Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease by Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai

“…The hygiene hypothesis has led researchers to notice that worm infections can regulate the immune system, which might help treat inflammatory diseases. Nippostrongylus brasiliensis (Nb), similar to human hookworms in life cycle and symptoms, is often used in hookworm research. …”
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Edgetic perturbation models of human inherited disorders by Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal

“…Abstract Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. …”
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Nanocarrier-mediated RNAi of CYP9A306 and CYB5R enhances susceptibility of invasive tomato pest, Tuta absoluta to cyantraniliprole by Farman Ullah, Guru-Pirasanna-Pandi G, Hina Gul, Rudra Madhab Panda, Ghulam Murtaza, Zhijun Zhang, Jun Huang, Xiaowei Li, Nicolas Desneux, Yaobin Lu

“…These findings show that CYB5R and CYP9A306 might play a key role in cyantraniliprole resistance evolution in T. absoluta. …”
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Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol by Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group

“…However, it is unclear whether and to which extent these events might affect frailty, fastening its development or hampering its reversion. …”
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SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury by Tingzi Yu, Cong Ding, Jinying Peng, Gaoshuang Liang, Yongyi Tang, Jinqiu Zhao, Zhuan Li

“…Our data thus uncovered previously unidentified role of SIRT7 in modulating NRF2 nuclear localization and activation via deacetylation. Activating SIRT7 might offer protection against chemodrug-induced liver injury.…”
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Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer by Raffaello Roesel, Francesco Strati, Camilla Basso, Samantha Epistolio, Paolo Spina, Julija Djordjevic, Elisa Sorrenti, Martina Villa, Agnese Cianfarani, Francesco Mongelli, Jacopo Galafassi, Sotirios G. Popeskou, Federica Facciotti, Cecilia Caprera, Federica Melle, Pietro Edoardo Majno-Hurst, Alessandra Franzetti-Pellanda, Sara De Dosso, Ferdinando Bonfiglio, Milo Frattini, Dimitrios Christoforidis, Giandomenica Iezzi

“…A minority of patients show complete response (CR) to nCRT and may avoid surgery and its functional consequences. Instead, most patients show non-complete response (non-CR) and may benefit from additional treatments to increase CR rates. …”
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Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress by Lauren A. Hennessy, Bhedita J. Seewoo, Liz A. Jaeschke, Leah A. Mackie, Abbey Figliomeni, Yasmin Arena-Foster, Sarah J. Etherington, Sarah A. Dunlop, Paul E. Croarkin, Jennifer Rodger

“…Accelerated protocols might confer unique advantages for adolescents and young adults but there are many knowledge gaps related to dosing in this age group. …”
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Response Patterns of Three Types of Biocrust to Reduced Rainfall by Hongyu Jiang, Qianhai Ye, Siqing Wang, Liping Yang, Yali Ma, Yuhan Qi, Haoran Luo, Zhixin Zhou, Qinqin Chang, Li Ma, Hao Wang, Changming Zhao, Ning Chen

“…Biological soil crusts (biocrusts), compound organisms covering the terrestrial land surface and consisting of living organisms—algae, lichen, moss, and soil particles—cover ~30% of global drylands and play crucial roles in ecosystem functions and services. Climate change, especially rainfall regime, has been significantly reshaping biocrust dynamic. …”
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Improved corrosion inhibition effect of a green three-component compound to Q235 steel in acidic solution by Chengjia Bao, Weijian Qi, Zhuanjun Zhu, Ting Xu, Long Zhao, Yanhong Ma, Yang Liu, Bowen Yang, Xueru Luo, Hui Yun, Xiaojuan Li

“…The Tafel results indicated Chi+Cur + Ger functioned as a mixed-type corrosion inhibitor, inhibiting the cathodic reaction more significantly. …”
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Fluridone promotes the germination of Polygonatum cyrtonema seeds by modulating hormone signal transduction, phenylpropanoid biosynthesis, and energy metabolism by Xiaogang Jiang, Darong Li, Hua Wang, Yuying Yang, Kaidi Yu, Jinwen You, Haihua Liu, Xiaoliang Guo, Yinsheng He, Wuxian Zhou, Qingfang Wang

“…Abstract Polygonatum cyrtonema Hua functions as a highly valued medicinal herb. However, the seeds of P. cyrtonema exhibit morphophysiological dormancy. …”
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Uncovering common transcriptional features shared by mature peripheral blood PMN-MDSCs and tumor-infiltrating neutrophils in humans by Chiara Lattanzi, Francisco Bianchetto-Aguilera, Marta Donini, Francesca Pettinella, Elena Caveggion, Monica Castellucci, Sara Gasperini, Barbara Mariotti, Ilaria Signoretto, Maurizio Cantini, Sara Pilotto, Lorenzo Belluomini, Cristina Tecchio, Flavia Bazzoni, Sven Brandau, Nicola Tamassia, Marco A. Cassatella, Patrizia Scapini

“…Altogether, these data uncover that human circulating mPMN-MDSCs and TANs from different cancer types share scRNA-seq cell clusters with transcriptomic similarities, supporting the notion that they might be strictly related.…”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…We hypothesized that TRPM4 might participate in human VIC transition to osteoblastic phenotype. …”
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Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner by Beatriz Pacheco-Sánchez, Sonia Melgar-Locatelli, Raquel López-Merchán, María José Benítez-Marín, Marta Blasco-Alonso, Ernesto González-Mesa, Rubén Tovar, Pablo Rubio, Juan Suárez, Carlos Sanjuan, Fernando Rodríguez de Fonseca, Francisco Alén, Marialuisa de Ceglia, Patricia Rivera

“…Abstract Background Certain events that occur in early life, such as changes in nutrition, can promote structural and functional modifications in brain development, projecting to either short, medium, and/or long terms, resulting in metabolic programming. …”
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Villa d’époque romaine et habitat médiéval à Mont-Saint-Jean (Sarthe) : bilan des recherches 2008-2020 by Florian Sarreste, Paul-André Besombes, Phaedra Bouvet, Chloé Genies, Étienne Jaffrot, Florian Jedrusiak, Thomas Jubeau, Anthony Ledauphin, Annaïg Le Martret, Christophe Loiseau, Hugo Meunier, Aurore Noël, Sandrine Paradis-Grenouillet, Boris Robin

“…The absence of ceramics characteristic of the Late Roman period, derived from Early Christian Atlantic group or Argonne terra sigillata, is noteworthy, though the absence might simply be related to the very partial excavation of the residence.Even if it is difficult to situate the event with chronological precision, it is likely that the destruction of the pars urbana occurred before the 5th century. …”
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Social Confrontation with Menstruation: A Feminist Ethnography of Menstrual Experience among Female Instagram Users by Rana Mohammad Taghinejad Esfahani, Majid Movahed, Halimeh Enayat, Aliyar Ahmadi

“…Given the qualitative nature of this research, the findings were context-specific, while different outcomes might emerge in other settings with different participants. …”
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Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs by Zhen Wang, MD, Mingxiao Li, MD, Peng Xia, BS, Chao Jiang, MD, Ting Shen, MD, Jiaming Ma, MD, Yu Bai, MD, Suhui Zhang, MD, Yiwei Lai, MD, Sitong Li, MS, Hui Xu, MD, Yang Xu, MD, Tong Ma, MS, Lie Ju, PhD, Liu He, PhD, Li Dong, MD, Caihua Sang, MD, Deyong Long, MD, Yuzhong Chen, PhD, Xin Du, MD, Zongyuan Ge, PhD, Jianzeng Dong, MD, Wen-Bin Wei, MD, Changsheng Ma, MD

“…Conclusion: A vision-ensemble model based on fundus images might be practical for preliminary screening of CI in AF patients.…”
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Leveraging the enrichment analysis from a genome-wide association study against epilepsy—focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epil... by Alice Y. W. Chang, Alice Y. W. Chang, Chin-Wei Huang, Ping-Lin Tsai, Chun-An Liang, Chun-An Liang, Wei Chen Liao, Tzu-Fun Fu, Tzu-Fun Fu, Hui Hua Chang, Hui Hua Chang, Hui Hua Chang, Hui Hua Chang

“…Therefore, the balance of TRYCATs might be a new biomarker and therapeutic strategy for epilepsy.…”
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Inhaled Nitric Oxide ReDuce postoperatIve pulmoNAry complicaTions in patiEnts with recent COVID-19 infection (INORDINATE): protocol for a randomised controlled trial by Hui Zhang, Xiaomei Wang, Xue Yang, Ziyu Zheng, Gang Luo, Qianqian Fan, Huang Nie, Baobao Gao, Lini Wang, Chong Lei, Shuxiu Wang, Bingqing Zhao, Hailong Dong

“…Accumulating evidence suggests that nitric oxide (NO) inhalation might be effective in treating COVID-19. NO functions in COVID-19 by promoting vasodilation, anticoagulation, anti-inflammatory and antiviral effects. …”
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Spatial Distribution and Intraspecific and Interspecific Associations of Dominant Tree Species in a Deciduous Broad-Leaved Forest in Shennongjia, China by Jiaxin Wei, Linsen Yang, Zhiguo Jiang, Hui Yao, Huiliang Yu, Fanglin Luo, Xiujuan Qiao, Yaozhan Xu, Mingxi Jiang

“…We analyzed the spatial distribution patterns of 20 dominant species with univariate and bivariate g(r) functions, as well as intraspecific and interspecific associations across different life-history stages. …”
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Finite element model-based evaluation of the effectiveness of the incisional skinbridge procedure for posterior horseshoe perianal abscess by Shi Rong, Wang Jing, Ke Minhui, Chen Zuqing, Huang Juan, Chen Riqi, Wang Zhaochu

“…Tailoring the skin-bridge design might be crucial in preserving postoperative anal integrity and functionality following perianal abscess surgery.…”
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