Effect of Aeromonas hydrophila infection on leptin receptor overlapping transcript expression in Rana amurensis by Yugang Sun, Tong Wu, Zhaodong Chen, Huimin Ren, Yufen Liu, Peng Liu, Wenge Zhao

“…The NF-кB signaling pathway exhibited robust expression levels, which might be explained by the positive feedback regulation function of LepROT. …”
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Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury by Boris Betz, Reinhard Schneider, Tobias Kress, Martin Alexander Schick, Christoph Wanner, Christoph Sauvant

“…NO produced by endothelial NO-synthase (eNOS) has protective functions whereas NO from inducible NO-synthase (iNOS) induces impairment. …”
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Optimizing dsRNA sequences for RNAi in pest control and research with the dsRIP web platform by Doga Cedden, Gözde Güney, Michael Rostás, Gregor Bucher

“…Abstract Background RNA interference (RNAi) is a tool for studying gene function and has emerged as a promising eco-friendly alternative to chemical pesticides. …”
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Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients. by Yuki Fujimura, Yohei Yamauchi, Takayo Murase, Takashi Nakamura, Shu-Ichi Fujita, Tomohiro Fujisaka, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka

“…Whether pharmaceutical modification of plasma XOR activity might inhibit cardiac remodeling and improve cardiovascular outcome should be investigated in future studies.…”
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Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. by Mark Hamer, Romano Endrighi, Shreenidhi M Venuraju, Avijit Lahiri, Andrew Steptoe

“…The mechanisms are incompletely understood, although dysfunction of the hypothalamic pituitary adrenal (HPA) axis might be involved. We examined the association between cortisol responses to laboratory-induced mental stress and the progression of coronary artery calcification (CAC).…”
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Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction by Miguel Ángel Arrabal-Polo, Salvador Arias-Santiago, Fernando López-Carmona Pintado, Sergio Merino-Salas, Clara Lahoz-García, Armando Zuluaga-Gómez, Miguel Arrabal-Martin

“…Chronic inflammation found in patients with ED might explain the association between ED and metabolic syndrome.…”
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Association between the high-dose use of benzodiazepines and rehospitalization in patients with schizophrenia: a 2-year naturalistic study by Takita Y, Takaesu Y, Ono K, Futenma K, Shimura A, Murakoshi A, Komada Y, Inoue Y, Inoue T

“…Yukika Takita,1 Yoshikazu Takaesu,1 Kotaro Ono,1 Kunihiro Futenma,1 Akiyoshi Shimura,1 Akiko Murakoshi,1 Yoko Komada,2 Yuichi Inoue,1,2 Takeshi Inoue1 1Department of Psychiatry, 2Department of Somnology, Tokyo Medical University, Tokyo, Japan Background: High-dose use of benzodiazepines (BZPs) reportedly causes adverse effects on cognitive function and quality of life in patients with schizophrenia. …”
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KLF4 promotes cisplatin resistance by activating mTORC1 signaling in ovarian cancer by Wanzhen Zhou, Huixian Huang, Yincheng Teng, Rong Hua, Yan Hu, Xiao Li

“…Subsequent validation through immunohistochemistry and western blotting confirmed the upregulated KLF4 expression in cisplatin-resistance OC cells lines and tissues. To investigate the function of KLF4, functional experiments were performed both in vitro and in vivo. …”
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Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Nondiabetic Adults: A Meta-Analysis of Randomized Controlled Trials by Huilin Tang, Deming Li, Yufeng Li, Xi Zhang, Yiqing Song, Xinli Li

“…Our meta-analysis found that vitamin D supplementation might improve glucose and insulin metabolism without affecting the risk of T2D among nondiabetic adults.…”
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Can the TLR-4-Mediated Signaling Pathway Be “A Key Inflammatory Promoter for Sporadic TAA”? by Giovanni Ruvolo, Calogera Pisano, Giuseppina Candore, Domenico Lio, Cesira Palmeri, Emiliano Maresi, Carmela R. Balistreri

“…Thoracic aorta shows with advancing age various changes and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur as pathological entities responsible principally for the sporadic TAA onset. …”
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How to map soil organic carbon stocks at field scale in South Africa? by Willie Herman Cloete, Gerhard du Preez, George Munnik Van Zijl

“…For dry bulk density (ρb), a pedo-transfer function was created for predicting the ρb at unsampled locations. …”
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Maintaining Cyber Resilience in the Reconfigurable Networks with Immunization and Improved Network Game Methods by Maxim Kalinin, Evgeny Pavlenko, Georgij Gavva, Maxim Pakhomov

“…Immunization presumes an adaptive set of protective reconfigurations destined to ensure the functioning of a network. It is a protective reconfiguration aimed to preserve/increase the functional quality of the system. …”
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Absolute Quantitative Metagenomic Analysis Provides More Accurate Insights for the Anti-Colitis Effect of Berberine via Modulation of Gut Microbiota by Jiaguo Zhan, Jiale Cheng, Wenhui Chang, Yuying Su, Xixin Yue, Chongming Wu

“…However, under certain circumstances, while the relative quantitative abundance of these bacteria may remain stable, the absolute quantities of specific bacteria can vary considerably. Since the function of bacteria is directly linked to their total numbers, absolute quantification is crucial. …”
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Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling by Jin Yao, Xiao‐Qun Wang, Yu‐Jie Li, Kun Shan, Hong Yang, Yang‐Ning‐Zhi Wang, Mu‐Di Yao, Chang Liu, Xiu‐Miao Li, Yi Shen, Jing‐Yu Liu, Hong Cheng, Jun Yuan, Yang‐Yang Zhang, Qin Jiang, Biao Yan

“…Abstract The nervous and vascular systems, although functionally different, share many common regulators of function maintenance. …”
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Polymorphism of the Fractalkine Receptor CX3CR1 and Systemic Sclerosis-associated Pulmonary Arterial Hypertension by Bianca Marasini, Roberta Cossutta, Carlo Selmi, Maria Rosa Pozzi, Marco Gardinali, Marco Massarotti, Maddalena Erario, Lodovica Battaglioli, Maria Luisa Biondi

“…Further, the 249I allele might be associated with susceptibility to SSc.…”
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Association of plasma IL-6 and Hsp70 with HRV at different levels of PAHs metabolites. by Jian Ye, Rui Zhu, Xiaosheng He, Yingying Feng, Liangle Yang, Xiaoyan Zhu, Qifei Deng, Tangchun Wu, Xiaomin Zhang

“…<h4>Objectives</h4>We hypothesized that PAHs might induce systemic inflammation and stress response, contributing to altered cardiac autonomic function.…”
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Mechanobiological cues to bone cells during early metastasis drive later osteolysis: A computational mechanoregulation framework prediction by Anneke S.K. Verbruggen, Elan C. McCarthy, Roisin M. Dwyer, Laoise M. McNamara

“…Changes in the local mechanical environment of bone tissue occur during early metastasis, which might activate mechanobiological responses by resident bone cells (osteocytes) to activate resorption (osteoclasts) and thereby contribute to tumour invasion. …”
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Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. by Terrence E Forrester, Asha V Badaloo, Michael S Boyne, Clive Osmond, Debbie Thompson, Curtis Green, Carolyn Taylor-Bryan, Alan Barnett, Suzanne Soares-Wynter, Mark A Hanson, Alan S Beedle, Peter D Gluckman

“…Metabolic patterns among marasmic patients define them as metabolically thrifty, while kwashiorkor patients function as metabolically profligate. Such differences might underlie syndromic presentation and prognosis. …”
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Silencing of RNFT2 suppresses cell proliferation and migration through mTORC1 signaling pathway in gastric cancer by Younan Wang, Qianyun Ma, Zeyu Zhu, Huaiming Sang, Hao Fan, Zhipeng Li

“…A series of in vitro cell function experiments were performed, we found that knockdown of RNFT2 expression in GC cells could inhibit cell invasion, migration and proliferation. …”
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Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway by Xinhang Meng, Minfeng Shi, Jinfeng Qian, Yujie Luo, Liyuan Cui, Dajin Li, Songcun Wang

“…To further characterize its function in early pregnancy, we explored the effect of FK506 on the human-derived first trimester extravillous trophoblast cells (HTR8/SVneo cells) and found that FK506 promoted invasion, tube formation and proliferation, but inhibited apoptosis of HTR8/SVneo cells. …”
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