Mrgprb2-dependent Mast Cell Activation Plays a Crucial Role in Acute ColitisSummary by Samuel Van Remoortel, Lana Lambeets, Benedicte De Winter, Xinzhong Dong, Juan Pablo Rodriguez Ruiz, Samir Kumar-Singh, Sales Ibiza Martinez, Jean-Pierre Timmermans

“…Methods: Mrgprb2 expression and functionality was studied using a genetic labeling strategy combined with advanced microscopic imaging. …”
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Dysregulated tRNA-derived fragments impair fatty acid metabolism in intrahepatic cholestasis of pregnancy by Lian Yang, Xia Yu, Shimao Zhang, Jinzhu Fu, Mengjun Luo, Wei Shen, Cheng Huang, Xiao Yang, Xiao Yang

“…Furthermore, GO and KEGG analyses suggested that fatty acid degradation might be associated with 3003a_trf-3 and 3005b_trf-3.ConclusionThis study provides preliminary data for the validation of serum-based biomarkers in ICP patients. …”
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BASS - Biodiversity Assessments at Small Scales by Fernando Ascensão, Pedro Cardoso, Rui Rebelo, Mário Boieiro, Alice Nunes, Sergio Chozas, Inês do Rosário, Adriana Príncipe, Cristina Máguas, Cristina Branquinho, Paulo Borges

“…Yet, we know that small scale is critical to fully understand biodiversity change, particularly for plants and small or less mobile organisms which might seek refuge in sites that keep specific microclimatic and biotic conditions dampening the effects of large-scale changes. …”
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Microbiological and Physicochemical Approach in the Feeding of Superworm (<i>Zophobas morio</i>) with Petroleum-Derived Polymer Diets by Brandon R. Burgos, Fabiola Morales, Rodrigo Morales-Vera, Cristian Valdés, Jorge Y. Faundez, Eduardo Pereira de Souza, Flavio Henrique-Silva, Ariel D. Arencibia

“…However, recently, some studies have shown that some insects might be able to adapt, consuming a wide range of hydrocarbon base polymers. …”
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Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy by Anna K. Tobiasch, Georg F. Lehner, Clemens Feistritzer, Andreas Peer, Birgit Zassler, Viktoria M. Neumair, Sebastian J. Klein, Michael Joannidis

“…Only EV-associated and functionally active TF and not TF antigen levels showed a predictive potential regarding DIC. …”
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Immunoregulatory Effects of <i>Codonopsis pilosula</i> Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice by Yan Long, Hongfei Ji, Jiajing Yang, Haiyu Ji, Keyao Dai, Wenjie Ding, Guoqiang Zheng, Juan Yu

“…These findings could provide theoretical support and data foundation for further development of CPP-SeNPs as functional food and drug adjuvants.…”
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Home-use transcranial direct current stimulation (tDCS) as a safe, effective, and feasible application in depression: A randomized, single-blind, placebo-controlled trial by Tuba Aktürk, Mehmet Yücel Ağargün, Sümeyye Özdemir, Esra Dalmızrak, Bahar Güntekin

“…Introduction: Anodal transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) alleviates depression symptoms and enhances cognitive functions in major depressive disorder (MDD) patients. …”
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Viscoelastic to elastic transformation of soft polymer properties for accelerated materials selection based on tissue dynamics in tissue engineering applications by Kamil Elkhoury, Guan-Lin Chen, Erfan Noorbakhsh Noshahri, Julio Zuazola, Nikhil Gupta, Sanjairaj Vijayavenkataraman

“…This dynamic behavior is critical for tissue functionality, influencing the design of biomaterials for tissue engineering. …”
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Incremental data integration for tracking genotype-disease associations. by Tomasz Konopka, Damian Smedley

“…Functional annotation of genes remains a challenge in fundamental biology and is a limiting factor for translational medicine. …”
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Culturing of Giardia lamblia under microaerobic conditions can impact metronidazole susceptibility by inducing increased expression of antioxidant enzymes by Kateryna Starynets, Ana Paunkov, Anja Wagner, Klaus Kratochwill, Christian Klotz, David Leitsch

“…However, most attempts to isolate metronidazole-resistant G. lamblia strains from patients have failed so far because the parasites were not resistant when tested in vitro.We hypothesized that this failure might be caused by drug assay conditions which are standardly anaerobic, and performed metronidazole susceptibility testing with two well studied strains, i.e. …”
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Effects of gintonin-enriched fraction on hippocampal gene expressions by Rami Lee, Na-Eun Lee, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Sung-Hee Hwang, Seung-Yeol Nah

“…Conclusion: We found that GEF affects mouse hippocampal gene expressions, associated with memory, cognitive, anti-stress and anti-anxiety functions, and neurodegeneration at differential degree, that might explain the genetic bases of GEF-mediated neuroprotective effects.…”
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A Missense Mutation in IRS1 is Associated with the Development of Early-Onset Type 2 Diabetes by Juyi Li, Shan Sun, Xiufang Wang, Yarong Li, Hong Zhu, Hongmei Zhang, Aiping Deng

“…Variants were filtered according to their frequency, location, functional consequences, and bioinformatics software. …”
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Size-dependent effects of oxo-degradable plastic contamination on soil quality and the growth of Zea mays by Do Thi Kim THANH, Robert W. BROWN, Martine GRAF, Michaela K. REAY, Charlotte E. M. LLOYD, Gupeng LI, David R. CHADWICK, Davey L. JONES

“…These findings indicate that at realistic field concentrations, ODPs are likely to have little effect on agroecosystem functioning in the short-term but might persist in soil for long periods of time, leading to their progressive accumulation in agricultural soils if used over repeated cropping cycles.…”
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Increase in disturbance-induced canopy gaps leads to reorganization of Central European bird communities by Anne Graser, Claudia Frank, Friederike Kunz, Andreas Schuldt, Cornelius Senf, Christoph Sudfeldt, Sven Trautmann, Johannes Kamp

“…We conclude that the recent increase in disturbance-induced canopy gaps across Central Europe has led to community reorganization, including species-specific changes in abundances. These changes might have important implications for priority-setting in species conservation.…”
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Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD by Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Anayali Estudillo-Guerra, Lna Ali, Diana Martinez, Roberto Hornero, Roberto Hornero, Leon Morales-Quezada

“…IntroductionAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition that affects cognitive, academic, behavioral, emotional, and social functioning, primarily in children. Despite its high prevalence, current pharmacological treatments are not effective in 30% of cases and show poor long-term adherence. …”
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Identification of A1/A2 β-Casein Genotypes and Comparison of Their Digestive Properties by Shihang LI, Hongtao XU, Xiao LI, Meiling SUN, Xinyan YANG, Pengyu XIANG, Zhihao YANG, Chaoxin MAN, Yujun JIANG

“…To more comprehensively explore the possible biological activity effects on the human body, by analyzing and monitoring the changes of this protein during the digestion process, the exploration of the biological functions of A1/A2 β-casein is further achieved. In this study, allele-specific PCR was initially performed on milk samples collected from different cows in the pasture to identify A1 and A2 milk types. …”
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Shedding light on biochemical changes in single neuron-like pheochromocytoma cells following exposure to synchrotron sourced terahertz radiation using synchrotron source Fourier tr... by Palalle G. Tharushi Perera, Jitraporn Vongsvivut, Denver Linklater, Zoltan Vilagosh, Dominique Appadoo, The Hong Phong Nguyen, Mark J. Tobin, Rodney Croft, Elena P. Ivanova

“…The PCA analysis further suggests that PC 12 cells might maintain cell membrane stability after SS THz irradiation through higher volumes of cholesterol and cell morphology via regulation of the synthesis of cytoskeleton proteins such as actin-related proteins. …”
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Comparison of the inflammatory biomarkers IL- 6, TNF-α, and CRP to predict the effect of nutritional therapy on mortality in medical patients at risk of malnutrition by Carla Wunderle, Elisabeth Martin, Alma Wittig, Pascal Tribolet, Thomas A. Lutz, Christina Köster-Hegmann, Zeno Stanga, Beat Mueller, Philipp Schuetz

“…Apparently, CRP and IL- 6 effectively predict treatment response, but IL- 6 may additionally serve as a prognostic marker for increased mortality. This finding might help to develop improved treatment strategies for patients with elevated inflammatory profiles. …”
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Immune suppressive activities of low-density neutrophils in sepsis and potential use as a novel biomarker of sepsis-induced immune suppression by Awirut Charoensappakit, Kritsanawan Sae‑khow, Nuntanuj Vutthikraivit, Patinya Maneesow, Thitiwat Sriprasart, Monvasi Pachinburavan, Asada Leelahavanichkul

“…In conclusion, LDN in sepsis, partly generated by LPS activation, was associated with secondary infection and T cell suppression, mainly through the expression of PD-L1, which might be an immune suppression biomarker, especially with a less expensive microscopic-based method.…”
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Identification of Potential Inhibitors Targeting Non-Structural Proteins NS3 and NS5 of Dengue Virus Using Docking and Deep Learning Approaches by Alomgir Hossain, Faria Tasnin Joti, Md. Shohag Hossain, Abdullah Al-Noman, Chomong Thowing, Mehjabin Mursona, Md. Robiul Islam, Md. Ekhtiar Rahman, Mohammad Nurul Matin, Md Azizul Haque

“…Our identified new drug candidates might help for developing effective antiviral inhibitors against the DENV. …”
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