Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction. by Elena Quaglio, Elena Restelli, Anna Garofoli, Sara Dossena, Ada De Luigi, Luigina Tagliavacca, Daniele Imperiale, Antonio Migheli, Mario Salmona, Roberto Sitia, Gianluigi Forloni, Roberto Chiesa

“…Because ER stress favors the formation of untranslocated PrP that might aggregate in the cytosol and impair proteasome function, we also measured the activity of the ubiquitin proteasome system (UPS). …”
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Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization. by Tomoka Ishida, Takeshi Yoshida, Kosei Shinohara, Kejia Cao, Ken-Ichi Nakahama, Ikuo Morita, Kyoko Ohno-Matsui

“…Glial fibrillary acidic protein expression and angiogenesis-related gene expression were examined using quantitative polymerase chain reaction and phagocytosis, as a marker of Müller glial cell function; in addition, a latex bead assay was used to analyze cell function. …”
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Splicing and the evolution of proteins in mammals. by Joanna L Parmley, Araxi O Urrutia, Lukasz Potrzebowski, Henrik Kaessmann, Laurence D Hurst

“…It is often supposed that a protein's rate of evolution and its amino acid content are determined by the function and anatomy of the protein. Here we examine an alternative possibility, namely that the requirement to specify in the unprocessed RNA, in the vicinity of intron-exon boundaries, information necessary for removal of introns (e.g., exonic splice enhancers) affects both amino acid usage and rates of protein evolution. …”
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Apoptosis Inhibitor of Macrophages in Cats: A Potential Link Between an Exon 3 Variant Allele and Progression of Naturally Occurring Chronic Kidney Disease by Gabriela C. L. Evangelista, Julianne K. Hwang, Liam E. Broughton‐Neiswanger, Emily C. Carlo Reis, Michael H. Court, Katrina A. Mealey, Nicolas F. Villarino

“…An AIM (fAIM) genetic variant in cats resulting in a domain duplication might abrogate fAIM's protective effect on kidney function. …”
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Characteristics of B-lymphocyte subpopulations in renal transplant recipients by S. V. Zybleva, S. L. Zyblev

“…The presence of multiple subsets of B-cells with specific regulatory functions capable of modulating inflammatory responses havebeen detected. …”
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Roles of Oncogenic Long Non-coding RNAs in Cancer Development by Hyunhee Do, Wanyeon Kim

“…Oncogenic lncRNAs have the potential to become promising biomarkers and might be potent prognostic targets in cancer therapy. …”
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Premises for Success of Corporate Social Responsibility Initiatives in Romania and the Students’ Perspectives by Cătălina RADU, Alecxandrina DEACONU, Ramona PUIA

“…In order to familiarize ourselves with the current situation, we decided to determine the perception level students had in relation to this concept, not forgetting the fact that they might be employed in companies operating in this specific field and, also, that all of them are members of the community where these organizations function. …”
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Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves by Sushma Devi, Randhir Singh

“…During the experimental periods parameters like lipid profile, liver function test, atherogenic index and histopathological studies were analysed. …”
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Research on Seismic Resistance of Precast Concrete Shear Walls with Bolt Splicing by XU Zhuang, ZHANG Ruigang

“…A design scheme of fully-assembled precast concrete shear walls with unit components spliced by bolts is proposed for the prefabricated unit residence system.An integral precast wall and two overlapped precast ones (consisting of two thin panels spliced horizontally by bolts) are designed,and low-cycle static loading tests of the walls under the bend-shear coupled loading mode are performed to study the seismic resistance of the structures.The research results indicate that the failure mode of the overlapped wall is the same as that of the integral one,and the crack development of the wall body is insufficient.The bearing capacity of the overlapped wall is equivalent to that of the integral one.The former is more ductile,whose displacement ductility factor is about 1.1 times that of the latter.The initial stiffness of the integral wall is larger than that of the overlapped one,but the former's stiffness degrades faster.In addition,the quantity and locations of bolts have little effect on the energy dissipation capacities of overlapped walls,and joint connection might be the only function of bolts for overlapped walls.…”
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"Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation". by Stella Prins, Christina Kiel, Alexander J E Foss, Moussa A Zouache, Philip J Luthert

“…Together these finds provide an integrated framework for the study of outer retinal metabolism and how it might change with age.…”
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Rapid Evaluation of the Severity and Prognosis of Acute Carbon Monoxide Poisoning by Z. N. Marupov, G. N. Sukhodolova, A. V. Badalyan, A. N. Yelkov

“…Objective: to assess whether cardiointervalography (CIG) might be used to define the health status of patients with carbon monoxide poisoning. …”
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Tips and Tricks in Experimental Nerve Defect Surgery by Andrei MARIN, Ruxandra Ioana MIHAI, Georgiana Gabriela MARIN

“…Microsurgery in itself might be considered a challenge for some plastic surgeons, as it requires patience and perseverance. …”
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A review of the tolerability and safety of levocabastine eye drops and nasal spray. Implications for patient management by Peter H. Howarth

“…Clinically, levocabastine is well tolerated with an adverse effect profile comparable with that of sodium cromoglycate and placebo. As might be expected from the route of drug administration, local irritation is the most frequent adverse event seen with levocabastine eye drops and nasal spray with an incidence comparable with that in placebo-treated controls. …”
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Cinephilistinism and the Second Coming by William Brown

“…It is through the twin lenses of disability theory and critical race theory that I propose the concept of cinephilistinism, a term that attempts two things: firstly, to express an essayistic opposition to both a cinematic settler-colonial occupation and the support, be that tacit or explicit, lent to that occupation by various purportedly cinephilic institutions; and, secondly, to function as a means for currying what Steven Salaita might term, apropos of Indigenous and Palestinian relations (but here applied to Palestinian solidarity networks more generally), “inter/nationalism” or “solidarity, transnationalism, intersectionality, kinship, or intercommunalism” with Palestine at this moment of intensified Israeli state brutality. …”
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Reinforcement learning when your life depends on it: A neuro-economic theory of learning. by Jiamu Jiang, Emilie Foyard, Mark C W van Rossum

“…The objective of the flies is to maximize their lifespan, which is calculated with a hazard function. We find that strategies that switch between the LTM and ARM pathways, based on energy reserve and reward prediction error, prolong lifespan. …”
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A conversation on academic freedom and freedom of expression at the university by Robert C. Post, Jordi Pujol

“…At their best, universities function as ‘disciplinary communities’ who must act in professionally competent ways. …”
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The role of conformity in mask-wearing during COVID-19. by Anna Woodcock, P Wesley Schultz

“…How social normative information might be used to increase mask-wearing behavior is discussed. …”
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The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases by Núria Mach

“…Emerging evidence also shows that noncoding regulatory RNAs might modulate the structure and function of the microbiome-mucin relationship. …”
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Hemispheric contribution to vertex augmentation/reduction of the auditory evoked potential by C. Collin, F. Lolas

“…Ss who were augmenters at the vertex showed positive Amplitude-Intensity function slopes over the left hemisphere; when Ss were Reducers at the vertex, the slopes were negative on the right hemisphere. …”
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Subtitling Tarantino’s offensive and taboo dialogue exchanges into european spanish: the case of Pulp Fiction by José Javier Ávila-Cabrera

“…The omission of offensive/taboo words can therefore be said to entail a loss in their communicative function. From a Descriptive Translation Studies approach, the goals of this paper attempt to shed some light on the way the film Pulp Fiction (Quentin Tarantino, 1994) was subtitled into European Spanish by delving into diverse matters such as: (1) the translation strategies utilised by the subtitler; (2) the way offensive/taboo dialogue exchanges were transferred on the screen; and (3) proving whether the cases of neutralisation and omission of the load of these terms might have been justified by the technical constraints of subtitling.…”
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