Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

“…Diabetic and vehicle control animals were randomly divided into groups with/without AKG treatment. Cardiac function was monitored by performing cardiac catheterization. …”
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Role of Toll-Like Receptor 4 on Lupus Lung Injury and Atherosclerosis in LPS-Challenge ApoE−/− Mice by Jing-qin Ni, Qiufang Ouyang, Ling Lin, Ziyang Huang, Huixia Lu, Xiaoqing Chen, Huili Lin, Zhenhua Wang, Dongming Xu, Yun Zhang

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Transcriptome analysis of jejunal mucosal tissue in breeder hens exposed to acute heat stress by Yongcai Zhu, Satoshi Kubota, Phocharapon Pasri, Sitthipong Rakngam, Supattra Okrathok, Chayanan Pukkung, Shenglin Yang, Sutisa Khempaka

“…Heat stress (HS) severely compromises intestinal barrier function in poultry, resulting in significant production losses. …”
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Real world data on characteristics and management of community patients receiving anticoagulation therapy who presented with acute bleeding to the emergency department at a regiona... by Fayez Hanna, Annemarie Hyppa, Ajay Prakash, Usira Vithanarachchi, Hizb U Dawar, Zar Sanga, George Olabode, Hamish Crisp, Alhossain A. Khalafallah

“…Data included: demographics, investigations (kidney and liver function tests, coagulation profile, FBC), LoS, bleeding site, type of and reason for anticoagulation therapy, and management provided. …”
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Group 2 innate lymphoid cells boost CD8+ T-cell activation in anti-tumor immune responses by Jing Wen, Shipeng Cheng, Ran Wang, Yuying Huang, Long Xu, Liyan Ma, Zhiyang Ling, Jinfu Xu, Deping Zhao, Yaguang Zhang, Bing Sun

“…In this study, we showed that IL-33-activated ILC2s could boost CD8+ T-cell function through direct antigen cross-presentation. …”
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Assessing the impact of oscillating dietary crude protein on the stability of the rumen microbiome in dairy cattle by F. L. Viquez-Umana, M. G. Erickson, J. D. Young, G. I. Zanton, M. A. Wattiaux, G. Suen, H. C. Mantovani

“…Additionally, volatile fatty acids (VFAs) were measured to evaluate rumen microbial function.ResultsResults indicated that dietary CP level did not alter microbial diversity (p = 0.30), but oscillating diets increased rumen microbial diversity (Shannon index, p = 0.04). …”
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Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure by Minfei Qian, Qixuan Wang, Zhongying Wang, Qingping Ma, Xueling Wang, Kun Han, Hao Wu, Zhiwu Huang

“…Notably, repeated moderate-intensity noise exposures (97 and 100 dB SPL) not only caused hearing threshold shifts and the inner hair cell ribbon synaptopathy but also impaired MOC efferent synapses, which might contribute to complex patterns of damages on cochlear function and morphology. …”
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Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans by Steffi M. Jonk, Alan Nicol, Vicki Chrysostomou, Emma Lardner, Shu-Che Yu, Gustav Stålhammar, Jonathan G. Crowston, James R. Tribble, Peter Swoboda, Pete A. Williams

“…Skeletal muscle is a source of systemic metabolites and macromolecules important for neuronal health, function, and healthy neuronal aging. Age-related loss of skeletal muscle might result in decreased metabolite and macromolecule availability, resulting in reduced neuronal function or increased susceptibility to unhealthy aging and neurodegenerative diseases. …”
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Analysis of the ‘Anti-scattering’ Capacity of Computational Ghost Imaging System in Solid Scattering Material by Ruiqing He, Wenwen Zhang, Baoqing Sun, Miguel A. Olvera, Zitao Lin, Qian Chen

“…Recent researches showed that the traditional ghost imaging (TGI) using pseudo-thermal light can be affected by the solid scattering material placed between the object and the light source. This scattering case might also affect the computational ghost imaging (CGI) and is considered in this paper. …”
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Sll1725, an ABC transporter in Synechocystis sp. PCC 6803 for the detoxification of cadmium ion stress by Gang Ruan, Changzi Liu, Gaofei Song, Jing Qian, Tao Bao, Yafei Zhao, Shaoqiang Sun, Dong Wan, Wujuan Mi, Man He, Bin Hu, Yonghong Bi

“…Foldchange of Sll1725 ranked fourth in DEGs/DEPs but its function was unexplored. Phylogenetic analysis and 3D structure identified Sll1725 as an ABC transporter and molecular simulation determined its cadmium-efflux function. …”
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Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes by Nikunj Satani, Kaavya Giridhar, Chunyan Cai, Natalia Wewior, Dominique D. Norris, Jaroslaw Aronowski, Sean I. Savitz

“…MSCs are proposed to promote recovery through the release of secretomes that modulate the function of beneficial immune cells. The majority of stroke patients have comorbidities including hypertension, for which they are prescribed antihypertensive medications that might affect the function of MSCs, when they are administered in stroke patients. …”
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Clinical and Histopathological Determinants for Kidney Allograft Survival in the Eurotransplant Senior Program (ESP) at the Time of Allocation by Tom N. Langer, Tom N. Langer, Thorsten Wiech, Thorsten Wiech, Mercedes Noriega, Sergey Biniaminov, Tobias B. Huber, Tobias B. Huber, Lutz Fischer, Lutz Fischer, Florian Grahammer, Florian Grahammer, Florian Grahammer, Malte A. Kluger, Malte A. Kluger

“…Arteriolosclerosis (arteriolar hyalinosis) correlated with a higher risk for primary non-function (P < 0.05). The number of HLA mismatches was not significantly associated with graft outcome. …”
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Molecular cloning, bioinformatics of the duck RIG-1 promoter region, and its differential expression profiles in embryo stages by LUO Jun, LIU Hehe, LIU Junying, ZHANG Tao, WANG Yushi, HAN Chunchun

“…Clustering of gene expression pattern showed that RIG-1 had similar expression patterns with IRF-1, RXR, AP1, NF-κB and IL6 in bursa of Fabricius, which may be due to that the bursa of Fabricius, compared with thymus and spleen, had relatively complete structure and function in duck embryo stages. This result indicated that they might regulate the transcription of RIG-1. …”
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TKN3 affects cell expansion to regulate fruit development in tomato by Shuai Sun, Yaqin Yuan, Meng Xu, Zhiqiang Liu, Xiaowei Yuan, Xingsheng Li, Ren Li, Xia Cui

“…Genome-wide identification of genes regulated by TKN3 indicated that the auxin and gibberellin (GA) pathways might mediate the function of TKN3. Our works revealed that TKN3 controls cell expansion in pericarps, and provides new insights into the roles of KNOX proteins in fruit development.…”
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Intradialytic Changes and Prognostic Value of Ventriculo-Arterial Coupling in Patients With End-Stage Renal Disease: Protocol for an Observational Prospective Trial by Alessandro Salustri, Giovanni Tonti, Gianni Pedrizzetti, Aizhan Zhankorazova, Zaukiya Khamitova, Bauyrzhan Toktarbay, Dinara Jumadilova, Marina Khvan, Dinara Galiyeva, Makhabbat Bekbossynova, Murat Mukarov, Alexey Kokoshko, Abduzhappar Gaipov

“…We believe that this method allows a comprehensive evaluation of the hemodynamic status of the patients undergoing HD, including the relationships between cardiac function and arterial elastance, and might provide prognostic information. …”
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Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury by Jason-Alexander Hörauf, Cora Rebecca Schindler, Inna Schaible, Minhong Wang, Birte Weber, André El Saman, Christiane Pallas, Marek Widera, Ingo Marzi, Dirk Henrich, Liudmila Leppik

“…The expression of the CD47 epitope was found to correlate positively with the American Spinal Injury Association (ASIA) impairment scale.ConclusionWe identified four potential EV-based tSCI biomarkers (CD47+, CD56+, CD68+, and ADAM17+ EVs) that differ in tSCI, with CD47+ EVs showing a strong correlation with the neurological function in tSCI. Thus, future studies might further specify the relevance of potential tSCI-specific biomarkers and investigate underlying mechanisms of tSCI.…”
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Attachment and Mentalizing Abilities in Patients with Inflammatory Bowel Disease by Alessandro Agostini, Eleonora Scaioli, Andrea Belluzzi, Massimo Campieri

“…Further knowledge about the interplay among IBD, mentalization, and attachment might shed more light into the psychopathological mechanisms leading to insecurity and vulnerability to stress in IBD. …”
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Integrating machine-readable user interface requirements into open networked operating rooms by Okan Yilmaz, Dominik Stegemann, Klaus Radermacher, Miriam Lange, Armin Janß

“…Addressing the complexity of use cases with multiple network participants requires defining use context, hazardous situations, user profiles, user interfaces, system function contributions, limitations, configurations, and required conditions for safe use. …”
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Presence and Location of CatSper 1–4, Opioid (μ, δ and κ) and CD44 Receptors in Spermatozoa from Aoudad, Iberian Ibex and Mouflon by Alejandro Vicente‐Carrillo, Manuel Álvarez‐Rodríguez, Cristina Castaño, Adolfo Toledano‐Díaz, Eva Martínez‐Nevado, Heriberto Rodríguez‐Martínez, Julián Santiago‐Moreno

“…Data confirmed their presence and putative role on sperm function in wild ruminant species. Inter‐species differences in the location of CatSper 1–4, μ, δ and κ‐opioid and CD44 receptors might underlie the variable response to reproductive technologies in these species.…”
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Effects of proprioceptive training in the recovery of patients submitted to meniscus surgery: systematic review and meta-analysis by Song Jin, Xiaoxiao Liu, Di Zhang, Ju Wang, Tianyu Zhao, Jiang Ma, Huaimin Lu

“…Based on very low quality evidence, the pooled effect showed significant improvement for proprioceptive training group in proprioception test (p<0.05, I2=18%), knee extensor muscle strength (p<0.05, I2=29%), knee flexor muscle strength (p<0.05, I2=0%) and knee function score (p<0.05, I2=0%) compared with conventional training group in patients after APM.Conclusion Based on very low quality, adding proprioceptive training to conventional rehabilitation programmes might be beneficial to promote functional recovery for patients after APM. …”
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