PANDAS in an Adult?: A Case Report by Rohit P Deshmukh, Astik B Mane, Shachi Singh

“…Hemoglobin (13.5 g/dL), TLC (5700/mm³), and ESR (05 mm in the first hour), blood sugars, renal function test (RFT), and liver function test (LFT) were within normal limits. …”
Get full text

The role of ferroptosis and oxidative stress in cognitive deficits among chronic schizophrenia patients: a multicenter investigation by Zhenlei Peng, Qiyu Jia, Junxiong Mao, Shijie Jiang, Qi Ma, Xiao Luo, Zhiguo An, Anqi Huang, Chuang Ma, Qizhong Yi

“…Notably, GPX4 emerged as a key predictor for cognitive function in abstraction and language domains. Our study revealed alterations in the altered plasma levels of GPX4, GSH, iron, ACSL4, FE, and SOD in chronic SCZ patients, which might indicate a close association between biomarkers of ferroptosis and OS and the psychiatric symptoms and cognitive deficits observed in these individuals.…”
Get full text

Comparison of the Clinical Outcomes between Echelette Extended Range of Vision and Diffractive Bifocal Intraocular Lenses by Xin Liu, Xiaohui Song, Wei Wang, Yanan Zhu, Danni Lyu, Xingchao Shentu, Peiqing Chen, Yibo Yu, Ke Yao

“…Superior modulation transfer function (MTF) and higher Strehl ratio (P<0.05) were shown in ZXR00. …”
Get full text

Idiopathic Retroperitoneal Fibrosis-Related Hydronephrosis: Evaluation of Comprehensive Management and Prediction of Inflammatory Markers for Stent-Free Outcomes by Huang Z, Liu Y, Xiao Y, Hu H, Xu T

“…Decline in serum IgG (− 5.80 g/L vs. − 2.30 g/L), CRP (− 18.93 mg/L vs. − 1.72 mg/L) and erythrocyte sedimentation rate (− 22.00 mm/h vs. − 1.50 mm/h) levels in the stent-free group surpassed those in the treatment-failure group (p< 0.05).Conclusion: Comprehensive management benefits iRPF patients with hydronephrosis by preserving renal function. The 24-month scale might guide stent/tube removal. …”
Get full text

A co-feeding strategy of formate and H2 for methanogens – Enhancing growth parameters and methane production by Björn Sabel-Becker, Nicolas Patrick Jost, Anne-Kristin Kaster, Dirk Holtmann

“…Formate could link the electrical and chemical sectors as its production can be realized through the electrochemical reduction of CO2. Its function could be either a long-term energy storage medium or a starting material in a bioprocess. …”
Get full text

Roles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2 by Hongguang Li, Lihong Zhao, Zhenhua Zhang, Heng Zhang, Chao Ding, Zijie Su

“…Moreover, high-mobility group A2 reintroduction reversed the anti-proliferation, anti-migration, and anti-invasion roles of let-7b. Let-7b might function as a tumor suppressor in papillary thyroid carcinoma by suppressing the expression of high-mobility group A2, and therefore might provide a promising therapeutic target for patients with papillary thyroid carcinoma.…”
Get full text

Potential Health Implications of the Consumption of Thermally-Oxidized Cooking Oils – a Review by Falade Ayodeji Osmund, Oboh Ganiyu, Okoh Anthony Ifeanyi

“…Furthermore, several in vivo studies had suggested that consumption of thermally-oxidized cooking oils might not be healthy as it might negatively influence the lipid profile (increased low density lipoprotein (LDL), decreased high density lipoprotein (HDL) and elevated cholesterol level), haematological system (alteration in concentration of heamoglobin (Hb), packed cell volume (PCV), white blood cell (WBC) count, neutrophil and lymphocyte counts), kidney function, and induce lipid peroxidation and oxidative stress which have been associated with the pathogenesis of various degenerative diseases. …”
Get full text

Unveiling novel susceptibility genes and drug targets for basal cell carcinoma by a cross-tissue transcriptome-wide association study by Hong Sun, Ling Li, Xiu Xin, Jingchao Yan, Taomin Huang

“…The cross-tissue TWAS was conducted to discover the candidate genes for BCC. Functional Summary-based Imputation (FUSION) analysis was used to validate these genes in the single tissues. …”
Get full text

Strategic scheduling of the electric vehicle-based microgrids under the enhanced particle swarm optimization algorithm by Saeed Abdollahi Khou, Javad olamaei, Mohammad Hassan Hosseini

“…Moreover, EVs (electric vehicles), being dynamic loads, might significantly affect the security administration of the microgrid. …”
Get full text

Accounting for Withdrawal of Life-Sustaining Treatment in the Analysis of Traumatic Brain Injury Studies by Brian C. Healy, Brian L. Edlow, Yelena G. Bodien

“…If we are willing to assume that some of the patients who die of WLST might have had a good outcome at 6 months, the choice of analytic approach may impact the results. …”
Get full text

A Not-So-Pleasant Surprise: Ochronotic Knee Encountered During Primary Arthroplasty by Bana Awad, Shahem Elias, Bezalel Peskin, Nabil Ghrayeb, Farouk Khury

“…Furthermore, the diagnosis might be of clinical relevance, since this case demonstrated postoperative anemia which required blood transfusion. …”
Get full text

Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis. by Gia Deyab, Trine Marita Reine, Tram Thu Vuong, Trond Jenssen, Gunnbjørg Hjeltnes, Stefan Agewall, Knut Mikkelsen, Øystein Førre, Morten Wang Fagerland, Svein Olav Kolset, Ivana Hollan

“…The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet. …”
Get full text

Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders by Thayse Pinheiro da Costa, Marcia Cury El-Cheikh, Katia Carneiro

“…In this sense, iHDACs might emerge as a promising new approach for translational studies in this field. …”
Get full text

TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. by Alessia Franceschini, Sandra Vilotti, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti

“…Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. …”
Get full text

Severe respiratory acidosis contributing to refractory hyperkalemia: a case series of COVID-19 patients with renal failure by Nabadwip Pathak, Sunil Kumar Nanda

“…All of these patients had worsening pulmonary function, after which the hyperkalemia could not be corrected, corresponding to persistent RA. …”
Get full text

Translational Insights into Cancer-Associated Fibroblast Infiltration-Related Biomarkers in Glioblastoma and Their Clinical Prognostic Value by Zhang Y, Huang Q

“…Besides, the genes in high-risk groups were associated with the functions of epithelial mesenchymal transition (EMT) and angiogenesis. …”
Get full text

Spawning Potential Ratio Can Provide Reference Points for Fishery Management That Are Robust to Environmental Variability by Kyle W. Shertzer, Matthew D. Damiano, Erik H. Williams

“…For many fisheries worldwide, biological reference points are based on the spawning potential ratio (SPR), which measures per-recruit reproductive output as a function of the fishing rate relative to that when fishing is absent. …”
Get full text

Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy by Montserrat Romero, Arantxa Ortega, Nuria Olea, María Isabel Arenas, Adriana Izquierdo, Jordi Bover, Pedro Esbrit, Ricardo J. Bosch

“…Recently, we hypothesized that PTHrP involvement in the mechanisms of renal injury might not be limited to conditions with predominant damage of the renal tubulointerstitium and might be extended to glomerular diseases, such as diabetic nephropathy (DN). …”
Get full text

Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. by Thomas J Carney, Natália Martins Feitosa, Carmen Sonntag, Krasimir Slanchev, Johannes Kluger, Daiji Kiyozumi, Jan M Gebauer, Jared Coffin Talbot, Charles B Kimmel, Kiyotoshi Sekiguchi, Raimund Wagener, Heinz Schwarz, Phillip W Ingham, Matthias Hammerschmidt

“…In addition, the novel genes might prove helpful to unravel the molecular nature of thus far unresolved cases of the human disease.…”
Get full text

Characterisation and validation of insertions and deletions in 173 patient exomes. by Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka

“…These insertions and deletions might play a significant role in disease genetics, contributing specifically to the underlining rare and private variation predicted to be discovered through next generation sequencing.…”
Get full text