Comparison of clinical features and 3-month treatment response among three different choroidal thickness groups in polypoidal choroidal vasculopathy. by Mingui Kong, Sung Min Kim, Don-Il Ham

“…Eyes with polypoidal choroidal vasculopathy (PCV) were recently reported to have various choroidal thickness, and choroidal thickness might be associated with visual outcome in the treatment of many retinal disorders. …”
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Trimetazidine stimulates intracellular Ca2+ transients and zebrafish locomotor activity in spinal neurons by Sara Bernardi, Sara Vitolo, Chiara Gabellini, Maria Marchese, Elisabetta Ferraro

“…The mechanism underlying the effect of TMZ on locomotor activity has been proposed to rely on its ability to enhance metabolic efficiency with a consequent improvement of myogenesis and of neuromuscular junction (NMJ) and muscle function. However, although promising and therefore under clinical trials, the mechanism of action of TMZ has not been clearly disclosed; here we hypothesized that it might involve the modulation of neuronal Ca2+ flows. …”
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Adaptive strategies of Caribbean sponge holobionts beyond the mesophotic zone by Benoît Paix, Alexane Thivet, Celso Domingos, Özlem Erol, Niels van der Windt, Young H. Choi, Nicole J. de Voogd

“…Abstract Background Marine sponges and their microbiomes function together as holobionts, playing essential roles in ecosystem dynamics and exhibiting remarkable adaptability across depth gradients. …”
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Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma by Liu Yang, Long-fei Zeng, Guo-qing Hong, Qing Luo, Xing Lai

“…Differentially expressed genes (DEGs) associated with clinical stage of HCC were analyzed based on TCGA datasets. Functional enrichment analysis was carried out by the use of stage-related DEGs. …”
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Fitness landscape of a dynamic RNA structure. by Valerie W C Soo, Jacob B Swadling, Andre J Faure, Tobias Warnecke

“…We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should capture mutational effects across multiple conformational states simultaneously. …”
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Serum Elabela Level as a Reliable Biomarker for Predicting of Liver Fibrosis in Iraqi Patients with Chronic Hepatitis C by Eham Amer Ali, Ali Abdulateef Hasan Al-Bayati, Alea Farhan Salman

“…Objective:The main objective of the current work is to assess whether variations in blood Elabela levels among chronic hepatitis C (CHC) patients from Iraq might be used as a biomarker for liver fibrosis. …”
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Comparative analyses of the gut microbiome of two sympatric rodent species, Myodes rufocanus and Apodemus peninsulae, in northeast China based on metagenome sequencing by Jing Cao, Shengze Wang, Ruobing Ding, Yijia Liu, Baodong Yuan

“…The gut microbiota of A. peninsulae and M. rufocanus differed marginally in functional profiles, specifically in the breakdown of complex carbohydrates, which might reflect their distinct food preferences albeit both being herbivores with a substantial dietary overlap. …”
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Circadian Rhythms, Regular Exercise, and Cognitive Performance in Morning-Trained Dancers by Mariana Marchesano, Alejandra Carboni, Bettina Tassino, Ana Silva

“…Our findings suggest that regular morning training might help mitigate cognitive impairments experienced by dancers with later chronotypes in challenging morning scenarios.…”
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Safe Use of Contrast Media in Radiology (Clinical Guidelines) by V. E. Sinitsyn, I. E. Tyurin, N. L. Shimanovskiy, G. G. Karmazanovskiy, V. G. Bychenko, N. A. Rubtsova, D. A. Filatova

“…In addition, it is important to highlight the issues of interactions between CA and other drugs that patient might take, in particular, the possible deterioration of renal function when using CA in diabetes mellitus patients taking metformin. …”
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The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development by Hashum Sum, Alison C. Brewer

“…This review will evaluate the extensive evidence that environmental risk factors, known to be associated with atherosclerosis, such as diabetes, metabolic disorder, smoking, hypertension and hypercholesterolaemia etc. can affect the methylome of the endothelium and consequently act to alter gene transcription and function. Further, the potential mechanisms whereby such risk factors might impact upon the activities and/or specificities of the epigenetic writers and erasers which determine the methylome [the DNA methyl transferases (DNMTs) and Ten Eleven translocases (TETs)] are considered here. …”
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Bias of selection on human copy-number variants. by Duc-Quang Nguyen, Caleb Webber, Chris P Ponting

“…Although large-scale copy-number variation is an important contributor to conspecific genomic diversity, whether these variants frequently contribute to human phenotype differences remains unknown. If they have few functional consequences, then copy-number variants (CNVs) might be expected both to be distributed uniformly throughout the human genome and to encode genes that are characteristic of the genome as a whole. …”
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Pneumococcal meningitis associated with glomerulonephritis: A case report by Vuletić Biljana, Stojković Anđelka, Igrutinović Zoran, Stanković Lidija, Medović Raša, Dajić Katerina, Stojković Tanja, Janković Marijana, Janković Sveta, Vujić Ana

“…The absence of the latent period might point to the development of IgA nephropathy, but since the renal function was stable, without any abnormalities in urine tests documented during follow-up, our opinion is that this was rather the case of postinfectious nephropathy. …”
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Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model by D. K. C. Cooper, L. Mou, J. D. Cleveland, J. H. Simmons, D. C. Cleveland

“…More recently, the pig-to-human brain-dead decedent model was introduced with claims that this might replace (or at least augment) the pig-to-NHP model. …”
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The impact of impulse control disorders on cognitive decline in de novo Parkinson’s disease: a study based on structural MRI by Ruohong Xu, Beisheng Yang, Juanling Li, Xiaofan Wei, Limin Zhang, Jiaqi Tian, Wei Zhang

“…Current research has not clarified the impact of ICDs on cognitive function nor provided sufficient objective evidence. …”
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Proteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cells. by Xiaoting Fan, Qian Zhang, Chao You, Yuanxia Qian, Jing Gao, Peng Liu, Huiqing Chen, Huifang Song, Yan Chen, Keping Chen, Yajing Zhou

“…In calcium-triggered apoptotic HeLa cells, the p12 is degraded at 12 hours post-induction (hpi), restored thereafter by 24 hpi, and then depleted again after 36 hpi in a time-dependent manner while the other three subunits are not affected. It suggests a dual function of Pol δ by its interconversion between Pol δ4 and Pol δ3 that is involved in a novel unknown apoptosis mechanism. …”
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Chromatin accessibility profiling of Treg cells in acute urticaria by Leilei Wen, Xiaojing Zhang, Qiaoshan Yang, Fusheng Zhou

“…The elevated expression of IL-1b may be due to the diminished immune-suppressive function following the decline of Tregs in this study. …”
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Small Interfering RNA Efficiently Suppresses Adhesion Molecule Expression on Pulmonary Microvascular Endothelium by Tobias Walker, Julian Siegel, Andrea Nolte, Silke Hartmann, Angela Kornberger, Volker Steger, Hans-Peter Wendel

“…Adhesion molecules are known to influence postoperative organ function, they are hardly involved in the inflammatory response following the ischemia-reperfusion injury. …”
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Effect of surgical mandibular setback on the occurrence of obstructive sleep apnea by Thanyaphat Engboonmeskul, Narit Leepong, Premthip Chalidapongse

“…The aims were to assess the airway morphologic changes, and to evaluate sleep respiratory function and the occurrence of obstructive sleep apnea (OSA) after mandibular setback. …”
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Synergistic impact of aflatoxin and ochratoxin A exposure in Charles foster rats: a toxicological study by Kanchan Gopal Choudhary, Choudhary Sharfuddin, Arun Kumar, Ashok Kumar Ghosh

“…There was significant increase in liver function tests such as AST and ALP with significant increase in the Kupffer cells in the liver of AF and OTA treated groups. …”
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Characterizing physical activity bouts in people with stroke with different ambulation statuses. by David Moulaee Conradsson, Burcin Aktar, Lucian Bezuidenhout

“…<h4>Background and purpose</h4>While physical activity is crucial for maintaining function, health, and well-being after a stroke, there is limited understanding of how individuals post-stroke accumulate their daily activity in terms of bouts and intensities. …”
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