Lightweight deep learning system for automated bone age assessment in Chinese children: enhancing clinical efficiency and diagnostic accuracy by Pang Hai, Zhang Bin, Liu Kesheng, Li Cong, Xu Fei

“…The second stage employs a modified EfficientNetB3 architecture for fine-grained epiphyseal grade classification, enhanced by the Rectified Adam (RAdam) optimizer and a composite loss function combining center loss and weighted cross-entropy to mitigate class imbalance. …”
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Photographic assessment of hyperdivergent class II patients by Liliane Rosas Gomes, Karla Horta, Luiz Gonzaga Gandini Júnior, Marcelo Gonçalves, João Roberto Gonçalves

“…Although cephalometric radiographs represent the gold standard for diagnosing craniofacial morphology in clinical practice, it might not be feasible for large-scale epidemiological research. …”
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Hotspots and Frontiers of Host Immune Response in Idiopathic Pulmonary Fibrosis: A Bibliometric and Scientific Visual Research from 2000 to 2022 by Shirong Li, Pengyue Zhao, Chao Wang, Yun Xia, Haoyan Wang, Wenjie Qi

“…Idiopathic pulmonary fibrosis (IPF) is a disease with significant morbidity, progressive deterioration of lung function till death, and lack of effective treatment options. …”
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Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice by Yao Xu, Yuqing Liu, Honglei Guo, Wei Ding

“…Inflammation might be one of the essential underlying mechanisms of renal fibrosis, which is considered a key pathological feature of end-stage renal disease and is closely associated with proteinuria and decreased renal function. …”
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Impact of Dietary Interventions on Depression in Adolescents and Young Adults: A Systematic Review and Meta-Analysis by Hanhwa Koo, Kodai Ishihara, Yuji Kanejima, Miki Nakatani, Kazuhiro P. Izawa

“…This review aimed to evaluate the effects of dietary interventions on depressive symptoms, quality of life (QOL), and daily functioning in adolescents and young adults with depression. …”
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Activity dependent degeneration explains hub vulnerability in Alzheimer's disease. by Willem de Haan, Katherine Mott, Elisabeth C W van Straaten, Philip Scheltens, Cornelis J Stam

“…Resulting structural and functional network changes were assessed with graph theoretical analysis. …”
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SIRT2-dependent DKK1 deacetylation aggravates polycystic ovary syndrome by targeting the TGF-β1/Smad3 signaling pathway by Lan Chen, Caixia Kong

“…The above results indicated that DKK1 might function as a latent target for P COS treatment.…”
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Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway by Lanping Zhu, Yang Luo, Yaxin Liu, Siyuan Sun, Junjie Yuan, Lijun Zhang, Weilong Zhong, Shuang Ma, Zihan Yu, Jinjie Zhou, Xin Chen, Jingwen Zhao

“…Caco2 cells were stimulated with IND to evaluate the effect of CB supernatant (CBS) on the intestinal barrier function, and LS174T cells were used to validate the modulatory action of CBS on the Notch signaling pathway. …”
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Current Clinical and Pharmacological Approaches to the Prescription of Loop Diuretics in Patients with Chronic Heart Failure by N. M. Gafurova, E. V. Shikh, O. D. Ostroumova

“…A Cochrane meta-analysis has shown that in patients with chronic HF, loop and thiazide diuretics might reduce the risk of death and worsening of HF in comparison to placebo and could lead to improved exercise capacity. …”
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A green tea extract catechin EGCg: Therapeutic potential for pediatric cardiomyopathies by Junjun Quan, Dustin Gerber, Ang Li, Xupei Huang, Jie Tian

“…In the past, we and other researchers have found that (−)‐epigallocatechin‐3‐gallate (EGCg), the major biomedical polyphenol extracted from green tea, possess multiple therapeutic effects on protecting cardiac function and correcting impaired relaxation. Given its therapeutic effects, EGCg might be a potential drug candidate for administration to patients with cardiomyopathy and heart failure. …”
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ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics. by Jamie S Lin, Jin Seok Jeon, Qingfeng Fan, Hetty N Wong, Matthew B Palmer, Lawrence B Holzman

“…In several cellular systems, ARF6 was shown to regulate actin dynamics in coordination with Rac1, a Rho small GTPase. We examined the function of ARF6 in the kidney podocyte because Rac1 was implicated in kidney diseases involving this cell. …”
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Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children. by Anika Nier, Anna Janina Engstler, Ina Barbara Maier, Ina Bergheim

“…Metabolic parameters, markers of intestinal barrier function and inflammation were determined.<h4>Results</h4>Activity of alanine aminotransferase, concentrations of some markers of inflammation and insulin resistance were significantly higher in plasma of NAFLD children than in controls. …”
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Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence by Domenico D’Amario, Stefano Migliaro, Josip Andjelo Borovac, Rocco Vergallo, Mattia Galli, Attilio Restivo, Matteo Bonini, Enrico Romagnoli, Antonio Maria Leone, Filippo Crea

“…While some studies suggest that electronic cigarettes use might be associated with endothelial dysfunction, impaired platelet function and increased risk of adverse clinical events, other studies did not confirm these findings and epidemiological data mostly suggest that the use of electronic cigarettes appears to be safer than that of traditional tobacco cigarettes. …”
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Evaluation of thrombomodulin (THBD) plasma levels in sickle cell disease and correlation with disease severity by Yasmeen M.M. Selim, Amina Abdelsalam, Eman A. Youssef, Abdelkarem Bahy, Dalia El-Sayed

“…It is a known biomarker of endothelial injury and its elevated serum levels with subsequently, reduced endothelial function have been implicated in various disorders. …”
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Skin Sceneries of Thyroid Disorders and Impact of Thyroid on Different Skin Diseases: A Scoping Review Focused on Pediatric Patients by Ignazio Cammisa, Margherita Zona, Cristina Guerriero, Clelia Cipolla, Donato Rigante

“…Thyroid function plays a seminal role in the growth and development of children, and alterations in signaling pathways which interfere with the biosynthesis, transport, and metabolism of thyroid hormones might impact on the skin of such patients: this review explores the relationship between different thyroid disorders and dermatological manifestations with a particular focus on the pediatric population. …”
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage by Pedro Ortega, Desiré García-Pichardo, Marta San Martin-Alonso, Ana G. Rondón, Belén Gómez-González, Andrés Aguilera

“…The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. …”
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Neuroprotective effects of ethanol extraction from Rubia yunnanensis Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stre... by Jianghao Cheng, Xiaoxia Ma, Jie Tao, Xiaoli Jiang, Pu Chen, Xiaohua Duan

“…RNA-seq and metabolomic analysis showed that RY-A might help to normalize changes in gene and metabolite expression caused by CCH. …”
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Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports by Liwen Wang, Hua Ke, Chengdi Wang, Ke Wang

“…These findings suggest that ICI-based immunotherapy combined with chemotherapy might be a promising therapy for SMARCA4-dNSCLC and may warrant early implementation following diagnosis to potentially prolong patient survival.…”
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SARS-CoV-2 Nsp6-Omicron causes less damage to the Drosophila heart and mouse cardiomyocytes than ancestral Nsp6 by Jun-yi Zhu, Jin-Gu Lee, Guanglei Wang, Jianli Duan, Joyce van de Leemput, Hangnoh Lee, Wendy Wenqiao Yang, Zhe Han

“…Together, the results indicate that the amino acid changes in Omicron might hinder its interaction with host proteins thereby minimizing its pathogenicity.…”
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Automatic Data Downloading Program (DDP) in Determining Regional Ionosphere Model by Cevat İnal, Ömer Yıldırım, Sercan Bülbül, Fuat Başçiftçi

“…One of the important parameters that express thecharacteristics of the Ionosphere is the Total Electron Content (TEC), which isa function of the electron density that shows variations with the radiation ofthe Sun. …”
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