Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis by So Hyun Park, Ji-Young Hong, Won Kyung Kim, Joon-Shik Shin, Jinho Lee, In-Hyuk Ha, Hwa-Jin Chung, Sang Kook Lee

“…Lumbar spinal stenosis (LSS) is a major cause of chronic low back pain; however, only a few therapies which have been used in clinics still have limited effects on functional recovery. SHINBARO2 is a refined traditional formulation for inflamed lesions and relieve pain of muscular skeletal disease. …”
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Integrated analysis of transcriptome, sRNAome, and degradome involved in the drought-response of maize Zhengdan958 by Yang Shuqiong, Liu Jiafei, Cao Lingling, Chen Jibao, Duan Pengfei

“…As a significant epigenetic regulator, small RNA also functions in connecting the transcriptional and post-transcriptional regulatory network. …”
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Genome Mining of Terpene Synthases from Fourteen <i>Streptomyces</i> Strains by Yuanyuan Li, Xi Xiang, Zhiyuan Ren, Rui Wang, Minghui Xie, Gen Li, Xiaohui Yan, Zhilong Zhao, Zixin Deng, Min Xu, Anwei Hou

“…Despite their abundance, the functional diversity of bacterial terpene synthases (TPSs), particularly from <i>Streptomyces</i> species, remains largely unexplored. …”
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Longitudinal changes in striatocortical connectivity in first-episode psychosis associated with the emergence of treatment resistance by Angeles Tepper, Javiera Vásquez, Camila Díaz Dellarossa, Juan Pablo Ramirez-Mahaluf, Juan Aguirre, Daniella Barbagelata, David Aceituno, Juan Undurraga, Ruben Nachar, Cristian Mena, Robert A. McCutcheon, Philip McGuire, Alfonso Gonzalez-Valderrama, Nicolas A. Crossley

“…Overall, treatment-resistant psychosis is characterized by longitudinal changes in striatal systems in early psychosis, which might be used as the basis of future prognostic biomarkers.…”
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Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning by Yude Hong, Xiao Hu, Libo Chen, Mingyong Li, Mingxiao Zhang, Weiming Deng

“…The high-MLRS group was characterized by a phenotype of immune suppression and was less likely to benefit from immunotherapy, while some small molecule inhibitors might serve as promising treatment options. Single-cell analysis revealed that MLRS was highly enriched in endothelial cells. …”
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Older patients affected by COVID-19: investigating the existence of biological phenotypes by Alberto Zucchelli, Marta Parigi, Silvia Giliani, Davide Liborio Vetrano, Daniela Lucente, Emanuele Marzetti, Riccardo Calvani, Giuseppe Bellelli, Alessandra Marengoni

“…Conclusion Biological phenotypes might be used to identify different clinical and functional phenotypes in individuals affected by COVID-19.…”
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Isolation and characterization of fMGyn-Pae01, a phiKZ-like jumbo phage infecting Pseudomonas aeruginosa by Kira Ranta, Mikael Skurnik, Saija Kiljunen

“…Whole genome sequencing of the host bacterium and phage resistant mutants revealed that the mutations had inactivated either a flagellar or rpoN gene, thereby preventing the biosynthesis of a functional flagellum. The lack of functional flagella was confirmed in motility assays. …”
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Identification of lipid metabolism-related genes in dapagliflozin treated rats with diabetic cardiomyopathy by bioinformatics by Xun Huang, Yunhong Wang, Rong Wan, Zhigang You, Lin Huang

“…The findings of GSEA indicated that Acsbg1 and Etnppl might affect the occurrence and progression of DCM through lysosome. …”
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IDH1 Mutation Impacts DNA Repair Through ALKBH2 Rendering Glioblastoma Cells Sensitive to Artesunate by Olivier Switzeny, Stefan Pusch, Markus Christmann, Bernd Kaina

“…Gliomas harboring mutated <i>IDH1/2</i> show a better prognosis than <i>IDH1</i> wild-type (wt) tumors of the same grade, which might result from the inhibition of DNA repair functions. …”
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Influence of ADAM metallopeptidase with thrombospondin type 1 motif 9 on the prognosis of patients with thyroid cancer and its mechanism of action by CAO Xiaodong, XIANG Cheng

“…In addition, the effect of ADAMTS9 might offset the adverse effect of age on prognosis to a certain degree.…”
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The impact of deregressed foreign breeding values on national beef cattle single-step genomic evaluation by Damilola Adekale, Zengting Liu, Ross Evans, Thierry Pabiou, Reinhard Reents, Dierck Segelke, Jens Tetens

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Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease by Fabiana Sassone, Catherine Estay-Ahumada, Michel J. Roux, Dominique Ciocca, Paola Rossolillo, Marie-Christine Birling, Janet R. Sparrow, Diego Montenegro, David Hicks

“…Abca4 gene-deletion mouse models of STGD1 accumulate lipofuscin, a hallmark of the disease, but unlike the human disease show no or only moderate structural changes and no functional decline. The human macula is highly enriched in cones, and reasoning that the low cone percentage in mice retinas (< 3%) might compromise faithful modelling of human maculopathies, we performed sub-retinal injections of CRISPR/Cas9-abca4 Adeno-Associated Virus constructs into young Sand Rats (Psammomys obesus), a diurnal rodent containing > 30% cones. …”
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Exploring the involvement of serine proteases in neutrophil extracellular traps: a review of mechanisms and implications by Aleksandra Korba-Mikołajczyk, Katarzyna Dominika Służalska, Paulina Kasperkiewicz

“…Therefore, understanding the functions of NSPs and their role in NET formation might facilitate the development of new diagnostic and therapeutic strategies.…”
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Sequence-based GWAS reveals genes and variants associated with predicted methane emissions in French dairy cows by Solène Fresco, Marie-Pierre Sanchez, Didier Boichard, Sébastien Fritz, Pauline Martin

“…It has been proposed that such emissions might be reduced using genetic selection; proposed phenotypes differ in the measurement methods used (direct or predicted methane emissions) and in the unit under consideration (g/d, g/kg of milk, g/kg of intake, residual methane emissions). …”
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Nontargeted Metabolomic Analysis of Plasma Metabolite Changes in Patients with Adolescent Idiopathic Scoliosis by Lige Xiao, Guanteng Yang, Hongqi Zhang, Jinyang Liu, Chaofeng Guo, Yang Sun

“…Plasma biomarkers and functional metabolic pathways were correlated with clinical indexes, which might provide new insights for the diagnosis and treatment of AIS.…”
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Comprehensive analysis of human keratinocyte interactions with Candida albicans and Candida parapsilosis by Ádám Novák, Erik Zajta, Máté Csikós, Emese Halmos, Márton Horváth, Orsolya Tildy, András Szekeres, Gergő Svorenj, Nikolett Gémes, Gábor J. Szebeni, Renáta Tóth, Attila Gácser

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Selection for domestication favored taxa characterized by fast growth and tolerance of high intraspecific density by Rafael Rubio deCasas, Irene Martín‐Brull, Ruben Milla, Francisco J. Ocaña‐Calahorro

“…Summary In spite of a large history of research, it is still unclear which functional traits may have mediated plant domestication. …”
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A N, S-Containing Graphene Oxide Composite for the Adsorptive Removal of p-Nitrophenol from Aqueous Solutions by Bi Yang, Tao-Tao Shi, Wei-Guo Hu, Guan-Jin Gao, Yi-Ping Liu, Jin-Gang Yu

“…A novel 3-amino-5-mercapto-1,2,4-triazole functionalized graphene oxide composite (GO-ATT) was successfully prepared via a covalent coupling method, then employed for the removal of p-nitrophenol (PNP) from wastewater. …”
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Positive selection at core genes may underlie niche adaptation in Fusobacterium animalis by Diego Forni, Audun Sivertsen, Rachele Cagliani, Alessandra Mozzi, Cristian Molteni, Øyvind Kommedal, Manuela Sironi

“…We hypothesized that, because they promote bacterial fitness in the intracellular niche, these genes might be targets of positive selection, a process that often underlies adaptation to variable environments. …”
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Changes in Biochemical Components of Obesity in Wistar Rats Fed Mentha Piperita-Supplemented High-Fat Diet by A S Idoko, Usman Ahmed Madaki, L Nura, M E Sadiq, S Umar

“…At the end of six (6) weeks of the experiment, organ to body weight ratio, serum insulin level and HOMA-IR were determined. Markers of hepatic functions (transaminases, total bilirubin, albumin, globulin, conjugated bilirubin and total protein), markers of renal functions (electrolyte concentrations, urea and creatinine), serum activities of antioxidant enzymes (catalase, glutathione peroxidase, reduced glutathione and superoxide dismutase) and serum concentrations of malondialdehyde (MDA) were also determined. …”
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