Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport. by Enrica San Pietro, Mariagrazia Capestrano, Elena V Polishchuk, Alessio DiPentima, Alvar Trucco, Pasquale Zizza, Stefania Mariggiò, Teodoro Pulvirenti, Michele Sallese, Stefano Tete, Alexander A Mironov, Christina C Leslie, Daniela Corda, Alberto Luini, Roman S Polishchuk

“…Here, we examine the mechanisms of generation and the function of these tubules. In principle, tubule formation might depend on several protein- and/or lipid-based mechanisms. …”
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A Comprehensive Review and Update on Cannabis Hyperemesis Syndrome by Priyadarshini Loganathan, Mahesh Gajendran, Hemant Goyal

“…At the same time, the thermoregulatory function of endocannabinoids might explain compulsive hot bathing in CHS patients. …”
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Anesthetic challenges in a cardiac patient undergoing noncardiac surgery by Vaishali S Badge, Pankaj Patil

“…The case was done on an urgent basis thinking that the patient might lose eyesight if he is not operated quickly. …”
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Emergence of New Predictors Projecting the Definite Article Variability: Evidence from Nigerian English by Mayowa Akinlotan

“…In addition to the fact that little has been done in quantifying this phenomenon, too little number of predictors explicating the scenarios where we might find certain definite article usages in different but specific contexts in emerging varieties has also been put forward. …”
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Mussel periostracum protects against shell dissolution. by Alisha M Saley, Aaron T Ninokawa, Abigail Doan, Brian Gaylord

“…We quantified shell dissolution rates as a function of periostracum cover across three levels of reduced pH (7.7, 7.5, and 7.4 on the total scale). …”
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Identifying Metaphors as a Way to Strengthen Qualitative Findings by Malene Kaas Larsen, Lene Lehmkuhl, Malene Missel

“…Therefore, this paper explores how metaphors function as interpretative tools in qualitative research and what meaning patients assign to their illness narratives through metaphors. …”
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Impact of tidal fluctuations on bacterial community structure in Wuyuan Bay: A comparative analysis of waters inside and outside the tidal barrage. by Dandan Xie, Chen Feng, Jiehua Hu, Huina Lin, Hong Luo, Qi Zhang, Haibin He

“…Higher Nitriliruptoraceae inside the barrage might be a cue for the change of water quality.…”
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A single nucleotide polymorphism possibly associated with fat deposition is methylated in the bovine TFAM promoter by Tanja KUNEJ, Zeping WANG, Jennifer J. MICHAL, Peter DOVČ, Nancy S. MAGNUSON, Zhihua JIANG

“…Our results showed that the cytosine at this SNP position is methylated and therefore results in gain/loss of the functional CpG locus (5mC>T). Promoter constructs developed based on three TFAM SNPs showed that the C/C/C haplotype associated with fat deposition in beef cattle had lower promoter function/activity than A/T/T haplotype. …”
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Identification and characterization of Csa-miR159s and their expression patterns under different abiotic stresses in cucumber (Cucumis sativus L.) by Zhenxiang Zhao, Zhenxiang Zhao, Wenhong Ao, Wenhong Ao, Weirong Luo, Weirong Luo, Yaoguang Sun, Yaoguang Sun, Vijay Yadav Tokala, Junjun Liu, Junjun Liu, Shenshen Zhi, Shenshen Zhi, Yongdong Sun, Yongdong Sun

“…Nevertheless, there are no reports defining its specific function in cucumber fruit expansion and response to abiotic stresses. …”
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Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement by Jia-jia Wu, Ye-chen Lu, Mou-xiong Zheng, Xu-yun Hua, Jian-guang Xu, Wei Ding, Chun-lei Shan

“…Furthermore, increased ALFF of the ipsilateral insula in the slow-6 band was significantly related with better facial nerve function. Conclusion. Increased ALFF values in the ipsilateral insula might reflect an abnormal state of hypercompensation in motor control of facial synkinesis patients. …”
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Clinical pathological features and prognosis of diabetic nephropathy patients with stage 4 chronic kidney disease by YU Tian-yu, JIANG Shi-min, YANG Yue, FANG Jin-ying, GAO Hong-mei, ZOU Gu-ming, LI Wen-ge

“…Objective To investigate the relationship of clinical manifestations and pathological features with prognosis of diabetic nephropathy（DN） patients with stage 4 chronic kidney disease（CKD）.Methods The study subjects were those patients,who were diagnosed as DN by renal biopsy pathology with renal function in stage 4 CKD in Department of Nephrology of Chino-Japan Friendship Hospital from January 2005 to August 2019.The follow-up deadline was either the primary endpoint or until November 30,2019.The primary endpoints of observation were initiation of maintenance kidney replacement therapy,death or estimated glomerular filtration rate（eGFR） less than 15 mL·min^-1·（1.73 m²）^-1.The secondary endpoints were cardiovascular and cerebrovascular events.Based on the pathological classification of renal biopsy,the clinical and pathological parameters of the patients were respectively analyzed and survival analysis was performed.Results A total of 24 patients were included in the study,3 cases of type Ⅱa,with 3 cases of type IIb,15 cases of type III and 3 cases of type IV.The total median follow-up time was 20.7（range 5.9～72.4） months.The total median survival time was 17.3 months.7 patients with stage 4 CKD were still maintained,with the median follow-up time of 14.6（range 5.9～46.8） months;17 patients developed the primary endpoint event,with the median follow-up time of 14.2（range 6.1～72.4） months.The renal cumulative survival rates in 6 months,12 months and 18 months were 82.6%,59.3% and 41.6%,respectively.The comparison between the two groups with and without the primary endpoint events showed that systolic blood pressure and cardiovascular events were statistically different（P<0.05）.Conclusions The median survival time of progression to composite kidney endpoint events in DN patients with stage 4 CKD is 17.3 months.Control level of blood pressure and cardiovascular events might be the major relevant factors in progression of renal function.…”
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Benefits from Implementing Low- to High-Intensity Inspiratory Muscle Training in Patients Undergoing Cardiac Surgery: A Systematic Review by Aphrodite Evangelodimou, Irini Patsaki, Alexandros Andrikopoulos, Foteini Chatzivasiloglou, Stavros Dimopoulos

“…Preoperative and postoperative programs could improve inspiratory muscle strength, pulmonary function, and functional capacity as well as decrease the length of hospital stay in patients undergoing cardiac surgery. …”
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The last two transmembrane helices in the APC-type FurE transporter act as an intramolecular chaperone essential for concentrative ER-exit by Yiannis Pyrris, Georgia F. Papadaki, Emmanuel Mikros, George Diallinas

“…APC-type transporters are charac-terised by a 5+5 inverted repeat fold made of ten transmembrane segments (TMS1-10) and function through the rocking-bundle mechanism. Most APC-type transporters possess two extra C-terminal TMS segments (TMS11-12), the function of which remains elusive. …”
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Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients-A systematic review and meta-analysis. by Leonard Bergau, Tobias Tichelbäcker, Barbora Kessel, Lars Lüthje, Thomas H Fischer, Tim Friede, Markus Zabel

“…All-cause mortality was significantly associated with increasing age (HR 1.41, CI 1.29-1.53), left ventricular function (LVEF; HR 1.21, CI 1.14-1.29), ischemic cardiomyopathy (ICM; HR 1.37, CI 1.14-1.66) and co-morbidities such as impaired renal function (HR 2.30, CI 1.97-2.69). …”
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PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation by Xiaomin Zhang, Siyu Chen, Penghui Zhou, Danyang Wang, Liping Xu, Jingjing He, Wende Li, Xinxin Xiong, Ziqian Fang, Jianeng Zhang

“…Background The highly organized structures of the immunological synapse (IS) are crucial for T cell activation. PDZ domains might be involved in the formation of the IS by serving as docking sites for protein interactions. …”
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An intact S-layer is advantageous to Clostridioides difficile within the host. by Michael J Ormsby, Filipa Vaz, Joseph A Kirk, Anna Barwinska-Sendra, Jennifer C Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R Chaudhuri, Paula S Salgado, Robert P Fagan, Gillian R Douce

“…Structural determination of SlpA from FM2.5varB indicated an alteration in the orientation of protein domains, resulting in a reorganisation of the lattice assembly, and changes in interacting interfaces, which might alter function. Interestingly, variant FM2.5varB displayed an attenuated, FM2.5-like phenotype in vivo compared to FM2.5varA, which caused disease severity more comparable to that of R20291. …”
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p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. by Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga

“…<h4>Methodology/principal findings</h4>Given the many factors that might influence p53 function, including expression levels, mutations, cofactor proteins and small molecules, we expanded our previously described yeast-based system to provide the opportunity for efficient investigation of their individual and combined impacts in a miniaturized format. …”
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Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic by Agnieszka Żak‐Bochenek, Zuzana Drábková, Vaiva Sergedaite, Natalia Siwińska, Joanna Bajzert, Dominika Pasak, Anna Chełmońska‐Soyta

“…ABSTRACT Background Colic‐related obstructions can reduced intestinal mucosa function and cause dysbiosis in horses, but it is unclear how defense barrier and secretory immunoglobulin A (SIgA) secretion is disrupted. …”
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Integrative analysis of intestinal flora and untargeted metabolomics in attention-deficit/hyperactivity disorder by Jiamin Lu, Maoying Jiang, Dingyue Chai, Yuzi Sun, Lihui Wu

“…Simultaneously, our findings revealed that modifications to the microbiome could potentially trigger behavioral changes in animals, providing an experimental basis for comprehending the function and influence of gut flora on ADHD. These results might provide new perspectives for the development of novel treatment strategies.…”
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Metabolic Alterations in Women with Lipedema Compared to Women with Lifestyle-Induced Overweight/Obesity by Małgorzata Jeziorek, Maciej Wuczyński, Monika Sowicz, Agnieszka Adaszyńska, Andrzej Szuba, Angelika Chachaj

“…Unlike obesity, lipedema might be associated with a lower prevalence of metabolic alterations despite often coexisting with overweight or obesity. …”
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