Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume by Weijia Gao, Kejing Zhang, Qing Jiao, Linyan Su, Dong Cui, Shaojia Lu, Rongwang Yang

“…Abstract Background The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. …”
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Ectopic fat accumulation in human astrocytes impairs insulin action by Martin Heni, Sabine S. Eckstein, Jens Schittenhelm, Anja Böhm, Norbert Hogrefe, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Harald Staiger

“…Furthermore, astrocytes are important for glucose sensing, possess neuroendocrine functions and also play an important role in cerebral lipid metabolism. …”
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Characteristics of tongue images and tongue coating bacteria in patients with colorectal cancer by Wu Zheng, Wu Yinhang, Chu Jian, Jin Congjian, Qu Zhanbo, Jean-Marie Nianga, Louis Wang, Wang Zefeng, Huang Jiaqun, Yu Xiaojian, Yang Shujing, Duan Jinlong, Liu Jiang, Han Shuwen

“…Abstract Background Tongue diagnosis can assess the physiological functions and pathological conditions of colorectal cancer (CRC). …”
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Three Growth Factors Induce Proliferation and Differentiation of Neural Precursor Cells In Vitro and Support Cell-Transplantation after Spinal Cord Injury In Vivo by Alexander Younsi, Guoli Zheng, Moritz Scherer, Lennart Riemann, Hao Zhang, Mohamed Tail, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger

“…Growth factors have been successfully used to improve NPC transplantation in animal models, but their extensive application is associated with a relevant financial burden and might hinder translation of findings into the clinical practice. …”
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The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance by Aayush Rastogi, Rong Qiu, Rachel Campoli, Usama Altayeh, Sarai Arriaga, Muhammad J. Khan, Subaranjana Saravanaguru Vasanthi, Robert Hillwig, Neelu Puri

“…<b>Conclusions</b>: These findings suggest FTO might mediate resistance and tumor growth by augmenting cell proliferation. …”
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FMT reduces systemic inflammatory response in severe acute pancreatitis by increasing the abundance of intestinal Bifidobacteria and fecal bacteria by Yanning Mao, Yandong Huang, Weiwei Zhang, Huiping Liang, Fengming Liu, Qi Luo, Chunqin Xu, Yi Qin, Jiawen Liu, Shaobo Tang, Huaying Liu, Xiaolong Ge

“…Receiver operating characteristic (ROC) curve analysis indicated that Bifidobacterium longum might play a critical role in the efficacy of FMT, with an area under the curve (AUC) value of 0.84. …”
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Association of tinnitus with obstructive sleep apnea and rapid eye movement-related obstructive sleep apnea in similar hearing threshold groups by Sun Choi, Seok Hyun Park, Su Yeon Kim, Su Kyoung Park, Sang Chul Park, Jiwon Chang

“…Objectives: Obstructive sleep apnea, a multisystem disease, affects cochlear and vestibular functions due to chronic intermittent hypoxia and recurrent oxygen desaturation. …”
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AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway by Zhipeng Quan, Bo Peng, Kai Hu, Lixing Liang, Mingjiang Liu, Lijuan Liao, Shilian Chen, Jing Qin, Songqing He, Zeyuan Li

“…Conclusions AP5Z1 influences autophagy and apoptosis in HCC cells by interacting with PTEN to modulate the PI3K/Akt/mTOR pathway. This gene might promote PTEN ubiquitination and degradation by recruiting tripartite motif-containing protein 21 (TRIM21), making it a potential biomarker for diagnosing and predicting the outcome of HCC as well as a target for new treatment strategies.…”
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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…These data suggest, albeit at the transcriptional level, the existence of a negative feedback loop necessary for sustaining cellular functions when metabolic demands might shift towards conserving energy during prolonged cold exposure. …”
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VdPAT1 encoding a pantothenate transporter protein is required for fungal growth, mycelial penetration and pathogenicity of Verticillium dahliae by Stephen Mwangi Kamau, Yongtai Li, Tiange Sun, Feng Liu, Qian-Hao Zhu, Xinyu Zhang, Jie Sun, Yanjun Li

“…The ratio change of chitin and β-1,3-glucan content in VdPAT1 deletion mutants might lead to abnormal branching of mycelium, resulting in the reduced penetration ability of V. dahliae. …”
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Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial by Jorge Francisco Vázquez-Castellanos, Lucas Ferreira Maciel, Lucas Wauters, Ann Gregory, Lukas Van Oudenhove, Karlien Geboers, Kristin Verbeke, Tamara Smokvina, Jan Tack, Tim Vanuytsel, Muriel Derrien, Jeroen Raes

“…Direct and indirect effects through the gut microbiome might lie at the basis of these observations. Here, in a post-hoc analysis, we assessed the effect of 4-week consumption of a probiotic candidate strain on the gut microbiome in students exposed to academic stress. …”
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Correlation study of LINC02609 and SNHG17 as prognostic biomarkers of kidney renal clear cell carcinoma and therapeutic sensitivity based on public data and In Vitro analysis by Chaoqun Xing, Weiwei Zou, Yangqin Li, Ti Zhang, Fan Yao, Zhi-Yong Yao, Xiao-Liang Xing

“…The risk model constructed using LINC02609 and SNHG17 was significantly correlated with multiple immunotherapy-related signatures, suggesting that it might be used for the determination of immunotherapy options in KIRC…”
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Analysis and Identification of Therapeutic Targets for Neuronal Regeneration After Ischemic Stroke by Xiao‐Li Min, Li Guo, Zhenyu Wang, Lei Zhao, Chenglong Shi, Xiaoyong Liu, Zhen Wang, Fei‐Fei Shang, Jiaping Wang

“…To identify the key genes, functional enrichment and Protein–Protein Interaction (PPI) network analysis were conducted. …”
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Repeated intestinal perforations in vascular Ehlers-Danlos syndrome: a case report of a novel mutation in the COL3A1 gene by Taichi Horino, Yuji Miyamoto, Mayuko Ohuchi, Katsuhiro Ogawa, Naoya Yoshida, Takatoshi Ishiko, Chieko Kukinaka, Rumi Sasaki, Takashi Ohba, Hideo Baba

“…The identified missense mutation in the COL3A1 gene (c.2095G>T, p.Gly699Cys) might be a novel pathogenic variation causing vascular Ehlers-Danlos syndrome. …”
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In vitro antibacterial and antibiofilm activities of isobavachalcone against Enterococcus faecalis clinical isolates from China by Lili Ouyang, Zhicao Xu, Yuanyuan Tang, Duoyun Li, Zhijian Yu, Zewen Wen, Haigang Zhang, Chaoqin Zhang

“…PurH protein in E. faecalis might serve as a potential target of isobavachalcone and the specific action mechanism of isobavachalcone needs further study.…”
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A Comparative Transcriptomic Analysis of miRNAs and Their Target Genes During the Formation of Melanin in <i>Apis mellifera</i> by Xiangjie Zhu, Yuanmingyue Tian, Mingjie Cao, Chenyu Zhu, Jiaqi Shang, Jiaqi Sun, Yiming Liu, Bingfeng Zhou, Shujing Zhou, Xinjian Xu

“…A total of 171, 94, and 19 DEmiRNAs were identified in these groups, respectively, which regulate 1481, 690, and 182 differentially expressed target mRNAs (target DEmRNAs). The functional analysis of target DEmRNAs indicated that DEmiRNAs might regulate the formation of capped brood melanin in honeybees by activating expression changes in key genes in signaling pathways, such as the Wnt signaling pathway, melanogenesis, and the Toll and Imd signaling pathway, through activating miR-315-x, miR-8, <i>ple</i>, <i>yellow</i> family genes, <i>wnt1</i>, etc. …”
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A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma by Anshun Wu, Fayin Liu, Lei Zhou, Runyi Jiang, Shangjiang Yu, Zihuan Zhou, Qi Zhang, Qian Zhang, Dongjie Jiang, Shaohui He, Haifeng Wei

“…Abstract Histone acetylation is an important epigenetic modification, modulating the development of many tumors. However, the functions of most histone acetylation-related genes (HARGs) and their prognostic values in Ewing sarcoma (EWS) remain unclear. …”
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Aqueous humor cytokines levels and illuminated microcatheter-assisted circumferential trabeculotomy outcome in open-angle glaucoma patients: a 24-month prospective study by Tingyi Wu, Tingyi Wu, Qianqian Ji, Qianqian Ji, Yanfeng Liao, Yanfeng Liao, Xiaoyu Zhao, Ying Hong, Ying Hong

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Doing Good Instead of Doing Well? What Lawyers Could be Doing in a World of “Too Many” Lawyers by Carrie Joan Menkel-Meadow

“…The paper explores issues of what constitutes “legal knowledge and expertise” and how such knowledge might be deployed to solve complex social and legal problems outside of conventional legal professional boundaries. …”
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Potential confounding mutations in Keio knockout strains: implications for research accuracy by Oishi Sen, Xianghui Liu, Staffan Kjelleberg, Scott A. Rice, Thomas Seviour

“…Mutations in the coding regions of genes (different from the actual gene knocked out in the mutants) led to different types of mutations in the affected genes, ranging from nonsense mutations to frameshift mutations, which could affect the functionality of the resulting gene products. These mutations in the intergenic and coding regions could lead to phenotypic differences in the single-gene knock-out mutant strains in comparison to the parent strain, independent of the desired gene deletion. …”
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