Spermidine Enhances Mitochondrial Bioenergetics in Young and Aged Human-Induced Pluripotent Stem Cell-Derived Neurons by Leonora Szabo, Imane Lejri, Amandine Grimm, Anne Eckert

“…Overall, our findings suggest that nutritional spermidine supplementation might represent an attractive therapeutic approach to enhance mitochondrial function, consequently decelerating aging.…”
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Upregulated LIMD1 alleviates pressure overload-induced cardiac hypertrophy via inhibits YAP1/AKT/GSK3β signaling. by Fengwen Xie, Bin Yuan, Ye Zhang, Liru Chen, Yingmei Zhong, Quan Xu

“…Mechanistically, both in vitro and in vivo experiments suggested that the beneficial effects of LIMD1 might be associated with the inhibition of the YAP1/AKT/GSK3β signaling pathway.…”
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Integrated global and unique metabolic characteristics to reveal the intervention effect of Yiyi decoction on acute pancreatitis. by Guanwen Gong, Yongping Wu, Yanwen Jiang, Yuan Cao

“…A previous study has suggested that resveratrol, emodin, rhein and their derivatives might be the potential pharmacodynamic components in Yiyi decoction, and researchers have proposed that resveratrol, emodin and rhein are candidate markers for quality control. …”
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Issue characterization of electoral change (and how recent elections in Western Europe were won on economic issues) by Davide Angelucci, Lorenzo De Sio

“…To do so we leverage an issue-rich public opinion dataset to estimate individual-level vote change towards each party as a function of issue-based party-voter affinity measures in 6 European countries. …”
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Individuality and stability in male songs of cao vit gibbons (Nomascus nasutus) with potential to monitor population dynamics. by Jun-Juan Feng, Liang-Wei Cui, Chang-Yong Ma, Han-Lan Fei, Peng-Fei Fan

“…This time- and labor-saving method might be the most effective way to detect dispersal patterns in this transboundary population.…”
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Security analysis of the RSSP-II protocol and a novel security enhancement approach by FENG Tao, TIE Xiaoping, WU Yi, SHI Jianming

“…However, existing research revealed that RSSP-Ⅱ’s message authentication security layer (MASL) had security vulnerabilities like key recovery and forgery, which might endanger the train control system’s stable operation. …”
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Daily and seasonal rhythms in immune responses of splenocytes in the freshwater snake, Natrix piscator. by Manish Kumar Tripathi, Ramesh Singh, Atanu Kumar Pati

“…The enhancement of immune function coinciding with one of its crucial reproductive phases might be helping it to cope with the seasonal stressors, including abundance of pathogens, which would otherwise jeopardize the successful reproduction and eventual survival of the species.…”
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Evolutionary History With Chronic Malnutrition Enhances Pathogen Susceptibility at Older Ages by Saubhik Sarkar, Biswajit Shit, Joy Bose, Souvik De, Tadeusz J. Kawecki, Imroze Khan

“…Such adverse effects on immunity might increase with ageing, worsening disease conditions later in life. …”
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Impact of Time-To-Treatment on Outcomes in Autoimmune Membranous Nephropathy by Patrick Hamilton, Sebastian Bate, Omar Ragy, Mrityunjay Hiremath, Samar Bukhari, Anirudh Rao, Arif Khwaja, Durga Anil K Kanigicherla

“…Immunosuppression is initiated after ''watchful-wait'' to avoid side effects in patients who might achieve spontaneous remission; however, the impact of this approach on kidney function is unclear. …”
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Acute Sarcopenia: Systematic Review and Meta‐Analysis on Its Incidence and Muscle Parameter Shifts During Hospitalisation by Luke Aldrich, Theocharis Ispoglou, Konstantinos Prokopidis, Jasem Alqallaf, Oliver Wilson, Antonis Stavropoulos‐Kalinoglou

“…Muscle mass and quality indices might need to become the primary determinants for muscle health assessment in hospitalised populations.…”
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The autophagy protein ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy by Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Yong Zhang, Michael J Holtzman, Ramya Masand, John P Lydon, Shizuo Akira, Kelle Moley, Ramakrishna Kommagani

“…In addition to embryo quality and endometrial function, proper oviduct function is also essential for successful pregnancy establishment. …”
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Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT... by Johan Jakobsson, Chris Burtin, Mattias Hedlund, Carl-Johan Boraxbekk, Jonas Westman, Nina Karalija, Per Stål, Thomas Sandström, David Ruttens, Harry R. Gosker, Jana De Brandt, André Nyberg

“…In both phases, the primary outcomes are a change from baseline in cognitive function, cardiorespiratory fitness, and muscle power. …”
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Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis: A Hypothesis by Oswald Moling, Alfonsina Di Summa, Loredana Capone, Josef Stuefer, Andrea Piccin, Alessandra Porzia, Antonella Capozzi, Maurizio Sorice, Raffaella Binazzi, Lathá Gandini, Giovanni Rimenti, Peter Mian

“…The immune system protects the organism from foreign invaders and foreign substances and is involved in physiological functions that range from tissue repair to neurocognition. …”
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Stenotrophomonas maltophilia virulence and specific variations in trace elements during acute lung infection: implications in cystic fibrosis. by Arianna Pompilio, Domenico Ciavardelli, Valentina Crocetta, Ada Consalvo, Roberta Zappacosta, Carmine Di Ilio, Giovanni Di Bonaventura

“…Metal ions are necessary for the proper functioning of the immune system, and, therefore, they might have a significant influence on the interaction between bacteria and host. …”
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Brain reserve in hepatic encephalopathy: Pathways of damage and preventive strategies through lifestyle and therapeutic interventions by Jacqueline Cordova-Gallardo, Andres Manuel Vargas-Beltran, Samantha Melanie Armendariz-Pineda, Jesus Ruiz-Manriquez, Javier Ampuero, Aldo Torre

“…Brain reserve is an important concept to understand the variability of damage associated with brain-related diseases and includes the adaptation of cognitive processes to preserve brain function. A good cognitive reserve might delay the onset of clinical manifestations of neurodegenerative diseases as well as hepatic encephalopathy, improving the quality of life in patients with chronic liver diseases. …”
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CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a by Rachel Vaivoda, Christine Vaine, Cassandra Boerstler, Kristy Galloway, Peter Christmas

“…There were no changes in expression of other CYP4 enzymes in knockout neutrophils that might compensate for loss of CYP4F18 or lead to differences in activity. …”
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The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance by Haiqing Jia, Jing Wei, Wei Zheng, Zhuo Li

“…Progressing in this area might unveil novel, accurate strategies to tackle therapy resistance, lessen tumor recurrence, and ultimately enhance patient outcomes.…”
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Neutrophil hypersegmentation in children receiving angiotensin converting enzyme inhibitors by Vedat Okutan, A Emin Kürekçi, S Umit Sarici, A Avni Atay, Yilmaz Yozgat, Fatih Azik, M Koray Lenk, Okan Ozcan

“…On the other hand, the intrinsic renin-angiotensin system in the bone marrow might affect the growth of hematopoietic colonies and cellular production, proliferation and differentiation in physiological and pathological states. …”
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How Does Neural Network Reparametrization Improve Geophysical Inversion? by Yuping Wu, Jianwei Ma

“…Moreover, the comparison experiments of FWI using TV regularization, over‐ and under‐parameterized NN regularization indicate that the proposed method might move further towards practical application and proves a way to develop inverse problems through an under‐parameterized NN regularization framework.…”
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Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength. by Jiajie Shao, Jana F Liewald, Wagner Steuer Costa, Christiane Ruse, Jens Gruber, Mohammad S Djamshedzad, Wulf Gebhardt, Alexander Gottschalk

“…Here, we assessed the role of neuropeptide signaling in the plasticity of NMJ function in Caenorhabditis elegans. We show that the CAPS (Ca2+-dependent activator protein for secretion) ortholog UNC-31, which regulates exocytosis of dense core vesicles, affects both pre- and post-synaptic functional properties, as well as NMJ-mediated locomotion. …”
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