Comorbidity between Type 2 Diabetes and Depression in the Adult Population: Directions of the Association and Its Possible Pathophysiological Mechanisms by Line Iden Berge, Trond Riise

“…We argue that unspecific pathophysiological mechanisms involved in the stress response might, at least to some extent, explain each of the directions of the association between type 2 diabetes and depression, while changes in brain structure and function among persons with diabetes and possible increased risk of development of type 2 diabetes after use of antidepressant agents could represent more disease specific mechanisms underlying the comorbidity.…”
Get full text

Fatigue in Patients with Parkinson’s Disease by Kazuo Abe, Mayako Takanashi, Takehiko Yanagihara

“…Conclusions: The present study suggested that sense of fatigue in patients with PD might be associated with frontal lobe dysfunction.…”
Get full text

DJ-1: A Potential Biomarker Related to Prognosis, Chemoresistance, and Expression of Microenvironmental Chemokine in HR-Positive Breast Cancer by Yinghong Xie, Yuancheng Li, Mengzhu Yang

“…It is involved in a range of pathways and might behave as a novel biomarker of prognostic value for the immune environment and drug sensitivity in HR+ breast cancer.…”
Get full text

Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9 by Koki Higashioka, Noriko Koizumi, Hidetoshi Sakurai, Chie Sotozono, Takahiko Sato

“…MYOGENIN might be expected to have an analogous function in human myogenic cells. …”
Get full text

Alzheimer’s Disease: The Impact of Gut Microbiota and Sex Differences on Pathogenesis and Treatment Strategies by Kh. A. Abdel-Sater

“…The higher prevalence of AD in females is due to their genetics, brain structure, and function, estrogen, lifestyle factors (e.g., education, occupation, exercise, and sleep), and incidences of infection and inflammations. …”
Get full text

Behavioral Activation Therapy for Multiple Sclerosis: Potential Effects on Cognition, Neuropsychiatric Symptoms, and Quality of Life by Daniela Taranu, Hayrettin Tumani, Visal Tumani, Patrick Fissler

“…Finally, we propose that BAT in MS should specifically focus on reducing stressful activities (i.e., unenjoyable, high-arousal activities) and increasing relaxing activities (i.e., enjoyable, low-arousal activities), as this dimension might tackle the neuroinflammatory etiology of MS.…”
Get full text

Transition metal abundance as a key parameter for the search of Life in the Universe by Giovanni Covone, Donato Giovannelli

“…The availability of these transition metals is not uniform in the Universe, and it is a function of the distribution (in time and space) of complex dynamics. …”
Get full text

Nonhistone Lysine Methylation as a Protein Degradation Signal by Nicholas A. Lehning, Brad E. Morrison

“…However, these small signals might be responsible for orchestrating a large portion of the protein degradation activity in the cell. …”
Get full text

Microsaccades and Exploratory Saccades in a Naturalistic Environment by Simone Benedetto, Marco Pedrotti, Bruce Bridgeman

“…Microsaccades, small saccadic eye movements made during fixation, might accompany shifts of visual attention, serve to refresh the retinal image, or have some other function. …”
Get full text

Regional Facts Matter: A Comparative Perspective of Sub-State Fact-Checking Initiatives in Europe by Ferre Wouters, Michaël Opgenhaffen

“…Although the fact-checking movement is diverse, the majority of organisations function at a national level. However, some organisations operate on a sub-state scale, based either on community or geographic region. …”
Get full text

Stability Results of a Class of Hybrid Systems under Switched Continuous-Time and Discrete-Time Control by M. De la Sen, A. Ibeas

“…A main novelty with respect to previous research is that the various individual parameterizations might be continuous-time, discrete-time, or mixed so that the whole switched system is a hybrid continuous/discrete dynamic system. …”
Get full text

Metabolic reprogramming in polycystic kidney disease and other renal ciliopathies by Sara Clerici, Alessandra Boletta

“…Alterations in their function cause a plethora of human conditions collectively called the ciliopathies. …”
Get full text

HYDRODYNAMIC FUNDAMENTALS FOR PHYSICAL-MATHEMATICAL MODEL OF MYOCARDIUM CIRCULATION by V. E. Milyukov, T. S. Zharikova

“…Recent understanding of myocardial angioarchitectonics does not reveal fully the relation of coronary anatomy with their function related to their aim for sufficient blood supply in coronary system at tissue level. …”
Get full text

Economic impacts of the maritime silk road initiative on the Suez Canal by Anas Rakha, Khadiga El-Aasar

“…We use the Vector Auto-Regressive (VAR) model and Impulse Response Function to account for the interaction effect of the variables. …”
Get full text

« For the Childlike is the Divine » : la quête de la jeunesse éternelle dans les contes et romances de George MacDonald by Benjamine Toussaint-Thiriet

“…A link may be found between the Bildungsroman genre and MacDonald’s fairy tales and romances because of the obvious didactic function of the latter. In the Bildungsroman, the maturation process of the main protagonist is seen as a rather positive phenomenon, focusing on its growing up (both physically and mentally) rather than growing old. …”
Get full text

Silver Nanoparticle-Doped Titanium Oxide Thin Films for Intermediate Layers in Organic Tandem Solar Cell by Wanyi Nie, Robert C. Coffin, David L. Carroll

“…This suggests that such doping schemes might provide a simple approach to the creation and use of TiOx layers for tandem cells.…”
Get full text

Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis by Zhen Gao, Stella E. Tsirka

“…Microglia activation classically accompanies MS development, and regulation of microglia function changes the outcome of the disease. In this paper, we review the contributions of microglia to MS pathogenesis and discuss microglial functions in antigen presentation, cytokine release, and phagocytosis. …”
Get full text

Surgery-induced neuroinflammatory transcriptional programs in medial prefrontal cortex of mice during early phase of perioperative neurocognitive disorders by Xiaodong Tang, Xuwu Xiang, Yang Yu, Shuyuan Huang, Caifei Pan, Shuyuan Gan, Yongxing Yao

“…Patients receiving anesthesia and surgery may experience cognitive dysfunction, memory deficits, and mental disturbances, which are referred to as perioperative neurocognitive disorders (PND). The function of the medial prefrontal cortex (mPFC) is disrupted during early phase of PND. …”
Get full text

Adipositas & Bewegung by Wackerhage H

“…Aging is a time-dependent functional decline that affects most living organisms. …”
Get full text

Preliminary study on the neural mechanisms of four tone recognition in deaf children using fMRI by Qiang Li, Yuan Meng, Qiuli Li, Heng Zhao, Shiyu Li

“…The results revealed that (1) Due to hearing loss, some of the auditory cortices responsible for processing vocal intonation in deaf children do not function optimally, (2) When decoding vocal intonation information, deaf children might utilize alternative neural pathways or networks, (3) Deaf children exhibit hemispheric specialization in their processing of vocal intonation cues.…”
Get full text