Identification and expression analysis of TALE superfamily genes explore their key roles in response to abiotic stress in Brassica napus by Meili Xie, Xiaojuan Zhang, Kexin Liu, Zhixian Qiao, Xiaohui Cheng

“…Conclusions Our study paves the way for future gene functional research of BnTALE and facilitate their applications in the genetic improvement of B. napus in response to abiotic stresses.…”
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Not just semantics: CO2 fertilization can be a disturbance leading to worldwide forest degradation by David M. Lapola, Carolina C. Blanco, Barbara R. Cardeli, Adriane Esquivel‐Muelbert, João V. Martinelli, Carlos A. N. Quesada, Bianca F. Rius, Celso H. L. Silva‐Junior

“…Societal Impact Statement The physiological effects of increased atmospheric CO2 (CO2 fertilization) on intact forests are generally seen as a process that might buffer them against the impacts of climate change. …”
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Against Futility Judgments for Patients with Prolonged Disorders of Consciousness by William Choi

“…A physician who determines the futility of continuing life-sustaining treatment might decide that the treatment would not be worth the cost to other patients who are more likely to benefit from the same resources. …”
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CAREUP: An Integrated Care Platform with Intrinsic Capacity Monitoring and Prediction Capabilities by Marcin Kolakowski, Andrea Lupica, Seif Ben Bader, Vitomir Djaja-Josko, Jerzy Kolakowski, Jacek Cichocki, Jaouhar Ayadi, Luca Gilardi, Angelo Consoli, Irina Georgiana Mocanu, Oana Cramariuc, Lionello Ferrazzini, Eva Reithner, Magdalena Velciu, Barbara Borgogni, Sofia Rivaira, Sara Leonzi, Giacomo Cucchieri, Vera Stara

“…Besides standard functionalities like storing health measurement data or providing users with personalized recommendations, the platform includes novel intrinsic capacity assessment and prediction algorithms. …”
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Targeting GATA transcription factors – a novel strategy for anti-aging interventions? by Andreas Zimmermann, Katharina Kainz, Sebastian J. Hofer, Maria A. Bauer, Sabrina Schroeder, Jörn Dengjel, Federico Pietrocola, Oliver Kepp, Christoph Ruckenstuhl, Tobias Eisenberg, Stephan J. Sigrist, Frank Madeo, Guido Kroemer, Didac Carmona-Gutierrez

“…GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. …”
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Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway by Angelisa Frasca, Federica Miramondi, Erica Butti, Marzia Indrigo, Maria Balbontin Arenas, Francesca M Postogna, Arianna Piffer, Francesco Bedogni, Lara Pizzamiglio, Clara Cambria, Ugo Borello, Flavia Antonucci, Gianvito Martino, Nicoletta Landsberger

“…We therefore investigated whether Rett syndrome (RTT), that represents the first cause of severe intellectual disability in girls, might benefit from NPC-based therapy. Using in vitro co-cultures, we demonstrate that, by sensing the pathological context, NPC-secreted factors induce the recovery of morphological and synaptic defects typical of Mecp2 deficient neurons. …”
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Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes by Qi Hu, Yang Liu, Qiuyu Yue, Shuo Zhou, Xianghong Jin, Fan Lin, Xiao-Jun Huang, Junling Zhuang, Jin Lu, Xiaofei Gao, Hsiang-Ying Lee

“…Unexpectedly, the patient’s erythroid cells display abnormally high expression of genes in the antigen presentation pathway, particularly those for major histocompatibility class I (MHC-I) molecules. Functional assays demonstrate that lenalidomide treatment further augmented MHC-I expression in the patient’s erythroid cells. …”
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Complete Resection without Any Ostomies by Laparoscopic Extended Surgery for Locally Advanced T4 Sigmoid Colon Cancer Invading the Urinary Bladder and Ureter by Atsushi Ogura, Tsukasa Aritake, Satoru Kawai, Shigeki Yamamoto, Kenji Takagi, Kiyotaka Kawai, Takashi Maeda, Ryutaro Kobayashi, Natsuki Nagano, Satoaki Kamiya

“…We believe laparoscopic magnified and multidirectional approach might be useful for pathologically complete resection and minimizing an unnecessary extended surgery for these cases. …”
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Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity informing a looping-mediated therapeutic avenue by Lavanya Choppavarapu, Kun Fang, Tianxiang Liu, Aigbe G. Ohihoin, Victor X. Jin

“…We demonstrate 3D chromatin-regulated breast tumor heterogeneity and identify a looping-mediated target gene, CA2, which might play a role in driving tamoxifen resistance. …”
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RAB26 promotes prostate cancer progression via the MAPK/ERK-TWIST1 signaling axis by Hexi Wang, Simin Liang, Xiaoyi Du, Guozhi Zhao, Yuanyuan Bai, Junwu Li, Haoyu Xu, Senlin Peng, Ye Yuan, Wei Tang

“…Recently, RAB26 has received increasing attention in cancer research. However, the functional role of RAB26 in prostate cancer (PCa) remains to be elucidated. …”
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Plant tolerance to drought stress: Complexity and mechanism across physiological, molecular and biochemical scales by Asfa Batool, Dong-Xia Yue, Yun-Li Xiao, Shi-Sheng Li, Hai-Xia Duan, Zeeshan Haq, Khalil Ahmed, Ling Zhao, Li Zhu, Y.C. Xiong

“…However, drought stress during the generative phase might result in yield losses that are irreversible. …”
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Tumor vessel-adaptable adhesive and absorbable microspheres for sustainable transarterial chemoembolization therapy by Jiakun Guo, Jintao Huang, Zuliang Huang, Di Hu, Hujing Tan, Yan Wang, Chao Deng, Xiaoli Zhu, Zhiyuan Zhong

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Childhood abuse and health outcomes in patients with fibromyalgia: a cross-sectional exploratory study of the moderating effects of pain catastrophizing and mindfulness by Jolin B. Yamin, Samantha M. Meints, Bethany D. Pester, Madelyn Crago, Lauren Papianou, Asimina Lazaridou, Myrella Paschali, Vitaly Napadow, Robert R. Edwards

“…Objective This study investigated the impact of childhood abuse on pain-related symptoms and functioning in individuals with (FM) and examined how the critical psychosocial constructs of pain catastrophizing and mindfulness might moderate this relationship. …”
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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

“…Abstract The spatial proteomic profiling of complex tissues is essential for investigating cellular function in physiological and pathological states. …”
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Anogeissus leiocarpus (DC.) Guill. & Perr. extract-protected rats against CCl4-induced liver fibrosis by Omokolade O. Alejolowo, MSc, Olarewaju M. Oluba, PhD, Oluyomi S. Adeyemi, PhD

“…These findings indicate that the antifibrotic action of AL might involve the downregulation of α-SMA and TGF-β expression. …”
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Maternal asthma and newborn DNA methylation by Casper-Emil Tingskov Pedersen, Thanh T. Hoang, Jianping Jin, Anna Starnawska, Raquel Granell, Hannah R. Elliott, Anke Huels, Heather J. Zar, Dan J. Stein, Yining Zhang, Herman T. den Dekker, Liesbeth Duijts, Janine F. Felix, Júlia Sangüesa, Mariona Bustamante, Maribel Casas, Martine Vrijheid, Latha Kadalayil, Faisal I. Rezwan, Hasan Arshad, John W. Holloway, Stefan Röder, Ana C. Zenclussen, Gunda Herberth, Nicklas Heine Staunstrup, Henriette Thisted Horsdal, Jonathan Mill, Eilis Hannon, iPSYCH-MINERvA Group, Isabella Annesi-Maesano, Giancarlo Pesce, Nour Baïz, Barbara Heude, Sahra Hosseinian-Mohazzab, Carrie V. Breton, Sophia Harlid, Justin Harbs, Magnus Domellof, Christina West, Edwina Yeung, Xuehuo Zeng, Wenche Nystad, Siri E. Håberg, Maria C. Magnus, Diana Schendel, Stephanie J. London, Klaus Bønnelykke

“…These findings might shed light on underlying mechanisms for asthma susceptibility.…”
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Opportunities for <i>Helicobacter pylori</i> Eradication beyond Conventional Antibiotics by Camilia Metadea Aji Savitri, Kartika Afrida Fauzia, Ricky Indra Alfaray, Hafeza Aftab, Ari Fahrial Syam, Masrul Lubis, Yoshio Yamaoka, Muhammad Miftahussurur

“…As the search for new antibiotics lags behind the bacterium’s ability to mutate, studies have been directed toward finding new anti-<i>H. pylori</i> agents while also optimizing current drug functions. Targeting biofilm, repurposing outer membrane vesicles that were initially a virulence factor of the bacteria, phage therapy, probiotics, and the construction of nanoparticles might be able to complement or even be alternatives for <i>H. pylori</i> treatment. …”
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The Causal Relationship between Inflammatory Cytokines and Liver Cirrhosis in European Descent: A Bidirectional Two-Sample Mendelian Randomization Study and the First Conclusions by Shiya Shi, Yanjie Zhou, He Zhang, Yalan Zhu, Pengjun Jiang, Chengxia Xie, Tianyu Feng, Yuping Zeng, He He, Yao Luo, Jie Chen

“…Additionally, the progression of cirrhosis was associated with elevated levels of HGF, suggesting a possible role for liver repair functions.…”
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Emerging roles of intratumoral microbiota: a key to novel cancer therapies by Pengzhong Fang, Jing Yang, Jing Yang, Jing Yang, Huiyun Zhang, Huiyun Zhang, Huiyun Zhang, Diankui Shuai, Min Li, Lin Chen, Liping Liu

“…This review summarizes the latest advancements in this field, including techniques and methods for identifying and culturing intratumor microbiota, their potential sources, functions, and roles in the efficacy of immunotherapy. …”
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Characterization of Human Knee and Chin Adipose-Derived Stromal Cells by Magali Kouidhi, Phi Villageois, Carine M. Mounier, Corinne Ménigot, Yves Rival, David Piwnica, Jérôme Aubert, Bérengère Chignon-Sicard, Christian Dani

“…Animal study findings have revealed that individual fat depots are not functionally equivalent and have different embryonic origins depending on the anatomic location. …”
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