Has_circRNA_0122683 (circ-PRKCI) relieves ferroptosis of HPAEpiCs in sepsis-induced acute lung injury by sponging miR-382-5p by Limei Yan, Xiajun Lu, Ning Wang, Peng Jia

“…Our study demonstrated that circ-PRKCI may be a promising biomarker for septic ALI diagnosis. circ-PRKCI inhibits ferroptosis and inflammatory response in sepsis-induced ALI by sponging miR-382-5p, indicating that the circ-PRKCI/miR-382-5p axis might be a novel therapeutic target for the treatment of sepsis-induced ALI.…”
Get full text

Knockdown of nrf2 Exacerbates TNF-α-Induced Proliferation and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes through Activating JNK Pathway by Yu Du, Qian Wang, Na Tian, Meng Lu, Xian-Long Zhang, Sheng-Ming Dai

“…In this study, we aimed to explore the expression and upstream regulatory factors of nrf2 and revealed its functions in modulating the proliferation and invasion in RA-FLS. …”
Get full text

State Educational Order as a Factor in the Socio-Economic Development of Regions by E. V. Frolova, T. M. Ryabova, O. V. Rogach, N. V. Medvedeva

“…Successful solution of the tasks of socio-economic development in the modern world is possible only in the case of effective functioning of the education system, which would provide training for a competitive personality, focused on continuous development and capable of “complying” with rapidly changing conditions of social reality. …”
Get full text

C3c intrathecal synthesis evaluation in patients with multiple sclerosis Evaluación de la síntesis intratecal de C3c en pacientes con esclerosis múltiple by Bárbara Padilla-Docal, Alberto J Dorta-Contreras, Hermes Fundora-Hernández, Elena Noris-García, Raisa Bu-Coifiu-Fanego, Marlen González-Hernández, Alexis Rodríguez-Rey

“…OBJECTIVE: To determine if the complement system might be involved in the MS immunopathogeny favouring the mechanism intervening in the myelin destruction. …”
Get full text

Family Resilience and Its Influencing Factors Among Patients With Lung Cancer Based on Double ABC‐X Theoretical Framework by Ziyi Shen, Yan Fang, Chengcheng Li, Xin Luo, Junling Cui, Yanchang Liu, Jingfang Hong

“…Clinically, interventions targeting these factors might significantly improve family functioning and coping mechanisms, contributing to better patient and family outcomes during cancer treatment and care.…”
Get full text

Peranan Tanaman terhadap Pencemaran Udara di Jalan Protokol Kota Semarang by Nana Kariada Tri Martuti

“…</p><p>The increasing number of motor vehicles might potentially increase the air pollution in main roads. …”
Get full text

Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury by Liu X, Zhou Y, Lu Z, Yang F, Wang Y, Zhang S, Zhang J, Zou H, Lin M

“…Molecular docking and enzyme activity assay was carried out to evaluate the effects of Cur on MAOA.Results: Our results showed that in vivo Cur preserved renal functions in AKI mice by lowering levels of serum creatinine, blood urea nitrogen, while in vitro ameliorated the cell viability of HK-2 cells damaged by ferroptosis. …”
Get full text

Identification of a Prognosis-Related Risk Signature for Bladder Cancer to Predict Survival and Immune Landscapes by Linhui Wang, Yutao Wang, Jianfeng Wang, Luanfeng Li, Jianbin Bi

“…The potential biological functions of the selected genes were analyzed using CIBERSORT and ESTIMATE algorithms. …”
Get full text

Transcranial Doppler sonography follow-up study in mild vascular cognitive impairment. by Mariagiovanna Cantone, Manuela Pennisi, Giuseppe Lanza, Raffaele Ferri, Francesco Fisicaro, Francesco Cappellani, Emanuele David, Vito Nicosia, Klizia Cortese, Giovanni Pennisi, Valentina Puglisi, Rita Bella

“…Together with compatible clinical and cognitive features, the exploration of early TCD markers that possibly indicate a higher risk of progression might represent an intriguing research direction and a significant clinical perspective.…”
Get full text

The Effect of a Manni Telescopic Herbst Appliance with Four Miniscrews (STM4) on the Treatment of a Class II Division I Malocclusion: A 3D Finite Element Study by Andrea Boggio, Abdolreza Jamilian, Antonio Manni, Giorgio Gastaldi, Rosana Farjaminejad, Mojtaba Hasani, Mauro Cozzani

“…This method might be a good treatment option for growing skeletal Class II patients.…”
Get full text

Electroencephalography-Based Recognition of Low Mental Resilience Using Multi-Condition Decision-Level Fusion Approach by Rumaisa Abu Hasan, Tong Boon Tang, Muhamad Saiful Bahri Yusoff, Syed Saad Azhar Ali

“…While having high spatial resolution, these modalities might not be cost-effective and accessible to serve larger populations. …”
Get full text

Parietal-specific activation reveals pain from inadequate levels of altitude acclimatization/ adaptation. by Shurong Jia, Niannian Wang, Rui Su, Hailin Ma, Hao Li

“…The enhancement of EEG activity might be regarded as a compensatory mechanism. It endeavors to maintain the normal operation of the body's physiological functions by increasing the efficiency of neural activities, thereby helping individuals to improve their adaptability to the HA environment. …”
Get full text

Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time by André Luiz Musmanno Branco Oliveira, Gabriel Dias Rodrigues, Gabriel Dias Rodrigues, Bruno Moreira Silva, Philippe de Azeredo Rohan, Pedro Paulo da Silva Soares

“…Therefore, sex might moderate cardiorespiratory responses to acute hypoxia exposure. …”
Get full text

Exome analysis reveals species divergence in TYR and identifies species genetic markers in five endemic Macaca species on Sulawesi Island by Xiaochan Yan, Nami Arakawa, Kanthi Arum Widayati, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Bambang Suryobroto, Yohey Terai, Hiroo Imai

“…This study aims to investigate highly divergent regions that might contribute to the distinct genetic and phenotypic characteristics differentiating the five Sulawesi macaque species. …”
Get full text

Bioinformatics analysis identifies BST1 as a potential therapeutic target linked to neutrophil extracellular traps in patients with acute liver failure by Mengyu Tao, Jiwei Fu, Xiaoping Wu

“…A total of 1694 DEGs were identified, and the biological functions and signaling pathways closely related to ACLF were monocyte differentiation and immune-metabolic processes. …”
Get full text

Compensatory mechanisms in γδ T cell-deficient chickens following Salmonella infection by Felix Tetzlaff, Felix Tetzlaff, Ulrich Methner, Theresa von Heyl, Christian Menge, Benjamin Schusser, Benjamin Schusser, Angela Berndt

“…In later stages of the infection, the γδ T cells and their functions appear to be replaced by other cells.…”
Get full text

FOXO1 and FYN Expression Trends in Breast Cancer Stem Cells: An Integrative Study of Single Nucleotide Polymorphism (SNP) Array and Quantitative PCR (qPCR) Analysis by Ay Ly Margaret, Septelia Inawati Wanandi, Fadilah Fadilah, Rafika Indah Paramita

“…Genotyping results of CD24-/CD44+ MDAMB-231 cells revealed 36 mutations in BCSCs compared to non-BCSCs, with upregulated FOXO1 and FYN that might represent promising candidate biomarkers for this subpopulation. …”
Get full text

Enhancing CAR T‐cell therapy manufacturing efficiency through semi‐automated bioprocessing by Jason Isaacson, Prajakta Bhanap, Nicholas Putnam, Jasmine Padilla, Nujhat Fatima, Max Dotson, Danny Hayoun, Moloud Ahmadi, Gertrude Nonterah, Yongchang Ji

“…Results The results demonstrated the successful generation of functional CAR T cells using a semi‐automated instrument workflow. …”
Get full text

Decoding ferroptosis in ischemic stroke: key genes and the therapeutic potential of acupuncture by Chunxiao Wu, Chunxiao Wu, Zhirui Xu, Qizhang Wang, Shuping Zhu, Chunzhi Tang

“…Bioinformatics analysis and RT-qPCR suggested that FTH1, SLC40A1, NRAS, CD82, and PTPN18 might serve as potential key targets underlying the antiferroptotic effects of acupuncture on ischemic stroke.…”
Get full text

Effect of discontinuing antipsychotic medications on the risk of hospitalization in long-term care: a machine learning-based analysis by Mikko Nuutinen, Riikka-Leena Leskelä, Daniela Fialova, Ira Haavisto, Harriet Finne-Soveri, Jokke Häsä, Johanna Edgren, Hein van Hout, Daniel E. da Cunha Leme, John P. Hirdes, Graziano Onder, Rosa Liperoti

“…While discontinuation of these drugs might help reduce their associated morbidity, the impact of stopping antipsychotics on the risk of hospitalization has not been studied yet. …”
Get full text