Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study by Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu

“…Abstract Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. …”
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Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology by Chen Zheng, Ting Liu, An Qi Wang, Xing An Chen, Rong Zhe Zhang, Xuan Chao Wang, Chao Yue Lv, Ru Lu Pan, Ou Chen Wang, Xin-Cheng Lu

“…In this review, we elucidate the structural characteristics and functional roles of PTPRK in cellular signaling and disease pathogenesis. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…Experimental validation demonstrated that both variants led to alterations in the molecular size, expression level, and localization of the Sall1 protein, suggesting that these SALL1 gene variants might contribute to FSGS by impacting podocyte function.…”
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Functional characterization of conserved small open reading frames on the genomic RNA of sonchus yellow net virus by Mengxin Gao, Shuang Ni, Yaqin Wang, Zhenghe Li, Pan Gong, Xueping Zhou, Fangfang Li

“…However, the functions of these additional sORFs remain largely unexplored. …”
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Silent but significant: Functional elucidation of a synonymous ATP7B mutation in Wilson’s disease pedigrees by Qi Zhang, Qi Zhang, Xiaoming Xie, Hairong Li, Yulei Li, Hongyao Huang, Hongyao Huang

“…Bioinformatics tools (HSF, SpliceAI and ESEfinder 3.0) were used to predict the impact of mutations on the splicing function of precursor mRNA. The in vitro minigene experiment was conducted to verify the impact of the mutation on the splicing function of the precursor mRNA.ResultsWhole-exome sequencing of the proband identified a synonymous variant c.2145C>T (p. …”
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Predictive value of percutaneous peripheral arterial compliance T in left ventricular diastolic function with coronary artery disease by Wenhao Zhang, Wenhao Zhang, Guoliang Liang, Guoliang Liang, Liang Lv, Xinxin Gu, Xinxin Gu, Qiong Zhang, Ankang Liu, Jiangwei Ma, Jiangwei Ma

“…At the same time, linear analysis of the average values of peripheral arterial compliance indices in both groups revealed that the average compliance indices in Groups C and D had a linear correlation with their LV-T (P < 0.05).When coronary artery stenosis exceeds 50%, the changes in peripheral arterial T values are significantly correlated with changes in LV-T.ConclusionsWhen coronary artery stenosis exceeds 50%, there is a decrease in peripheral artery compliance, showing a positive correlation with changes in left ventricular diastolic function. Measuring this compliance might offer an early diagnostic tool for assessing diastolic function.…”
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Lead Causes Lipid Droplet Accumulation by Impairing Lysosomal Function and Autophagic Flux in Testicular Sertoli Cells by Chengwei Guo, Lingqiao Wang, Ke Cui, Guowei Zhang, Yao Tan, Weiyan Chen, Yiqi Wang, Jijun Liu, Wenbin Liu, Guanghui Zhang, Ziyuan Zhou

“…Our findings indicate that the Pb hindered the autophagic clearance by impairing the lysosomes’ function and then obstructing the fusion of lysosomes and autophagosomes. …”
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Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses by Antonella Izzo, Rosanna Manco, Tiziana de Cristofaro, Ferdinando Bonfiglio, Rita Cicatiello, Nunzia Mollo, Marco De Martino, Rita Genesio, Mariastella Zannini, Anna Conti, Lucio Nitsch

“…Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. …”
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Aberrant Whole-Brain Resting-State Functional Connectivity Architecture in Obsessive-Compulsive Disorder: An EEG Study by Bo Tan, Jing Yan, Junjun Zhang, Zhenlan Jin, Ling Li

“…Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disorder characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions), and few studies have assessed the whole-brain functional connectivity architecture of OCD with electroencephalogram (EEG) during different resting states. …”
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Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. by Sakthivel Vaiyapuri, Simon C Wagstaff, Kimberley A Watson, Robert A Harrison, Jonathan M Gibbins, E Gail Hutchinson

“…Similar to mammalian aminopeptidases, rhiminopeptidase A might be capable of playing roles in altering the blood pressure and brain function of victims. …”
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Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8+ T cells by Yan Wu, Da Jiang, Xing-Chen Liu, Yong-Hao Ruan, Limin Zheng, Aiqi Huang, Bai-Xi Zhu, Jiangling Gong

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Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease by Yuxia Li, Xiaoni Wang, Yongqiu Li, Yu Sun, Can Sheng, Hongyan Li, Xuanyu Li, Yang Yu, Guanqun Chen, Xiaochen Hu, Bin Jing, Defeng Wang, Kuncheng Li, Frank Jessen, Mingrui Xia, Ying Han

“…We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD.…”
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Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury by Peng-Fei Dong, Tian-Bin Liu, Kai Chen, Dan Li, Yue Li, Cai-Yu Lian, Zhen-Yong Wang, Lin Wang

“…Conclusion: In summary, these findings reveal that TFEB phosphorylation, nuclear export and acetylation independently suppress TFEB activity to cause Cd-induced AKI via regulating autophagy-lysosome function, suggesting that TFEB activation might be a promising treatment strategy for Cd-induced AKI.…”
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The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions by Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, Evgeni Ponimaskin

“…However, the functional consequences of this interaction on 5-HT7R-mediated signaling remained enigmatic. …”
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Exploring the Influence of a Pomegranate Extract on the Functionality of Healthy and Diseased Human Gut Microbiota: An In Vitro Study by Daniele Giuseppe Buccato, Adriana Delgado-Osorio, Lorenza Francesca De Lellis, Maria Vittoria Morone, Hammad Ullah, Luana Izzo, Sonia Lombardi, Alessandro Di Minno, Costanza Valentina Riccioni, Dafni Moriki, José Ángel Rufián-Henares, Maria Daglia

“…These compounds make pomegranate a functional food with the potential to modulate chronic disease risk factors and enhance gut health by modulating microbiota. …”
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Downregulation of AdipoR1 in the hippocampus impairs synaptic function and structure and causes depression-like behavior by Peilin Zhu, Yanmin Luo, Yue Li, Jing Tang, Li Liu, Yuhui Deng, Jing Li, Lin Jiang, Wenyu Yang, Qian Xiao, Shun Wang, Yuning Zhou, Fenglei Chao, Lei Zhang, Chunni Zhou, Yong Tang, Xin Liang

“…Adiponectin, an adipokine, crosses the blood‒brain barrier to function in specific brain regions. Previous studies have suggested that the downregulation of adiponectin signaling is involved in the occurrence of depression. …”
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SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications by Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue

“…We found that people with overactive SCN1A function might respond differently to certain medications.…”
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Antioxidant, Physiochemical, and Sensory Properties of Functional Marshmallow Produced from Honey, Strawberry Concentrates, and Hibiscus Extract by Maher M. Al-Dabbas, Etaf G. Abu Samaan, Sehar Iqbal, Hani J. Hamad, Rawan Al-Jaloudi, Mohammad Shahein, Bha’a Aldin Al-Nawasrah, Abdalrahman Al-Zabt, Doa`a Al-Refaie, Nisreen Shehadeh, Mahmoud Abughoush

“…However, its high sugar contents and low nutritive value might lead to adverse health outcomes. This study, therefore, aimed to develop optimal formulations for functional marshmallow candy using honey, aqueous hibiscus extract, cow’s milk, and strawberry concentrates with partial replacement of table sugar and glucose syrup. …”
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Individual alpha frequency tACS reduces static functional connectivity across the default mode network by Martín Carrasco-Gómez, Martín Carrasco-Gómez, Martín Carrasco-Gómez, Alejandra García-Colomo, Alejandra García-Colomo, Jesús Cabrera-Álvarez, Jesús Cabrera-Álvarez, Alberto del Cerro-León, Alberto del Cerro-León, Carlos J. Gómez-Ariza, Andrés Santos, Andrés Santos, Fernando Maestú, Fernando Maestú, Fernando Maestú

“…IntroductionResearch on the influence of transcranial alternating current stimulation over alpha functional connectivity (FC) is scarce, even when it poses as a potential treatment for various diseases. …”
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Greater Central Adiposity Is Associated With Poorer Left Atrial Function: The Atherosclerosis Risk in Communities (ARIC) Study by Jorge L. Reyes, MD, MS, Joseph J. Decker, MD, Romil Parikh, MBBS, MPH, Michael Zhang, MD, PhD, Anne Eaton, PhD, MS, Riccardo M. Inciardi, MD, PhD, Chiadi Ndumele, MD, PhD, Jeremy Van’t Hof, MD, MS, Alvaro Alonso, MD, PhD, Amil M. Shah, MD, Scott D. Solomon, MD, Lin Yee Chen, MD, MS

“…Change in WC, WHR, and BMI were not associated with LA contractile function. Conclusion: Worsening central adiposity from mid-life to late life is associated with reduced LA reservoir and conduit function, independent of LA size and LV size and function. …”
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