ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…ITGA4 positively correlated with immune cell infiltration, immune regulatory genes, chemokines, and might reduce microsatellite instability (MSI) and tumor mutation burden (TMB) by promoting MMR gene expression. …”
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Inhibition of -type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment by Supak Yothaisong, Hasaya Dokduang, Naohiko Anzai, Keitaro Hayashi, Nisana Namwat, Puangrat Yongvanit, Sakkarn Sangkhamanon, Promsuk Jutabha, Hitoshi Endou, Watcharin Loilome

“…Our previous study reported that l -type amino acid transporter-1 and its co-functional protein CD98 were highly expressed and implicated in cholangiocarcinoma progression and carcinogenesis. …”
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Root Coverage Techniques: Coronally Advancement Flap vs. Tunnel Technique: A Systematic Review and Meta-Analysis by Luis Chauca-Bajaña, Alba Pérez-Jardón, Fábio França Vieira E Silva, Mercedes Conde-Amboage, Byron Velásquez-Ron, Elena Padín-Iruegas, Mario Pérez-Sayáns

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Gut health predictive indices linking gut microbiota dysbiosis with healthy state, mild gut discomfort, and inflammatory bowel disease phenotypes using gut microbiome profiling by Joann Phan, Suneer Jain, Jurgen F. Nijkamp, Rajkumar Sasidharan, Ashish Agarwal, Julia K. Bird, Anneleen Spooren, Jonas Wittwer Schegg, Emiel Ver Loren van Themaat, Tim N. Mak

“…Therefore, it is difficult to predict who has a gut microbiome associated with a healthy gut and who might develop disease or experience gut discomfort. …”
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Integrating Interpretability in Machine Learning and Deep Neural Networks: A Novel Approach to Feature Importance and Outlier Detection in COVID-19 Symptomatology and Vaccine Effic... by Shadi Jacob Khoury, Yazeed Zoabi, Mickey Scheinowitz, Noam Shomron

“…The results suggest that booster shots might be necessary for this population to ensure adequate immunity, given the observed immune response patterns. …”
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Abstract 157: Evaluating the Impact of Pre‐Procedural CTA on Fluoroscopy Time and Conversion Rates by Zachary Lodato, Ivo Bach, Humza Haque, Elan Meltzer, Priyank Khandelwal

“…Conclusion This retrospective analysis suggests that prior computed tomography angiography (CTA) might lead to reduced fluoroscopy times and dosage during procedures, but the results are not statistically significant at this stage. …”
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Description of a New Simple and Cost-Effective Molecular Testing That Could Simplify MUC1 Variant Detection by Victor Fages, Florentin Bourre, Romain Larrue, Andrea Wenzel, Jean-Baptiste Gibier, Fabrice Bonte, Claire-Marie Dhaenens, Kendrah Kidd, Stanislav Kmoch, Anthony Bleyer, François Glowacki, Olivier Grunewald

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Cycloserine resistance among drug-resistant tuberculosis cases in Taiwan by Sheng-Han Wu, Hsin-Yi Liu, Kuang-Hung Liu, Hseuh-Chien Hsiao, Ruwen Jou

“…Of the 114 MTBC isolates, we found 5 (4.4%) CS-MGIT-resistant isolates, which all harbored mutations in the alr gene, including three previously known mutations M343T, T20M, L113R, and a novel mutation R243S, whereas seven low-MIC isolates harboring alr Q30R mutations might not be associated with CS resistance. Notably, M1I, E118K, and A184T in the ald gene and L113R, R243S, S261N, and M343T in the alr gene were predicted to have a destabilizing effect, which could interfere with protein functions and induce drug resistance. …”
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The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation. by Mark Jeffries, Nde-Eshimuni Salema, Libby Laing, Azwa Shamsuddin, Aziz Sheikh, Anthony Avery, Antony Chuter, Justin Waring, Richard N Keers

“…Engagement between stakeholders was considered important for the intervention in ensuring prescribers continued to utilise its functionality. Sustained implementation might be enhanced by careful profile management of the suite of alerts in the system. …”
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Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) und... by Arpita Tripathi, Praveen Pandey, Shakti Nath Tripathi, Alok Kalra

“…In summary, our study reflects the potential of the endophytic consortium for strengthening one endophyte's functional vulnerability with another to gain maximum artemisinin yield and plant tolerance against various stresses via regulating essential metabolic pathway genes.…”
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Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection by Faried M. Wagdy

“…AS-OCT was beneficial in the analysis of bleb morphology after AGV surgery where there were more diffuse functioning multicystic blebs and less thinning in the bleb wall thickness during the hypertensive phase after resection of the Tenon capsule, which might be related to the less incidence of fibrosis around the surgical site.…”
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Travel in Omani Maqamat Writings: A Textual Semiotic Study [In Arabic] by Saeed Al-Salti

“…Spatially, the journey might occur within a small space like a village or a vast area across continents.…”
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Electroencephalographic changes after one nigth of sleep deprivation Respostas eletrencefalográficas após uma noite de privação de sono by Camila Ferreira, Andréa Deslandes, Helena Moraes, Maurício Cagy, Fernando Pompeu, Luis Fernando Basile, Roberto Piedade, Pedro Ribeiro

“…Total or partial sleep deprivation (SD) causes degrading effects on different cognitive and psychomotor functions that might be related to electrophysiological changes frequently observed. …”
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Frontal Transcranial Direct Current Stimulation in Moderate to Severe Depression: Clinical and Neurophysiological Findings from a Pilot Study by Florin Zamfirache, Gabriela Prundaru, Cristina Dumitru, Beatrice Mihaela Radu

“…The Theta/Alpha Ratio may serve as a promising biomarker for tracking tDCS response, whereas other EEG metrics might represent more stable trait characteristics. …”
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Cognitive-Discursive Study of Migration Discourse (Based on English-Language Media Texts) by N. V. Stepanova

“…From the viewpoint of intertextual references, a high percentage of numerals and proper names, which give the impression of the authority of the material, might be of particular interest. The cognitive layer of intertext is widely represented by a conceptual metaphor. …”
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The Effects of Pregnancy and Childbirth on Women's Health-Related Quality of Life: A Scoping Review by Asmaa Othman

“…Although the changes that pregnant women experience are only transitory, they might affect their quality of life. Aim: This scoping review highlight the effect of pregnancy and childbearing on women’s health-related quality of life. …”
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The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism by Wilhelm Gottschall, Florent Ailloud, Christine Josenhans, Sebastian Suerbaum

“…Methylation has been associated with multiple functions in H. pylori, including the defense against foreign DNA and transcriptional regulation. …”
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Effects of supplementing bile acids on the production performance, fatty acid and bile acid composition, and gut microbiota in transition dairy cows by Lei Li, Jiaxiao Li, Zhihui Liu, Zihan Jin, Mengyang Wang, Ying Wu, Zhihong Zhang, Xinfeng Hou, Junhu Yao, Jun Zhang

“…In addition, BA supplementation significantly altered the composition of plasma and fecal BAs, particularly increasing circulating secondary BA concentration, which might induce the complete oxidation of fatty acids in the liver and further reduce the concentration of β-hydroxybutyrate. …”
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Insights into the blood, gut, and oral microbiomes in Chinese patients with myocardial infarction: a case-control study by Ikram Khan, Imran Khan, Ping Xie, Yu Xiaohui, Shengnan Lei, Tianzhu Song, Zhiqiang Li, Xiaodong Xie

“…Abstract Background Emerging evidence suggests that changes in the blood microbes might be associated with cardiovascular disease, especially myocardial infarction (MI). …”
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Insights into a rapid access angina clinic (RAAC): are we capturing the right cohort of patients? by Kumail Abbas Dewji, Erica Zhang, Taqiyah Nusrat, Asgher Champsi, Nadia Sunni

“…Aside from conventional cardiac risk factors, there must be a further level of stratification; this might include validated strategies, such as QRISK3 scores or stricter criteria for referral based on presenting complaint. …”
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