A Novel Nomogram for Early Identification of CFS-Like Symptoms in University Students with Infectious Mononucleosis by Deping Sun, Yanan Liang, Fuwei Yang, Lan Liu, Yuqin Yan

“…The variables included age, gender, smoking and drinking habits, relationship status, university grade, residence registration, number of symptoms and signs (NSS), body mass index (BMI), C-reactive protein (CRP) level, neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR), aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT, DeRitis), basophil percentage (Baso%), eosinophil percentage (Eos%), and albumin-to-globulin ratio (ALB/GLO). …”
Get full text

Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus) by Jiale Shi, Congji Yang, Yuanyuan Qin, Qingqing Liu, Shengqi Hua, Defeng Wu, Wei Dong

“…There are 6 genes with non-synonymous mutation SNP sites. The predicted target gene, ClCG04G001930, encodes a Phytoalexin deficient 4 (PAD4), a protein that plays an important regulatory role in leaf senescence in many plant species. …”
Get full text

A systematic review of circulating IP-10/CXCL10 in patients with Plasmodium infections in relation to disease severity by Manas Kotepui, Aongart Mahittikorn, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui

“…Abstract Interferon γ-induced protein 10 kDa (IP-10) or C–X–C motif chemokine 10 (CXCL10) is produced and secreted from specific leukocytes such as neutrophils, eosinophils, and monocytes, which play key roles in the immune response to Plasmodium infections. …”
Get full text

HISTOLOGICAL ANALYSIS OF LYMPHOID MASSES OF THE STOMACH AND SMALL INTESTINE IN THE CLINICAL AND PATHOGENETIC PROFILE OF BABESIOSIS by I. I. Torianyk

“…Neutrophilic granulocytes, monocytes and plasma cells predominated among the cellular leucocyte populations. …”
Get full text

Habitat associations of six‐lined racerunners in longleaf pine managed with a short fire rotation for northern bobwhites by Isaiah W. Samek, Steven J. Price, Theron M. Terhune II, Darin J. McNeil

“…Although bobwhite management in these systems is mostly synonymous with longleaf pine restoration, additional conservation practices aimed at game birds (promoting fallow fields, supplemental feeding, meso‐carnivore control, cross sectional mowing, etc.) might affect the extent to which squamates benefit from habitat management. …”
Get full text

A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease by Zexin Li, Lili Zhang, Yingshi Huang, Peixuan Yang, Wencan Xu

“…After matching age, gender, uric acid (UA), and creatinine (Cr) by propensity score matching (PSM), subjects with MS had higher prevalence of TNs than those without MS, as well as higher thyroid-stimulating hormone (TSH) and inflammatory levels, indicated by the higher white blood cell (WBC), lymphocyte (LY), and monocyte/high-density lipoprotein (Mo/HDL). After matching age, gender, UA, Cr, TSH, free triiodothyronine (FT3), thyroxine (FT4), WBC, NE, LY, Mo, NE/LY, LY/Mo, and Mo/HDL by PSM, no significant difference of the prevalence of TNs was found between MS and non-MS groups. …”
Get full text

Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation by Alexey Ferapontov, Anders Mellemkjær, Helen M. McGettrick, Thomas Vorup-Jensen, Tue W. Kragstrup, Kristian Juul-Madsen

“…Here, we show evidence that sCD18 found in serum regulates release of the proinflammatory cytokine monocyte chemoattractant protein-1 (MCP-1/CCL2) from fibroblast-like synovial cells. …”
Get full text

Disulfidptosis-related lncRNA signature to assess the immune microenvironment and drug sensitivity in acute myeloid leukemia by Yuying Zhao, Hai-en Cheng, Jingfei Wang, Yunke Zang, Zhijun Liu, Yanhua Sun, Yanli Sun

“…Patients with high-risk AML evaluated based on the model had shorter survival, significant infiltration of monocytes and M2 macrophages, and elevated transcriptional levels of immune checkpoint genes. …”
Get full text

Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

“…One of the other isoforms, HLA-G2, lacks a α2 domain or β2m to form a nondisulfide-linked homodimer, and its ectodomain specifically binds to LILRB2 expressed in human monocytes, macrophages, and dendritic cells. The administration of the ectodomain of HLA-G2, designated the soluble HLA-G2 homodimer, showed significant immunosuppressive effects in mouse models of rheumatoid arthritis and systemic lupus erythematosus, presumably by binding to a mouse ortholog of LILRB2, paired immunoglobulin-like receptor B. …”
Get full text

Village Savings, Loan Associations (Vsla) and Socio -Economic Empowerment of Vulnerable People in Kamuganguzi Sub County, Kabale District by Deus, Mwijukye

Get full text

CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients by Tao Yang, Yuan Zhang, Chujun Duan, Hui Liu, Dong Wang, Qingshan Liang, Xiao Chen, Jingchang Ma, Kun Cheng, Yong Chen, Ran Zhuang, Jikai Yin

“…We observed a similar phenomenon of liver regeneration in cirrhotic mice and further confirmed that CD300E+ monocyte-derived macrophages facilitated hepatocyte NAD+ synthesis via the secretion of NAMPT, which subsequently promoted hepatocyte proliferation. …”
Get full text

Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

“…Here, we illustrate the utility of a high-dimensional spectral flow cytometry panel that permits simultaneous evaluation of intratumoral CD4/CD8 T cell, Treg, γδ-T cell, natural killer T (NKT) cell, B cell, NK cell, monocyte, macrophage, granulocyte, myeloid-derived suppressor cell (MDSC), and dendritic cell functional changes from RUX+oHSV-treated MPNSTs.…”
Get full text

Breeding for Heat Tolerant Aromatic Rice Varieties and Identification of Novel QTL Regions Associated with Heat Tolerance During Reproductive Phase by QTL-Seq by Surangkana Chimthai, Sulaiman Cheabu, Wanchana Aesomnuk, Siriphat Ruengphayak, Siwaret Arikit, Apichart Vanavichit, Chanate Malumpong

“…The candidate QTL regions were then aligned to confirm SNPs/InDels in synonymous F7 candidate heat-tolerant lines. The results revealed that four promising lines, namely 84-7-1-9, 84-7-1-10, 159-3-3-1, and 159-3-3-10, were classified as heat-tolerant with low amylose content. …”
Get full text

Analysis of serum levels and DNA methylation of fibroblast growth factor 21 using peripheral blood-derived genomes in patients with obesity by Hiroyuki Shinozaki, Shiori Kawai, Mami Gamo-Kawasaki, Ayano Takei, Kyoko Tsujikado, Kazunori Fukuda, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Koshi Hashimoto

“…In the present study, we analyzed the DNA methylation state of the FGF21 gene (FGF21) in obese patients using genomic DNA extracted from human monocytes and macrophages and investigated the pathophysiological significance of the FGF21 expression response to pemafibrate (PM), a PPARα ligand. …”
Get full text

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…MMP-1, MMP-3, MMP-9, Interleukin-6 (IL-6), and monocyte chemoattractant protein-1 mRNA and protein levels were all decreased after treatment with iguratimod. …”
Get full text

Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma by Koržinek Martha, Ćelap Ivana, Fabijanec Marija, Žanić Tena, Ljubičić Neven, Baršić Neven, Verbanac Donatella, Barišić Karmela, Rajković Marija Grdić

“…Total leukocyte count (p = 0 .006), absolute neutrophils (p = 0.005), and absolute monocytes (p = 0.007) were lower while relative eosinophils (p = 0.001) and relative basophils (p = 0.001) were higher in CRC patients. …”
Get full text

New insights into freshwater ascomycetes: discovery of novel species in diverse aquatic habitats by Lu Li, Lu Li, Lu Li, Darbhe Jayarama Bhat, Darbhe Jayarama Bhat, Hong-Bo Jiang, Hong-Bo Jiang, Hong-Bo Jiang, Hong-Bo Jiang, Jun-Fu Li, Jun-Fu Li, Jun-Fu Li, Jun-Fu Li, Turki M. Dawoud, Fangqi Sun, Fangqi Sun, Fangqi Sun, Fangqi Sun, Sukanya Haituk, Sukanya Haituk, Ratchadawan Cheewangkoon, Ratchadawan Cheewangkoon, Rungtiwa Phookamsak, Rungtiwa Phookamsak, Rungtiwa Phookamsak, Rungtiwa Phookamsak

“…Therefore, C. beijingensis is formally synonymized under C. fulva, with an amended species circumscription. …”
Get full text

Polydomus karssenii gen. nov. sp. nov. is a dark septate endophyte with a bifunctional lifestyle parasitising eggs of plant parasitic cyst nematodes (Heterodera spp.) by Samad Ashrafi, Jan-Peer Wennrich, Yvonne Becker, Jose G. Maciá-Vicente, Anke Brißke-Rode, Matthias Daub, Torsten Thünen, Abdelfattah A. Dababat, Maria R. Finckh, Marc Stadler, Wolfgang Maier

“…The strains were found to represent a distinct phylogenetic lineage most closely related to Equiseticola and Ophiosphaerella, and Polydomus karssenii (Phaeosphaeriaceae, Pleosporales) is introduced here as a new species representing a monotypic genus. The pathogenicity tests against nematode eggs fulfilled Koch’s postulates using in vitro nematode bioassays and showed that the fungus could parasitise its original nematode host H. filipjevi as well as the sugar beet cyst nematode H. schachtii, and colonise cysts and eggs of its hosts by forming highly melanised moniliform hyphae. …”
Get full text

Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated L... by Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang

“…Additionally, we noted shifts in myeloid populations, with expanded APOE+ macrophage and FCGR3B+ monocyte subsets in ALD samples relative to MASLD and healthy tissues. …”
Get full text

Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic stroke by Ali Ata Tuz, Nils Hoerenbaum, Özgür Ulusoy, Adel Ahmadi, Alana Gerlach, Alexander Beer, Andreas Kraus, Anja Hasenberg, Nina Hagemann, Dirk M. Hermann, Matthias Gunzer, Matthias Gunzer, Vikramjeet Singh

“…In addition, stroke led to an increased expression of the activation markers Ly6C and CD68 on monocyte/macrophages (MΦ) in HFD mice but not in ND mice. …”
Get full text