CLU, FOS, and CXCL8 as diagnostic biomarkers for heart failure progression post-acute myocardial infarction: an integrated RNA-Seq and multi-machine learning study by Jingjing Wei, Peng Yu, Peng Yu, Yucai Hu, Lijie Qiao, Lijie Qiao, Bin Li, Bin Li, Haitao Li, Shiyang Xie, Zhengwei Dong, Aolong Wang, Yilin Zhang, Xinlu Wang, Yongxia Wang, Mingjun Zhu

“…We aimed to identify PBMCs-related critical genes as diagnostic biomarkers for HFpAMI and analyze the immune infiltration patterns.MethodsDifferential expression genes (DEGs) from PBMCs microarray data of AMI with or without HF were identified. Functional enrichment analysis was used to explore the biological roles of DEGs. …”
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The effect of iron deficiency on cardiac resynchronization therapy: results from the RIDE‐CRT Study by Philipp Lacour, Phi Long Dang, Daniel Armando Morris, Abdul Shokor Parwani, Wolfram Doehner, Franziska Schuessler, Felix Hohendanner, Frank R. Heinzel, Andrea Stroux, Carsten Tschoepe, Wilhelm Haverkamp, Leif‐Hendrik Boldt, Burkert Pieske, Florian Blaschke

“…Abstract Aims Cardiac resynchronization therapy (CRT) improves functional status, induces reverse left ventricular remodelling, and reduces hospitalization and mortality in patients with symptomatic heart failure, left ventricular systolic dysfunction, and QRS prolongation. …”
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Maternal Clostridium butyricum supplementation during late gestation and lactation enhances gut bacterial communities, milk quality, and reduces piglet diarrhea by Morakot Nuntapaitoon, Piraya Chatthanathon, Matanee Palasuk, Alisa Wilantho, Jakavat Ruampatana, Sissades Tongsima, Sarn Settachaimongkon, Naraporn Somboonna

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Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition by Siddhartha Mukherjee, Cindy Garda, Letizia Boffa, Angela Rita Elia, Matteo Massara, Maria Teresa Balia, Daniela Brina, Simone Mosole, Anna Campagnari, Giada Andrea Cassanmagnago, Andrea Rinaldi, Giacomo Lazzaroni, David Jarrossay, Diego Morone, Ilaria Ceppi, Riccardo De Sillo, Isabella Giacomini, Ilaria Craparotta, Laura Di Rito, Simon Barry, Endre Laczko, Sebastian Streb, Francesco Meani, Simona Di Lascio, Nancy Hynes, Enrico Lugli, Simone Puccio, Stephen-John Sammut, Ulrike Perriard, Yves Harder, Lorenzo Rossi, Maria Luisa Gasparri, Marco Bolis, Petr Cejka, Arianna Calcinotto

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Leflunomide monotherapy in patients with early rheumatoid arthritis: Results of the Russian national Arava mono study by Rimma Mikhailovna Balabanova, Yu A Olyunin

“…If adverse reactions occurred, the dose might be reduced to 10 mg/day. The patients were examined before and 12, 24, 36, and 48 weeks after LEF therapy. …”
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Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach by Mohd Yasir Khan, Abid Ullah Shah, Nithyadevi Duraisamy, Mohammed Cherkaoui, Maged Gomaa Hemida

“…These results further support the potential repurposing of GS441524 as a promising therapeutic candidate against H5N1 avian influenza clade 2.3.4.4b. However, further functional studies are required to validate these in silico predictions and support the inhibitory action of GS441524 against the targeted proteins of H5N1, specifically clade 2.3.4.4b.…”
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Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology by Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr

“…TDP-43 influences neuronal functions and might also affect glial cells. However, specific intracellular effects of TDP-43 alterations on glial cells and underlying mechanisms are not clear. …”
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Neural signatures underlying the effect of social structure on empathy and altruistic behaviors by Xia Tian, Zixin Zheng, Renhui Li, Yue-Jia Luo, Chunliang Feng

“…Furthermore, whole-brain and local neural patterns in the anterior insula and premotor cortex robustly discriminated painful (but not non-painful) stimulation of different innocents, suggesting that social structure altered emotional and sensorimotor aspects of empathy. These alterations might be driven by top-down regulation, as indicated by heightened functional connectivity between the lateral prefrontal cortex and sensorimotor areas, as well as between the anterior insula and subgenual anterior cingulate cortex when witnessing the pain of innocents resembling fair (vs. unfair) targets. …”
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ROS-responsive adaptive injectable hydrogel promoting inflammatory mastoid bone repair through efficient sterilization and regulating oxidative stress and macrophage phenotype by Yiwen Chen, Ying Lin, Zeyang Liu, Yuanhui Zhang, Ziwei Hu, Maomao Ai, Yanxiong Shen, Dongling Lian, Chenxinwei Wang, Xiaoping Liu, Qunfeng Liu, Huilong Guo, Feng Yu

“…Thus, the hydrogels facilitate bone structure repair by reducing inflammation, promoting macrophage polarization, eliminating harmful microorganisms, and modulating the immunological and microbial milieu in injured tissues. The hydrogels might be a versatile material for healing defects of mastoid portion bone structure in the middle ear. …”
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Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke by Ping Li, Yao Wang, Yuan Xu, Linyu Feng, Na Jiang, Yongkang Fang, Guini Song, Lingling Yu, Li Xu, Zhou Zhu, Suiqiang Zhu, Wei Wang, Minjie Xie

“…However, the spatiotemporal expression and functional role of histone lactylation in microglial reprogramming and neurological injuries after ischemic stroke remain elusive. …”
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Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium by Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, The RReSTORe Consortium, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson

“…RGC repopulation is a promising therapeutic approach to reverse vision loss from optic neuropathies if the newly introduced neurons can reestablish functional retinal and thalamic circuits. In theory, RGCs might be repopulated through the transplantation of stem cell-derived neurons or via the induction of endogenous transdifferentiation. …”
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Oxidative stress gene signature construction to identify subtypes and prognosis of patients with lung adenocarcinoma by Lan Li, Rujia Qin, Xuefeng Wang, Ke Cao, Fei Lu, Zhengting Chen, Jingyan Gao, Linbo Qiu, Sisong Shu, Han Lu, Li Chang, Wenhui Li

“…Background: Although oxidative stress and malignancies are intimately connected, it is unknown how lung adenocarcinoma (LUAD) is affected by oxidative stress response-related genes (OSRGs).Our goal in this work was to create a genetic signature based on OSRGs that might both predict prognosis and hint to potential treatment options for LUAD. …”
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Immunoglobulins G from Patients with Systemic Sclerosis Modify the Molecular Signatures of Endothelial Cells by Eric Hachulla, David Launay, Alain Lescoat, Valérie Lecureur, Vincent Sobanski, Sylvain Dubucquoi, Martin Figeac, Aurélien Chepy, Solange Vivier, Fabrice Bray, Clément Chauvet, Abderrahmane Elhannani, Lucile Guilbert, Frédéric Leprêtre, Louisa Bourel, Christian Rolando

“…Objective Antinuclear antibodies (ANA) are powerful biomarkers in systemic sclerosis (SSc). Functional antibodies (FA) might be implicated in vasculopathy, in which endothelial cells (EC) are key players. …”
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Advancing Understanding of Anorectal Malformations Through Microfocus Computed Tomography Imaging of Resected Material by Daniël Docter, Bernadette S. de Bakker, Jaco Hagoort, Joris J.T.H. Roelofs, Sjoerd de Beer, Ernst van Heurn, Joep Derikx, Marc A. Benninga, Justin de Jong, Ramon R. Gorter

“…Background and Aims: Patients born with anorectal malformations (ARMs) might experience constipation and fecal incontinence. …”
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Single-Nucleus RNA Sequencing Reveals the Transcriptome Profiling of Ovarian Cells in Adolescent <i>Cyprinus carpio</i> by Mingxi Hou, Jin Zhang, Qi Wang, Ran Zhao, Yiming Cao, Yingjie Chen, Kaikuo Wang, Ning Ding, Yingjie Qi, Xiaoqing Sun, Yan Zhang, Jiongtang Li

“…In addition, the dynamic genes expressed in granulosa cells might relate to the complex communication between different cell types. …”
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Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents by Teng Teng, Fang Huang, Ming Xu, Xuemei Li, Lige Zhang, Bangmin Yin, Yuping Cai, Fei Chen, Luman Zhang, Jushuang Zhang, Aoyi Geng, Chengzhi Chen, Xiaofei Yu, Jing Sui, Zheng-Jiang Zhu, Kai Guo, Chenhong Zhang, Xinyu Zhou

“…Causal analyses suggested that plasma AAs might mediate the impact of altered gut microbiota on depressive and anxious symptoms. …”
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Identification of key modules and hub genes for sepsis-induced myopathy using weighted gene co-expression network analysis by Siming Lin, Siming Lin, Siming Lin, Kexin Cai, Kexin Cai, Kexin Cai, Ai Chen, Weibin Wu, Guili Lian, Shaodan Feng, Shaodan Feng, Zhihong Lin, Zhihong Lin, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie

“…Additionally, we performed functional enrichment analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network approaches.ResultsOur findings revealed that the identified gene clusters predominantly pertained to immune response, inflammation, and apoptosis pathways. …”
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Core effectorome of Fusarium oxysporum f. sp. conglutinans deciphered using a multiomics method exhibits diverse roles following infection in cabbage by Miaomiao Xing, Cunbao Zhao, Xizhe Sun, Ailing Zhou, Yong Wang, Jialei Ji, Aisong Zeng, Biju V. Chellappan, Yangyong Zhang, Lisong Ma, Honghao Lv

“…In total, a core set of 14 candidate effectors were identified, among which 11 induced pronounced programmed cell death (PCD) in different cabbage lines, whereas only 1 candidate triggered partial cell death on the leaves of Nicotiana benthamiana, indicating that natural host cabbage is ideal for functional study of Focn effectors compared with N. benthamiana. …”
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Multidimensional analysis of sedentary behaviour and participation in Spanish stroke survivors (Part&Sed-Stroke): a protocol for a longitudinal multicentre study by Pablo Bellosta-Lopez, Victor Domenech-Garcia, Maria Pilar López-Royo, Javier Gueita-Rodriguez, Jorge Alegre-Ayala, Julia Blasco-Abadía, Cristina de Diego-Alonso, Almudena Buesa, Patricia Roldán-Pérez, Rafael Giner-Nicolás, Natalie Ann Fini, Alicia Tornero Navarro, Ana Conte Lamenca, Andrea Yerro Astrain, Beatriz Martín Lamata, Carina Salgueiro, Claudia Marín Marín, Diana Ruiz Ramos, Elena Sanz Sanza, Enrique Villa Berges, Fernando Cuesta Ruiz, Inés Cortés Cabeza, Javier Harguindey, Juan Luis Abeledo Alcón, Laura Ares Barge, Leyre Leceaga Gaztambide, Lilian Le Roux, Lourdes Martín Gros, Lucía Díez Fuentes, María Carmen Grácia Sen, María Pilar Pardo Sanz, Paloma Rodríguez Escudero, Paz Cristina Sánchez Lecina, Rebeca Yebra Vilarchao, Sara Beltrán Roche, Verónica Montoya Murillo

“…Introduction Stroke survivors usually experience long-lasting functional, emotional and social consequences that might contribute to sedentary behaviour and participation restrictions, which are important targets to address during rehabilitation. …”
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Cutaneous dysbiosis in girls with vulvar lichen sclerosus by Liying Sun, Huihui Gao, Hongyu Chen, Chenfei Ren, Junwen Zhang, Qiuxiang Shen, Li Zhu, Dandan Chen, Lingling Jin, Chaoqun Wang, Fengxia Li, Lan Yu

“…Microbial diversity was assessed using α diversity, β diversity, and LEfSe, and functional microbial pathways were predicted. No differences were observed in α diversity among groups. …”
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