Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1 by Laura Serra, Matteo Mancini, Gabriella Silvestri, Antonio Petrucci, Marcella Masciullo, Barbara Spanò, Mario Torso, Chiara Mastropasqua, Manlio Giacanelli, Carlo Caltagirone, Mara Cercignani, Giovanni Meola, Marco Bozzali

“…The current findings suggest that measures of functional connectivity may offer the possibility of characterizing individual patients with the potential to become a clinical tool.…”
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Remote work – the new normal needs more research by Annina Ropponen

“…In the short-term or occasionally, this might be fun. However, the long-term effects of poor physical working conditions or positions may negatively impact musculoskeletal organs, eye ergonomics, or cognitive functions (35, 36). …”
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Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy by Miaoli Lin, Yuxiang Mao, Siming Ai, Guangming Liu, Jian Zhang, Jianhua Yan, Huasheng Yang, Aimin Li, Yusha Zou, Dan Liang

“…Secondary outcome was the change of quality of life score (QoL, including visual functioning subscale and appearance subscale). Adverse events were also recorded. …”
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Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice by Marthe M. Vandeputte, Grant C. Glatfelter, Donna Walther, Nathan K. Layle, Danielle M. St. Germaine, István Ujváry, Donna M. Iula, Michael H. Baumann, Christophe P. Stove

“…Here, we report the synthesis and pharmacological characterization of 15 structurally diverse nitazenes that might be predicted to emerge or grow in popularity. …”
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Cellulase activity and age-based variation of intestinal microbiota in Hezuo pigs by Yuhao Liang, Fei Wang, Rui Jia, Jie Li, Longlong Wang, Yajuan Li, Yao Li, Shuangbao Gun, Shuangbao Gun, Shuangbao Gun, Qiaoli Yang, Qiaoli Yang, Qiaoli Yang

“…Its cellulose-degrading enzyme secretion capacity enhanced with age to meet the high-fiber dietary demands of Hezuo pigs. Functional prediction of intestinal microbiota in adjacent age groups using PICRUSt revealed that the differences between lactating piglets and weaned piglets were primarily due to the enrichment of various metabolic pathways functional genes, while differences between fattening pigs and adult sows were negligible. …”
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Addressing the need for non-invasive lung assessment with time-resolved diffuse optics by Giulia Maffeis, Nicola Serra, Alessandro Bossi, Alessandro Bossi, Elisabetta Avanzi, Alberto Dalla Mora, Laura Di Sieno, Rinaldo Cubeddu, Antonio Pifferi, Antonio Pifferi, Paola Taroni, Paola Taroni

“…Photons in the 600–1,300 nm range might have the potential to reach lungs and provide compositional and functional information. …”
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Low intensity rTMS in adolescent mice affects visuomotor behaviour with no impact on visual topography by Maitri Tomar, Joseph JF Pow, Marissa A Penrose-Menz, Jamie L Beros, Aleksandra Miljevic, Bruno Meloni, Jennifer Rodger

“…Conclusion: While we cannot rule out that changes in functional connectivity might be transient and/or beneficial in a disease context, our findings highlight that more clinical and preclinical studies are needed to validate the safety and mechanism of action of rTMS for children and adolescents.…”
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Decreased expression of TCF12 contributes to progression and predicts biochemical recurrence in patients with prostate cancer by Qing-biao Chen, Ying-ke Liang, Yan-qiong Zhang, Min-yao Jiang, Zhao-dong Han, Yu-xiang Liang, Yue-ping Wan, Jie Yin, Hui-Chan He, Wei-de Zhong

“…As a member of helix–loop–helix protein family, transcription factor 12 functions as either an oncogene or a tumor suppressor in various human cancers. …”
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Identification of Endophytic Bacterial Community Associated With Roots of Desert Vegetation by Shafeeq Rahman, Mughair Abdul Aziz, Azra Shamim, Manzoor Ahmad, Juma Ali Saif Alneyadi, Ahmed Nasser Youssef, Abdulrahman Saeed Alreyashi, Abdulla Mohammed Alshamsi, Khaled Masmoudi

“…ABSTRACT Native plants thriving in extreme environments host unique microbial communities that might play crucial roles in promoting their growth and enhancing tolerance to harsh environmental conditions. …”
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Association of CYP2D6*4 Polymorphism With Response to Atorvastatin in Patients With High Low-Density Lipoprotein Level in Northern Iran, Guilan Provice by Raziyeh Asadollahpour, Faeze Khaghani, Fardin Mirbolouk, Anvarsadat Kianmehr, Omid Goodarzvand, Sara Dabirian, Mohammad Sadegh Alipour, Ehsan Zamani, Mehdi Evazalipour

“…Individuals who carry two non-functional alleles in this gene are considered as poor metabolizers. …”
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HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer by Xu Li, Xu Li, Xiwen Li, Yanlin Ren, Ling Wang, Zehao Mao, Shikun Gao, Shikun Gao, Peng Ma, Junjie Chen, Junjie Chen

“…Functional experiments were carried out on the AGS and HGC-27 GC cell lines. …”
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Software with artificial intelligence-derived algorithms for detecting and analysing lung nodules in CT scans: systematic review and economic evaluation by Julia Geppert, Peter Auguste, Asra Asgharzadeh, Hesam Ghiasvand, Mubarak Patel, Anna Brown, Surangi Jayakody, Emma Helm, Dan Todkill, Jason Madan, Chris Stinton, Daniel Gallacher, Sian Taylor-Phillips, Yen-Fu Chen

“…However, artificial intelligence might increase the detection of both cancer as well as harmless nodules. …”
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Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity by Wei Qiu, Ruiming Guo, Hongwen Yu, Xiaoxin Chen, Zehao Chen, Dian Ding, Jindou Zhong, Yumeng Yang, Fuchun Fang

“…Despite the critical role of NETs in the development and progression of periodontitis, their specific functions and mechanisms remain unclear. Objectives: To demonstrate the important functions and specific mechanisms of NETs involved in periodontal immunopathology. …”
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Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer by Jiejie Xu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Yijia Xu

“…Background Tumor-associated macrophages (TAMs) secreting IL-10 could be a specific functional cell subset with distinct polarization state and suppressive role in antitumor immune response. …”
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Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression by Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si

“…Functional assays demonstrated that GTF2F2 knockdown significantly suppressed ovarian cancer cell migration and invasion. …”
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Management approach matters: meeting seagrass recovery and carbon mitigation goals by Melissa Ward, Connor Dibble, Maddie Millington-Drake, John Lynch, Karen McGlathery, Richard J. Lilley, Aaron L. Strong, Lisa M. Wedding

“…This work highlights the need for careful, context-specific consideration for if and how carbon finance might support seagrass recovery goals. Seascape-level approaches that pair strategic sediment management and avoided emissions with habitat restoration may lead to the highest climate mitigation benefits, while simultaneously supporting biodiversity and other ecosystem functions.…”
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Exploring How Older Adults Experience semAPP, a 360° Media–Based Tool for Memory Assessment: Qualitative Study by Francesca Bruni, Valentina Mancuso, Jonathan Panigada, Marco Stramba-Badiale, Pietro Cipresso, Elisa Pedroli

“…Moreover, the results match the idea that usability might be influenced by different factors depending on instrument and personal features, such as presentation, functionality, system performance, interactive behavior, attitudes, skills, and personality. …”
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Identification of biomarkers and target drugs for melanoma: a topological and deep learning approach by Xiwei Cui, Xiwei Cui, Jipeng Song, Qingfeng Li, Jieyi Ren

“…Advanced network analysis tools were employed to identify structural disparities and functional module shifts. Key driver genes were validated through topological centrality metrics. …”
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The UFMylation pathway is impaired in Alzheimer’s disease by Tingxiang Yan, Michael G. Heckman, Emily C. Craver, Chia-Chen Liu, Bailey D. Rawlinson, Xue Wang, Melissa E. Murray, Dennis W. Dickson, Nilufer Ertekin-Taner, Zhenkun Lou, Guojun Bu, Wolfdieter Springer, Fabienne C. Fiesel

“…These changes are significantly associated with pathological tau, supporting the idea that the UFMylation cascade might indeed act as a modifier of tau pathology in human brain. …”
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Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface by Albert Neil Gura Dulay, Richelle Mae Evasco Padilla, Nyzar Mabeth Obenio Odchimar, Fredmoore Legaspi Orosco

“…Results: Simulations report poor affinity of CD2v to CD58 in the "canonical" pose and present a novel pose backed by docking, simulation data, and recent observations. The new site might have developed due to immunological considerations and may reproduce observed lymphocyte non-proliferation by hijacking CD58-CD2 ruler functions in immunological synapse formation. …”
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