MiR-543/SNTB1 axis modulates immune microenvironment in colorectal cancer by ZHANG Min, LI Min, XIAO Meng

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Deciphering the role of Wnt/β-catenin and miR-214 in knee osteoarthritis: molecular and clinical insights by Waad A. Samman, Esraa M. Mosalam, Esraa M. Mosalam, Dalia S. Saif, Mahmoud S. Abdallah, Mahmoud S. Abdallah, Abdel-Aziz A. Zidan, Amany Said Sallam, Shimaa Abdelsattar, Fatma Omar Khalil, Amany E. Elashkar, Somia Mokabel Mohamed, Mohamed Al-Ghannam, Hend E. Abo Mansour, Hend E. Abo Mansour

“…Besides, a correlation between Western Ontario and McMaster Universities (WOMAC) score, clinical, and radiological data, and the measured parameters was conducted.Results and discussionPatients with KOA showed downregulated miR-214 with upregulated β-catenin, Wnt4, MMP3, Bax, caspase 3, and pGSK3β compared to healthy individuals. …”
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M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis by Qian Zhang, Yan Yi, Tiange Chen, Ying Ai, Ziyang Chen, Ganzhi Liu, Zexuan Tang, Jianwei Chen, Tao Xu, Xin Chen, Jinfang Liu, Yuguo Xia

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LncRNA LINC01128 promotes prostate cancer cell proliferation, metastasis, and epithelial-mesenchymal transition by modulating miR-27b-3p by Yuhui Zhao, Zhihang Zhang, Yi Zheng, Huiming Bai, Xiaotong Wu, Yantao Yang, Junfeng Zhang, Chao Yu

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Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTO... by Ke Huang, Jing Fang, Weiming Sun, Yujia Zeng, Bowen Shi, Bingkai Ren, Haidi Bi, Lang Shuai

“…Collectively, our findings demonstrate that BMMSCs coordinate miR-202-3p to inhibit mTOR activation via the AMPK, MAPK, and PI3K/AKT pathways, thereby promoting TFEB dephosphorylation, modulating autophagy and neuronal apoptosis, and ultimately fostering functional recovery post-SCI.…”
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Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults by Otávio T. Nóbrega, Gilberto S. Morais-Junior, Nayara I. Viana, Sabrina T. Reis, Diego I. V. Perez, Wladimir M. Freitas, Andrei C. Sposito, Kátia R. M. Leite, Miguel Srougi

“…Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute and relative scores of BMD in specific osseous site of Brazilian very-old adults. …”
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The impact of hsa-miR-1972 on the expression of von Willebrand factor in breast cancer progression regulation by Changjiang Yu, Tao Zhang, Fan Chen, Zhenyang Yu

“…Key modules and hub genes related to cell migration and signaling pathways were identified. …”
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Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis by Guangyun Luo, Guangyun Luo, Xiangyi Kong, Fang Wang, Zhiming Wang, Zhuo Zhang, Huan Cui, Yiwen Zhang, Wen Huang, Xuesong Yang, Jianzhou Ye, Jianzhou Ye

“…Dual-luciferase assays confirmed that IGF-1R is a direct target of miR-29a-5p. Mechanistic studies revealed that FLM upregulated miR-29a-5p expression while downregulating IGF-1R (p < 0.05), with evident co-localisation in lesional tissues.ConclusionOur findings demonstrate that FLM effectively ameliorates MS-P comorbidity through modulation of the miR-29a-5p/IGF-1R axis, showing significant therapeutic efficacy across different genetic backgrounds.…”
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Cullin-3 and Regulatory Biomolecules Profiling in Vitiligo: Integrated Docking, Clinical, and In Silico Insights by Hidi A. A. Abdellatif, Mohamed Azab, Eman Hassan El-Sayed, Rwan M. M. M. Halim, Ahmad J. Milebary, Dhaifallah A. Alenizi, Manal S. Fawzy, Noha M. Abd El-Fadeal

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Relationship between peripheral blood miR-146b-5p levels and lymphocyte subsets in patients with sepsis and its predictive value for prognosis: a single-center study by Sha Cheng, Jiaojiao Wang, Pengfei Wang, Xianli Long, Huiling Liu, Xueyin Li, Xiaowei Zhang, Xuemei Zhao, Hang Sun, Chuanxin Wu

“…The combination of miR-146b-5p with APACHE II scores enhances diagnostic accuracy. …”
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Transplantation of miR-216a-5p-overexpressing mesenchymal stem cells encapsulated in a thermosensitive hydrogel promotes functional recovery in a rat model of spinal cord injury by Zhi Dou, Liangliang He, Jianning Yue, Wenxing Zhao, Hongyan Wang, Jie Lu, Chao Wang, Liqiang Yang

“…Rats treated with hydrogel-encapsulated MSC-miR-216a-5p showed significantly improved functional recovery, evidenced by higher BBB, MWT, and TWL scores than control groups. …”
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Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodolo... by Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang

“…While previous studies have demonstrated that microRNA-502-5p (miR-502-5p) can protect chondrocytes through p53/NF-κB pathway modulation, its role in human synovial tissue remains unclear. …”
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Research on the Classification Method of Tea Tree Seeds Quality Based on Mid-Infrared Spectroscopy and Improved DenseNet by Di Deng, Hao Li, Jiawei Luo, Jiachen Jiang, Hongbo Mu

“…This study proposes a high-precision quality classification method for tea tree seeds by integrating mid-infrared (MIR) spectroscopy with an improved deep learning model. …”
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Identification of biomarkers associated with energy metabolism in hypertrophic cardiomyopathy and exploration of potential mechanisms of roles by Songyan Cai, Tianying Jin, Mintong Liu, Qingyuan Dai

“…Utilizing NetworkAnalyst, miRNAs and TFs regulating biomarkers expression in HCM were predicted, with hsa-mir-16-5p, hsa-mir-147a, hsa-mir-210b-3p, hsa-let-7b-5p, and hsa-mir-34a-5p identified as regulators of both IGFBP3 and JAK2. …”
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Construction and validation of a prognostic model of angiogenesis-related genes in multiple myeloma by Rui Hu, Fengyu Chen, Xueting Yu, Zengzheng Li, Yujin Li, Shuai Feng, Jianqiong Liu, Huiyuan Li, Chengmin Shen, Xuezhong Gu, Zhixiang Lu

“…Weighted gene coexpression network analysis (WGCNA) was applied to derive modules linked to the ARG scores and obtain module genes in GSE47552. …”
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Exploring the effect of LncRNA DANCR to regulate the Keap1‐Nrf2/ARE pathway on oxidative stress in rheumatoid arthritis by Shaohong Cai, Yue Sun, Yuan Wang, Zhangying Lin

“…In addition, pcDNA‐DANCR clearly showed stronger cell invasion and migration ability and exacerbated its inflammatory response, which may be related to the regulatory role of miR‐486‐3p and Keap1‐Nrf2/ARE signaling pathway, and we verified their targeting relationship using dual luciferase, showing that DANCR could regulate Keap1‐Nrf2/ARE through miR‐486‐3p modulates the Keap1‐Nrf2/ARE pathway and affects inflammatory and oxidative responses in RA patients. …”
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Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysis by Basavaraj Vastrad, Chanabasayya Vastrad

“…Meanwhile, using the Integrated Interactions Database (IID) database and Cytoscape software to construct protein–protein interaction (PPI) network and module analysis, and identify hub genes with the highest value node degree, betweenness, stress and closeness scores. miRNA-hub gene regulatory network and TF-hub gene regulatory network were constructed and analyzed. …”
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Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis by Yi-Ming Li, Chen‑Xi Li, Reyila Jureti, Gulinuer Awuti

“…Weighted gene coexpression network analysis (WGCNA) was applied to capture the key modules and modular genes related to periodontitis, utilizing the candidate FRG scores as trait. …”
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MicroRNA-486: a dual-function biomarker for diagnosis and tumor immune microenvironment characterization in non-small cell lung cancer by Jun Yu, Yi Shen, Yao Xu, Zhengyang Feng, Yuntian Shen, Yaqun Zhu, Jian Huan, Qiliang Peng

“…Notably, these hub genes were found to be significantly associated with immune infiltration levels, immune microenvironment scores, and immune-related proteins in NSCLC. Conclusions This dual-modality investigation establishes miR-486 as a multi-functional biomarker in NSCLC, demonstrating both diagnostic utility and immunoregulatory potential through tumor microenvironment modulation.…”
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CHAC1 in urological tumors: contextual dualism and therapeutic implications by Deyu Wang, Yongquan Wan, Yunxiang Li, Yuan Ren, Jiakai Ma, Si Ge, Ziqiang Zeng, Zuoping Wang, Lei Zhen

“…CHAC1, a glutathione-degrading enzyme, governs context-dependent pathophysiological processes in urological malignancies through modulation of endoplasmic reticulum stress and ferroptotic pathways. …”
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