Preferences and access to community-based HIV testing sites among men who have sex with men (MSM) in Côte d’Ivoire by Christine Danel, Joseph Larmarange, Lazare Sika, Maxime Inghels, Arsène Kra Kouassi, Serge Niangoran, Anne Bekelynck, Séverine Carilon, Mariatou Koné, Annabel Degrées du Loû

“…MSM who preferred undifferentiated HIV testing sites mentioned the lack of discretion and anonymity of community-based sites and the desire to avoid the gaze of others.Conclusion Community-based HIV testing is well suited for MSM who identify as homosexual and those close to the MSM community, while maintaining undifferentiated HIV testing is essential for others. …”
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RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study by Andrea Miranda-Mendizabal, Diana Vetter, Juan Zambrano, Jeff Zarp, Victor Chavarría, Anna Giménez-Palomo, Meritxell Gonzalez-Campos, Marc Valenti, Lara Walczer Baldinazzo, Sara Siddi, Maurizio Ferrari, Dinah Weissmann, Chantal Henry, Josep Maria Haro, Lars Vedel Kessing, Eduard Vieta

“…Any publication will use fully anonymized data. Publications with the final study results will be disseminated in international peer-reviewed journals and presented at international conferences. …”
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Perceptions and future perspectives of medical students on the use of artificial intelligence based chatbots: an exploratory analysis by Juan José Gualda-Gea, Juan José Gualda-Gea, Juan José Gualda-Gea, Lourdes Estefanía Barón-Miras, Lourdes Estefanía Barón-Miras, Lourdes Estefanía Barón-Miras, Maria Jesús Bertran, Maria Jesús Bertran, Anna Vilella, Anna Vilella, Anna Vilella, Isabel Torá-Rocamora, Isabel Torá-Rocamora, Isabel Torá-Rocamora, Andres Prat, Andres Prat, Andres Prat

“…The students were invited to complete a specific questionnaire anonymously and voluntarily, which they could respond to using their mobile devices by scanning a QR code projected on the classroom screen, we used Microsoft Forms to perform the survey.ResultsOut of the 61 students enrolled in the subject, 34 (56%) attended the seminar, of whom 29 (85%) completed the questionnaire correctly. …”
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Integrating psychiatry into basic clinical skills: A three‐year nationwide quantitative assessment of postgraduate training programs by Hidetaka Tamune, Hirohisa Fujikawa, Hiroyuki Harada, Tomoyuki Kodama, Masaaki Sasaki, Daichi Sone, Miwa Sekine, Masanobu Ito, Tadafumi Kato, Yuji Nishizaki, Yasuharu Tokuda

“…Methods A nationwide cross‐sectional study was conducted over 3 fiscal years (2021–2023). An anonymous online questionnaire was distributed to postgraduate year 1 and 2 residents who completed the GM‐ITE. …”
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Contemporary Management of Patients With Chagas Cardiomyopathy in Bolivia by Evan Czulada, BS, Sascha Bercovitch, BA, Yazan Alshawkani, MD, Natalia Noya Weise, MD, Adriana E. Hernani Rodrigo, BS, Ronald Gustavo Durán Saucedo, MD, Marcelo Buhezo Chamón, MD, Robert H. Gilman, MD, David T. Martin, MD

“…The Qualtrics survey was distributed anonymously. Survey questions were developed by Bolivian and U.S. researchers with extensive Chagas disease experience. …”
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The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China by Nan Wang, Fanrong Meng, Li Deng, Ling Wu, Yu Yang, Hua Li, Yuanjin Chen, Zeyou Wei, Bei Xie, Lan Gong, Qun Niu, Jie Lei, Junwen Gao, Bo Huang, Qi Wang, Xiaomin Lai, Zhihui Liu, Jinxing Hu

“…Mutations in pncA were found in 8 out of 223 PZA-sensitive isolates (3.59%) and 105 of 179 (58.66%) PZA-resistant isolates. Conversely, non-synonymous mutations in rpsA were identified in 5 of 137 (3.65%) PZA-resistant isolates, whereas the mutation ratio of rpsA among PZA-sensitive isolates was high at 14.03% (31/221). …”
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Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster) by A. E. Castro, L. J. Young, F. J. Camacho, R. G. Paredes, N. F. Diaz, W. Portillo

“…Microtus ochrogaster is a rodent with a monogamous reproductive strategy characterized by strong pair bond formation after 6 h of mating. …”
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Circulating CD3+CD8+ T Lymphocytes as Indicators of Disease Status in Patients With Early Breast Cancer by Han‐Kun Chen, Yi‐Ling Chen, Wei‐Pang Chung, Zhu‐Jun Loh, Kuo‐Ting Lee, Hui‐Ping Hsu

“…Results We analyzed 19 healthy controls and 27 patients (22 testing group and 5 validation group) with breast cancer and revealed distinct populations, including CD3+CD4+ T lymphocytes, cytotoxic T lymphocytes (CTLs; CD3+CD8+), polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSCs), and monocytic (M)‐myeloid‐derived suppressive cells. Patients with breast cancer exhibited reduced CD3+CD4+ T lymphocyte, CD3+CD8+ CTL, and CD33+CD15− M‐MDSC levels compared with healthy controls. …”
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Genomic characterization of three marine fungi, including Emericellopsis atlantica sp. nov. with signatures of a generalist lifestyle and marine biomass degradation by Ole Christian Hagestad, Lingwei Hou, Jeanette H. Andersen, Espen H. Hansen, Bjørn Altermark, Chun Li, Eric Kuhnert, Russell J. Cox, Pedro W. Crous, Joseph W. Spatafora, Kathleen Lail, Mojgan Amirebrahimi, Anna Lipzen, Jasmyn Pangilinan, William Andreopoulos, Richard D. Hayes, Vivian Ng, Igor V. Grigoriev, Stephen A. Jackson, Thomas D. S. Sutton, Alan D. W. Dobson, Teppo Rämä

“…The Pezizellaceae genome and the genome of the monotypic Amylocarpus genus represent the first published genomes of filamentous fungi that are restricted in their occurrence to the marine habitat and form thus a valuable resource for the community that can be used in studying ecological adaptions of fungi using comparative genomics.…”
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Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency by Fabiola Del Carpio-Cano, Natthapol Songdej, Liying Guan, Guangfen Mao, Lawrence E. Goldfinger, Jeremy G.T. Wurtzel, Kiwon Lee, Michele P. Lambert, Mortimer Poncz, A. Koneti Rao

“…FXIII-A is synthesized by hematopoietic cells, megakaryocytes, and monocytes. Objectives: To understand RUNX1 regulation of F13A1 expression in platelets/megakaryocytes and the mechanisms and consequences of decreased F13A1 in RHD. …”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…Multiparametric analysis was performed on the peripheral blood of 60 MDD patients using flow cytometry to identify lymphocytes (naïve/effector, memory, regulatory) and myeloid cells (dendritic cells, monocytes). We studied the associations between immunophenotype and depressive symptoms, social and working functioning, and subjective quality of life during the acute phase and after three months of treatment. …”
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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

“…Elevated levels of 1a,1b-dihomo-PGJ2 and adrenic acid suggested potential aging markers. rhGH treatment also significantly reduced meteorin-like (METRNL) and monocyte chemoattractant protein-1 (MCP1) serum levels to control levels. rhGH influences the serum lipidome, promoting changes in maturation and metabolism. …”
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The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine by Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang Fu

“…Compared with porcine small intestinal submucosa (SIS) in vivo, the homogeneous decellularized ADSC sheets had less monocyte-macrophage infiltrating in vivo implantation. …”
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Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring by Bing Li, Yong Wang, Charles R. Owens, Touka Banaee, Charleen T. Chu, Kayvon Jabbari, Anna D. Lee, Neil J. Khatter, Alan G. Palestine, An-Jey A. Su, Christene A. Huang, Kia M. Washington

“…These methodologies collectively contribute to the development of non-invasive diagnostic and monitoring strategies for WET.ResultsOur study revealed a rapid and acute immune response following WET, characterized by an early innate immune response dominated by complement involvement, and infiltration of neutrophils and monocytes by post-operative day (POD) 2. This was succeeded by an acute T-cell-mediated immune reaction, predominantly involving T helper 1 (Th1) cells and cytotoxic T lymphocytes (CTLs). …”
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The effect of meningococcal vaccines on new generation of systemic inflammatory markers in children by Omer Okuyan, Neval Elgormus, Seyma Dumur, Ugurcan Sayili, Hafize Uzun

“…Neutrophil, lymphocyte, monocyte, platelet counts, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation response index (SIR-I), and systemic immune inflammation index (SII) were evaluated. …”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…GScore was significantly associated with neutrophils and non-classical monocytes. Potential agents including esmolol, estradiol, ganciclovir, and felbamate, targeting the 12 diagnostic signatures were identified. …”
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Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis by Nadja Pinto Garcia, Alexander Leonardo S. Júnior, Geyse Adriana S. Soares, Thainá Cristina C. Costa, Alicia Patrine C. dos Santos, Allyson Guimarães Costa, Andréa Monteiro Tarragô, Rejane Nina Martins, Flávia do Carmo Leão Pontes, Emerson Garcia de Almeida, Erich Vinícius de Paula, Olindo Assis Martins-Filho, Adriana Malheiro

“…High expression of TLR2 in monocytes and VLA-4 in TCD8+ lymphocytes and high levels of MIP-1β and RANTES appear to be relevant in high death risk conditions. …”
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Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients by Liu Yang, Zhuo Xu, Zhenyan Wang, Fangping Ding, Zhipeng Wu, Xiaoqian Shi, Jing Wang, Yingmin Ma, Jiawei Jin

“…Furthermore, the in vitro studies confirmed that the pro-SFTPB enriched HDL significantly promoted M1 polarization of monocyte-derived macrophages. Conclusions The increase of HDL-pro-SFTPB promotes HDL pro-inflammatory transition during septic ARDS, leading to exacerbated progression of ARDS through enhancing M1 macrophage polarization. …”
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Myelitis associated with glial fibrillary acidic protein IgG: characterization and comparison with aquaporin-4 IgG and myelin oligodendrocyte glycoprotein IgG myelitis by Yinyin Xie, Wanwan Zhang, Aoya Han, Wenlin Sun, Xinru Zhou, Yi Xie, Yunqing Ma, Yajun Lian, Cui Wang, Nanchang Xie

“…Features favoring GFAP-IgG over the other types included presence of fever and neck stiffness, requirement of intensive care and mechanical ventilation, higher monocyte-to-lymphocyte ratio (MLR), presence of hyponatremia, markedly elevated CSF leukocyte counts, increased CSF total protein levels, and decreased CSF glucose levels. …”
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Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer by D. E. Betancourt, P. A. Baldion, J. E. Castellanos

“…Several studies have shown that the dentin-resin interface is unstable due to poor infiltration of resin monomers into the demineralized dentin matrix. This phenomenon is related to the incomplete infiltration of the adhesive system into the network of exposed collagen fibrils, mainly due to the difficulty of displacement and subsequent replacement of trapped water between interfibrillar spaces, avoiding adequate hybridization within the network of collagen fibrils. …”
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