Non-inferiority and cost-effectiveness trial of isolated biceps tenotomy versus tenotomy with rotator cuff repair in patients with stage 2–3 Goutallier fatty degenerative cuff lesi... by Freek Hollman, Nienke Wolterbeek, Gie Auw Yang

“…Even more, rehabilitation after an isolated tenotomy is much less cumbersome as compared with rehabilitation after rotator cuff repair and, therefore, might result in improved patient satisfaction. The goal of this trial is to study function and quality-of-life of patients undergoing arthroscopic biceps tenotomy with or without an additional cuff repair and to include an economic evaluation.Methods and analysis This multicentre randomised controlled non-inferiority trial, including an economic evaluation, is designed to compare the short-term and long-term outcome of patients who underwent an arthroscopic tenotomy of the long head of the biceps tendon with or without a cuff repair. …”
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Efficacy of Curcuma longa in relieving pain symptoms of knee osteoarthritis patients: a systematic review and metaanalysis of clinical trials by Rudy Hidayat, Faisal Parlindungan, Jihan Izzatun Nisa, Arya Ivan Mahendra, Muhammad Izza Indika, Cristopher Efendi

“…Antioxidant and anti-iflammatory properties of Curcuma longa might decrease pain thus improving joint function.Methods: This systematic review and meta-analysis evaluated randomized controlled trials (RCTs) on Curcuma longa efficacy for knee OA. …”
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Kidney Transplant Outcome Is Associated with Regulatory T Cell Population and Gene Expression Early after Transplantation by Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Dorota Kamińska, Marcelina Żabińska, Marta Myszka-Kozłowska, Agnieszka Gomułkiewicz, Piotr Dzięgiel, Marian Klinger

“…Our goal was to find a phenotypic and/or transcriptional pattern that might be considered prognostic for the kidney transplant outcome. …”
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Association of TP73-AS1 gene polymorphisms with the risk and survival of gastric cancer in a Chinese Han Population by Wangwang Chen, Jian Xiao, Liang Shi, Linling Lin, Mingkun Jiang, Yugang Ge, Zengliang Li, Hao Fan, Li Yang, Zekuan Xu

“…It was investigated that TP73-AS1(TP73 antisense RNA 1) could function as an oncogene in gastric cancer (GC). The expression and function of long noncoding RNAs (lncRNAs) could be impacted by single nucleotide polymorphisms (SNPs), which are related to cancer susceptibility and prognosis. …”
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Can targeted cognitive intervention improve rehabilitation outcome in hip fracture patients: a randomized controlled trial by Yedida Borow, Renata Efrati, Noa Doron, Michal Tzin, Yaara Ginsburg, Daniela Gesner, Avital Hershkovitz

“…Rehabilitation success depends on various factors, such as, age, pre-fracture function, level of cognitive function, nutritional status, comorbidity, and family support. …”
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The endoglucanase gene LOC_Os09g23084 is involved in rice development and susceptibility to sheath rot disease by Ping Wan, Chi-Kuan Tu, Kai-Jie Jang, Su-May Yu, Shuen-Fang Lo, Meng-Yi Lin, Zun-Jie Syu, Yu-Hsuan Chiu, Tuan-Hua David Ho, Miin-Huey Lee

“…In this study, we analyzed the function of LOC_Os09G23084, encoding an endoglucanase-1 precursor, through gene overexpression. …”
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γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders by Zhong-Peng Dai, Qiang Wen, Ping Wu, Yan-Ni Zhang, Cai-Lian Fang, Meng-Yuan Dai, Hong-Liang Zhou, Huan Wang, Hao Tang, Si-Qi Zhang, Xiao-Kun Li, Jian-Song Ji, Liu-Xi Chu, Zhou-Guang Wang

“…This review examines clinical applications of γ neuromodulations, including enhancing cognitive function through 40 Hz multisensory stimulation in Alzheimer’s disease, improving motor function in Parkinson’s disease, controlling seizures in epilepsy, and modulating emotional dysfunctions in depression. …”
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Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF. by Isabelle Dichamp, Paule Séité, Gérard Agius, Alice Barbarin, Agnès Beby-Defaux

“…These results point to a mutually functional interaction between p14ARF and E7 that might partly explain why the sustained p14ARF expression observed in most cervical pre-malignant lesions and malignancies may be ineffective.…”
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Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption. by Qi Qi Lu, Wen Wen Zheng, Zhao Yu Zhang, Pei Kun Cong, Xin Guo, Yao Zhang, Xin Zhuo Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui

“…Interestingly, pretreatment of Caco-2 cells with apoptosis inhibitor Z-VAD-FMK abrogated and recovered the barrier function of Caco-2 monolayer destroyed by IIL ESP. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Finally, the function of CDKN3 in LUAD was verified by in vitro experiments. …”
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Mutation of the SUMOylation site of Aurora-B disrupts spindle formation and chromosome alignment in oocytes by Shan-Shan Chen, Li Li, Bo Yao, Jia-Lun Guo, Ping-Shuang Lu, Hao-Lin Zhang, Kun-Huan Zhang, Yuan-Jing Zou, Nan-Jian Luo, Shao-Chen Sun, Lin-Lin Hu, Yan-Ping Ren

“…However, whether Aurora-B is SUMOylated in oocytes and how SUMOylation of Aurora-B impacts its function in oocyte meiosis remain poorly understood. …”
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Phosphorylation of Plant Ferredoxin-like Protein Is Required for Intensifying PAMP-Triggered Immunity in <i>Arabidopsis thaliana</i> by Tzu-Yi Chen, Rui-Wen Gong, Bo-Wei Chen, Yi-Hsien Lin

“…These findings suggest that phosphorylation at the T90 residue might be essential for PFLP-mediated enhancement of plant immune responses, implying that this post-translational modification is likely required for its disease resistance function in planta. …”
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Defibrillation Threshold Testing After ICD Implantation in Patients with Chronic Kidney Disease by Rohit J. Timal, Lano Osman, Joris I. Rotmans, Marianne Bootsma, Bart Mertens, Martin J. Schalij, Ton J. Rabelink, J. Wouter Jukema

“…However, patients with severe chronic kidney disease (CKD) were not included in these trials and might benefit from DFT testing. International guidelines shed no light on the subject of the effect of kidney function on DFT testing in patients with CKD. …”
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Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) by Xiaoqian Zhou, Weifeng Liu, Bailin Cong, Aifang Deng, Jing Lin, Linlin Zhao, Shenghao Liu

“…Among these genes, those encoding the components of the electron transport chain presented an initial increase in expression followed by a decrease, indicating that TCEP stress might affect mitochondrial function and lead to cell damage. …”
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New Possibilities in Quantitative Assessment of Albuminuria in Patients with Atrial Fibrillation and Chronic Kidney Disease by A. A. Sokolova, A. I. Skripka, I. I. Ivanov, V. V. Kogay, A. I. Listratov, A. A. Gindis, D. A. Napalkov

“…When comparing the renal function of patients with and without DM after 15 months statistically significant differences were also not found (p = 0.510).Conclusion. …”
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The Role of Regulatory T Cell in Nontypeable Haemophilus influenzae-Induced Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Xuewa Guan, Yanjiao Lu, Guoqiang Wang, Peter Gibson, Fang Chen, Keyong Fang, Ziyan Wang, Zhiqiang Pang, Yingqiao Guo, Junying Lu, Yuze Yuan, Nan Ran, Fang Wang

“…Collectively, these data suggested that NTHi might play a necessary role in downregulating Foxp3 to impair the function of Tregs, helping development into AECOPD.…”
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Metabolome and transcriptome analyses for explore heat stress responses and adaptation mechanisms in Rhododendron henanense subsp. lingbaoense by Yonghui Li, Xufeng Li, Mengxin Lei, Junwang Han, Ziming Huang, Kai Zhang, Yifan Yang, Ning Yang, Xiangli Yu, Xiaojun Zhou

“…Overall, 9 TF families might be the key regulators of Heat stress response pathways in Rhl. …”
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Temperature and WNK-SPAK/OSR1 Kinases Dynamically Regulate Antiviral Human GFP-MxA Biomolecular Condensates in Oral Cancer Cells by Pravin B. Sehgal, Huijuan Yuan, Susan V. DiSenso-Browne

“…Unexpectedly, the WNK1-selective inhibitor (WNK-IN-11), triggered a dramatic and rapid (within 1 h) spheroid to fibril transition of GFP-MxA condensates in live cells, but without affecting MxA antiviral function. The new data suggest a novel hypothesis for the anatomic localization of oral cancer in the U-shaped “high-risk” zone in the mouth: dysfunction of biomolecular condensates in oral cells along the beverage transit pathway through the mouth due to repetitive tonicity and temperature stresses that might underlie a prooncogenic progression.…”
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Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia: Role of Hypoxia-Inducible Factor-1α by A. Ortega, A. Fernández, M. I. Arenas, P. López-Luna, C. Muñóz-Moreno, I. Arribas, N. Olea, L. García-Bermejo, J. Lucio-Cazana, R. J. Bosch

“…Since VEGF is considered a survival factor for tubular cells, our findings suggest that diabetes displays HIF-1α upregulation that might function as a “precondition state” offering protection from endotoxic AKI.…”
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Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials by Filippo Migliorini, Nicola Maffulli, Luise Schäfer, Joshua Kubach, Marcel Betsch, Mario Pasurka

“…The current level I of evidence suggests that intra-articular HA injections in the knee might reduce pain in the short term.…”
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