GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1β in THP-1 cells. …”
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Effect of Curry Leaf (Murraya koenigii) as Edwardsiellosis Treatment on Gourami Fish (Osphronemus goramy) by Muyassar H. Abualreesh, Agus Pariawan, Annisa Isti Fauziyyah, Farid Mukhtar Riyadi, Mohammad Fadjar, Arief Prajitno, Arif Syaifurrisal, Muhammad Browijoyo Santanumurti, Suciyono Suciyono

“…The most effective dose in treating Edwardsiellosis in gourami fish was found to be 600 mg/L, as it significantly improved various hematological parameters, including hematocrit, hemoglobin, erythrocyte count, leukocyte count, lymphocytes, monocytes, and neutrophils. Additionally, histopathological analysis showed improvements in tissue conditions, with lower scores for degeneration, congestion, and necrosis. …”
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RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia by Tim Kong, Angelo B. A. Laranjeira, Christopher T. Letson, LaYow Yu, Shuyang Lin, Jared S. Fowles, Daniel A. C. Fisher, Sherwin Ng, Wei Yang, Fan He, Minyoung Youn, Kailen Mark, Ana San Jose, Jingxian Liu, Alexander B. Kim, Maggie J. Cox, Mary C. Fulbright, Aarthi Jayanthan, Gerrit Los, Stacey L. Rentschler, Li Ding, Kathleen M. Sakamoto, Sandra E. Dunn, Grant A. Challen, Stephen T. Oh

“…Here, we establish a comprehensive transcriptional atlas across the spectrum of myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML) through RNA-sequencing of 158 primary samples encompassing CD34+ hematopoietic stem/progenitor cells and CD14+ monocytes. Supported by mass cytometry (CyTOF) profiling, we reveal aberrant networks of PI3K/AKT/mTOR signalling and NFκB-mediated hyper-inflammation. …”
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Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression by Liqin Ruan, Ningbo Fang, Xinhua Zhao, Weili Chen, Zhaoping Wu, Xiaoyong Wu

“…Overall, HB-LC genes were significantly negatively correlated with Th17, MAIT, monocytes, and CD4 Naive cells, while they were positively correlated with B cells, nTreg cells, and Tr1 cells. …”
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Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct... by Yunqian Guan, Xiaobo Li, Wenxiu Yu, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen

“…Circulation-derived infiltrating cells in the brain were identified by Ly6C, a majority of which were monocytes/macrophages. Without MSC transplantation, among the infiltrated Ly6C+ cells, some were positive for BDNF, IL-1β, or TNF-α. …”
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GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…Additionally, GV1001 reduced systemic and vascular inflammation, lipid accumulation, and monocyte/macrophage infiltration within arterial walls in mice. …”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…Chronic inflammation plays a pivotal role in PCOS pathogenesis.The monocyte chemoattractant protein-1 (MCP-1) is an important chemotactic factor for inflammatory response ofmonocytes. …”
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Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature by Umar Darr, Zubair Khan, Muhammad Ali Khan, Anas Renno, Turki Alkully, Sehrish Kamal, Tariq Hammad, Yaseen Alastal, Muhammad Imran Khan, Ali Nawras

“…Flow cytometry revealed a lambda monotypic population of B cells displaying dim CD19 and CD10. …”
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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…IgG-mediated phagocytosis and NTHi adherence, engulfment and phagocytosis were measured in human alveolar macrophages and monocyte-derived macrophages (MDM) isolated from patients with AATD and from healthy individuals. …”
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Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade by Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung

“…Based on the trajectory analysis, ICI-activated T cells from whole blood are proposed to serve as the initial cells involved in inflammation, that lead to monocytes differentiating into macrophages and increasing their susceptibility to migrate to the lesion sites. …”
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Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis by Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang

“…The foam cell model was induced with human monocytes (THP-1) and co-cultured with foam cells using siRNAs targeting GAL8, DO05, and UO126. …”
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The Term ‘Ebda’ in the Comparative View of Fakhr Razi and Allameh Tabatabai by Mohammad Bahrami

“…Some see Ebda as approximately synonymous with creation, formation, invention, etc., while others do not accept this equivalence. …”
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Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…We identified a derivative of a traditional herbal monomer, Etoposide, commonly isolated from the roots and rhizomes of Podophyllum spp. …”
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n the identification of some characters in Plano Carpini’s “History of the Mongols” by Trepavlov V.V.

“…This article suggests the identification of the Mongol governors in the southern Russian steppes, Mautsi and Karbon, with Noyon Mugedu and an anonymous Gurgan (i.e., Batu’s son–in-law) respectively; Batu’s court dignitary Eldegai can be associated with Eldeke from the Juryat tribe. …”
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Charles William Dyson Perrins as a Collector of Medieval and Renaissance Manuscripts c. 1900-1920 by Laura Cleaver

“…Cockerell may also have been involved in Perrins’ decision to sell some of his manuscripts, anonymously, in 1907. These decisions have had significant consequences for the long-term ownership of and scholarship on these manuscripts, and provide a case study of the impact of early twentieth-century collectors on the development of the study of medieval books.…”
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Hubungan Sikap Terhadap Informasi Terkait Covid-19 Dengan Kecenderungan Perilaku Prososial Pengguna Media Sosial by Dzikrina Iffa Yohanida, Ike Herdiana

“…Uji korelasi dengan Pearson's Product Moment menunjukkan hubungan positif dan sedang antara sikap informasi COVID-19 dengan dimensi altruism (r(375)=.557; p<.001), compliant (r(375)=.564; p<.001), emotional (r(375)=.571; p<.001), public (r(375)=.54; p<.001), dan dire (r(375)=.563; p<.001), dan berkorelasi positif dan lemah pada dimensi anonymous (r(375)=.349; p<.001). Hasil penelitian ini mendukung penelitian sebelumnya yang menunjukkan sikap positif pengguna media sosial terhadap penyebaran informasi seputar krisis dapat menggerakkan perilaku kolektif.…”
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Illustrating Animals and Visualizing Natural History in Chambers’s Encyclopaedias by Rose Roberto

“…More than 10 years before Darwin’s Origin of Species, a book titled Vestiges of the Natural History of Creation about evolution or ‘transmutation’ was anonymously authored by Scottish publisher Robert Chambers. …”
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An approach to teaching the psychiatric interview by Timothy Hierlihy, Andrew Latus

“…The flexibility allows for students to repeat and vary their approach in response to feedback. Anonymous course evaluations showed improvement in student satisfaction with the new psychiatry clinical skills teaching. …”
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La biodiversité, une ressource, mais aussi un fardeau ? Intérêt et limites des notions de services et disservices écosystémiques pour repenser les interactions nature-sociétés dans... by Julien Blanco, Clémence Moreau, Chloé Guerbois, Cécile Barnaud, Pierre-Cyril Renaud, Marc Deconchat, Émilie Andrieu

“…In total, 119 semi-structured interviews or anonymous essays were conducted and analysed through two axes: i) people’s representations and practices around E(D)S, and ii) E(D)S governance. …”
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Exploring the Spatial Variation of Access/Egress Distances of Subway Stations Using Mobile Phone Positioning Data in Chengdu, China by Chao Wang, Zhongquan Qiu, Renbin Pan, Xiaojian Wang, Yusong Yan

“…Therefore, this study aims to explore the influencing factors and spatial variation of the distances at the station level by using the mobile phone positioning data of more than 1.2 million anonymous users in Chengdu, China. First, this study proposes a method to extract the access and egress trips of the subway. …”
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