USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway by Shuo Fang, Zishuo Wang, Jianguo Xu, Miao Xu, Jiesong Zhou, Yuntong Zhang, Chunyu Xue

“…Moreover, USP37/SALL4 axis could increase the activity of PI3K/AKT pathway, and PI3K pathway inhibitor LY294002 abolished SALL4-mediated the promoting on keloid fibroblast functions. USP37-activated SALL4 might enhance keloid fibroblast growth, invasion, migration, ECM accumulation and glycolysis via activating PI3K/AKT pathway.…”
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Case Report: Treating Atrial Fibrillation with the Neubie Direct Current Electrical Stimulation by Ennis R, Husted C

“…Richard Ennis,1,2,* Cynthia Husted2,3,* 1Whidbey Island Rolfing, Freeland, WA, USA; 2Science and Spirit Institute, Greenbank, WA, USA; 3Integrative Functional Medicine, Freeland, WA, USA*These authors contributed equally to this workCorrespondence: Richard Ennis, Science and Spirit Institute, P.O. …”
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Climate change anxiety in the scientific community: an exploratory study with Chilean climate change-related scholars by Rodolfo Sapiains, Rodolfo Sapiains, Gabriela Azócar, Gabriela Azócar, Gonzalo Palomo-Vélez, Gonzalo Palomo-Vélez, Roberto Rondanelli, Roberto Rondanelli

“…However, high levels of self-reported ecoanxiety contrast with more moderate results when measuring ecoanxiety as a whole and in both subscales, cognitive-emotional and functional. Women, young people, and those who do not have children, express more emotional and functional impacts. …”
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DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER by G. M. Mkrtchyan, L. P. Hovhannisyan, A. A. Ayvazyan, E. Y. Nazaretyan, A. S. Boyajyan

“…From the data obtained, following conclusions have been made: 1) pathogenesis of FMF is characterized by a complement dysfunction, including hyperactivation of classical complement pathway and hypoactivation state of alternative pathway; 2) alterations in functional activities of classical and alternative complement activation pathways in FMF are interdependent; 3) the alternative pathway is suppressed on the initial stage of its activation; 4) high blood levels of C-reactive protein, serum amyloid P component, and circulating immune complexes, associated with FMF, might be responsible for hyperactivation of classical complement pathway in this disease.…”
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DATA MINING IN RELATIONAL SYSTEMS by Valentin Filatov, Valerii Semenets, Oleg Zolotukhin

“…To develop a method for evaluating a relational data model and a procedure for constructing functional associative rules when solving problems of mining relational databases. …”
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Boosting CO2 separation in porphyrinic MOF-based mixed matrix membranes via central metal atom integration by Nicholaus Prasetya, Hasan Can Gülbalkan, Seda Keskin, Christof Wöll

“…Further analysis on the gas transport reveals that such a performance improvement mainly comes from the enhanced CO2 solubility, which might be attributed to the presence of the metal atoms in the post-metalated MOF 525. …”
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Identification of diversity-generating retroelements in host-associated and environmental genomes: prevalence, diversity, and roles by Mariela Carrasco-Villanueva, Chaoxian Wang, Chaochun Wei

“…However, their existence, phylogenetic and structural diversity, and functions in a wide range of environments are largely unknown. …”
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Identification, characterization and expression analysis of the CDPK family in kelp Saccharina japonica by Minghui Sun, Zihan Gai, Xiufeng Zhou, Cailing Yi, Linan Zhang

“…Given its independent taxonomic position, brown algae CDPKs might exhibit unique structural and functional characteristics in ecological adaptation. …”
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Orientation reversal and the Chern-Simons natural boundary by Griffen Adams, Ovidiu Costin, Gerald V. Dunne, Sergei Gukov, Oğuz Öner

“…Our new resurgent perspective leads to a practical numerical algorithm that generates q-series which are dual to unary q-series composed of false theta functions. Until recently, these duals were only known in a limited number of cases, essentially based on Ramanujan’s mock theta functions, and the common belief was that the duals might not even exist in the general case. …”
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Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation by Joseph Dias, Puvan Tharmanathan, Catherine Arundel, Charlie Welch, Qi Wu, Paul Leighton, Maria Armaou, Belen Corbacho, Nick Johnson, Sophie James, John Cooke, Christopher Bainbridge, Michael Craigen, David Warwick, Samantha Brady, Lydia Flett, Judy Jones, Catherine Knowlson, Michelle Watson, Ada Keding, Catherine Hewitt, David Torgerson

“…This interferes with hand function and dexterity, impacting on quality of life. …”
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Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different process parameters by Nayiri M. Kaissarian, Stephanie L. Sandefur, Arnab Ghosh, Upendra K. Katneni, Wendy Walton, Christopher C. Frye, Anton A. Komar, Chava Kimchi‐Sarfaty

“…To investigate how changing mRNA sequence composition under different protein production parameters might affect the quality of recombinantly produced mAbs, we performed a comprehensive and systematic study assessing impact of synonymous gene recoding (commonly referred to as codon optimization) strategies in the context of varied cell culture parameters on product quality, biochemical and functional characteristics. …”
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ATP Is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro by Pablo J. Sáez, Kenji F. Shoji, Mauricio A. Retamal, Paloma A. Harcha, Gigliola Ramírez, Jean X. Jiang, Rommy von Bernhardi, Juan C. Sáez

“…Here, we studied the role of extracellular ATP and several cytokines as modulators of the functional state of microglial HCs and GJCs using dye uptake and dye coupling techniques, respectively. …”
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Carnosol attenuates Acinetobacter baumannii virulence by interfering with indole-mediated quorum sensing by Binbin Cui, Ganjin Peng, Mingfang Wang, Xiaohan Kong, Hanqi Wei, Xiwen Ling, Guangliang Wu, Yinyue Deng

“…Many bacterial pathogens utilize quorum sensing (QS) signals to modulate the biological functions in a cell density-dependent manner. Acinetobacter baumannii is a harmful pathogen and a major cause of hospital-acquired infections due to its severe drug-resistance and pathogenic nature. …”
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Does Speculation Matter in the Carbon Pricing Framework? Insights from the EU Emissions Trading System by Kazeem O. ISAH, Joy E. A. EBEH, Damilola ABOLUWODI, Monday ALIU, Salam S. MOHAMMED, Yusuf YAKUBU, Muhammad ALI

“…However, while the carbon allowances traded at the ETS are mostly held and traded by polluting companies, financial actors engage in “speculation”, activities that might be detrimental to the functioning of the ETS have also invested in the ETS. …”
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Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice by Ekaterina Veniaminova, Raymond Cespuglio, Chi Wai Cheung, Alexei Umriukhin, Nataliia Markova, Elena Shevtsova, Klaus-Peter Lesch, Daniel C. Anthony, Tatyana Strekalova

“…These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. …”
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Impact of Melatonin Application in Winemaking on Phenolic Content, Tryptophan Metabolites, and Bioactivity of Red Wine by Neda Đorđević, Nevena Todorović Vukotić, Ivana Perić, Otilija Keta, Vladana Petković, Snežana B. Pajović, Branislav Nastasijević

“…These findings offer promising avenue for future research of melatonin-driven functional properties of wine and provide step forward to a natural product with added value.…”
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Neuroprotective Effect of <i>Ixeris dentata</i> Extract on Trimethyltin-Induced Memory Impairment in Rats by Minsook Ye, Daehyuk Jang, Sun-young Lee, Kyu-Ri Kim, Sung Ja Rhie, Jin Kyung Oh, Insop Shim

“…These results suggest that ethanol extracts of ID might be useful for improving cognitive functions in neurodegenerative diseases such as Alzheimer’s disease.…”
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ALK5 i II Accelerates Induction of Adipose-Derived Stem Cells toward Schwann Cells through a Non-Smad Signaling Pathway by Seiji Sawai, Tsunao Kishida, Shin-ichiro Kotani, Shinji Tsuchida, Ryo Oda, Hiroyoshi Fujiwara, Kenji Takahashi, Osam Mazda, Yoshihiro Sowa

“…The procedure described here results in highly efficient induction of ADSCs into transgene-free and highly functional SCLCs. This approach might be applicable to regeneration therapy for peripheral nerve injury.…”
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Geobacter-associated prophages confer beneficial effect on dissimilatory reduction of Fe(III) oxides by Guiqin Yang, Annian Lin, Xian Wu, Canfen Lin, Siyue Zhu, Li Zhuang

“…Bioinformatic analysis predicted 185 phage-related genes in the G. soli genome, comprising functional prophages that were verified to be induced to form tailed phage particles. …”
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Regulator of G-Protein Signaling 5 Reduces HeyA8 Ovarian Cancer Cell Proliferation and Extends Survival in a Murine Tumor Model by Molly K. Altman, Duy T. Nguyen, Santosh B. Patel, Jada M. Fambrough, Aaron M. Beedle, William J. Hardman, Mandi M. Murph

“…Its other functional role is to promote apoptosis in hypoxic environments. …”
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