Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. by Liqun Wang, Haihua Luo, Xiaohuan Chen, Yong Jiang, Qiaobing Huang

“…The results also showed the calcium dependency in S100A8- and S100A9-evoked endothelial response, indicating that calcium dependency on formation of S100A8 or A9 dimmers might be the prerequisite for this endothelial functional alteration.…”
Get full text

Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: an observational study by Joe West, Joanne R Morling, Trevor Alexander Hill, Colin John Crooks

Get full text

Trunk kinematics during seated functional activities in individuals with spinal cord injury: a systematic review and meta-analysis by Maria del Rocio Hidalgo Mas, Ruo-Yan Wu, Tom Nightingale, Eduardo Martinez Valdes, Zubair Ahmed, Shin-Yi Chiou

“…Forward flexion and trunk rotation might be useful strategies to compensate for muscle weakness during transfers and wheelchair propulsion. …”
Get full text

Mindfulness Meditation Is Related to Long-Lasting Changes in Hippocampal Functional Topology during Resting State: A Magnetoencephalography Study by Anna Lardone, Marianna Liparoti, Pierpaolo Sorrentino, Rosaria Rucco, Francesca Jacini, Arianna Polverino, Roberta Minino, Matteo Pesoli, Fabio Baselice, Antonietta Sorriso, Giampaolo Ferraioli, Giuseppe Sorrentino, Laura Mandolesi

“…To this aim, we used magnetoencephalography to study functional resting-state brain networks in Vipassana meditators. …”
Get full text

Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Although several forward genetic screens performed in the same context have identified a broad range of resistance genes that poorly overlap, an integrative analysis revealed a much smaller functional diversity of resistance mechanisms, including reactivation of the MAPK pathway, PI3K-AKT pathway, and Hippo pathway, suggesting that a relatively small number of therapeutic strategies might overcome resistance manifested by a large gene set. …”
Get full text

Longitudinal Associations of Newly Diagnosed Prediabetes and Diabetes with Cognitive Function among Chinese Adults Aged 45 Years and Older by Xiaojie Wang, Xiuwen Li, Wanxin Wang, Guangduoji Shi, Ruipeng Wu, Lan Guo, Ciyong Lu

“…With population aging, diabetes mellitus and cognitive function decline are common health problems among older adults worldwide. …”
Get full text

Understanding trauma-impaired executive function and its impacts on homeless adults in the UK: a realist evaluative synthesis protocol by Monique Lhussier, Christina Cooper

“…At present, there is little evidence exploring the impacts of executive function (EF) deficits in adulthood as a result of childhood trauma from a lived experience perspective, with none specifically exploring the role these deficits might play in homelessness.Methods and analysis The proposed research takes a realist evaluative synthesis approach combining evidence from the extant literature with qualitative data from professionals involved in the delivery of services to support people with experience of homelessness (n=15–20) and people with experience of homelessness who have previously engaged with services (n=15–20).A combination of keywords (Adverse childhood experiences, executive function, social functioning and complex needs) and their synonyms will be used to search databases MEDLINE, PubMed, SCOPUS, Web of Science and CINAHL. …”
Get full text

The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function by Jingjing Wang, Jinlong Qie, Danrong Zhu, Xuemei Zhang, Qingqing Zhang, Yuyu Xu, Yipeng Wang, Kai Mi, Yang Pei, Yang Liu, Guozhong Ji, Xingyin Liu

“…Some potential probiotic species, such as Desulfovibrio piger, Gordonibacter pamelaeae, Odoribacter splanchnicus, and Ruminococcaceae bacterium D5 were enriched with aging, which might possibly support health maintenance. The level of Amyloid-β (Aβ) and brain-derived neurotrophic factor (BDNF) related to neural function showed increased and decreased with aging, respectively. …”
Get full text

Exploring the biological function of dreaming: lessons learned from recruitment challenges in a pilot study with PCA stroke patients by Tamara Fischmann, Luisa Peters, Vanessa Rieker, Michael Koslowski

“…BackgroundThis methodological report draws conclusions about a study that aimed to investigate the biological function of dreams. The main hypothesis in the study posited that dreams serve to maintain sleep by hallucinatory wish fulfillment in response to affect-laden impulses. …”
Get full text

Use of Indices Combining Diastolic and Systolic Tissue Doppler Variables to Evaluate Right Ventricular Function in Dogs With Pulmonary Stenosis by Randolph L. Winter, Kara L. Maneval, Claudio Serrano Ferrel

Get full text

Associations between per- and polyfluoroalkyl substances exposure and renal function as well as poor prognosis in chronic kidney disease patients by Jiayin Wang, Tianyun Gao, Xiaohua Li, Ling Pan

“…Urinary protein and drug use might interact with the associations between PFAS and renal function.Conclusions PFAS single and mixed exposure were closely related to renal function and renal progression in adult CKD patients. …”
Get full text

Identification and functional analysis of the S-layer protein SplA of Paenibacillus larvae, the causative agent of American Foulbrood of honey bees. by Lena Poppinga, Bettina Janesch, Anne Fünfhaus, Gerhard Sekot, Eva Garcia-Gonzalez, Gillian Hertlein, Kati Hedtke, Christina Schäffer, Elke Genersch

“…Recently, comparative proteome analyses have revealed that P. larvae ERIC II but not ERIC I might harbour a functional S-layer protein, named SplA. …”
Get full text

A comparison of pulmonary function pre and post mild SARS-CoV-2 infection among healthy adults by Raz Roje Taib, Yuval Kozlov, Aya Ekshtein, Barak Gordon, Ori Wand, Oded Ben-Ari

“…Abstract Background SARS-CoV-2 infection frequently involves the respiratory system and may impact on pulmonary function tests (PFT) of recovered individuals. Studies which compare post-COVID-19 PFT to pre-illness measurements are scarce. …”
Get full text

Functional identification of Annexin B1 and Annexin B2 from Cysticercus cellulosae and their mechanism in plasma membrane repair. by Peixia He, Dejia Zhang, Mengqi Wang, Rui Duan, Yuyuan Zhao, Sirui Wang, Xing Yang, Xiaolei Liu, Shumin Sun

“…However, its invasion mechanism is still not clear, which might provide the important evidence for treatment or vaccine. …”
Get full text

Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading by Lan Cheng, Hui Chen, R. Nfornah Maboh, Huan Wang

“…Renal function and renal histopathology did not significantly differ among the three groups. …”
Get full text

Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…TsCTL might be a novel candidate target molecule for anti-Trichinella vaccines.…”
Get full text

Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review by Bianca Georgescu, Adelina Elena Cristea, Doinița Oprea, Andreea Alexandra Lupu, Liliana-Elena Stanciu, Erdin Borgazi, Bogdan Marian Caraban, Viorela Mihaela Ciortea, Laszlo Irsay, Mădălina Gabriela Iliescu

“…While the exact link between vitamin D and osteoarthritis is still being studied, recent research indicates that low vitamin D levels might influence the articular cartilage’s structure and function, potentially accelerating osteoarthritis. …”
Get full text

Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis by Yanyao Zhou, Na Dong, Letian Lei, Dorita H. F. Chang, Charlene L. M. Lam

“…Although findings have been mixed, resting-state functional connectivity (rsFC) at baseline shows promise as a predictive biomarker. …”
Get full text

Overexpression of MMP Family Members Functions as Prognostic Biomarker for Breast Cancer Patients: A Systematic Review and Meta-Analysis. by Fanghui Ren, Ruixue Tang, Xin Zhang, Wickramaarachchi Mihiranganee Madushi, Dianzhong Luo, Yiwu Dang, Zuyun Li, Kanglai Wei, Gang Chen

Get full text

Capturing the Abnormal Brain Network Activity in Early Parkinsons Disease With Mild Cognitive Impairment Based on Dynamic Functional Connectivity by Guosheng Yi, Yanbo Wang, Liufang Wang, Chunguang Chu, Jiang Wang, Xiao Shen, Xiaoxuan Han, Zhen Li, Lipeng Bai, Zhuo Li, Rui Zhang, Yanlin Wang, Xiaodong Zhu, Chen Liu

“…The aberrant duration of network state in ePD-MCI patients was significantly negatively correlated with cognitive function in the alpha band, which might pave the way to identify and predict cognitive impairment in early PD patients.…”
Get full text