Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness by Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner

“…The underlying mechanisms might inspire new therapeutic strategies aimed at shifting the balance towards tumor-suppressive miRNA species. …”
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The m6A modification of LINC01133 suppresses ER+ breast cancer progression by modulating IGF2BP2 protein stability via a ubiquitination-dependent mechanism by Mai-dong Li, Mai-dong Li, Ben-jie Shan, Lei Wang, Shuang Gao, Li Hao, Hai-yang Yu, Yue-yin Pan, Yue-yin Pan

“…Additionally, RNA immunoprecipitation (RIP), RNA pull-down, mass spectrometry (MS), and RNA stability assays were conducted to elucidate its mechanisms.ResultsLINC01133 was dramatically downregulated in ER+ breast cancer, which results in unfavorable prognosis. Functionally, LINC01133 inhibited migration and invasion in vitro and metastasis in vivo of ER+ breast cancer cells. …”
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Pregnancy exacerbates neutrophil responses in murine lungs and alters gut microbiota composition after cigarette smoke exposure by Ali Dehghani, Ali Dehghani, Lei Wang, Lei Wang, Johan Garssen, Johan Garssen, Eirini Styla, Thea Leusink-Muis, Ingrid van Ark, Gert Folkerts, Jeroen van Bergenhenegouwen, Jeroen van Bergenhenegouwen, Saskia Braber, Saskia Braber

“…Microbiota functional and compositional states are also affected by both pregnancy and CS exposure, possibly indicating a gut-lung bidirectional effect.…”
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Phylogenomic Signatures of a Lineage of Vesicular Stomatitis Indiana Virus Circulating During the 2019–2020 Epidemic in the United States by Selene Zarate, Miranda Bertram, Case Rodgers, Kirsten Reed, Angela Pelzel-McCluskey, Ninnet Gomez-Romero, Luis L. Rodriguez, Christie Mayo, Chad Mire, Sergei L. Kosakovsky Pond, Lauro Velazquez-Salinas

“…Finally, using a representative group of viruses from Colorado, we established a positive correlation between genetic and geographical distances, suggesting that positive selection on specific codon positions might have favored the adaptation of different subpopulations to circulation in specific geographical settings. …”
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Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding by Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Liesbet Geris, Liesbet Geris, Bernard Staumont

“…In this study, we introduce two Liver Physiological Maps (PMs); comprehensive and machine-readable graphical representations of the intricate mechanisms governing two major liver functions.MethodsTwo PMs were developed through manual literature curation, integrating data from established pathway resources and domain expert knowledge. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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Unveiling intraspecific diversity and evolutionary dynamics of the foodborne pathogen Bacillus paranthracis through high-quality pan-genome analysis by Yuhui Du, Chengqian Qian, Xianxin Li, Xinqian Zheng, Shoucong Huang, Zhiqiu Yin, Tingjian Chen, Li Pan

“…Significant divergences in the phylogenetic relationships, functional enrichment, and degree of selective pressure between the different components demonstrated different evolutionary dynamics between the core and accessory genomes driven by ecological forces. …”
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Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways by Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu

“…The phenotypic profile, transcriptomic characteristics, functionality and anti-tumor activity of CAR-21 NK cells and CAR-15 NK cells were compared. …”
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Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands by Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher L. M. Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jen Alexander-Brett, Tom J. Brett

“…Our findings imply that pharmaceutical strategies targeting these surfaces might be effective to modulate TREM2 functions.…”
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Local cerebral neurofilament light chain during acute stage is associated with clinical outcomes in stroke patients receiving endovascular thrombectomy by Kunxin Lin, Youliang Wang, Wenlong Zhao, Yiru Zheng, Xiaohua Sun, Ling Fang, Ying Fu, Ning Wang, Qianqian Lin

“…Conclusions Our study suggested that elevated baseline local NfL accumulated in the ischemic vasculature might be a promising predictor for increased adverse clinical outcome of patients receiving EVT.…”
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Community-level physiological profiling of carbon substrate metabolization by microbial communities associated to sediments and water in karstic caves from Romania by Diana Felicia PANAIT, Andrei Marian PANAIT, Adorján CRISTEA, Erika Andrea LEVEI, Oana Teodora MOLDOVAN, Horia Leonard BANCIU

“…Our findings suggested that metabolic profiling using Biolog® EcoPlate™ method combined with multivariate statistical methods might prove a suitable analysis approach to effectively screen for cave microbial functionality and the probable environmental drivers. …”
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Mating from a female perspective: Do brown bear females play an active role in mate searching? by Vincenzo Penteriani, María del Mar Delgado, Ilpo Kojola, Samuli Heikkinen, Ancuta Fedorca, Pino García-Sánchez, Mihai Fedorca, Slavomír Find’o, Michaela Skuban, Javier Balbontín, Alejandra Zarzo-Arias, Daniele Falcinelli, Andrés Ordiz, Jon E. Swenson

“…Theory primarily focuses on male reproductive behaviours, suggesting male distribution follows that of females, while female distribution is influenced by food resources and habitat. This approach might underestimate the females’ role in shaping mating strategies. …”
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A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma by Yonglin Luo, Wenyang Wei, Yaxuan Huang, Jun Li, Weiling Qin, Quanxiang Hao, Jiemei Ye, Zhe Zhang, Yushan Liang, Xue Xiao, Yonglin Cai

“…Conclusions Our ARGs-based signature model shows promising results in predicting the prognosis of NPC patients and might be associated with immune cell infiltration.…”
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UBE2D1 as a key biomarker in systemic juvenile idiopathic arthritis: a new perspective on diagnosis and disease activity assessment by Qiang Luo, Han Hao, Luo Xiwen, Xiang Qiu, Dawei Liu, Yun Liu, Fengning Li, Kening Lu, Xiya Luo, Chenxi Ma, Xiaodong Zhao, Yunfei An, Xuemei Tang

“…The UBE2D1 complication map indicates that UBE2D1 might contribute to the development of various diseases across 17 different systems, including autoimmune diseases, the digestive system, and ocular conditions. …”
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IMDM-20 enhances neutrophilic features during 1.3 % DMSO-mediated differentiation of HL-60 cells by Jorge Andrés Cázares-Preciado, José Antonio Cruz-Cárdenas, Alejandra López-Arredondo, Marco V. Gallardo-Camarena, Marion E.G. Brunck

“…Multiple differentiation protocols have been reported to generate neutrophil-like HL-60 cells, with limited consideration of how methodological variations might influence cell identity and functions. Here, we conducted a systematic search of the PubMed database, to investigate the current heterogeneity in published protocols used to differentiate HL-60 towards neutrophil-like cells. …”
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MicroRNA-122 overexpression suppresses the colon cancer cell proliferation by downregulating the astrocyte elevated gene-1/metadherin oncoprotein by Sarubala Malayaperumal, Sushmitha Sriramulu, Ganesan Jothimani, Antara Banerjee, Hong Zhang, Shabana Thabassum Mohammed Rafi, Ilangovan Ramachandran, Rajesh Kanna NR, Xiao-Feng Sun, Surajit Pathak

“…Background MicroRNAs (miRNAs) are small non-coding RNAs that regulate essential cellular functions, such as cell adhesion, proliferation, migration, invasion, and programmed cell death, and therefore, alterations in miRNAs can contribute to carcinogenesis. …”
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A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma by Wenjiao Tang, Yan Li, Zhongqing Zou, Jian Cui, Fangfang Wang, Yuhuan Zheng, Li Hou, Ling Pan, Bing Xiang, Hong Chang, Li Zhang, Ting Niu

“…Regulatory B cells (Bregs) can be involved in immune defects by exerting immune regulatory functions in MM. In order to provide more evidence‐based practice for the elderly MM, the study established and assessed a stratified therapeutic model with studies on Bregs for Chinese Elderly Multiple Myeloma in 2021 (CEMM2021). …”
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Optimisation of bioaerosol sampling using an ultralight aircraft: A novel approach in determining the 3-D atmospheric biodiversity by Maria P. Plaza, Athanasios Charalampopoulos, Vivien Leier-Wirtz, Pia Viuf Ørby, Mathilde Kloster, Michael Dines Christiansen, Claudia Traidl-Hoffmann, Athanasios Damialis, Ulrich Gosewinkel

“…The device consisted of duplicate isokinetic impactors that match the physical functioning and the microscopic quantification method of the widely used ground-based Hirst-type impactors. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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An oncolytic vaccinia virus expressing anti-CD47 nanobody exerts enhanced antitumor activity by mediating innate and adaptive immune cell infiltration and activation in the lymphom... by Mengyuan Li, Yinyin Zhang, Lihong Zong, Minghuan Zhang, Shibing Wang, Wen Lei, Wenbin Qian

“…Our findings establish that arming OVV with a CD47-blocking nanobody and IgG1 Fc creates a dual-functional therapeutic platform, offering a paradigm-shifting strategy for lymphoma immunotherapy through coordinated innate and adaptive immune activation. …”
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