MiRNA-455-5p regulates the growth and development of adipose tissue by targeting IGF-1R gene by Min Wu, Lingli Feng, Yubin Wang, Kun Zhang, Ganqiu Lan, Jing Liang

“…Bioinformatic analysis with Targetscan predicted that IGF-1R might be a target gene of miRNA-455-5p. Moreover, mouse 3T3-L1 preadipocytes were transfected with chemically modified mimics and inhibitors to observe the expression of miR-455-5p and IGF-1R genes from 0 to 8 days after transfection. …”
Get full text

Development and validation of a 14-CpG DNA methylation signature and drug targets for prognostic prediction in breast cancer by Bao-xing Tian, Zhi-xi Yu, Xia Qiu, Li-ping Chen, Yu-lian Zhuang, Qian Chen, Yan-hua Gu, Meng-jie Hou, Yi-fan Gu

“…Patients in the high-risk group might benefit from drugs targeting DNA replication and repair processes in tumor cells.ConclusionThe 14-CpG model serves as a useful biomarker for predicting prognosis in BC patients. …”
Get full text

NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…In addition, we provide first mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might contribute to the neuroprotective effects of NPT100-18A.…”
Get full text

Mycorrhizal and nutrient controls of carbon sequestration in tropical rainforest soil by Jie Chen, Xin Tang, Han Xu, Yanpeng Li, Adriana Corrales, Yide Li, Yakov Kuzyakov, Zhanfeng Liu, Shirong Liu

“…Such counteracting effects from AM trees might attenuate SOC accumulation along the P gradient, resulting in a positive trend in SOC with soil total N:P ratios. …”
Get full text

The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke by Monika Thapa, Jordyn Courville, Reese Leonhard, Prabandh Buchhanolla, Mohammad Abdurrehman Sheikh, Rahul Shah, Prashant Rai, Himanshu Chokhawala, Md Ismail Hossain, Mohammad Alfrad Nobel Bhuiyan, J. Dedrick Jordan, Roger E. Kelley

“…Our results revealed that WBV at high and low shear rates did not impact the functional outcome of mechanical thrombectomy. This result might be affected by the potential limitation of the formula used to derive the given shear rates. …”
Get full text

The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…In this study, we formulated a hypothesis suggesting that carvacrol (Car), an aromatic hydrocarbon present in some plant species, might decrease I/R injury by implication of its antioxidant, anti-apoptotic, and anti-inflammatory functions. …”
Get full text

A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression by Xiuqin Bao, Yuanyi Gao, Xiaoyi Chen, Zhongju Wang, Xiaoqin Feng, Liren Wang, Jing Du, Yuhua Ye, Feijing Chen, Li Du, Aihua Yin, Xiangmin Xu

“…At the same time, it activated histone modifications and RNA polymerase II (Pol II) in both distal and proximal HBG promoter and might inhibit the binding of BCL11A and ZBTB7A on -115 and − 200 sites on the HBG promoter respectively. …”
Get full text

Application of a Hybrid Model Based on CEEMDAN and IMSA in Water Quality Prediction by GUO Li-jin, WU Hao-tian

“…For outlier treatment, the study considered that outliers in the data might be caused by sudden pollution events and discontinuous non-point source pollution. …”
Get full text

IL-33 and soluble ST2 in follicular fluid are associated with premature ovarian insufficiency by Maoxing Tang, Xuedong Sun, Ping Li, Weifen Deng, Xi Zhan, Peng Sun, Yuhua Shi

“…Interleukin 33 (IL-33) is a pro-inflammatory IL-1 family cytokine, and functions as an alarmin reflecting inflammatory reaction. …”
Get full text

Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…As an additional therapy, the use of meloxicam 7.5–15 mg/day was permitted, and, if non-steroidal anti-inflammatory drugs were contraindicated, paracetamol 1–3 g/day might be used.Results and discussion. During treatment, both groups of patients showed improvement (compared to the baseline levels). …”
Get full text

Effect of yellow capsicum extract on the lipid metabolism in mice by CUI Xiaoman, YU Haining, XU Jielan, CHEN Zhongting, SHEN Shengrong

“…Yellow capsicum includes functional component capsaicin which has multifunctional pharmaceutical effects. …”
Get full text

Metabolomic analysis of bioactive compounds in dill (Anethum graveolens L.) extracts by Jirattiporn Thanuma, Jutarop Phetcharaburanin, Hasaya Dokduang, Watcharin Loilome, Poramate Klanrit, Arporn Wangwiwatsin, Nisana Namwat

“…Background Dill (Anethum graveolens L.) is a functional herb known for its dietary, medicinal, and health-promoting agents, as it enriches antioxidants that help to protect cells from oxidative stress and may reduce the risk of several chronic diseases. …”
Get full text

Technology Effects and Child Health: Wellness Impact and Social Effects (TECHWISE): Protocol for a Prospective, Observational, Real-World Study by Scott H Kollins, Jessica Flannery, Karen Goetz, Samir Akre-Bhide

“…Following electronic consent (eConsent), participants and their caregivers will complete a range of baseline measures electronically, including assessments of psychiatric and social functioning, as well as measures of loneliness, digital stress, and disordered eating. …”
Get full text

Participatory Intervention Development of a Peer-Guided Self-Help App for Anxiety Disorders: Mixed Methods Study by Laura Duddeck, Timo Stolz, Christian Zottl, Thomas Berger, Johanna Boettcher

“…In stage 2, feedback revealed unclear functionality, confusion in peer interaction, and safety concerns, leading to MVP revisions. …”
Get full text

HPV self-sampling acceptability in rural and indigenous communities in Guatemala: a cross-sectional study by Kristin Bevilacqua, Audrey R. Murchland, Anna Gottschlich, Andres Pineda, Berner Andrée Sandoval-Ramírez, Christian S Alvarez, Gina S Ogilvie, Thomas E Carey, Mark Prince, Michael Dean, Carlos Mendoza Montano, Alvaro Rivera-Andrade, Rafael Meza

Get full text

MEF2A, MEF2C, and MEF2D as potential biomarkers of pancreatic cancer? by Chunxia Zhai, Xiaorong Ding, Liping Mao, Yang Ge, Anqi Huang, Fan Yang, Yi Ding

“…MEF2A could be used as a prognostic biomarker for PAAD, MEF2C might be a potential oncogene for PAAD, and MEF2D had potential biological significance.…”
Get full text

Nurses’ perceptions regarding the establishment of clinical education and training units in public hospitals in the North-West Province: a qualitative study by Mmapule Motshabi Maria Mosete, Isaac Ontchebile Mokgaola, Leepile Alfred Sehularo, Miriam Mmamphamo Moagi

“…The research study results might contribute to the full establishment of CETUs in the hospitals of the North- West Province, South Africa. …”
Get full text

m6A-lncRNA landscape highlights reduced levels of m6A modification in glioblastoma as compared to low-grade glioma by Giedrius Steponaitis, Rugile Dragunaite, Rytis Stakaitis, Amit Sharma, Arimantas Tamasauskas, Daina Skiriute

Get full text

Methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa community acquired pneumonia: Prevalence and locally derived risk factors in a single hospital system by Bradley W. Frazee, Amarinder Singh, Matt Labreche, Partow Imani, Kevin Ha, Jonathan Furszyfer Del Rio, Eugene Kreys, Robert Mccabe

“…Findings from this project might inform efforts at other institutions.…”
Get full text

Tumor suppressor miR-29c regulates radioresistance in lung cancer cells by Elena Arechaga-Ocampo, Cesar Lopez-Camarillo, Nicolas Villegas-Sepulveda, Claudia H Gonzalez-De la Rosa, Isidro X Perez-Añorve, Reynalda Roldan-Perez, Ali Flores-Perez, Omar Peña-Curiel, Oscar Angeles-Zaragoza, Rosalva Rangel Corona, Juan A Gonzalez-Barrios, Raul Bonilla-Moreno, Oscar del Moral-Hernandez, Luis A Herrera, Alejandro Garcia-Carranca

“…Deregulation of microRNAs contributes to the molecular mechanism underlying resistance to radiotherapy in cancer cells. Although the functional roles of microRNAs have been well described in lung cancer, their functional roles in radioresistance are largely unclear. …”
Get full text