Motor and Non-motor Neurologic Symptoms of Wilson’s Disease: Exploring the Associations by Arka Prava Chakraborty, Adreesh Mukherjee, Uma Sinharoy, Madhushree Chakrabarty, Mainak Sengupta, Jasodhara Chowdhury, Atanu Biswas

“…Background and Objectives: Although the motor symptoms of Wilson’s disease have received particular attention from researchers and medical professionals, non-motor symptoms might become increasingly prevalent with the advancement of the disease and can even appear before the onset of motor symptoms. …”
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The Role of CXCR3 in the Induction of Primary Biliary Cirrhosis by Wen Zhang, Yunyun Fei, Jinming Gao, Bin Liu, Fengchun Zhang

“…Knockout of CXCR3 might delay and alleviate the PBC disease progression, but could not entirely block the disease development.…”
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Gene markers of fracture healing in early stage and the regulatory mechanism during the process using microarray analysis by Chengxue Wang, Baochang Qi, Lei Tan, Jieping Cheng

“…Eftud2, Snrpd2, Bub1b and Plk1 might function through the involvement of cell-cycle-related BP, while Ubc might influence the protein degradation during bone development. …”
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Simplification with Boosted Protease Inhibitor-Based ART Versus Maintenance of Conventional ART: Results from a Five-Year Controlled Cohort by Mateus Swarovsky Helfer, Guilherme Carvalho Serena, Tarsila Vieceli, Eduardo Sprinz

“…Boosted-protease inhibitors (bPI) might be an option in this scenario. Nevertheless, long-term outcomes have not been studied yet. …”
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Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). by Marta Szajnik, Malgorzata Czystowska, Miroslaw J Szczepanski, Magis Mandapathil, Theresa L Whiteside

“…<h4>Background</h4>Tumor-derived microvesicles (TMV) or exosomes are present in body fluids of patients with cancer and might be involved in tumor progression. The frequency and suppressor functions of peripheral blood CD4(+)CD25(high)FOXP3(+) Treg are higher in patients with cancer than normal controls. …”
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RETRACTED ARTICLE: Molecular mechanism and diagnostic marker investigation of endoplasmic reticulum stress on periodontitis by Qianqian Sun, Enqiang Zhu

“…Abstract Purpose The aim of this study was to reveal the biological function of endoplasmic reticulum stress (ERS)-related genes (ERSGs) in periodontitis, and provide potential ERS diagnostic markers for clinical therapy of periodontitis. …”
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The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity by Fangrui Xiu, Zhibo Gai, Peter Gehrig, Witold E. Wolski, Museer A. Lone, Michele Visentin

“…Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on the S-acylated proteome of mouse kidneys to uncover novel biochemical changes that might contribute to lipid-induced nephrotoxicity. …”
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Digital infrastructure's impact on tourism services in Boumerdes by Souiher Khalil, Belguesmia Sabiha, Aouda Said, Rezzaz Mohamed Abdessamad

“…The tourism industry is the subject of this study, which particularly looks at the function of travel agencies in light of these digital changes, which might allow them to provide creative services that are carried out fast and effectively. …”
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On expressive and aesthetic use of terminology: an attempt of communicative analysis (with russian and croatian linguistic terms as examples) by Albrekht Fedor

“…Thus, if creating terms transforms from a vital need into the process of designating for the sake of it, the main communicative aim of employing terms also shifts from its academic function to serving the goal of the writer/speaker to alienate him- or herself from anybody else (laymen, non-professionals, other nations etc.). …”
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Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion by Yuren Wang, Hua Qu, Xin Xiong, Yuyang Qiu, Yong Liao, Yingchun Chen, Yi Zheng, Hongting Zheng

“…Conclusions. Circulating asprosin might be a predictor of early diagnosis in DM and might be a potential therapeutic target for prediabetes and T2DM.…”
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Empagliflozin in patients with autosomal dominant polycystic kidney disease (EMPA-PKD): study protocol for a randomised controlled trial by Roland Schmitt, Sebastian Häckl, Armin Koch, Elisabeth Bahlmann-Kroll, Stefanie Kramer, Vera Christine Wulfmeyer, Julian Glandorf, Jessica Kaufeld, Dagmar Hartung, Bernhard M W Schmidt, Kai Schmidt-Ott

“…In particular, there has been speculation that SGLT2i might increase cyst growth and accelerate the loss of kidney function in ADPKD. …”
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Amlodipine improves symmetric dimethylarginine in dogs with chronic kidney disease by Shohei Morita, Youhei Mochizuki, Takahiro Kondo, Yasuyoshi Matsuda, Takahiro Ohmori, Aritada Yoshimura, Ryuji Fukushima

“…Amlodipine is used to treat hypertension in dogs, and we anticipated that amlodipine administration might improve renal function in dogs. However, the effect of amlodipine on canine renal function is unknown. …”
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Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes by Jorge A. Castorena-Gonzalez, Hae Jin Kim, Michael J. Davis

“…We recently reported that acute metabolic stress leads to activation of KATP channels in lymphatic muscle cells, resulting in impairment of the intrinsic lymphatic pacemaker that drives their spontaneous contractions and active lymphatic pumping.MethodsIn the present study, we tested whether lymphatic contractile dysfunction occurs in the db/db mouse, a model of metabolic syndrome, and, if so, to what extent dysfunction might be mediated by KATP channel activation. Contractile function was assessed ex vivo in cannulated and pressurized popliteal collecting lymphatics from age-matched db/db mice or their BKS controls (from males and females at 18–20 weeks of age).ResultsVessels from db/db mice exhibited pressure-dependent spontaneous contractions that were significantly reduced in amplitude, frequency, and calculated fractional pump flow at all tested pressures in the range 0.5 to 5 cmH2O, compared to BKS controls. …”
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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury by Yuanyuan Zhao, Xiaoxian Sun, Wenming Cao, Jie Ma, Li Sun, Hui Qian, Wei Zhu, Wenrong Xu

“…The results indicated that ligation of the LAD coronary artery reduced cardiac function and induced cardiomyocyte apoptosis. Administration of hucMSC-exosomes significantly improved cardiac systolic function and reduced cardiac fibrosis. …”
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Two‐dimensional echocardiographic right heart ratios for assessment of right heart size in dogs: Reference intervals and reproducibility by Jacqueline N. Sankisov, Lance C. Visser, Kate E. Davis, June A. Boon, Evan S. Ross, Abigail C. Laws

“…Conclusions and Clinical Importance Reference intervals for simple body weight‐independent right heart ratios are available to help detect abnormalities of right heart size and function. Reproducibility coefficients might be useful to help identify meaningful changes in right heart size during serial evaluations.…”
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The Adverse consequence of covid-19 causing liver and kidney dysfunctions by Omar Falah Ibrahim

“…This research aims is to evaluate the function of two main organs ‎in the human body, the ‎liver, and ‎kidney, assess the organ's function by measuring the clinical features and test abnormalities ‎in ‎COVID-19 ‎patients, and to compared with previous publications, and highlighted on adverse of ‎pharmacological utilized in ‎the treatment of covid-19 patients.‎ …”
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Poor Folk by Fyodor Dostoevsky as a Dialogue between the Old and the New Word by Victoria I. Buyanovskaya

“…Varvara Dobroselova’s language usually escapes critical attention, albeit her “verbal” function in the novel might even exceed her “plot” function. …”
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Studi Fenomenologi Pengalaman Perubahan Citra Tubuh pada Klien Kelemahan Pasca Sroke di RSUP Dr M Djamil Padang by Novi Herawati

“…It is expected nurse as nursing care providers can improve the role and function as counselors and nursing care providers with caring. …”
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Auditory-Cortex Short-Term Plasticity Induced by Selective Attention by Iiro P. Jääskeläinen, Jyrki Ahveninen

“…The ability to concentrate on relevant sounds in the acoustic environment is crucial for everyday function and communication. Converging lines of evidence suggests that transient functional changes in auditory-cortex neurons, “short-term plasticity”, might explain this fundamental function. …”
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Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism. by Ning Cheng, Fawaz Alshammari, Elizabeth Hughes, Maryam Khanbabaei, Jong M Rho

“…Since dendritic structure is critical for information integration and relay, our data suggest that altered development of dendrites could potentially contribute to impaired hippocampal function and behavior observed in the BTBR model, and that this might be related to increased activation of the ERK pathway.…”
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