Genomic imprinting of Grb10: coadaptation or conflict? by Jon F Wilkins

“…According to this "coadaptation theory," paternally inherited genes might be inactivated because maternally inherited genes are adapted to function harmoniously with the mother. …”
Get full text

Recurrent urinary tract infection in women and overactive bladder – Is there a relationship? by Qian-Sheng Ke, Cheng-Ling Lee, Hann-Chorng Kuo

“…The defective urinary microbiota is less common in women with recurrent UTI, suggesting that the normal flora in the urine might inhibit uropathogen growth and invasion. The defective urothelial barrier function, deficient basal proliferation, and deficient maturation might be owing to chronic suburothelial inflammation, resulting in activation of sensory nerves (causing OAB) and failure elimination of intracellular bacterial communities (causing recurrent UTI). …”
Get full text

Endophytic bacteriome data of Litchi chinensis established by metagenomic 16S rRNA gene sequencingMendeley Data by Dinh Sy Nguyen, Dinh Minh Tran

“…Actinomycetota was the most predominant phylum (84.49%), and biosynthesis was the bacteriome's primary function (75.42%). Data provided insight into the taxonomic distribution and metabolic function of lychee endophytic bacteria and might be helpful for the next steps concerning sustainable lychee cultivation using endophytic bacteria.…”
Get full text

Travel patterns in China. by Tini Garske, Hongjie Yu, Zhibin Peng, Min Ye, Hang Zhou, Xiaowen Cheng, Jiabing Wu, Neil Ferguson

“…Travel patterns in both populations were well-fitted by a gravity model with a lognormal kernel function. The results provide the first quantitative information on human travel patterns in modern China, and suggest that a pandemic emerging in a less developed area of rural China might spread geographically sufficiently slowly for containment to be feasible, while spatial spread in the more economically developed areas might be expected to be much more rapid, making containment more difficult.…”
Get full text

Cognitive-motor dual-task training on gait and balance in stroke patients: meta-analytic report and trial sequential analysis of randomized clinical trials by Lu Zhang, Jiangping Ma, Xiaoqing Liu, Aiping Jin, Kai Wang, Xiaobing Yin

“…Abstract Objective Cognitive-motor dual-tasking training (CMDT) might improve limb function and motor performance in stroke patients. …”
Get full text

CARBOHYDRATE METABOLISM DISORDERS IN THE HEART AGEING by D. U. Akasheva, I. A. Pokshubina, E. A. Plokhova, О. N. Tkacheva

“…The review focuses  on the influence of ageing  and  carbohydrate  metabolism  disorders  on the structure   and  function  of  myocardium,  and  the  obvious  fact  is discussed, that earlier screening  and correction  of insulin resistance and glucose metabolism disorders might prevent or delay the progression of age-related heart failure.…”
Get full text

Exploring the role of N-acetyltransferases in diseases: a focus on N-acetyltransferase 9 in neurodegeneration by Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Amit Singh

“…Close to 80%–90% of proteins are acetylated during translation, which is an irreversible process that affects protein structure, function, life, and localization. In this review, we have discussed the various N-acetyltransferases present in humans, their function, and how they might play a role in diseases. …”
Get full text

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors. by Christian Schmitt, Dagmar Kail, Marica Mariano, Martin Empting, Nadja Weber, Tamara Paul, Rolf W Hartmann, Matthias Engel

“…Furthermore, an inhibitor selective for Dyrk2 (24) was also identified, which might be are suitable as a pharmacological tool to dissect Dyrk2 isoform-mediated functions.…”
Get full text

Dengue Virus Directly Stimulates Polyclonal B Cell Activation. by Arturo Ramon Vargas Correa, Ana Carolina Egypto Rosa Berbel, Michelle Premazzi Papa, Ana Theresa Silveira de Morais, Ligia Maria Torres Peçanha, Luciana Barros de Arruda

“…B cells cultured with DENV also secreted IL-6 and presented increased expression of CD86 and HLA-DR, which might contribute to B lymphocyte co-stimulatory function. …”
Get full text

The astrocytic sigma-1 receptor constitutes in the fast antidepressant action of hypidone hydrochloride (YL-0919) in rodents by Jin-Feng Li, Jin-Feng Li, Hai-Xia Chang, Jia-Ning Zhao, Jia-Ning Zhao, Jin-Hao Bao, Wei Dai, Yun-Feng Li, Yun-Feng Li

“…Knocking down sigma-1R in primary astrocytes inhibited the YL-0919 induced enhancement of mitochondrial function and increased level of BDNF expression. In addition, increased BDNF in vHIP might play a role in fast antidepressant impact of YL-0919. …”
Get full text

Digital piracy debunked: a short note on digital threats and intermediary liability by Giancarlo F. Frosio

“…Two related arguments might run against this approach. First, market conditions might incentivise piracy. …”
Get full text

Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies. by Ilaria Vaccari, Giorgia Dina, Hélène Tronchère, Emily Kaufman, Gaëtan Chicanne, Federica Cerri, Lawrence Wrabetz, Bernard Payrastre, Angelo Quattrini, Lois S Weisman, Miriam H Meisler, Alessandra Bolino

“…Since FIG4 has a role in generation of PtdIns(3,5)P(2) and MTMR2 catalyzes its dephosphorylation, these two phosphatases might be expected to have opposite effects in the control of PtdIns(3,5)P(2) homeostasis and their mutations might have compensatory effects in vivo. …”
Get full text

A DIRIGENT Gene GmDIR26 Regulates Pod Dehiscence in Soybean by Zheng Wang, Xiaofang Zhang, Rui Hou, Huiying Zhang, Xu Guo, Xiaofei Ma, Aiqin Xu, Hong Zhu, Shuai Li

“…Synteny analysis of soybean and chickpea genomes shows that the genomic region surrounding GmDIR26 and CaPdh1 might be evolved from the same ancestor, and these two genes might have similar function. …”
Get full text

IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN-γ Release by Autologous NK Cells by Fabio Morandi, Irma Airoldi, Vito Pistoia

“…In conclusion, we delineated a novel immunoregulatory function of IL-27 involving HLA-E upregulation on monocytes that might in turn indirectly impair some NK cell functions.…”
Get full text

THROMBOCYTOPENIAS by S. A. Vasiliev, V. L. Vinogradov, A. V. Mazurov, M. L. Markova

“…Two major mechanisms responsible for development thrombocytopenia might be distinguished – decreased production and increased consumption of platelets. …”
Get full text

Sea Cucumber Hydrolysates Alleviate Cognitive Deficits in D-Galactose-Induced C57BL/6J Aging Mice Associated with Modulation of Gut Microbiota by Han Gong, Hang Zhao, Xueying Mao

“…Further, SCH enhanced hippocampal cholinergic function through elevating acetylcholine (ACh) levels and inhibiting acetylcholinesterase (AChE) activity and activated BDNF signaling, consistent with predictions of gut microbiota function. …”
Get full text

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. by Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T Neil Dear

“…This is the first demonstration that a defect in a gene involved in mitochondrial remodelling can result in cardiomyopathy, showing that the function of this gene is needed for the maintenance of normal cellular function in a relatively tissue-specific manner. …”
Get full text

Neuroprotective Effects of ZiBuPiYin Recipe on db/db Mice via PI3K-Akt Signaling Pathway by Activating Grb2 by Wei-ming Ren, Ze-bin Weng, Xin Li, Li-bin Zhan

“…In a previous preliminary proteomic study, we found that endoplasmic reticulum processing and PI3K-Akt signaling pathway might be impaired in DACD pathogenesis. In addition, growth factor receptor-bound protein 2 might be a crucial protein as a molecular target of the neuroprotective effects of ZiBuPiYin recipe (ZBPYR). …”
Get full text

Identification of subcellular localization of Arabidopsis AGO2 by ZHAO Li, XIA Wenqiang, CAI Xinzhong

“…However, the detailed molecular mechanism of AGO function is still largely unknown.To provide some insights into the mechanism of Arabidopsis AGO function, subcellular localization of all Arabidopsis AGO members was predicted using bioinformatics methods, and that of one member, AtAGO2, was further experimentally identified using a transient GFP reporting system in this study. …”
Get full text

Reticulocyte Count and Exercise Performance in Elite Athletes: A Retrospective Study by Kohei Ashikaga, Marco Alfonso Perrone, Antonio Gianfelici, Davide Ortolina, Simone Crotta, Alessandro Spinelli, Sara Monosilio, Giuseppe Di Gioia, Viviana Maestrini, Maria Rosaria Squeo, Antonio Pelliccia

“…However, accelerated turnover might also be a result of intravascular haemolysis caused by RBC destruction during exercise, impairing RBC function and oxygen transport. …”
Get full text