Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. by Rodrigo A Fuentealba, Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee, Mary Jo LaDu, Guojun Bu

“…<h4>Methodology/principal findings</h4>Here we show that LRP1 endocytic function is required for neuronal Abeta42 uptake. Overexpression of a functional LRP1 minireceptor, mLRP4, increases Abeta42 uptake and accumulation in neuronal lysosomes. …”
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Mechanisms of paroxysmal atrial fibrillation in patients with sick sinus syndrome by S. Yu. Ivanov, N. N. Burova, B. B. Bondarenko

“…Authors suggest that it might be explained by activation of ectopic automatism centers in patients with SSS. …”
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miR472 Deficiency Enhances Arabidopsis thaliana Defense Without Reducing Seed Production by Francois Vasseur, Patricia Baldrich, Tamara Jiménez-Góngora, Luis Villar-Martin, Detlef Weigel, Ignacio Rubio-Somoza

“…The potential evolutionary advantage of such regulation remains largely unknown and might be related to two nonexclusive scenarios: (i) miRNA-dependent regulation of NLR levels might prevent defense mis-activation with negative effects on plant growth and reproduction or (ii) reduction of active miRNA levels in response to pathogen-derived molecules (pathogen-associated molecular patterns [PAMPs] and silencing suppressors) might rapidly release otherwise silent NLR transcripts for rapid translation and thereby enhance defense. …”
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Biological pathways leading to septo-optic dysplasia: a review by Ludovica Pasca, Davide Politano, Federica Morelli, Jessica Garau, Sabrina Signorini, Enza Maria Valente, Renato Borgatti, Romina Romaniello

“…Those pathways may converge and thus, the implicated genes may function as cascading regulators at multiple levels. …”
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Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism by Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng

“…Our findings substantiated that the 435–457 position of SEMA3A might be very important for the secretion of SEMA3A. …”
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The origins of light-independent magnetoreception in humans by Takashi Shibata, Takashi Shibata, Noriaki Hattori, Hisao Nishijo, Satoshi Kuroda, Kaoru Takakusaki

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Determination of the composition of fatty acids from tea seed oil by GUO Hua, ZHOU Jian-ping, LUO Jun-wu, TAN Hui-yuan, LIU Dong-min

“…In addition, tea seeds contained 0.144% trans-18:1, which might be a precursor of 9c, 11t-CLA in human. This conjugated linoleic acid might be one of the functional components related to the function of anticancer, anti-atherosclerosis, antibacterial, antivirus or regulation of immunity. …”
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Neuromodulator and Emotion Biomarker for Stress Induced Mental Disorders by Simeng Gu, Wei Wang, Fushun Wang, Jason H. Huang

“…The reason for this discrepancy might be that NE is not only for flight (fear), but also for fight (anger). …”
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Funding the New Biologics – Public Policy Issues in Drug Formulary Decision Making by Steven Lewis

“…One function of drug formularies is to allow health care providers to exert some control over spending. …”
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Identification of Differentially Expressed Gene after Femoral Fracture via Microarray Profiling by Donggen Zhong

“…This study suggested that Rest and Cst8 might act as potential indicators for fracture healing. …”
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The Mobility Makeover: Exploring the Interest, Need and Feasibility of a Mobility Aid Personalisation Programme in Long-Term Care by Pauli Gardner, Jaclyn Ryder, Colleen Whyte, Norma Restivo

“…There are several important implications of this research including identifying the potential benefits of a device personalisation programme and how this might ‘work’ in a care home and providing insight into what may be lost in current systems where the function and efficiency of mobility device prescription are prioritised. …”
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MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity by Katy E. Pannoni, Quentin S. Fischer, Renesa Tarannum, Mikel L. Cawley, Mayd M. Alsalman, Nicole Acosta, Chisom Ezigbo, Daniela V. Gil, Logan A. Campbell, Shannon Farris

“…Fragmented mitochondria might have functional changes, such as altered ATP production, that could explain the structural and functional deficits at cKO synapses. …”
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LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells by Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin

“…ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and induced to differentiate into Th17 cells.XIST was over-expressed and silenced by plasmid transfection.Proliferation and apoptosis of Th17 cells with different levels of XIST expression were detected by flow cytometry and CCK-8 assay.Levels of XIST，TLR9 mRNA and protein were detected by quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blot.The effect of XIST on TLR9 expression was predicted by luciferase report analysis and TLR9 mRNA half-life detection.Potential RNA-binding proteins interacting with XIST were searched through Starbase database and detected by RNA immunoprecipitation and Western blot.GraphPad8.0 was utilized for statistical analysis and variables were expressed as average±SD.Student T test or one-way ANOVA was employed.ResultsXIST was distributed predominantly in cytoplasm.It hinted that XIST might be involved in post-transcriptional regulation.A down-regulation of lncRNA XIST expression promoted apoptosis and DNA damage and arrested cell proliferation by regulating TLR9.With an over-expression of lncRNA XIST，TLR9 expression spiked and XIST up-regulated the expression of TLR9 by promoting the stability of TLR9 mRNA.As an RNA-binding protein （RBP），FUS interacted with XIST and FUS antibodies could significantly enrich XIST transcripts.A down-regulation of lncRNA XIST expression had no effect on FUS protein expression.It suggested that XIST might affect FUS function rather than expression.It was further confirmed that a down-regulation of XIST significantly reduced FUS-TLR9 mRNA binding and FUS over-expression rescued a down-regulation and degradation of TLR9 mediated by si-XIST.ConclusionlncRNA XIST and TLR9 play a critical role in Th17 cell proliferation in IgAN through a FUS-mediated signaling pathway.This finding provides new therapeutic ideas for IgAN..…”
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Impact of vitamin A on aged people’s cognition and Alzheimer’s disease progression in an animal model by Pengfei Li, Jingjing Xu, Yujie Guo, Xiaojun Ma, Xixiang Wang, Lu Liu, Yu Liu, Xiuwen Ren, Jiahao Li, Ying Wang, Liping Meng, Shaobo Zhou, Linhong Yuan

“…Abstract The relation between vitamin A (VA) level and cognitive function and the underlying mechanisms have not been thoroughly investigated. …”
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Shor's Factoring Algorithm and Modular Exponentiation Operators by Robert L. Singleton Jr

“…We also delve into the number theory that establishes the link between factorization and the period of the modular exponential function. We then apply the QPE algorithm to obtain Shor's factoring algorithm. …”
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Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. by Lianggong Ding, Ye Lei, Yanping Han, Yuhong Li, Xunming Ji, Lei Liu

“…Because Vimar could co-immunoprecipitate with Miro in vitro, we speculated that Vimar might be the GEF of Miro. In support of this hypothesis, a loss-of-function (LOF) vimar mutant rescued mitochondrial enlargement induced by a gain-of-function (GOF) Miro transgene; whereas a GOF vimar transgene enhanced Miro function. …”
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Incomplete reverse remodeling in pulmonary hypertension‐induced right ventricular dysfunction in aged mice by Benjamin D. McNair, Sushumna B. Satyanarayana, Julian M. Matthews, Sydney M. Polson, Emma R. Mehl, Joshua P. Thornburg, Danielle R. Bruns

“…Abstract Right ventricular (RV) function is the strongest predictor of survival in pulmonary hypertension (PH) and age‐related heart disease; however, no therapies improve RV function. …”
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The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. by Erika Shor, Christopher L Warren, Joshua Tietjen, Zhonggang Hou, Ulrika Müller, Ilaria Alborelli, Florence H Gohard, Adrian I Yemm, Lev Borisov, James R Broach, Michael Weinreich, Conrad A Nieduszynski, Aseem Z Ansari, Catherine A Fox

“…Since HMR-E possessed a unique non-replication function, we reasoned that other tight sites might reveal novel functions for ORC on chromosomes. …”
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Clinical Features of Parkinson’s Disease in Patients with Early-Onset Freezing of Gait by Hiroo Terashi, Yuki Ueta, Takeshi Taguchi, Hiroshi Mitoma, Hitoshi Aizawa

“…There was also no significant difference in cognitive function, depressive symptoms, and olfactory function between the two groups. …”
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Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats by Jiayi Wang, Shunyi Lu, Ya Yuan, Lei Huang, Mengxuan Bian, Jieqin Yu, Jiapeng Zou, Libo Jiang, Dehua Meng, Jian Zhang

“…A decrease in pyroptosis in Schwann cells promoted regeneration of the sciatic nerve and recovery of motor function in rats. Conclusion. Given the role of Schwann cell pyroptosis in PNI progression, inhibition of Schwann cell pyroptosis might be a potential therapeutic strategy for PNI in the future.…”
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