Characterization of new otic enhancers of the pou3f4 gene reveal distinct signaling pathway regulation and spatio-temporal patterns. by Àlex Robert-Moreno, Silvia Naranjo, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Berta Alsina

“…Altogether, our results suggest that pou3f4 expression in inner ear might be under the control of distinct regulatory elements that fine-tune the spatio-temporal activity of this gene and provides novel data on the signaling mechanisms controlling pou3f4 function.…”
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Comparison of Blood Pressure Variability between 24 h Ambulatory Monitoring and Office Blood Pressure in Diabetics and Nondiabetic Patients: A Cross-Sectional Study by Ana Lídia Rouxinol-Dias, Marta Lisandra Gonçalves, Diogo Ramalho, Jose Silva, Loide Barbosa, Jorge Polónia

“…We found that diabetes is associated with higher variability of daytime BP than nondiabetics along with worse damage of vascular and renal function. However, in contrast to nondiabetics, in diabetics eGFR and PWV may not be dependent on BP variability, suggesting that other mechanisms might explain more rigorously the greater damage of target organ lesion markers.…”
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Reducing Wave Overtopping on Rubble Mound Breakwaters Using Floating Kelp Farms by Filipe Miranda, Tomás Calheiros-Cabral, Diogo Mendes, Paulo Rosa-Santos, Francisco Taveira-Pinto, Tiago Fazeres-Ferradosa

“…Near-surface floating kelp farms constitute a Nature-Based Solution (NBS) capable of damping incident wind-generated waves, which might be beneficial to reduce wave overtopping on maritime structures. …”
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Conserved Metabolic Changes in Nondiabetic and Type 2 Diabetic Bariatric Surgery Patients: Global Metabolomic Pilot Study by Konrad Sarosiek, Kirk L. Pappan, Ankit V. Gandhi, Shivam Saxena, Christopher Y. Kang, Heather McMahon, Galina I. Chipitsyna, David S. Tichansky, Hwyda A. Arafat

“…Changes in histidine and its metabolites following surgery might be an indication of altered gut microbiome ecology or liver function. …”
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Effects of silencing StSOBIR1-like gene on potato in response to herbivory by HE Wenjing, ZHANG Yadong, ZHANG Chao, ZHONG Jian, CHEN Chuzhen, GE Yang, HE Shuyan, ZHU Zengrong, ZHOU Wenwu

“…In summary, StSOBIR1-like gene might negatively regulate potato response to herbivory. …”
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Novel Heterozygous Sequence Variant in the HOXD13 Gene Underlie Non-syndromic Syndactyly by Safdar Abbas, Farooq Ahmad, Misbah Kanwal, Annum Sultan, Gulab Said, Muhammad Umair

“…Results: WES data analysis revealed a novel-HOXD13 gene missense variant (c.969G>T; p.Trp323Cys) that might explain the disease phenogenesis. 3D protein modeling of the normal and mutant protein predicated high level changes that might compromise the ultimate function of the protein. …”
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BmToll9-1 Is a Positive Regulator of the Immune Response in the Silkworm <i>Bombyx mori</i> by Jisheng Liu, Weijian Chen, Jinrong Situ, Jiaxuan Li, Jiahua Chen, Minchun Lai, Fengyi Huang, Baoqi Li

“…As a positive regulator, BmToll9-1 might function mainly in the gut to maintain microbial homeostasis to regulate the growth of silkworms. …”
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Comparative study of brain and eye infected by Escherichia coli Isolated From River Water in Male and Female Rats by Hawraa M AL-Rafyai, Raflaa SH Hussian, Zahraa M Al- Taee, Rasha Kadhim Mahdi

“… Objective: One important hormone and neurotransmitter that is vital to the body and brain is dopamine. It functions as a chemical messenger between neurons in the brain as a neurotransmitter, impacting several critical functions like mood regulation, reward and pleasure systems, motor control, and cognitive function. …”
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Key roles of the superficial zone in articular cartilage physiology, pathology, and regeneration by Li Guo, Pengcui Li, Xueqin Rong, Xiaochun Wei, Xiangxiang Pan

“…The SFZ is not only a crucial structure for maintaining the normal physiological function of articular cartilage but also the earliest site of osteoarthritis (OA) cartilage degeneration and a major site of cartilage progenitor cells, suggesting that the SFZ might represent a key target for the early diagnosis and treatment of OA. …”
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Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…Mortalin dysfunction associated with Parkinson's disease (PD) increases the vulnerability of cultured cells to proteolytic stress and leads to changes in mitochondrial function and morphology. To date, Drosophila melanogaster has been successfully used to investigate pathogenesis following the loss of several other PD-associated genes. …”
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Microstructure and Cerebral Blood Flow within White Matter of the Human Brain: A TBSS Analysis. by Stéphanie Giezendanner, Melanie Sarah Fisler, Leila Maria Soravia, Jennifer Andreotti, Sebastian Walther, Roland Wiest, Thomas Dierks, Andrea Federspiel

“…<h4>Conclusion</h4>The currently observed findings on a macroscopic level might reflect the metabolic demand of white matter on a microscopic level involving myelination processes or axonal function. …”
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Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest by Ruiyu Wang, Ning Zhou, Yue Luo, Xiaohong Zhang, Chuanzhu Lv

“…These findings highlight a strong association between cGAS upregulation and cardiac dysfunction after CA. Targeting cGAS might provide a promising therapeutic strategy for improving cardiac function in patients with CA.…”
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Reassessment of aviation risk safety barriers using stochastic and lexical uncertainty by Hendri Saputra, Sutanto Soehodho

“…Cumulative Distribution Function (CDF) and Fuzzy data processing provide some insight into the results of this research. …”
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Peripartum Cardiomyopathy-Induced Cardiogenic Shock Causing Hypoxic-Ischemic Encephalopathy in a COVID-19 Patient by Minh Khoi Le, Thanh Hieu Nguyen

“…The clinical course was favorable: the hemodynamics stabilized, the cognitive function fully recovered, and the patient was extubated on the second day of admission to the intensive care unit. …”
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Acute Lymphocytic Myocarditis in a Young Male Post-COVID-19 by Mintje Bohné, Sebastian Bohnen, Stephan Willems, Karin Klingel, Dietmar Kivelitz, Edda Bahlmann

“…Lymphocytic myocarditis might present as a relevant extrapulmonary manifestation after coronavirus disease 2019 (COVID-19) infection. …”
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What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus? by Hujun Shen, Hui Sun, Guohui Li

“…Poliovirus (PV) is a well-characterized RNA virus, and the RNA-dependent RNA polymerase (RdRp) from PV (3D(pol)) has been widely employed as an important model for understanding the structure-function relationships of RNA and DNA polymerases. …”
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Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy by Lampros Kousoulas, Uwe Wittel, Stefan Fichtner-Feigl, Stefan Utzolino

“…The early treatment of the patient with a Cytosorb hemoadsorber led to a rapid hemodynamic and metabolic stabilization and preservation of the renal function, suggesting that hemoadsorption might be a rescue therapy in patients with severe septic shock and traumatic rhabdomyolysis.…”
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Neuroprotective effect of cedrol in a male rat model of Parkinson's disease by Fatemeh Forouzanfar, Mahmoud Hosseini, Amir Mahmoud Ahmadzadeh, Ali Mohammad Pourbagher‐Shahri

“…Cedrol could benefit cognitive and motor functions in a rat model of PD. Its antioxidant properties might mediate these effects.…”
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αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis by Ying Chen, Ling V. Sun

“…Furthermore, the depletion of αSnap in ISCs promotes the expression of Calr, Prtp, LRP1 and Mcr, which might function downstream of αSnap in regulating the survival of ISCs. …”
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Tim-3 Is Differentially Expressed during Cell Activation and Interacts with the LSP-1 Protein in Human Macrophages by Ranferi Ocaña-Guzman, Lucero A. Ramon-Luing, Luis A. Vazquez-Bolaños, Michelle Rodríguez-Alvarado, Fausi Bulhusen-Rodriguez, Alonso Torres-Hatem, Karen Gonzalez-Torres, Mariana Citlalli de Alba-Alvarado, Isabel Sada-Ovalle

“…However, its expression and function in other cell types, such as macrophages, are poorly understood. …”
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