luciana F. Velloso-Monte, Lusmaia D.C. Costa, Mara R.F. Figueiredo, Marcela D. De-Sillos, Marcelo B. Fuccio, Marcelo T. Rodrigues, Maria A.C.A. Sousa, Maria Angelica Santana, Maria E.S.A. Moreira, Maria F.B.H. Perez, Maria I.M. Fernandes, Mariane G.M. Canan, Marina M. Gonçalves, Marina P. Nishi, Marta C. Duarte, Murilo C.A. Britto, Neiva Damaceno, Patricia G.M. Bezerra, Paulo C. Kussek, Paulo T.R. Dalcin, Paulo J.C. Marostica, Raphael F.J. Oliveira, Roberta C.N.C. Melotti, Rosangela V. Garcia, Samia Rached, Silvia O.T. Tanaka, Sonia E.L. Valente, Sonia M. Chiba, Suzana F.O. Melo, Tania W. Folescu, Tiago N. Veras, Valeria C. Martins, Vera M. Dantas, Virginia A.F. Castro

“…Interpretation: CF individuals affected by MI had more severe and earlier declines in lung function, slower rates of weight and height gain, and lower survival rates. …”
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Based on Knowledge Recognition and Using Binomial Distribution Function to Establish a Mathematical Model of Random Selection of Test Questions in the Test Bank by Yuan Chang

“…With the in-depth development of social reforms, the scientificization of enterprise online examinations has become more and more urgent and important. The key to realizing scientific examinations is the automation and rationalization of propositions. …”
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The frequency and particularities functional biomechanics disorders of the infantile cerebral paralysis inter children’s of native population (the Hakass), mestizo and european of... by I. G. Galantyuk, S. A. Solomin, I. R. Schmidt

“…The prevalence of the diagnosis ICP is in 6 time more in european group, as compared with hakas’s, and in 8 time more as compared with mestizo. …”
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Differences in Vegetative, Productive, and Physiological Behaviors in <i>Actinidia chinensis</i> Plants, cv. Gold 3, as A Function of Cane Type by Gregorio Gullo, Simone Barbera, Antonino Cannizzaro, Manuel Scarano, Francesco Larocca, Valentino Branca, Antonio Dattola

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A New Model for Predicting Settlement Within the Influence Area of Shield Construction Based on Dynamic Weight Function and Asymptotic Decay Term by ZongYang Li, Aiqing Zhang, Xin Zou, Zhengxin Du

“…In this article, a new settlement prediction model based on dynamic weight function and asymptotic decay term is proposed to address this problem. …”
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r1 and r2 Relaxivities of Dendrons Based on a OEG-DTPA Architecture: Effect of Gd3+ Placement and Dendron Functionalization by Peter Fransen, Daniel Pulido, Lorena Simón-Gracia, Ana Paula Candiota, Carles Arús, Fernando Albericio, Miriam Royo

“…These findings could contribute to the development of more effective contrast agents, either by placing the paramagnetic gadolinium ion in a strategic position or through functionalization of the dendron surface.…”
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Executive Functions Assessment in a Child with Autism: A Pilot Single-Case Study from a Longitudinal and Mixed Methods Approach by Marian Acero-Ferrero, Elena Escolano-Pérez

“…Results: The sequential patterns obtained indicate more appropriate and complex executive functioning after the three-month intervention, specifically increased cognitive flexibility, improved self-regulation, more accurate evaluation, and progress in inhibitory processes. …”
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How the spatial functional division of labor in urban clusters affects urban population size? Evidence from 19 urban clusters in China by Haoqing Zheng, Cody Yu-Ling Hsiao, Hong-Wai Ho, Chunli Ji, Songlin Zhang

“…Abstract Relying on datasets covering 19 urban clusters in China, this study delves into the impact of the spatial functional division of labor in urban clusters (SFDL) on urban population size and its underlying mechanisms. …”
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Exact theory of the finite-temperature spectral function of Fermi polarons with multiple particle-hole excitations: diagrammatic theory versus Chevy ansatz by Hui Hu, Jia Wang, Xia-Ji Liu

“…In addition, our clarification of the complete set of Feynman diagrams for the multi-particle polaron vertex functions may inspire the development of more accurate diagrammatic theories of population-imbalanced strongly interacting Fermi gases, beyond the conventional many-body T-matrix approximation.…”
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Integrated assessment of left atrial function and C-reactive protein levels for severity of coronary artery ectasia: observational case–control study by Eman Samy EL Shehawy, Badria Atef Ebrahim Elhalawany, Bassem Abdelhady

“…Conclusion Impaired LA phasic function and increased CRP in patients with CAE. The LA phasic function impairment is more pronounced in individuals with CAE and elevated CRP, and LA reservoir function is significantly linked to the severity of CAE. …”
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A surface-based cross-sectional fMRI study on brain function differences between comorbid mild or moderate depression and insomnia by Zhongxian Li, Zhongxian Li, Limei Chen, Limei Chen, Yingxin Huang, Yingxin Huang, Luda Yan, Luda Yan, Junquan Liang, Junquan Liang, Min Peng, Min Peng, Yifu Zhou, Yifu Zhou, Jiliang Fang, Mengyao Li, Mengyao Li, Peng Zhou, Peng Zhou

“…Correlation analysis suggests lower left DLPFC ALFF correlated with more severe depression and insomnia. Lower FC between left DLPFC and right IFG was associated with more severe depression, while lower FC between left DLPFC and right SMG correlated with more severe insomnia.ConclusionOur findings suggest that reduced ALFF in the left DLPFC may serve as the potential biomarker to distinguish CmiDaI from CmoDaI, and offer insights for the two disorders’ treatments.…”
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Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection. by Chandima Jeewandara, Thiruni N Adikari, Laksiri Gomes, Samitha Fernando, R H Fernando, M K T Perera, Dinuka Ariyaratne, Achala Kamaladasa, Maryam Salimi, Shamini Prathapan, Graham S Ogg, Gathsaurie Neelika Malavige

“…However, while DENV-NS3 specific T cells of those with mild/sub clinical dengue infection were more likely to produce only granzyme B (p=0.02), those who were hospitalized were more likely to produce both TNFα and IFNγ (p=0.03) or TNFα alone. …”
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Exploring levels of adoption of multi-function transport apps: Transtheoretical model of change on the customer journey of Transport-SuperApp (TSA) users by Muhamad Rizki, Tri Basuki Joewono, Yusak O. Susilo

“…The OE users are associated with authority/control and tend to be more disorganised. Whereas SBI users tend to be more creative and open to new experiences. …”
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Presentating a multi-objective optimization model for resource-constrained project scheduling regarding financial costs, time delays and the reliability function by Saeideh Naderi, Mohsen Vaez-Ghasemi, Farzad Movahedi Sobhani

“…Accordingly, it can be concluded that this meta-heuristic algorithm (GA) has more efficiency and more apposite performance for the recommended model compared with the Exact optimization software. …”
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Metagenomic insights into surface sediment microbial community and functional composition along a water-depth gradient in a subtropic deep lake by Peixuan Zhang, Peixuan Zhang, Minglei Ren, Yan Xu, Jianjun Wang

“…Our results showed that Shannon diversity peaked at the thermocline for microbial communities, while a U-shaped pattern for functional genes. Microbial communities and functional genes in the surface sediments showed higher spatial heterogeneity at the shallow layer, whereas those at deeper layers tended toward more homogenized. …”
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Ipsilateral Autologous Peroneus Longus and Bone Patellar Tendon Graft for Revision Anterior Cruciate Ligament Reconstruction Leads to Similar Functional Outcome by Vivek Kumar Gupta, Harish Mahesan, Vignesh Murali, Parthiban Jeganathan, Suresh Perumal, Arumugam Sivaraman

“…Introduction: Due to the yearly rise in primary anterior cruciate ligament (ACL) reconstructions, revision ACL reconstruction is becoming more and more common in knee surgery. Choosing the appropriate graft and determining the surgical treatment staging by assessing the likelihood of doing the most anatomical revision canals and placing them with the primary canals before surgery are crucial factors affecting treatment outcomes. …”
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Effect of power training on physical functional performance of patients with Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials. by Samuel Brito de Almeida, Emmanuelle Silva Tavares Sobreira, Charles Phillipe de Lucena Alves, Danielle Pessoa Lima, Janine de Carvalho Bonfadini, Manoel Alves Sobreira-Neto, Thiago Holanda Freitas, Simony Lira do Nascimento, Pedro Braga-Neto

“…<h4>Introduction</h4>Parkinson's disease (PD) is becoming more prevalent, highlighting the urgency of developing treatments to minimize its effects on muscular strength and physical function. …”
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Electromyography-Triggered Constraint-Induced Movement Cycling Therapy for Enhancing Motor Function in Chronic Stroke Patients: A Randomized Controlled Trial by Jaemyoung Park, Kyeongjin Lee, Junghyun Kim, Changho Song

“…Additionally, both groups showed significant improvements in balance as assessed by the Berg Balance Scale (BBS) and the Functional Reach Test (FRT). The CIMCT group exhibited more pronounced improvements than the GCT group, with large effect sizes of 0.83 for the BBS and 1.25 for the FRT. …”
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Research on the Coordination Relationship and Zoning Optimization of Territorial Spatial Functions in Southern Karst Regions Based on a Multi-Scale Fusion Model by Ting Feng, Xiaodong Yu, Yan Zhou, Renling Dong, Dong Wu, Meilin Zhang

“…Under grid units scale and multi-scale fusion, the high and low texture characteristics of production and ecological functions are more pronounced. (2) TSFs are primarily characterized by slight and moderate disorder. …”
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